LOCUS       NM_001374749            4564 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus zinc finger protein of the cerebellum 4 (Zic4),
            transcript variant 1, mRNA.
ACCESSION   NM_001374749 XM_011242727
VERSION     NM_001374749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4564)
  AUTHORS   Chen,Z., Snetkova,V., Bower,G., Jacinto,S., Clock,B., Dizehchi,A.,
            Barozzi,I., Mannion,B.J., Alcaina-Caro,A., Lopez-Rios,J.,
            Dickel,D.E., Visel,A., Pennacchio,L.A. and Kvon,E.Z.
  TITLE     Increased enhancer-promoter interactions during developmental
            enhancer activation in mammals
  JOURNAL   Nat Genet 56 (4), 675-685 (2024)
   PUBMED   38509385
REFERENCE   2  (bases 1 to 4564)
  AUTHORS   Ahmed,N.Y., Knowles,R., Liu,L., Yan,Y., Li,X., Schumann,U.,
            Wang,Y., Sontani,Y., Reynolds,N., Natoli,R., Wen,J., Del Pino,I.,
            Mi,D. and Dehorter,N.
  TITLE     Developmental deficits of MGE-derived interneurons in the Cntnap2
            knockout mouse model of autism spectrum disorder
  JOURNAL   Front Cell Dev Biol 11, 1112062 (2023)
   PUBMED   36819097
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4564)
  AUTHORS   Honda,M., Oki,S., Kimura,R., Harada,A., Maehara,K., Tanaka,K.,
            Meno,C. and Ohkawa,Y.
  TITLE     High-depth spatial transcriptome analysis by photo-isolation
            chemistry
  JOURNAL   Nat Commun 12 (1), 4416 (2021)
   PUBMED   34285220
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4564)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   5  (bases 1 to 4564)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   6  (bases 1 to 4564)
  AUTHORS   Ishiguro,A., Inoue,T., Mikoshiba,K. and Aruga,J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
  REMARK    GeneRIF: Results describe the molecular properties of Zic4 and Zic5
            proteins.
REFERENCE   7  (bases 1 to 4564)
  AUTHORS   Grinberg,I., Northrup,H., Ardinger,H., Prasad,C., Dobyns,W.B. and
            Millen,K.J.
  TITLE     Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved
            in Dandy-Walker malformation
  JOURNAL   Nat Genet 36 (10), 1053-1055 (2004)
   PUBMED   15338008
REFERENCE   8  (bases 1 to 4564)
  AUTHORS   Ding,Y.Q., Yin,J., Kania,A., Zhao,Z.Q., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b controls the differentiation and migration of the superficial
            dorsal horn neurons of the spinal cord
  JOURNAL   Development 131 (15), 3693-3703 (2004)
   PUBMED   15229182
  REMARK    Erratum:[Development. 2009 Jun;136(11):1961]
REFERENCE   9  (bases 1 to 4564)
  AUTHORS   Cho,K.I., Lee,J.W., Kim,K.S., Lee,E.J., Suh,J.G., Lee,H.J.,
            Kim,H.T., Hong,S.H., Chung,W.H., Chang,K.T., Hyun,B.H., Oh,Y.S. and
            Ryoo,Z.Y.
  TITLE     Fine mapping of the circling (cir) gene on the distal portion of
            mouse chromosome 9
  JOURNAL   Comp Med 53 (6), 642-648 (2003)
   PUBMED   14727813
REFERENCE   10 (bases 1 to 4564)
  AUTHORS   Aruga,J., Yozu,A., Hayashizaki,Y., Okazaki,Y., Chapman,V.M. and
            Mikoshiba,K.
  TITLE     Identification and characterization of Zic4, a new member of the
            mouse Zic gene family
  JOURNAL   Gene 172 (2), 291-294 (1996)
   PUBMED   8682319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116582.3.
            
            On Oct 11, 2019 this sequence version replaced XM_011242727.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028305.1, AK035908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1431              AC116582.3         139277-140707
            1432-1747           AC116582.3         145319-145634
            1748-4564           AC116582.3         147840-150656
FEATURES             Location/Qualifiers
     source          1..4564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 48.26 cM"
     gene            1..4564
                     /gene="Zic4"
                     /note="zinc finger protein of the cerebellum 4"
                     /db_xref="GeneID:22774"
                     /db_xref="MGI:MGI:107201"
     exon            1..1431
                     /gene="Zic4"
                     /inference="alignment:Splign:2.1.0"
     CDS             723..1748
                     /gene="Zic4"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein ZIC 4; Zic family member 4 (odd-paired
                     homolog, Drosophila)"
                     /codon_start=1
                     /product="zinc finger protein ZIC 4 isoform 1"
                     /protein_id="NP_001361678.1"
                     /db_xref="CCDS:CCDS90639.1"
                     /db_xref="GeneID:22774"
                     /db_xref="MGI:MGI:107201"
                     /translation="MRLGRVCPRGPGKVRSPRHRFSCTLFVSTTGSSCGHHGPQLAAS
                     SNPSVLPGLHEQPPQASHSRPLNGLLRLGIPGDMYARSEPFAPGPMARSDTLATATAL
                     HGYGGMNLTMNLTAPHGPGAFFRYMRQPIKQELICKWLGDDSPMSPRPCSKTFSTMHE
                     LVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGC
                     GKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYMCKVR
                     GCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSAITSALASPSLESGREPSVACSAAVVV
                     RGTDVSE"
     exon            1432..1747
                     /gene="Zic4"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..4564
                     /gene="Zic4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4468..4473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zic4"
                     /note="hexamer: AATAAT"
     polyA_site      4489
                     /gene="Zic4"
                     /note="major polyA site"
     regulatory      4530..4535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zic4"
                     /note="hexamer: AATAAA"
     polyA_site      4564
                     /gene="Zic4"
ORIGIN      
        1 atttccttaa gcgttcagcc gccgcctctg tagtgcccgg ggtttcacac ggacattaaa
       61 gactgagaaa acagaaagga ggagggggca aaccccaaac ttaaaaaaca aacaaacaaa
      121 caatctccgc cactttgcat aagtttctct ctctctctct ctctctctct ctctctctct
      181 ctctctctct ctctctctct gtctcctctc tctctcctct ctctctcttc ccttttcgtc
      241 tttatcggtt gtcctttctt tgcactatca cactgcagta gcattggtgg ctgccagacc
      301 gaggtgcagc aggcggtcct ttccgggccc agtgggacat tgaaattatt atatacacgt
      361 ctaggacgct ttaaaatcac tacctcttcc aacttcacca cctccgaaat gacccctcct
      421 atcatctcca tctttggctt gggagcaccc cttggtgttg gtggacaaag taatctggag
      481 ataagggtct tacacctctg cagcagaggc cgtgccccca ggcacccaca gactcagccc
      541 tgctgccttt cccacctacc ccattatcgc tacccctttc cagcgcatgg cgcggcaggg
      601 gattcggcag aactgcagcc cagccggacg aaggcggagg ctttttgact ttgcttggtc
      661 tgccagcttc actgctggca ccgaccggct caagatccca gcaccgactg ccagaaacct
      721 agatgcggct gggcagagtg tgtccccggg gtccggggaa agtgcgaagc ccacgccacc
      781 gcttctcatg cacgttattt gtctcgacaa caggtagcag ctgtggacac catgggcccc
      841 agctcgccgc ttcttcgaac ccctccgtgc ttccgggcct tcacgagcag cctcctcagg
      901 cctcccacag ccgtcctttg aacggactcc tgcgtctggg gatccctgga gacatgtatg
      961 cgaggtcgga accttttgca ccagggccta tggcccgcag cgacactctg gcaacagcca
     1021 cagccctgca cggttatggc ggcatgaacc tgaccatgaa cctcaccgca ccccatggcc
     1081 ctggagcctt tttccgctat atgcgccagc ccatcaaaca ggagctcatc tgcaagtggc
     1141 taggggatga cagcccgatg tccccgcgtc cctgctccaa aactttcagc accatgcacg
     1201 agctggtcac gcacgtcact gtggagcacg tcggtggccc agagcaggct aaccacattt
     1261 gcttctggga ggagtgtccg cgacagggca agcccttcaa agccaaatac aaacttgtaa
     1321 atcacatccg cgtgcacacg ggcgagaagc ccttcccttg tcctttccca gggtgtggga
     1381 aggtctttgc tagatcagaa aatctcaaaa tacacaaacg aacacataca ggcgagaaac
     1441 ctttcagatg tgagttcgag ggctgtgaga ggcgtttcgc caacagcagc gaccgcaaga
     1501 aacattcgca cgtgcacacg agcgacaagc cttatatgtg caaggtgcgc gggtgtgaca
     1561 agtgttacac gcaccccagc tctctgcgaa agcacatgaa agttcatggt cgctcaccgc
     1621 cacccagctc tggctacgac tcggctataa cgtctgctct cgcgtcgccc tcgttagaaa
     1681 gcggccgtga gccctcagtg gcttgctctg cggcggtggt tgtgcgtggc acagacgtga
     1741 gcgaatgatg ttgcttgcaa ggtaatcttg ccctgcgcag ctgagcgccc gcatcttgcg
     1801 cctgcgacat caaagggctc tctcacaaag cagtgtttct tcgccacggt gcatcttcat
     1861 ggtaagttag gatttctatg gcaatgggca agtctcactg aaatcctgaa aggccgatcc
     1921 tggagcccgt ccaggctttt cattaaggac ataatattta cgtctaacag gccttttttc
     1981 ttgtgtatac aagtatatat ttttgtttga cgcggactaa atcattttca tttaatttcc
     2041 ggtaaacaaa acccacgcga atgggcactt gttcccgatc ataataaaaa tggataataa
     2101 tgcgagggaa gaaaagggcc gcttgaatcg ccgctcagct ctctttgttt ctgctttctg
     2161 cggtgatcag agggcgtatt tgggtttgat ggcgagtttc taaaggcgag gaaatggttt
     2221 gtaagaggga aaagaaaagg agaaaggtcc aatcaagctc gggttgttca aagagtcgcg
     2281 ttttggggtt gaaagtgtga gtttgacggt gcatcagcat gccgcgttag gctcgccatg
     2341 gaaatgcgcg cggggagcgg ccgcttcaaa ggcggcacac ttcactgcgg acactctatt
     2401 aagatacatt tgcgctgacc tttgctttca cgccatttaa tactgtcact gtgctctcca
     2461 gtatatactt cctcccagga cctgtcttgc cagtgtttag gggttcacta tacatcctaa
     2521 tgtagcgggc tttggcaccc gggattcttt caagaaaggg aggaggaacc ggacccgaac
     2581 atcttgacag cgcccatagg ctccagagtc agagtaaatg actagggcat cctgagaagc
     2641 ttaccaaggg agcatcccca gttgagttgt gtgcaacaga atgaggattt aagacgaagg
     2701 tggccaactt gggggaagta tgggaactgt taactatgcc tcggggacag ttagtttccc
     2761 tgtgttcccc agaggtgcca tactgcttcc taaccctaga agtctctcag ccccttaagc
     2821 ttttcctctg acgtgccact gtgtggtatc cttaggtctg ggctggcttt tgggtacaaa
     2881 ctgaaaagcc caaggccaag gggatgggga agatggcagc aaagttagaa gtccatgttc
     2941 ccttaattgt cttgttgttt attttatcca agtaccctag tgaatagggg aaaaataaac
     3001 acggtggaaa aaaatcaaac agtagagtct tctttagtgc ccgtccttgt ggttgaataa
     3061 aaaggatggt ctgccttcta ttgagctgag aaatctttga agtgggagtt attatctgag
     3121 acattcctgc ttgtcgtcct aacaacgctg gtgaaatgta aaaggttctt tgtcagcgat
     3181 ttgttctcct ctctgtcaaa ctcactttgc cccattggtt ccaaaccatt gctaaagaga
     3241 taaaatcaaa tttctttaaa aagaaaaaga agaagaagag aagaaaagaa aagaaaaaag
     3301 acccctacac tccaccagta gataacttta ggaataagtt ttgctatgag ggaccctccc
     3361 tcccccaaag caacaaaaaa aaaaaaaaaa aaaacaaagc aaaacaaaac ccacaaaacc
     3421 attgtgtagt ttcagtcctg gtgatgtgtg tagatgtggg aaggccgttt gcacaaacac
     3481 tggtacttta ggtaatgcaa gaaggaaaga ggtagagggt gagtgtacca agtcgatgct
     3541 ctggatggtc ctgtgaccgt gcattctgtc cttgcctgca tcccatccac ccagatttac
     3601 taactggatg aattttgctg gagatcactt cagctccaaa tagtcccact tgggatattt
     3661 ggaacttaag cctgaataca ggtaatgtta aagctttccc cttttccaag aaacttctgg
     3721 tataaataga tccactgtgt ttcctaacca ttagcagcaa tcagcacacc gtttctgtca
     3781 tttaatctaa aggatggtag cataagggag agaaacattt taatatcccc cccccttttt
     3841 tttcctaatc atcttggagt tcagaaggtt tggtttacat gatagtgggg aaaaaatgca
     3901 tgcacgtgcc tcctccctcc ctatgtgcac ttcttcattt tatagtgtgc ctagaatgga
     3961 aactttgccc ctggtcaggt tttctagacc tcctattgta gttttaaagg tgatgaaaat
     4021 agataaggat gttcccatca ccctgctccc tgtgcttact aaatgatttg tgaagaactg
     4081 tccccaagtt gtaacccatg tactccctta gagttgctgc aaaatgtctc ttatattgat
     4141 gttgtttgtt tacctgactc tccatatgtc tgtttgtatt gccaatttat ggggaaaatg
     4201 taatgattgc aatgaaagtg aattatacat ccaggcagat ctcttatagt cataactgac
     4261 ataaacacaa gtctgagtca actgtaagat tattcgtacc ttgtctagct acactgtgat
     4321 tttaaaatct ttccccttaa cagcagttaa gttatgaact aatttgaagg ggaaaaaagt
     4381 tgttgtgtat atttgtcagt ggttgttgaa taaagttcaa agctgaggca taatctcctt
     4441 gaaaacatgt acctgtgagt taaataaaat aatttttctc cctccaaaac actctggatg
     4501 tgtagcttct ttttgctgtg ttatttggaa ataaaggatt tgatgttttc tttcctcctt
     4561 ggaa
//
