LOCUS       NM_172941               4074 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger with KRAB and SCAN domains 17 (Zkscan17),
            transcript variant 1, mRNA.
ACCESSION   NM_172941
VERSION     NM_172941.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4074)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4074)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4074)
  AUTHORS   Kahns,S., Losson,R. and Nielsen,A.L.
  TITLE     Nizp1 zinc finger protein localization is determined by SCAN-domain
            inclusion regulated through alternative splicing
  JOURNAL   Biochim Biophys Acta 1799 (8), 539-545 (2010)
   PUBMED   20538088
REFERENCE   5  (bases 1 to 4074)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 4074)
  AUTHORS   Mysliwiec,M.R., Kim,T.G. and Lee,Y.
  TITLE     Characterization of zinc finger protein 496 that interacts with
            Jumonji/Jarid2
  JOURNAL   FEBS Lett 581 (14), 2633-2640 (2007)
   PUBMED   17521633
REFERENCE   7  (bases 1 to 4074)
  AUTHORS   Nielsen,A.L., Jorgensen,P., Lerouge,T., Cervino,M., Chambon,P. and
            Losson,R.
  TITLE     Nizp1, a novel multitype zinc finger protein that interacts with
            the NSD1 histone lysine methyltransferase through a unique C2HR
            motif
  JOURNAL   Mol Cell Biol 24 (12), 5184-5196 (2004)
   PUBMED   15169884
  REMARK    GeneRIF: a novel NSD1-interacting protein(Nizp1)
REFERENCE   8  (bases 1 to 4074)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB528232.1, AK051711.1, CN530086.1 and BE988762.1.
            
            On Mar 21, 2014 this sequence version replaced NM_172941.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155490.1, AK171190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               CB528232.1         7-425
            420-853             AK051711.1         2-435
            854-1146            CN530086.1         254-546
            1147-3854           AK051711.1         436-3143
            3855-4074           BE988762.1         1-220               c
FEATURES             Location/Qualifiers
     source          1..4074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.72 cM"
     gene            1..4074
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /note="zinc finger with KRAB and SCAN domains 17"
                     /db_xref="GeneID:268417"
                     /db_xref="MGI:MGI:2679270"
     exon            1..477
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            478..612
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            613..719
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1146
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     CDS             757..2514
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 496; NSD1-interacting zinc finger protein
                     1; zinc finger protein with KRAB and SCAN domains 17"
                     /codon_start=1
                     /product="zinc finger protein 496 isoform 1"
                     /protein_id="NP_766529.3"
                     /db_xref="CCDS:CCDS24770.1"
                     /db_xref="GeneID:268417"
                     /db_xref="MGI:MGI:2679270"
                     /translation="MPTALCPRVLAPKESEEPRKMRSPPGENPSPQGEPPSPESSRRL
                     FRRFRYQEAAGPREALQRLWELCRGWLRLERHTKEQILELLVLEQFLAILPWEIQSWV
                     RAQEPESGEQAVAAVEALEREPGRPWQWLKHCEDPVVIDDGDGPAAPQDLEQERMSAE
                     SQSYPDAPPGALVQGTGLLSRSPGQPSEDLVPQDAFVVQEQSIRDAQPVATCQLPPNR
                     VSPFKDMILCFSEEDWSLLDPAQTGFYGEFIIGEDYAVSMPPNEPPVQPGHSHEEENG
                     LRVTEWTTDLQDKEIPQASCLDLSSLQPFQGEERRKWEELQVPELQPCPQVVLSQSPC
                     PAGGDPPALKSSLDQEVTIEIVLSSSGDEDSQHSPYCTEELRSPPEDLHSVPAHQSNA
                     SAEGEVQTSQKSYVCPNCGKIFRWRVNFIRHLRSRREQKPHKCSVCGELFSDSEDLDG
                     HLETHEAQKPYRCTACGKSFRLNSHLISHRRIHLQPASQQPMKKSEEEALETEGTGAS
                     DLLEKSKAKLSFQCGDCEKSFQRHDHLVRHRRHCHLKDETRPFQCRYCVKTFRQNYDL
                     LRHERLHMKRRSKQALNSY"
     exon            1147..1327
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1404
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1537
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1648
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1762
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..4060
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /note="hexamer: AATAAA"
     polyA_site      4060
                     /gene="Zkscan17"
                     /gene_synonym="Nizp1; Zfp496; Znf496"
                     /note="major polyA site"
ORIGIN      
        1 gatcccctta cacctcatcc ctcctcctcc caattctggc atttcgccag cgccgccaga
       61 ccagcccttc cctgcgccca cacaagagga gcagagaaga gcaaagcccc aagccggcct
      121 ccctggctgg tggccgcgcg aactggcccc cagcgcccgg gtcccgccgg ggcgcgcgcg
      181 cgcatcccga gcccgctagg aaggcccaca aagctaaagc ccgggccccg ggcccaggcc
      241 gggagagcac ggagcggggc ggggcggggc ggtccaggcg ggccgggggt gtcggatgtc
      301 acccccccgc gtacacctcg gccaggaggc ggggaagcga accactgaga tgaggagacc
      361 tcctcggtcc tagagcggtg caggaagtgt cccaggggag ggagccggag ggctccggcc
      421 tttcctttcc gcggcggccc ggcctacgcg gcccgccaac cgggacgctg cgcagcggcg
      481 tctcccttcg ctcccaagcc cagctgatgc attctagagg atcccgagac agggttggcc
      541 tggccaggga ccgagtctgg cccatgcatt ggagccgcct ctgccaaaac accagagaga
      601 ccgagctgga agttcaattt gtgaagacct caagaacaga gacggtgact tcgactccaa
      661 agcttcaaga ttgtggcctg ctggggctat tatcctccag gaggacctgt ccatcaaagg
      721 gtcgtcttct gccgctgacc cccatcaaat cccatcatgc ccacagccct gtgcccacga
      781 gtcttggctc caaaggaaag tgaggagccc aggaaaatga ggagtcctcc tggagagaac
      841 cccagccctc agggtgagcc tcccagccca gagtcctctc gacgcctctt ccgccgcttc
      901 cgctaccagg aggccgcagg ccctcgggag gccctgcagc gcctctggga gctgtgccgg
      961 ggctggctga ggctcgaaag gcacacgaag gagcagatcc tggagctact ggtgctggag
     1021 cagttcttgg ctatcctgcc gtgggagatc cagagctggg tgcgagccca ggagcctgag
     1081 agcggagagc aggctgtggc tgcagtagag gctctggaac gggagccagg gagaccctgg
     1141 cagtggctca agcactgtga agacccggtg gtgattgacg atggcgacgg gcctgctgcg
     1201 cctcaggacc tggaacaaga acgaatgtca gcagagtccc agagctaccc tgatgccccg
     1261 cctggggctc tagtacaggg cactgggctt ctaagcagat caccaggcca gcctagcgaa
     1321 gacttagttc cgcaagatgc gttcgttgtg caggagcaga gcatcaggga tgcccagccc
     1381 gtggccacct gccagcttcc cccgaaccga gtctccccat ttaaggacat gattttatgc
     1441 ttctcagaag aggactggtc ccttctggac ccggcacaga ctggtttcta tggcgaattc
     1501 atcattgggg aagactatgc agtctccatg cctccaaatg agcctccagt tcagccaggc
     1561 cactcccatg aagaggagaa cgggttgcgg gtcacagagt ggacgacaga cctccaggat
     1621 aaagaaatcc cccaggcctc ctgcttagac ctttccagcc tccagccatt ccaaggagaa
     1681 gaaagaagga agtgggagga gctgcaggtg ccagagctcc agccctgccc acaggtggtg
     1741 ctcagtcaga gtccctgtcc agcaggaggt gacccgccag ccctcaagag cagtctggac
     1801 caggaggtga ccatcgagat cgtgctgtcc agctctgggg atgaggactc ccagcacagc
     1861 ccatactgca cagaggagct gaggagccct ccagaagacc tgcacagtgt cccagcccac
     1921 cagagcaacg ctagtgctga gggggaggtg caaacctcac agaaatctta cgtgtgccca
     1981 aactgtggaa agatcttccg ctggagggtc aacttcatcc ggcacctgcg cagccgcagg
     2041 gagcagaagc cacacaaatg ctcagtgtgc ggggagttat tcagtgacag cgaggacctg
     2101 gatggtcacc tagagaccca cgaggcccag aagccctaca ggtgcactgc ctgcgggaag
     2161 agcttccgcc tcaactcaca cctcatctct caccgccgga tccacctgca gccagccagc
     2221 cagcagccca tgaagaagag tgaggaagaa gctctggaaa cagagggcac gggtgccagc
     2281 gacctgctgg agaagagcaa agccaagctg agcttccagt gtggggactg tgagaagagc
     2341 ttccagcggc atgaccatct ggtgagacac cgtagacact gtcatctaaa ggatgagacc
     2401 cgtcccttcc agtgtcggta ctgtgtcaaa actttccgac agaattatga cctcctccgc
     2461 catgagcgcc tgcacatgaa gcgacgctcc aagcaggctc tcaactcata ctgagcaggg
     2521 tgtggcccca caagccagcc cctgccccag cacagaaccc tcaccacctg ccctttgctc
     2581 tcaggtagtg tctaacttct ggtgccatgc ctcttgctcc ccagataaaa agcagtcccc
     2641 tgcgcattcc ttctactgtg ccaaaaccca gggaggtgat ccaacctcaa gacctgcatc
     2701 tctggatctt cagccacttg ctctggccct cagtggggct gggctacccc catcccagtg
     2761 gtgtctaggg atggggtgaa tacagtaggg agctggccaa aagcctgcac tgacgtctcc
     2821 tcagaagtca gcctgggttt agtcagggtg tcagccaggg gagcatccca cagatccacc
     2881 gacggccagg ccactggcca tcaggaggtc acattttgaa agttaatgaa tttatcccca
     2941 catcttcttt gtgccccaag acccttcaga aatgtgtgct ggaagttgcc tgtcaccact
     3001 cacattcctt cccgtcctgt ctaggagctg agagccaggc cctcaaggct cttctgggca
     3061 agccctgccc tggaacagaa gcttctgtga agtcgtcctt catgggtaga gattccaagg
     3121 catttattta gcttcctagc gctgtcgtca ctagtactaa acataggctc ttctaacagc
     3181 acacagcatt gtcacagtta tggaatttgc aaagctaggt ccggtgtcag tgggctggtt
     3241 ctttccgagg ctagaagggg gaatgaatca ttctgggcct gatggtcact gacacttgtc
     3301 tgtccccggg gacttgtaca accatctctc catctttgcc ttcatctccg ctgtgtcagt
     3361 ctccaagctt accttttata caaggatccc agtcttgggt tggggctcac cctgtctact
     3421 gtagcagagc cccaccttca tctggagtgg ccatttccaa atacagtcac atcctgaggt
     3481 actaggagtc aggacctcaa cactggggtt tgagtggaca tagccacaac tccagttaat
     3541 cccatggtgc tgttgctgtt cctgcctcag atgaaccaat gcaaccttga ggcagccatt
     3601 cctttgaatg ttgagctcag ttgtctgctt tcagggctgc tgtcctctgc cagggagaat
     3661 cttcatccat ggcctttaag ttcagagcct gagagtctgg gagttgttgt tgctaggaaa
     3721 cctcaagcaa ccaaacacgt ggtcccacac tgccctggca cactggtgtt ggccaggctc
     3781 agtgtggctg tgactggacc tgagagctgc aggcagccag tgggctgtaa cggctctcag
     3841 cagataggag gtttgggaaa tgagttcaag gcctctggtg ctctctgtcc tgattttcac
     3901 atgaagaagc ctctagtcca gacccaatca aagactctta agactttgga acagagtttc
     3961 tttttctgct cagtgcatca cccagaaata gtaaatgcaa taaaaccatt tggtcacacc
     4021 ttggagaaga aataaactgt ggaagctctt agtttctaaa aaaaaaaaaa aaaa
//
