LOCUS       NM_022987               2383 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus zinc finger protein of the cerebellum 5 (Zic5), mRNA.
ACCESSION   NM_022987 XM_981274
VERSION     NM_022987.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Thawani,A., Maunsell,H.R., Zhang,H., Ankamreddy,H. and Groves,A.K.
  TITLE     The Foxi3 transcription factor is necessary for the fate
            restriction of placodal lineages at the neural plate border
  JOURNAL   Development 150 (19) (2023)
   PUBMED   37756587
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Li,T., Zhang,G., Li,W., Xiao,J., Zhou,Z., Tan,G. and Ai,J.
  TITLE     MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell
            proliferation and cisplatin resistance through ZIC5 down-regulation
            by targeting SOX2
  JOURNAL   Biol Chem 404 (10), 961-975 (2023)
   PUBMED   36752150
  REMARK    GeneRIF: MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell
            proliferation and cisplatin resistance through ZIC5 down-regulation
            by targeting SOX2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Furushima,K., Murata,T., Kiyonari,H. and Aizawa,S.
  TITLE     Characterization of Opr deficiency in mouse brain: subtle defects
            in dorsomedial telencephalon and medioventral forebrain
  JOURNAL   Dev Dyn 232 (4), 1056-1061 (2005)
   PUBMED   15736266
REFERENCE   7  (bases 1 to 2383)
  AUTHORS   Ishiguro,A., Inoue,T., Mikoshiba,K. and Aruga,J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
  REMARK    GeneRIF: Results describe the molecular properties of Zic4 and Zic5
            proteins.
REFERENCE   8  (bases 1 to 2383)
  AUTHORS   Inoue,T., Hatayama,M., Tohmonda,T., Itohara,S., Aruga,J. and
            Mikoshiba,K.
  TITLE     Mouse Zic5 deficiency results in neural tube defects and hypoplasia
            of cephalic neural crest derivatives
  JOURNAL   Dev Biol 270 (1), 146-162 (2004)
   PUBMED   15136147
  REMARK    GeneRIF: findings suggested that Zic5 is involved in the generation
            of neural crest tissue in mouse development
REFERENCE   9  (bases 1 to 2383)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   10 (bases 1 to 2383)
  AUTHORS   Furushima,K., Murata,T., Matsuo,I. and Aizawa,S.
  TITLE     A new murine zinc finger gene, Opr
  JOURNAL   Mech Dev 98 (1-2), 161-164 (2000)
   PUBMED   11044622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154683.2.
            
            On Jun 27, 2009 this sequence version replaced NM_022987.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042155.1, AB114214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1767              AC154683.2         27597-29363
            1768-2383           AC154683.2         33480-34095
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.96 cM"
     gene            1..2383
                     /gene="Zic5"
                     /gene_synonym="1700049L20Rik; Opr"
                     /note="zinc finger protein of the cerebellum 5"
                     /db_xref="GeneID:65100"
                     /db_xref="MGI:MGI:1929518"
     exon            1..1767
                     /gene="Zic5"
                     /gene_synonym="1700049L20Rik; Opr"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2210
                     /gene="Zic5"
                     /gene_synonym="1700049L20Rik; Opr"
                     /note="Zic family member 5 (odd-paired homolog,
                     Drosophila); odd-paired related; opa-related protein; odd
                     paired-related protein"
                     /codon_start=1
                     /product="zinc finger protein ZIC 5"
                     /protein_id="NP_075363.1"
                     /db_xref="CCDS:CCDS27348.1"
                     /db_xref="GeneID:65100"
                     /db_xref="MGI:MGI:1929518"
                     /translation="MMEPPLSKRNPPALRLADLATAQAQQLQNMTGFPVLVGPPAHSQ
                     RRAVAMHLHPRDLGTDPGVASTALGPEHMAQASGQGPCPPSQGLPGLSQVPAPAARSV
                     ASGTHPGARTHPDGGGSSGAQASAPPPPAPPLPPSQSSSPPPPPPPPPALSGYTATNS
                     GGGSSSGKGHSRDFVLRRDLSATAPAAAMHGAPLGGEQRSGSSSPQHPTPPPHPAGMF
                     ISASGTYAGRDGGGSALFPALHDSPGAPGGHPLNGQMRLGLAAAAAAAAELYGRAEPP
                     FAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAAGPGPHLQHHAPPPAP
                     PPAPAPHPHHPHLPGAAGAFLRYMRQPIKRELICKWLDPEELAGPPASADSGVKPCSK
                     TFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPF
                     PCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDK
                     PYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGALGYSSVGTPVGDPLSPVLDPTR
                     SRSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSESEDEEMYGNPEVMRTIH"
     exon            1768..2383
                     /gene="Zic5"
                     /gene_synonym="1700049L20Rik; Opr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggggcacg aagtgaaagc acaggcggtg tggtacacgg gggcggtttc ccgctgggcc
       61 cagagcctga accagagcca atcgcgcagc cgaggcagct gccaatcaca cggctccctc
      121 caatcccacc cgtgccattt ccaaaaactc ggtcccactg tgcagctcaa atgtggtgtt
      181 cactctgcca atcgctggag gatagagtgg ggacaagaat aagcagctag gaggcccgga
      241 cacaagaagt taaagagccc ctaatatata catgtttttg aaggcgggca gagggggaaa
      301 aagtcccccc agtgagggtc catgggcctg attgtatagt tatgatggag ccccctttga
      361 gcaagaggaa cccgccagcg ctgagattag cggatttggc aacggctcag gcccaacagc
      421 ttcagaatat gacaggcttc ccggtgctgg tcggcccgcc cgcccactcc caacgccgcg
      481 cggtcgccat gcacctccac ccgcgggacc taggcactga ccccggcgta gccagcactg
      541 cgctcggacc cgagcacatg gcacaggcca gcgggcaggg cccctgtcct ccttcccagg
      601 ggctccccgg gctgtcccag gttcccgcac cagccgcccg ctccgtggcc tcagggactc
      661 acccaggcgc ccgcacccac cccgacggcg ggggcagcag tggcgcgcag gcctcggcgc
      721 ccccgcctcc agcccctcct cttcctccct cccagtcctc ctctccccct cccccgcctc
      781 ctcctcctcc tgccctctcg ggctacactg ccaccaacag tggcggcggc agcagcagcg
      841 gcaaaggcca cagcagggac ttcgtcctcc ggagggacct ttccgccacg gcccccgcgg
      901 cggccatgca cggggccccg ctcggagggg agcagcggtc cggcagcagc tccccccagc
      961 acccgacccc acctccccac ccggccggga tgttcatctc ggccagcggc acctacgcgg
     1021 gccgggacgg cggcggctcc gcgctctttc ccgcgctgca cgactctccc ggggctcccg
     1081 gtggccaccc gctaaacggc cagatgcgcc ttgggctggc ggccgccgcg gcggctgcgg
     1141 ccgagcttta cggccgcgcc gaaccaccct tcgctccgcg ctcaggggac gcgcactatg
     1201 gggcggtggc ggccgccgcg gccgccgccc tgcacggcta cggagccgtg aacttaaacc
     1261 tgaacctggc tgcggcagcg gcggccgcag cggccgcggg gcccgggccc cacctgcaac
     1321 accacgcgcc gcccccggcg ccaccgccgg cgcccgcgcc gcacccgcac cacccccacc
     1381 tcccgggggc ggccggggcc ttcctgcgct acatgcggca gccaatcaag cgggagctca
     1441 tctgcaagtg gctggaccca gaggagctgg ccggtccgcc ggcgtccgcg gacagcggcg
     1501 tcaagccctg ctccaaaact ttcggcacca tgcacgagct ggtgaaccac gtcacagtgg
     1561 agcacgtggg cggcccggaa cagagcagcc acgtctgctt ttgggaggac tgtccgcgcg
     1621 agggcaagcc cttcaaggcc aagtacaagc tcatcaacca catccgcgtg cacaccggcg
     1681 agaagccctt cccctgcccg ttcccgggct gcggcaaggt cttcgcgcgc tccgagaacc
     1741 tcaagatcca caagcgcact catacagggg aaaagccttt caaatgtgaa tttgacggtt
     1801 gtgataggaa gtttgccaat agcagcgatc gaaagaaaca ctcccatgtc cacaccagcg
     1861 acaagcccta ctactgtaag attcgaggct gtgataaatc gtacacccac ccaagctctc
     1921 tgaggaagca catgaagatt cactgcaagt cccccccacc ttcgcctgga gctcttggct
     1981 actcgtcggt ggggactccc gtgggtgacc ctttgtcccc tgtgctggac ccaaccagga
     2041 gtcgatccag cactctgtcc cctcaggtga ccaacctcaa tgagtggtat gtttgccagg
     2101 ccagtggggc ccccagccat ctccacacac cttccagcaa tggaaccacc tctgagtctg
     2161 aagatgagga aatgtatggg aaccctgaag tcatgcggac gatacattag aattattatt
     2221 aataagtgag gtagtaagtg gcagtccttg gaccatgtcc taacctgaaa caatgctgag
     2281 cctgagacaa actggtgact cagacttgcc accgggtcta attagcccta tttattcagt
     2341 atgaaaccct atggtgtttg tacatttaat taatttaatt aag
//
