LOCUS       NM_009574               2967 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus zinc finger protein of the cerebellum 2 (Zic2), mRNA.
ACCESSION   NM_009574 XM_981175 XM_981308
VERSION     NM_009574.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Barnada,S.M., Giner de Gracia,A., Morenilla-Palao,C.,
            Lopez-Cascales,M.T., Scopa,C., Waltrich,F.J. Jr., Mikkers,H.M.M.,
            Cicardi,M.E., Karlin,J., Trotti,D., Peterson,K.A., Brugmann,S.A.,
            Santen,G.W.E., McMahon,S.B., Herrera,E. and Trizzino,M.
  TITLE     ARID1A-BAF coordinates ZIC2 genomic occupancy for
            epithelial-to-mesenchymal transition in cranial neural crest
            specification
  JOURNAL   Am J Hum Genet 111 (10), 2232-2252 (2024)
   PUBMED   39226899
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Le,V.H., Orniacki,C., Murcia-Belmonte,V., Denti,L., Schutz,D.,
            Stumm,R., Ruhrberg,C. and Erskine,L.
  TITLE     CXCL12 promotes the crossing of retinal ganglion cell axons at the
            optic chiasm
  JOURNAL   Development 151 (2) (2024)
   PUBMED   38095299
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Fries,M., Brown,T.W., Jolicoeur,C., Boulan,B.,
            Boudreau-Pinsonneault,C., Javed,A., Abram,P. and Cayouette,M.
  TITLE     Pou3f1 orchestrates a gene regulatory network controlling
            contralateral retinogeniculate projections
  JOURNAL   Cell Rep 42 (8), 112985 (2023)
   PUBMED   37590135
REFERENCE   6  (bases 1 to 2967)
  AUTHORS   Nagai,T., Aruga,J., Minowa,O., Sugimoto,T., Ohno,Y., Noda,T. and
            Mikoshiba,K.
  TITLE     Zic2 regulates the kinetics of neurulation
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1618-1623 (2000)
   PUBMED   10677508
REFERENCE   7  (bases 1 to 2967)
  AUTHORS   Engelkamp,D., Rashbass,P., Seawright,A. and van Heyningen,V.
  TITLE     Role of Pax6 in development of the cerebellar system
  JOURNAL   Development 126 (16), 3585-3596 (1999)
   PUBMED   10409504
REFERENCE   8  (bases 1 to 2967)
  AUTHORS   Nagai,T., Aruga,J., Takada,S., Gunther,T., Sporle,R., Schughart,K.
            and Mikoshiba,K.
  TITLE     The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an
            essential role for Zic genes in body pattern formation
  JOURNAL   Dev Biol 182 (2), 299-313 (1997)
   PUBMED   9070329
REFERENCE   9  (bases 1 to 2967)
  AUTHORS   Aruga,J., Nagai,T., Tokuyama,T., Hayashizaki,Y., Okazaki,Y.,
            Chapman,V.M. and Mikoshiba,K.
  TITLE     The mouse zic gene family. Homologues of the Drosophila pair-rule
            gene odd-paired
  JOURNAL   J Biol Chem 271 (2), 1043-1047 (1996)
   PUBMED   8557628
REFERENCE   10 (bases 1 to 2967)
  AUTHORS   Aruga,J., Yokota,N., Hashimoto,M., Furuichi,T., Fukuda,M. and
            Mikoshiba,K.
  TITLE     A novel zinc finger protein, zic, is involved in neurogenesis,
            especially in the cell lineage of cerebellar granule cells
  JOURNAL   J Neurochem 63 (5), 1880-1890 (1994)
   PUBMED   7931345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB655427.1, AC154683.2, BE988982.1 and AK161979.1.
            
            On Aug 18, 2006 this sequence version replaced NM_009574.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D70848.2, BE988982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               BB655427.1         1-429
            430-970             AC154683.2         16902-17442         c
            971-1568            BE988982.1         1-598
            1569-2580           AC154683.2         13314-14325         c
            2581-2967           AK161979.1         571-957
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.97 cM"
     gene            1..2967
                     /gene="Zic2"
                     /gene_synonym="HPE5; Ku"
                     /note="zinc finger protein of the cerebellum 2"
                     /db_xref="GeneID:22772"
                     /db_xref="MGI:MGI:106679"
     exon            1..1364
                     /gene="Zic2"
                     /gene_synonym="HPE5; Ku"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1882
                     /gene="Zic2"
                     /gene_synonym="HPE5; Ku"
                     /note="Zic family member 2 (odd-paired homolog,
                     Drosophila); kumba; GENA 29"
                     /codon_start=1
                     /product="zinc finger protein ZIC 2"
                     /protein_id="NP_033600.3"
                     /db_xref="CCDS:CCDS27349.1"
                     /db_xref="GeneID:22772"
                     /db_xref="MGI:MGI:106679"
                     /translation="MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAA
                     AQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHA
                     AHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFP
                     GLPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMN
                     MNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTF
                     STMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPC
                     PFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPY
                     LCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSS
                     NLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSGGGGGGAGGGGGGSSG
                     GGSGTTGGHSGLSSNFNEWYV"
     exon            1365..1528
                     /gene="Zic2"
                     /gene_synonym="HPE5; Ku"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..2967
                     /gene="Zic2"
                     /gene_synonym="HPE5; Ku"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttggttctc cgcctggctt tggactcttc tcctcctcca cctcctcctc ccgcgcctcc
       61 tccgccgccg cctcctcttc ctctccgcgc cttcgctcgg tgcccggccg cctgaggcag
      121 atacaggcgg cggcggcggg cgcaccagcc cggctcccga gactgcagtc gccagtattt
      181 ccaccgccgg ttcacggagc cgggcgtcca gaggacgcgc ctcgccgatc cgaagaggaa
      241 atccaggcgg cggggttcac cggcgccggc ggggcggccg ggcgcgctgg ccatgcttct
      301 ggacgcgggg ccgcagttcc cggccatcgg ggtgggcagc ttcgcgcgcc accaccacca
      361 ctcggccgcg gcagcggcgg ctgcggcggc cgagatgcag gaccgcgagc tgagcctggc
      421 ggcagctcag aacggcttcg tggactcggc cgcggcgcac atgggcgcct tcaagctcaa
      481 ccccggggca cacgaactgt ctcctggtca gagttcggcg ttcacgtcgc aaggtccggg
      541 tgcttacccg ggttcggctg ctgcagccgc tgcggccgcg gctctagggc cccacgccgc
      601 acacgttggc tcctattcgg ggcctccctt taattccacc cgggacttcc tgttccgcag
      661 ccggggcttc ggggactcgg cgccgggagg cgggcagcac gggctcttcg gacccggcgc
      721 cggcggcctt caccacgcgc actcggacgc gcagggccac cttcttttcc ctggcctccc
      781 ggagcagcac gggccgcacg cctcgcagaa cgtgctcaat gggcaaatgc gcctagggct
      841 gccgggcgag gtgttcgggc gctcggagca ataccgccaa gtggccagcc cgcggaccga
      901 cccctactcg gcggcgcagc tccacaacca gtacggccct atgaatatga acatggggat
      961 gaacatggca gcggccgcag cccaccacca ccatcaccac caccaccctg gtgccttttt
     1021 ccgctacatg cggcagcagt gcatcaagca agagctcatc tgcaagtgga tcgacccgga
     1081 gcagctaagc aatcccaaga aaagctgcaa caaaactttc agcaccatgc acgagctggt
     1141 gacccacgtc tctgtggagc acgtcggcgg cccggaacag agcaaccacg tctgcttctg
     1201 ggaggagtgt ccacgcgagg gcaaaccctt taaggccaaa tacaaactgg tcaaccacat
     1261 ccgcgtgcac actggcgaga agcccttccc ctgtcctttc ccgggctgtg gcaaggtctt
     1321 cgcacgctcc gagaacctca agatccacaa aagaactcat acaggggaga aacctttcca
     1381 gtgtgagttc gagggctgtg accggcgctt cgccaacagc agcgacagga agaagcacat
     1441 gcatgtccac acctcagata agccctatct ctgcaagatg tgtgacaagt cctacacgca
     1501 tcccagctcg ttgcggaagc acatgaaggt ccatgagtcc tcccctcagg gctccgagtc
     1561 ctccccggct gccagctctg gctacgagtc gtccacaccc ccggggttgg tgtcccccag
     1621 cgcagagcca caaagcagct ccaacctgtc cccagcagcg gcggcagcag cagcagcggc
     1681 tgcggcagca gcggccgcgg tgtccgcagt gcaccgaggc gcgggttctg gcagcagcgg
     1741 ctccggaggg ggctcggcgg ccggcagcgg tgggggcggc ggcggggcgg gcggcggggg
     1801 cggcggcagc tctggcgggg gcagcgggac aaccggaggc catagcggcc tctcctccaa
     1861 cttcaatgaa tggtacgtgt gaggggccag gcctttctcc cattccctgt tcccttatcc
     1921 accgtcgccc tcccaaaacc catcgagggc accttaggat cgtcttatta aaattatgaa
     1981 tctgattttt atggtgaaaa aaaaaagatt ttaccagcag aaggattttt ttaactgttt
     2041 tttttttttt tttttaagaa aacaatctag gcatgaaaag caaaatctct ctgtatgtct
     2101 gaaactgaaa acataaaaaa aaattaagaa agtaaatccc acaaaaatat cgagccaaac
     2161 ttccctagcc cactttcctt cccacatgct tcctagtctt tttgacaaac tgtacatagc
     2221 ggacgccttc cttttccacg gtgattttaa tggcttattg gcttattggt ggatagaagt
     2281 ttgtccattt gtaaactccc ggattgcgtt ccctcccgcc tttctcccat ttcccttccc
     2341 caagtgatgg gccttttctt tttcctttta gtttcccggt ttctttcttt cttttatttt
     2401 tttaaagtaa tgtggaagaa aatggtttat tttgtattgt ggtattaaat attgtgttcc
     2461 ttttaaatga ggcaacttga ttgtaaactt catgcgacta tagactggaa aatatgagcc
     2521 gtgccaaagt ctcccttctg tttcttcaac ataccaaccc atagcacaca tcaccaacac
     2581 caccaacgct tgtgaatgta ttttttctgt tagctgggtt tacatgtgat gtttcagtgc
     2641 ttttgcgacg ttcgatttgt tagttcttgt atgaaagatt ggggggtggg tgggtgggag
     2701 taaacgttgt gccgttagct tttttccgaa ataacaccct tctgtaaata tccgttgcca
     2761 tatttatcca tttgtaatta aattatggta ttaacttgct acagaggaaa caatatttat
     2821 aaagaatgtt tcttaactat aaatatgtac aattgtgggc ataaactgtt tcagattttt
     2881 tatttgaagg tttaagtggt ttgatcattt cttgtgatgt tttgagagta atgcatacag
     2941 aaatataata aaatgtgttg aaactgc
//
