LOCUS       NM_009575               4035 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein of the cerebellum 3 (Zic3), mRNA.
ACCESSION   NM_009575
VERSION     NM_009575.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Gao,J., Liu,L., Wu,Z. and Gan,H.
  TITLE     Zic family member 3 attenuates oxidative stress-induced vascular
            smooth muscle cell apoptosis in patients with chronic kidney
            disease
  JOURNAL   Tissue Cell 86, 102286 (2024)
   PUBMED   38091851
  REMARK    GeneRIF: Zic family member 3 attenuates oxidative stress-induced
            vascular smooth muscle cell apoptosis in patients with chronic
            kidney disease.
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Lin,X., Swedlund,B., Ton,M.N., Ghazanfar,S., Guibentif,C.,
            Paulissen,C., Baudelet,E., Plaindoux,E., Achouri,Y., Calonne,E.,
            Dubois,C., Mansfield,W., Zaffran,S., Marioni,J.C., Fuks,F.,
            Gottgens,B., Lescroart,F. and Blanpain,C.
  TITLE     Mesp1 controls the chromatin and enhancer landscapes essential for
            spatiotemporal patterning of early cardiovascular progenitors
  JOURNAL   Nat Cell Biol 24 (7), 1114-1128 (2022)
   PUBMED   35817961
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Bellchambers,H.M. and Ware,S.M.
  TITLE     Loss of Zic3 impairs planar cell polarity leading to abnormal
            left-right signaling, heart defects and neural tube defects
  JOURNAL   Hum Mol Genet 30 (24), 2402-2415 (2021)
   PUBMED   34274973
  REMARK    GeneRIF: Loss of Zic3 impairs planar cell polarity leading to
            abnormal left-right signaling, heart defects and neural tube
            defects.
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Bellchambers,H.M., Barratt,K.S., Diamand,K.E.M. and Arkell,R.M.
  TITLE     SUMOylation Potentiates ZIC Protein Activity to Influence Murine
            Neural Crest Cell Specification
  JOURNAL   Int J Mol Sci 22 (19), 10437 (2021)
   PUBMED   34638777
  REMARK    GeneRIF: SUMOylation Potentiates ZIC Protein Activity to Influence
            Murine Neural Crest Cell Specification.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Lusis,A.J. and West,J.D.
  TITLE     X-linked and autosomal genes controlling mouse alpha-galactosidase
            expression
  JOURNAL   Genetics 88 (2), 327-342 (1978)
   PUBMED   205481
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Eicher,E.M., Southard,J.L., Scriver,C.R. and Glorieux,F.H.
  TITLE     Hypophosphatemia: mouse model for human familial hypophosphatemic
            (vitamin D-resistant) rickets
  JOURNAL   Proc Natl Acad Sci U S A 73 (12), 4667-4671 (1976)
   PUBMED   188049
REFERENCE   8  (bases 1 to 4035)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
REFERENCE   9  (bases 1 to 4035)
  AUTHORS   Huijing,F., Eicher,E.M. and Coleman,D.L.
  TITLE     Location of phosphorylase kinase (Phk) in the mouse X chromosome
  JOURNAL   Biochem Genet 9 (2), 193-196 (1973)
   PUBMED   4726088
REFERENCE   10 (bases 1 to 4035)
  AUTHORS   Lyon,M.F.
  TITLE     Order of loci on the X-chromosome of the mouse
  JOURNAL   Genet Res 7 (1), 130-133 (1966)
   PUBMED   5948402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954389.5 and AK134355.1.
            
            On Nov 3, 2006 this sequence version replaced NM_009575.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134355.1, SRR7652917.1020167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-664               AL954389.5         14562-15225
            665-3343            AK134355.1         284-2962
            3344-4035           AL954389.5         19873-20564
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 32.56 cM"
     gene            1..4035
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /note="zinc finger protein of the cerebellum 3"
                     /db_xref="GeneID:22773"
                     /db_xref="MGI:MGI:106676"
     exon            1..1610
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..1954
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /note="Zic family member 3 (odd-paired homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="zinc finger protein ZIC 3"
                     /protein_id="NP_033601.2"
                     /db_xref="CCDS:CCDS30155.1"
                     /db_xref="GeneID:22773"
                     /db_xref="MGI:MGI:106676"
                     /translation="MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDST
                     HAAAAAAAAAAFKLSPATAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHASQVPT
                     YGGAASAAFNSTRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLL
                     FPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAASAQFPNY
                     SPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIEEAQLSRPKKSCDRTFSTMHE
                     LVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGC
                     GKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVC
                     DKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTS
                     TSHNPGLPPNFNEWYV"
     exon            1611..1774
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..4035
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3942..3947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /note="hexamer: AATAAA"
     polyA_site      3963
                     /gene="Zic3"
                     /gene_synonym="Bn; Ka"
                     /note="major polyA site"
ORIGIN      
        1 atcagtccaa ggacattact ctggaggtga agaggcttgg actcgcgaag cgagcagtga
       61 ggttcgagcc tgcttactgc aggctgcctg ccctctggcc acgttccgcc tctgcttctt
      121 ggtgcagttg ctcctgaaag ccgggacccg aggagcctct ggccccgtgg ttccgcgctc
      181 ttgagtagag gaggggtgtc cgggacagga ttgacaaacc ccgccctcca cttattattt
      241 tgcttatttt tctttgtgcg ctcctgttag tttgttaagc agatttagtc ctagagtctt
      301 ttctcctccc ttctcctccc tcctcctctc ccatcgccct ccccccaatc ctttttcttc
      361 ccctcctccc tcccgtccct ctgcaggaga ctctcgcagc ctaggaaagt tgcagctccg
      421 ggtagcgcct agggggtctc caggcagtgt tcaaccgccg ccatcccttt ccgactacgg
      481 cccttcaggg atctccttcg cctgcaccct tgctcacttc ggccggatct tctgtgtcca
      541 gaacacccta cctatgacga tgctcctgga cggaggcccg cagttccctg ggttgggagt
      601 gggcagcttc ggtgctccgc gccaccacga gatgcccaac cgcgagcctg caggcatggg
      661 attgaatccc ttcggggact caacccacgc tgcggccgcc gccgctgccg ccgctgcctt
      721 caagctgagc ccagccaccg ctcacgatct gtcttcgggc cagagctcag cgttcacacc
      781 gcagggttca ggttatgcca atgccctggg ccaccatcac caccaccatc accaccatca
      841 cgccagccag gtgcccacct acggcggcgc tgcctccgcc gctttcaact ccacgcgcga
      901 ctttctgttc cgtcagcgcg gttctgggct cagcgaggca gcctccgggg gcgggcagca
      961 cgggcttttc gctggctcgg cgagcagtct tcacgctcca gctggtattc ctgagcctcc
     1021 tagctacttg ctctttcctg ggcttcatga gcagggcgct gggcacccgt cgcccacagg
     1081 gcacgtggac aacaaccagg tccatctggg gctgcgcggg gagctatttg gccgtgcaga
     1141 cccataccgc cccgtggcta gcccgcgcac ggacccctac gcggccagtg cgcagttccc
     1201 taactatagc cccatgaaca tgaacatggg cgtgaacgtg gcggcccacc acgggccggg
     1261 cgccttcttc cgttacatgc ggcagcccat caagcaggag ctgtcctgta agtggatcga
     1321 ggaggctcag ctgagccggc ccaagaagag ctgcgaccgg accttcagca ccatgcatga
     1381 gttggttacg catgttacca tggagcatgt ggggggcccg gagcagaaca accacgtctg
     1441 ctattgggag gaatgtcccc gcgaaggcaa gtccttcaag gcgaagtaca aactggtcaa
     1501 ccatatccga gtgcacactg gcgagaaacc cttcccgtgt cccttcccgg gctgcgggaa
     1561 gatttttgcc cgctctgaga acctcaagat ccacaagagg acccatacag gtgagaaacc
     1621 tttcaaatgt gaattcgaag gctgtgacag acggtttgcc aacagcagcg accgcaagaa
     1681 gcacatgcat gtgcacacct cggacaagcc ctatatctgt aaagtgtgcg acaagtccta
     1741 cacacacccg agctccctgc gcaaacacat gaaggttcat gaatctcaag ggtcagattc
     1801 ctcccctgct gccagttcag gctatgaatc ttccactcca cccgctatag cttctgcaaa
     1861 cagtaaagat accactaaaa ccccttctgc agttcaaact agcaccagcc acaaccctgg
     1921 acttcctccc aattttaacg aatggtacgt ctgaggacaa ccaaaatgca tttaaaaaag
     1981 aaaactgaga caaatcagat ggaaatggag ttttaaagca agaggccata tatatagggc
     2041 tacatcttgg taactgcaat tgttcaggaa ggtttggggc aagatccaaa agtagctatg
     2101 cccttttctc aggattagaa aatatgtttt ggcatttgaa ggaatttttt acaaaatctt
     2161 ttcactgctt ttcctgcccc cctcctcttg ctctctgtac accccgttct ggaactcctt
     2221 caaatcattt taattaacac tgtcctgttt cttgaggaag ttatcgatgg cttggtggtg
     2281 gtgatgttaa actgatgaaa agtcttcttc gccttagtgg tgattgtttc ttaaaccatg
     2341 ccaaagtcct gttatgtctt gaacttttct tcaaagcatt acacttgtga atgtatcttc
     2401 gtctaatggg gtcgaaactt gttgttcagt attttttcag gctgaggata tgatgttact
     2461 ctacacagat tgtaacgttt agtatacagt tgccttttgt aataactttt ctttttgtaa
     2521 atacatatcc gttgatgcca tatttatcgt ttgtaattta attattgctg caagtgccgg
     2581 gaactgaaca atatttatgg ataaatgttt tctaacaaat tctgtacagc ttttgattat
     2641 aactgctttt agcattaaac aattattgtt ttgagaaaag gaacacaatt tacaattttt
     2701 gaaccatact gactttttgt tttgttttgt aacagcctcc tacaaatagg agatgtgagt
     2761 aaattgaatt ttgtttgttg gtatttataa ctcactcaga tccctttttt aattgttaaa
     2821 ttatttttct attgcagtct agattcctta caatgtcagt ttccatctgg ggaggaccct
     2881 cctgtcttta tctctagctc agatggttgt ttaactggga gtttaaatgt gtttgtcctg
     2941 gattttcggc atgcaaatca aataatactg atcaattcac ttagtggcca tgacatctca
     3001 atcttgtact tcaaagactg agaggctggg tttaatcatt cctgccctat atatatatat
     3061 acatatatat ataaacagaa ggtaacctaa ttagctttat gtcccttagt tctttattac
     3121 tttacataaa aatgaaaatt atggcaggat gcatgtctgt tgagagatca ctcatatacc
     3181 tatatgtttg tatctatgac gtacctaatc tgcctatcaa atctatttag cttcaaagga
     3241 tagcacacct ctgaaatggc aatgagcaag gccagttgaa cagtgcttct catggttaaa
     3301 gtgcttctta aaaaaattaa aaaaaaacaa aaaacaaaaa aaaacaaaaa aacaacagtc
     3361 tttaaatttt ggatggcaaa ggctgatttg tatatagttc aattcatgat tatcacaatt
     3421 actcataacg tttatatagc ggtgtaataa ctgcagcagt tcctaaatga tactgtggaa
     3481 agaaaaacat ttgcaaaata ctttattttt aaagttcatt acttgtaggc aaagatgtta
     3541 agagcattgt ttccattaaa atcagtaaca atgaaaaacg gttgtttgtt ttgtgataaa
     3601 atgttaacaa tccatttaat cttcagtgaa gcaactcatt tggacaaaca gttcttttta
     3661 caatgggtct gtggaaaaga aactgatcag tattttgggg ggttgaagtg ggtagagttt
     3721 ggagagtttt ttagggtgct gttggttatt gagagcccaa tctctgcatg aataacagaa
     3781 aagtggagat aaggaattgt aaagtgttta gaaatgtaat gaataggttt aagcacctct
     3841 ttcgctttaa ggggcaatgc tctcagtttt tggtggcagt caatttgata ttatataatc
     3901 attttcaatt ctagaatttt gttgattgtt ctttctgaag aaataaagtc ttggcacatc
     3961 ctatttatgt tataactttt tttgtatttg gtgcccaata tttttcccat gttcaaataa
     4021 atcaatctaa aattg
//
