LOCUS       NM_199449               4392 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus zinc fingers and homeoboxes 2 (Zhx2), mRNA.
ACCESSION   NM_199449 XM_989653
VERSION     NM_199449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4392)
  AUTHORS   Creasy,K.T., Ren,H., Jiang,J., Peterson,M.L. and Spear,B.T.
  TITLE     Elongation of very long chain fatty acids-3 (Elovl3) is activated
            by ZHX2 and is a regulator of cell cycle progression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G582-G592 (2023)
   PUBMED   37847682
  REMARK    GeneRIF: Elongation of very long chain fatty acids-3 (Elovl3) is
            activated by ZHX2 and is a regulator of cell cycle progression.
REFERENCE   2  (bases 1 to 4392)
  AUTHORS   Zhang,Y., Fan,Y., Hu,H., Zhang,X., Wang,Z., Wu,Z., Wang,L., Yu,X.,
            Song,X., Xiang,P., Zhang,X., Wang,T., Tan,S., Li,C., Gao,L.,
            Liang,X., Li,S., Li,N., Yue,X. and Ma,C.
  TITLE     ZHX2 emerges as a negative regulator of mitochondrial oxidative
            phosphorylation during acute liver injury
  JOURNAL   Nat Commun 14 (1), 7527 (2023)
   PUBMED   37980429
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4392)
  AUTHORS   Tan,S., Wang,Z., Li,N., Guo,X., Zhang,Y., Ma,H., Peng,X., Zhao,Y.,
            Li,C., Gao,L., Li,T., Liang,X. and Ma,C.
  TITLE     Transcription factor Zhx2 is a checkpoint that programs macrophage
            polarization and antitumor response
  JOURNAL   Cell Death Differ 30 (9), 2104-2119 (2023)
   PUBMED   37582865
  REMARK    GeneRIF: Transcription factor Zhx2 is a checkpoint that programs
            macrophage polarization and antitumor response.
REFERENCE   4  (bases 1 to 4392)
  AUTHORS   Ding,L., Zhang,Y., Wang,Y., Wang,Y., Tong,Z., Li,P., Chen,C.,
            Wang,B., Yue,X., Li,C., Wu,Z., Liang,X., Ma,C. and Gao,L.
  TITLE     Zhx2 maintains islet beta-cell mass and function by
            transcriptionally regulating Pax6
  JOURNAL   iScience 26 (6), 106871 (2023)
   PUBMED   37275527
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4392)
  AUTHORS   Jiang,J., Turpin,C., Qiu,G.S., Xu,M., Lee,E., Hinds,T.D. Jr.,
            Peterson,M.L. and Spear,B.T.
  TITLE     Zinc fingers and homeoboxes 2 is required for
            diethylnitrosamine-induced liver tumor formation in C57BL/6 mice
  JOURNAL   Hepatol Commun 6 (12), 3550-3562 (2022)
   PUBMED   36194180
  REMARK    GeneRIF: Zinc fingers and homeoboxes 2 is required for
            diethylnitrosamine-induced liver tumor formation in C57BL/6 mice.
REFERENCE   6  (bases 1 to 4392)
  AUTHORS   Vacher,J., Camper,S.A., Krumlauf,R., Compton,R.S. and Tilghman,S.M.
  TITLE     raf regulates the postnatal repression of the mouse
            alpha-fetoprotein gene at the posttranscriptional level
  JOURNAL   Mol Cell Biol 12 (2), 856-864 (1992)
   PUBMED   1370712
REFERENCE   7  (bases 1 to 4392)
  AUTHORS   Duncan,R., Matthai,R., Huppi,K., Roderick,T. and Potter,M.
  TITLE     Genes that modify expression of major urinary proteins in mice
  JOURNAL   Mol Cell Biol 8 (7), 2705-2712 (1988)
   PUBMED   2900461
REFERENCE   8  (bases 1 to 4392)
  AUTHORS   Blankenhorn,E.P., Duncan,R., Huppi,K. and Potter,M.
  TITLE     Chromosomal location of the regulator of mouse alpha-fetoprotein,
            Afr-1
  JOURNAL   Genetics 119 (3), 687-691 (1988)
   PUBMED   2456965
REFERENCE   9  (bases 1 to 4392)
  AUTHORS   Blankenhorn,E.P., Duncan,R., Teuscher,C. and Potter,M.
  TITLE     Genetic map location of Afr-1: results from four genetic crosses
  JOURNAL   Curr Top Microbiol Immunol 137, 264-267 (1988)
   PUBMED   2458212
REFERENCE   10 (bases 1 to 4392)
  AUTHORS   Olsson,M., Lindahl,G. and Ruoslahti,E.
  TITLE     Genetic control of alpha-fetoprotein synthesis in the mouse
  JOURNAL   J Exp Med 145 (4), 819-827 (1977)
   PUBMED   67170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102895.7, BC059178.1 and BQ174722.1.
            
            On Sep 14, 2006 this sequence version replaced NM_199449.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157631.1, AK031782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC102895.7         97568-97813         c
            247-4369            BC059178.1         1-4123
            4370-4392           BQ174722.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.01 cM"
     gene            1..4392
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /note="zinc fingers and homeoboxes 2"
                     /db_xref="GeneID:387609"
                     /db_xref="MGI:MGI:2683087"
     exon            1..338
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            339..412
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /inference="alignment:Splign:2.1.0"
     exon            413..3132
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..3128
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /note="AFP regulator 1; regulator of AFP;
                     alpha-fetoprotein regulator 1; zinc finger and homeodomain
                     protein 2; alpha fetoprotein regulation 1, adult"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 2"
                     /protein_id="NP_955520.1"
                     /db_xref="CCDS:CCDS27483.1"
                     /db_xref="GeneID:387609"
                     /db_xref="MGI:MGI:2683087"
                     /translation="MASKRKSTTPCMVRTSQVLEQDMLEEADRAKDKGAGMPQSDVTK
                     DSWAAEPEHSSKETEVVEVKSMGENLSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHP
                     NVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATN
                     HVVPITASGPGSSDNDPGVSVGKTPMTKTGKLKADAKKVPKKPDEAAPENHMEGTARL
                     VTDTAEILARLGSVELLQDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNAT
                     MINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMF
                     NGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTTVSCSP
                     ITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQ
                     IAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAK
                     DQMAITGTRHGRTYHVYPDFAPQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVET
                     KLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDAVAPNGALSRLDQLSGAQLAG
                     SLPSPSSAIVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCL
                     LKTGTLSWLEQYQRHHMSDDRGRDAVSRKVAKQVAESPKNGSEAAHQYAKDPKALSEE
                     DSEKLVPRMKVGGDPTKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVG
                     EEDAISEKWGSWSRRVAEGTVERADSDSDSTPAEAGQA"
     exon            3133..4374
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4353..4358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /note="hexamer: ACTAAA"
     polyA_site      4374
                     /gene="Zhx2"
                     /gene_synonym="Afr-1; Afr1; mKIAA0854; Raf"
                     /note="major polyA site"
ORIGIN      
        1 gtgggttttg gcgtagattc cccactgatc gaggcatttt cccccttttt ttcttttttc
       61 ttttcttttt tttttctttt tcttttcttt ttttttttct tttaaaaaat tcgatcaacc
      121 gttctccgta ccggggcttt tttctgtcta tctgtctgtc tgtctgtctg ccaggctggc
      181 tttcccccac caccacctct ttcccacgga gcccgagtcg ggcgccgggt ggggagtggg
      241 gagtgggtgg ggggagccag cagagttcca ttttggaacg cccgtgcctc gtctccgcgt
      301 tcccagcccg ggtccccgcg ttcgcagccc cggcgcaggt ctccatgcac tggctgctct
      361 gggaatctgg ctgcaagatc cccaggatgt aaggaactca cagcagacac tgataggaag
      421 ctgcctggtt cgctcagaga ttgctacagt tacaattgtc tgtgctgaaa tccttctgaa
      481 acactcaccc ggaagacgtc agcaaccaag ggaagccaaa ggcatttgag agggagtaga
      541 gccaaaagct gagaatctca ctgtcctgca cccacccacc cactccagaa agaagctgtt
      601 gctcagaggc agacggcatg gcaagcaaac ggaaatctac aactccctgc atggttcgga
      661 catcacaggt actggaacaa gatatgctgg aggaggcaga cagggccaaa gacaaaggag
      721 cgggcatgcc acagtccgat gtgacaaagg acagctgggc agcggaacct gaacattcgt
      781 ccaaagaaac cgaagtggtt gaggtgaaat ctatggggga gaacctgtcc aaaaaactac
      841 agggcggtta tgagtgcaaa tactgccctt attccacgca aaatctgaat gagttcacag
      901 aacacgtgga catgcaacat cctaacgtga ttctcaaccc cctctacgta tgtgccgaat
      961 gtaacttcac aaccaaaaag tacgactcct tgtctgacca caactccaag ttccatccgg
     1021 gggagaccaa cttcaagctg aaattaatca agcgcaataa tcagacggtt ctagaacagt
     1081 ccatcgaagc caccaaccac gtcgtgccca tcactgccag tggtcctgga agtagtgata
     1141 acgaccctgg ggtctcggta ggaaaaaccc ccatgacaaa gacaggaaag ctgaaggcag
     1201 atgccaagaa agtgcccaag aagcctgatg aggctgcccc agaaaaccac atggaaggga
     1261 ccgcccgcct ggtgacagac acagctgaga tcctcgccag acttggtagc gtggagctcc
     1321 ttcaagattc actgggacat gtcatgcctt ccgtacagct gccaccaaat atcaaccttg
     1381 tccccaaggt ccccgtcccg ctgaatacta ccaaatacaa ctctgccctg gacacaaatg
     1441 ctaccatgat caactccttc aacaagttcc cttaccccac ccaggctgag ctctcctggc
     1501 tgacggcggc ctccaaacac ccagaggagc acatccgaat ctggtttgcc acccagcgtt
     1561 taaagcacgg tatcagctgg tccccagagg aggtggagga ggcccggaag aagatgttta
     1621 acggcacgat tcagtcagta cccccgacta tcactgtgct tcctgctcag ctgactccca
     1681 caaaagtgtc acagcccatc ctccagacag ccctaccatg ccagatcctt ggccagccca
     1741 gcctggtgct gactcaagtg acaagcgggt caacaactgt ctcctgctct cccatcacac
     1801 ttgcggtggc tggggtgacc aatcatggcc agaagagacc tctggtgact cctcaagctg
     1861 cccctgagcc gaagcgtcca cacattgccc aggtgccaga acctccaccc aaggtggcca
     1921 ataccccgct caccccagct agcgaccgca agaagaccaa gctacagata gctcacctca
     1981 aggcaagctt cttacagagc cagttccctg acgatgctga ggtctaccgg ctcattgagg
     2041 tgacaggcct tgcgaggagt gagatcaaga agtggttcag tgaccaccgc taccggtgtc
     2101 agaggggcat cgtccacatc accagcgaat cccttgccaa agaccagatg gccattactg
     2161 gcacccggca cggccgcacc taccatgtat acccagactt tgccccgcag aagttcaaag
     2221 agaaaagcca aggacagttg aaaaccctgg aagacagctt tctaaaaagc tcctttccca
     2281 cccaggcaga agtggaacgg ctgagggtgg agaccaagct gagcaggagg gaaatcgact
     2341 cctggttctc agagaggcgg aagcttcgag acagcatgga gcaggctgtg ttggattcca
     2401 tggggtctgg caaaaagggc tcagacgcgg tagcccccaa tggtgctcta tcccgacttg
     2461 atcagctctc tggtgcccag ttagctggtt ctttgcccag tccttcatca gcaattgtac
     2521 aaaatcaaga acaggttcac ctgctcagga gcacttttgc aagaacccag tggcccactc
     2581 ctcaggagta cgatcagtta gctgccaaga ccggcctggt ccgaactgag attgtgcgct
     2641 ggttcaagga gaacagatgc ttactaaaaa ctggaacgtt gagctggctg gagcagtacc
     2701 agcggcatca catgtcagat gaccgtggtc gtgatgccgt atcaagaaag gtggcaaaac
     2761 aagttgctga gagcccaaag aatggaagcg aggcggcaca tcagtatgcc aaggacccca
     2821 aagcactcag cgaggaggac tccgagaagc tggtcccgag gatgaaagtg ggtggtgatc
     2881 caaccaagga ctgtttggca ggcaagccct cagaggccac ctcagacaga tcagagggca
     2941 gccgagatgg ccagggcagt gaggagaacg aggagtcagg catcgtggac tttgtggagg
     3001 tgacagttgg tgaggaggac gccatctcag agaagtgggg tagctggagc cggagagtag
     3061 cagaaggcac agtggagagg gcagactccg actccgacag cacccctgca gaggccggcc
     3121 aagcctagac agggcatcgg gtctgaacct ccgcactgac gagggaggtg ctctgtcttt
     3181 gaagagagaa gaaagccccg ccccagtggc tgtgggccac ctcaccagcg actctgagca
     3241 ggcgtgcttc agtggtgcct ggaggccaca ggaactccgg agctctcaat gtccctccca
     3301 gaggctgggt gggagttgtt catagtgcca aagtcctact actgcgtttt caatgggtcc
     3361 ctgtgcgtag cctttgcctt cgccccagcc ccgcctcttg ctatactgga actgatttat
     3421 acaatgtggg aattttgtta cctttttaat cgagggcaac ttcctttttc cagcacttct
     3481 gtggtaaggc gtttgcattt tgttttgttt tgttttgttt cacccccagg aaggagggct
     3541 aaccacattg cttttctttt ctctttcttc ctttcacttt agtaacgagg gggagggagc
     3601 attagcataa gtaccactgt atctactgga ttttaggtag gacggatttc ttctttaagg
     3661 tagtttgaca tgggagatgc cttggtggga agggctgacg tctggcgcaa agtgggatga
     3721 gctcacaaag agccttcccc atcaaaccct tcccagttcc ccagctgcct tttggggacc
     3781 ctgcctcagc tggcttctca actgccttgg ataattgggg aacaggtggt tgccctcttt
     3841 acaaatcgtt ttgaaatacc agcagaaagg gctcccacaa cacttgatgt caccatcact
     3901 cttgggaaat taagagagtg gtcttcccgg cctaggtgta gtaccgaggt aaacatccct
     3961 gcttttcttt tctcttctca ccaccttttc ttggtgtggc ttttggcaag atttcagctc
     4021 aaagcctcac taatggattg atttgttgtt gttgttgttc ctgtgtctgt gtgtgtgtgc
     4081 gcgcgtgcgt gcgtgtgttg ggccaatttt agatacctga gtgcactttt tttttttttt
     4141 tagttagtcc tagcttttaa agaaagaaag ccaagagatc tagttggtgt aaatgtggag
     4201 acagggattc tgttcgctgt ccttgtcccc tcccccaccc cgcagacccc cgaccccact
     4261 ggagtacact gcacaaatta aatgctaggg agtttgaata aaagcagttt ttctaacttg
     4321 ttgctcatct gttgtaactc aataaagcaa agactaaacg tttttctaac cttcaaaaaa
     4381 aaaaaaaaaa aa
//
