LOCUS       NM_177263               4499 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc fingers and homeoboxes 3 (Zhx3), mRNA.
ACCESSION   NM_177263
VERSION     NM_177263.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4499)
  AUTHORS   Igata,T., Tanaka,H., Etoh,K., Hong,S., Tani,N., Koga,T. and
            Nakao,M.
  TITLE     Loss of the transcription repressor ZHX3 induces
            senescence-associated gene expression and mitochondrial-nucleolar
            activation
  JOURNAL   PLoS One 17 (1), e0262488 (2022)
   PUBMED   35085309
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4499)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 4499)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4499)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 4499)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 4499)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 4499)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   9  (bases 1 to 4499)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T. and Miyamoto,K.
  TITLE     The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a
            heterodimer with ZHX3
  JOURNAL   Gene 323, 133-140 (2003)
   PUBMED   14659886
REFERENCE   10 (bases 1 to 4499)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058111.1.
            
            On Dec 20, 2003 this sequence version replaced NM_177263.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058111.1, AK143296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 80.97 cM"
     gene            1..4499
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /note="zinc fingers and homeoboxes 3"
                     /db_xref="GeneID:320799"
                     /db_xref="MGI:MGI:2444772"
     exon            1..200
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..322
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..3301
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..3312
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /note="triple homeobox 1; triple homeobox protein 1; zinc
                     finger and homeodomain protein 3"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 3"
                     /protein_id="NP_796237.2"
                     /db_xref="CCDS:CCDS16997.1"
                     /db_xref="GeneID:320799"
                     /db_xref="MGI:MGI:2444772"
                     /translation="MASKRKSTTPCMIPVKTVVLPGASTEPQPVESLPEGPQQDLPSE
                     APDASSEAAPNPSSTDGSALANGHRSTLDGYVYCCKECEFRSQDVTHFIGHMNSEHTD
                     FNKDPTFVCTGCSFLAKNPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSVPDSAS
                     SSVLAGESTTEGTEIIITKTPIMKIMKGKAEAKKIHMLKENAPNQPGSEALPKPLAGE
                     REVKEGDHTFINGAAPGSQASAKSTKPPPAANGPLIGTVPVLPAGIAQFLSLQQQPPV
                     HAQHHTHQPLPTSKTLPKVMIPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLT
                     VVTKYPEEQLKIWFTAQRLKQGISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLV
                     ASAGNVQHLIQATLPGHAVGQPEGTAGGLLVTQPLMANGLQASSSSLPLTTASVPKPT
                     VAPINTVCSNSASAVKVVNAAQSLLTACPSITSQAFLDANIYKNKKSHEQLSALKGSF
                     CRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLKGSRAMMPGEHGSVLIDSV
                     PEVPFPLASKVPEVTCIPTATSLVSHPATKRQSWHQTPDFTPTKYKERAPEQLRVLEN
                     SFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKKVNTEETKKADGHMPKEEEEGA
                     EQEGRDEELANELRVPGENGSPEMFLSHALAERKVSPIKINLKNLRVTEASGKSEFPG
                     MGVCEPEEDGLNKLVEQPPSKVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGL
                     PRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLLVIAPGNRELLQDYYMTHKMLC
                     EEDLQTLCDKTQMSAQQVKQWFAEKMGEETRAVADISSEDQGPRNGEPVAVHKVLGDA
                     YSELSENSESWEPSAPEASSEPFDTSSPQSGRQLEAD"
     exon            3302..4480
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /note="major polyA site"
     regulatory      4066..4071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
                     /note="hexamer: AAGAAA"
     polyA_site      4090
                     /gene="Zhx3"
                     /gene_synonym="1810059C13Rik; 4932418O04Rik;
                     9530010N21Rik; mKIAA0395; Tix1"
ORIGIN      
        1 ccgagctcgg ccgagcggcc gggagtcagt tggtgctgct cgtcttcgcc ccagaagcag
       61 tccgtggatc tggcgtcgcc accgccgccg ccgccgcctc cgcggggcct gtgccggccg
      121 gccgcccacc aaggaaggag ggaggctcgc ggcgtgggga gagcagcggg ggccacgggt
      181 gccgccgccg ccgccgccag ggctgaattg cagctacaga ggcagcaaac gactccttaa
      241 agatgccaca ggactgcaga aagtgaaggg gaccttggag aagatgatga aggaaaaaga
      301 atgtttctcc caaggacaag aagcttaagg aaaagtggct ttctgcaaat aactgacaaa
      361 actgacctta gaagcacttc ccagggcctc atggagtagc tggaatttgt actacaaggc
      421 tttcttgcct actggttacc tgaagtggtt gtcgccatgg ccagcaaaag gaagtccacc
      481 accccatgca tgatccccgt taagaccgtg gtgctgccgg gtgccagcac agagcctcag
      541 cctgtggagt ctctgcctga aggtccccag caggatcttc cctcagaggc acctgatgcg
      601 agcagcgagg cagccccaaa ccccagcagc actgatggct ctgccctggc aaatgggcac
      661 cggagcactt tggatggcta tgtatattgc tgtaaagagt gtgagttcag gtcccaggat
      721 gtgacccact ttataggaca tatgaactca gagcacacag actttaataa agacccaact
      781 tttgtatgta cagggtgcag tttcctggca aaaaaccctg aaggactttc cctgcataat
      841 gccaagtgtc actcagggga agccagcttt ttgtggaatg tgaccaagcc agacaatcat
      901 gtagtagtgg agcagagtgt ccctgacagt gctagctcat ctgtcctagc aggtgagtct
      961 actacggaag ggactgaaat catcattacc aagactccaa tcatgaagat aatgaaaggc
     1021 aaagctgaag ccaaaaaaat ccatatgctt aaagagaacg ctcctaatca gcctgggagt
     1081 gaggccttgc ctaagccatt ggcaggggag agagaggtta aagaggggga ccacactttc
     1141 atcaatgggg cagctccagg cagtcaggca tctgctaagt ccacaaaacc ccctcctgct
     1201 gccaatgggc ccctgatagg aacagtgcct gtcttgccag ctggtatagc acagttcctc
     1261 tccctccagc agcagccccc agtacatgcc caacaccaca cccaccaacc cctgcctaca
     1321 tccaagaccc ttccgaaagt catgatcccc ttgagcagca tcccaacata taatgcagct
     1381 atggactcca acagctttct gaagaactcc ttccacaaat tcccctaccc aaccaaagct
     1441 gagctctgct atttgactgt ggtgaccaag tatccagaag aacagcttaa aatctggttc
     1501 acagcccaga ggctgaagca aggaatcagc tggtctcctg aggagattga agatgccagg
     1561 aaaaagatgt tcaatacagt catccagtct gtgcctcagc ccacaatcac agttctaaac
     1621 accccgcttg ttgccagtgc tggcaatgta cagcacctca tccaggctac tctcccaggt
     1681 catgctgtgg gacagcctga gggcacagca ggggggctgt tggtcactca accactgatg
     1741 gccaatgggt tacaagcatc aagctcatct ctccctctga caactgcatc tgttcccaag
     1801 ccaactgtgg cacccattaa cactgtgtgt tcaaattcgg catcagctgt gaaagttgtc
     1861 aatgcagccc agtcactcct cacagcatgc cccagcataa cttcccaagc tttccttgat
     1921 gcaaacatct acaaaaataa gaagtctcat gaacagctct cggctctgaa aggaagcttc
     1981 tgtcggaacc agtttcctgg gcagagtgaa gtagagcatc tgaccaaagt gacaggcctc
     2041 agtaccagag aggtgcggaa gtggttcagt gaccggagat atcactgccg gaatctgaag
     2101 ggctccaggg ccatgatgcc cggagagcat ggctctgttc tcattgactc tgtgccagag
     2161 gtgccctttc ccctggcatc taaagttcca gaggtgacct gtatcccaac agcaacctca
     2221 ctagtaagcc accctgccac caaacgacaa tcttggcacc agaccccaga cttcacacca
     2281 accaaataca aagaaagagc cccagagcag ctgcgagtcc tagagaacag ctttgcacaa
     2341 aacccacttc cccccgagga ggagctggac cgcctaagaa gtgaaacgaa aatgactcga
     2401 agggaaattg atggctggtt ctcagagagg cggaaaaagg tgaatactga ggagacaaag
     2461 aaagctgatg ggcacatgcc taaggaggag gaggagggtg ctgagcagga gggtagagat
     2521 gaagagttgg ccaatgagct gagggtccct ggtgaaaatg gctctcctga aatgtttctt
     2581 agccatgcct tggcagaacg gaaggtcagc cccatcaaaa tcaacctcaa gaacctgcgg
     2641 gtcactgaag ccagtggcaa gagtgagttt ccagggatgg gtgtctgtga gcctgaggaa
     2701 gatggtttga acaagttggt agaacagcca ccaagcaaag taagctacaa aaagaccgca
     2761 cagcagcgtc atttgcttcg gcagctcttt gtccaaacac agtggccaag caaccaggac
     2821 tatgactcca ttatggccca aacagggctg ccccggccag aggtggtacg ctggtttgga
     2881 gatagcaggt atgcccttaa gaatggccag ctcaagtggt acgaagacta taagagggga
     2941 aacttcccac caggtttgct ggtcatagcc cctggcaacc gagagctgct gcaagattat
     3001 tacatgacac acaagatgtt gtgtgaggaa gatctgcaga ccctctgtga taagacccag
     3061 atgagtgccc agcaggtcaa gcagtggttt gctgagaaga tgggtgaaga gacccgggct
     3121 gtggcagata taagcagtga ggatcagggc cctagaaatg gagagcctgt ggcagttcac
     3181 aaggtgctgg gtgatgccta ttcggagctg tctgagaaca gcgaatcatg ggagccaagt
     3241 gctcctgagg ccagctcaga gccttttgac acttcaagtc cccagtctgg acgtcaactc
     3301 gaagcagact gaatttgatc ttgattactg tgaaggaccg gccagtctgg gatgctgtat
     3361 gccatgtgga agggccaaaa ctgccacata tcatcttgat ggccagctgc caggcaccag
     3421 gagagcctct ggagcctcgc tgaacccaga acctgccacc gccccaacca ccttccgcct
     3481 gacatttctg agcaaatagc aatggtttct catcagccca tcttcccaca gagcaggacc
     3541 tttccatggc ctcccaggga caattcagat tgcatatacc tagacccaga atcaagttgt
     3601 tagcatatac agctgcctat attcatttaa taaagcatac tactacagac attttcaata
     3661 cataggaact cgggttacca aaacagtaca gctctgacaa tgccatgtct gttttctggg
     3721 aagctgagac cacagggacc ctcatcctct gcaacagtgg gagtcccagg catgctcaga
     3781 actgcaccag gcctggccct acttgtcttc tcaagggaac agattgttgg aagagatctc
     3841 tgcatcactg agtggaggca agccacattt tgtgccagac ttgtcttgtg ttctgattga
     3901 caaagagccc actgttacct tcagttctga acacaaccaa gctatgacat taccattgga
     3961 tgctaaccat tctctttagt taactgtaat tctggttttt ttttgtttgt ttgtttgttt
     4021 ttgagtttga atcatggacc aacttctcca ttatcagatc aactaaagaa accattgttg
     4081 taaagcccaa tctactgacc tgtagctccc ttcagccctt caatccagac tcctttagaa
     4141 caaaaggaaa gtgatcaaag tagagccaat tgctgtggct ttggtcacca aagtgctcaa
     4201 tgcctcctgc aggtcagaag gaaatacatg gtggctggag gaagaatgag gctgaagggc
     4261 ttgggagatt tgaagtgact agagctacac tgttcttgaa cacaaagacc tgcaggtcag
     4321 agttcctggc aaaatgcctg tcacacacca agggccctgg ccagctactg gtttcatgat
     4381 ccagaggtgc tgggcatcac tggacagatt cctgtgaggg tgtttttaaa gttccacatt
     4441 tatattccca acctgagaaa caagtactct atctactttt aaaaaaaaaa aaaaaaaaa
//
