LOCUS       NM_009572               5105 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc fingers and homeoboxes 1 (Zhx1), transcript
            variant 1, mRNA.
ACCESSION   NM_009572
VERSION     NM_009572.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5105)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5105)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 5105)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 5105)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   5  (bases 1 to 5105)
  AUTHORS   Brinkmeier,M.L., Davis,S.W., Carninci,P., MacDonald,J.W., Kawai,J.,
            Ghosh,D., Hayashizaki,Y., Lyons,R.H. and Camper,S.A.
  TITLE     Discovery of transcriptional regulators and signaling pathways in
            the developing pituitary gland by bioinformatic and genomic
            approaches
  JOURNAL   Genomics 93 (5), 449-460 (2009)
   PUBMED   19121383
REFERENCE   6  (bases 1 to 5105)
  AUTHORS   Shou,Z., Yamada,K., Kawata,H., Yokoyama,O. and Miyamoto,K.
  TITLE     A mechanism of induction of the mouse zinc-fingers and homeoboxes 1
            (ZHX1) gene expression by interleukin-2
  JOURNAL   Biochem Biophys Res Commun 314 (3), 885-890 (2004)
   PUBMED   14741719
REFERENCE   7  (bases 1 to 5105)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 5105)
  AUTHORS   Shou,Z., Yamada,K., Inazu,T., Kawata,H., Hirano,S., Mizutani,T.,
            Yazawa,T., Sekiguchi,T., Yoshino,M., Kajitani,T., Okada,K. and
            Miyamoto,K.
  TITLE     Genomic structure and analysis of transcriptional regulation of the
            mouse zinc-fingers and homeoboxes 1 (ZHX1) gene
  JOURNAL   Gene 302 (1-2), 83-94 (2003)
   PUBMED   12527199
REFERENCE   9  (bases 1 to 5105)
  AUTHORS   Hirano,S., Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Yazawa,T.,
            Kajitani,T., Sekiguchi,T., Yoshino,M., Shigematsu,Y., Mayumi,M. and
            Miyamoto,K.
  TITLE     Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear
            factor-YA-interacting nuclear protein, forms a homodimer
  JOURNAL   Gene 290 (1-2), 107-114 (2002)
   PUBMED   12062805
REFERENCE   10 (bases 1 to 5105)
  AUTHORS   Barthelemy,I., Carramolino,L., Gutierrez,J., Barbero,J.L.,
            Marquez,G. and Zaballos,A.
  TITLE     zhx-1: a novel mouse homeodomain protein containing two
            zinc-fingers and five homeodomains
  JOURNAL   Biochem Biophys Res Commun 224 (3), 870-876 (1996)
   PUBMED   8713137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113292.6, CJ093421.1, AK220508.1 and BC054543.1.
            
            On Nov 2, 2013 this sequence version replaced NM_009572.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220508.1, Z54200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC113292.6         102293-102296       c
            5-39                CJ093421.1         5-39
            40-4802             AK220508.1         1-4763
            4803-5100           BC054543.1         4387-4684
            5101-5105           AC113292.6         72791-72795         c
FEATURES             Location/Qualifiers
     source          1..5105
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.25 cM"
     gene            1..5105
                     /gene="Zhx1"
                     /note="zinc fingers and homeoboxes 1"
                     /db_xref="GeneID:22770"
                     /db_xref="MGI:MGI:109271"
     exon            1..352
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..463
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..3322
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             698..3319
                     /gene="Zhx1"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 1"
                     /protein_id="NP_033598.2"
                     /db_xref="CCDS:CCDS27488.1"
                     /db_xref="GeneID:22770"
                     /db_xref="MGI:MGI:109271"
                     /translation="MASRRKSTTPCMVLASEQDPDLELISDLDEGPPILTPVENAKAE
                     SVSSDEEVHGSVDSDNQQNKKVEGGYECKYCTFQTPDLNMFTFHVDSEHPNVVLNSSY
                     VCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTINDLTFDGSFVKE
                     ENTEQGESIDVSSSGISISKTPIMKMMKNKVENKRITVHHNSAEGTSEEKENGVKASQ
                     EENAESVSSSALESNTSTSTINRVHPSPASTVVTPTAVLPGLAQVITAVSAQQNSNLL
                     PKVLIPVNSIPTYNAALDNNPLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSA
                     QRLKHGVSWTPEEVEEARRKQFNGTVHTVPQTITVIPTHISTGSNGLPSILQTCQIVG
                     QPGLVLTQVAGTNTLPVTAPIALTVAGVPNQTNVQKSQVPAAQPATDTKPATAAVPSS
                     PSVRPEAALVNPDSFGIRAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEI
                     KKWFSDTRYNQRNSKSNQCLHLNNDSSATIIIDSSDETPEPPAAAASQQKQSWNPFPD
                     FAPQKFKEKTAEQLRALQASFLNSSVLTDEEVNRLRAQTKLTRREIDAWFTEKNKTKA
                     LKDEKIEVDESNVGSSKEEPGESSPGDETVAPKSGGTGKICKKTPEQLHMLKSAFVRT
                     QWPSAEEYDKLAEESGLARTDIVSWFGDTRYAWKNGNLKWYYYYQSSNSSSLNGLSSL
                     RRRGRGRPKGRGRGRPRGRPRGGKRMNTWDRVPSLIKFKTGTAILKDYYLKHKFLNEQ
                     DLDELVNRSHMGYEQVREWFAERQRRSELGIELFEENEEEDEVVDDQEEDEEETDDSD
                     TWEPPRHVKRKLSKSDD"
     exon            3323..5105
                     /gene="Zhx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4778..4783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zhx1"
                     /note="hexamer: ATTAAA"
     polyA_site      4803
                     /gene="Zhx1"
                     /note="major polyA site"
     regulatory      5083..5088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zhx1"
                     /note="hexamer: AATAAA"
     polyA_site      5104
                     /gene="Zhx1"
ORIGIN      
        1 gggcggggcg gcgcacacct cccgcagcgc ccggttctag aggagcggcc tgggtcgcat
       61 cccagaggag cggcggagtc ctcgagtggg gtgcccggct cgtccccgcc tcggctggct
      121 cctcctcgcg gcccttgtgg gttcagggag cggagtctct ctcgcaccct ggcctggcct
      181 ctcggcgctt ctgccgggct gcagagctcc gtggggggcc ccctcgcgcg agggccctcc
      241 gagtggttcc ggggttaggg ttcacgggtc agagttgact ccctgaaaag tgcagtcgct
      301 ctgaaatgca agatggcggc ggcgaggcgc tgaggcgagg cggcccctgc agaagactgc
      361 tagctacttt gggacaattt gtgatgatgg cctgagccaa gtacctcatt tgaagggata
      421 accttctgct ttaaggaaca gaatgctgaa gaagctatgg caggtgattg gagttgtgct
      481 tcatacattt cagcagttca gcagtgtttt atctgccaac taagcttttt acttgagtgc
      541 accatggaaa cgctactaat gagacttgtt gagcacaaaa gtggacttga agagctagaa
      601 gccactgttt tcaaatgaag gattccaaac agttttaagc ctcagtgctt ttaaatcacc
      661 actgagattc cccctcatcc ctgcccctaa aatcaaaatg gcaagcagac gaaaatcaac
      721 aacaccttgc atggtccttg ccagtgagca ggatccagat cttgagctga tatcggattt
      781 ggatgaaggc cctcccatcc ttacacctgt agagaatgct aaagcagaga gtgtctccag
      841 cgatgaagaa gttcacggat ctgtggattc tgacaatcag caaaataaga aagtggaagg
      901 gggctatgaa tgtaaatatt gtacttttca aactccagat ctaaatatgt ttactttcca
      961 tgtagattca gaacatccca atgttgtgct gaattcctcc tatgtttgtg ttgaatgcaa
     1021 ttttcttacc aaaaggtatg atgcactttc tgagcataat ctgaaatacc acccaggaga
     1081 agaaaatttc aagctgacta tggtgaagcg gaataaccag acaatctttg aacagacaat
     1141 aaatgatcta acttttgatg gcagttttgt taaagaggag aatacagaac aaggagaatc
     1201 catagatgtt tcttcttcgg gaatctccat tagtaaaact cccatcatga aaatgatgaa
     1261 aaataaggta gagaacaaac ggattacagt ccaccataac tcagctgagg gcacttctga
     1321 agagaaagag aatggagtaa aagcaagcca ggaagaaaat gcagaaagtg tgagttcttc
     1381 agctttagaa tccaatacaa gtacttccac catcaacaga gtgcatccca gtcctgccag
     1441 cacagtggtg actcccacag ctgttcttcc tgggttagca caggtgataa ctgcggtgtc
     1501 tgctcaacag aactcaaact tgctccctaa agtcttaatc cccgttaata gcattcctac
     1561 ctacaatgct gcattggata acaatcctct tctacttaat acctacaaca aattccctta
     1621 tcctacaatg tcagaaatta cagttctttc tgctcaagca aaatatacag aggaacaaat
     1681 caagatctgg ttttcagccc aacgtttaaa gcatggtgtt agttggactc ctgaagaagt
     1741 agaggaggcg agaagaaaac aattcaatgg aacagtacat actgtacctc agaccataac
     1801 tgttattcct acacacattt ccacagggag taacgggtta ccatctatct tacagacatg
     1861 ccaaattgtt ggtcagccag gtctggtcct tactcaagta gctggaacaa acaccttgcc
     1921 agtaacagca cccattgccc tgacagtggc aggggttcca aatcaaacaa atgtacaaaa
     1981 gagccaagtg cctgctgctc agcctgctac agacacaaaa ccagccacag cagcagttcc
     2041 atcctcgcca agtgtcagac ctgaagctgc actagtgaac ccagattcat ttggtattcg
     2101 ggccaaaaag actaaagagc agctggcaga actgaaagtt agctacctaa aaaatcagtt
     2161 tccccatgac tcagagatca tcaggcttat gaaaataaca ggccttacca aaggcgagat
     2221 taaaaaatgg tttagtgata caaggtacaa ccagagaaat tcaaagagta accagtgctt
     2281 acatctcaac aatgactcct ctgccactat catcatagac tccagtgatg aaaccccaga
     2341 acccccagcg gcagctgctt cacagcagaa acagtcctgg aatccctttc ctgactttgc
     2401 tccccagaag tttaaagaga aaactgcaga gcaactccgt gcccttcagg caagttttct
     2461 caacagttct gtacttactg atgaagaagt aaataggtta agagcgcaaa ccaaacttac
     2521 tagaagagaa attgatgctt ggtttacaga gaaaaataaa acaaaagctt taaaggatga
     2581 gaaaatagaa gtagatgaaa gtaatgtagg tagttccaaa gaagagcctg gagaaagttc
     2641 tcctggagat gaaacagttg cacctaagtc aggagggaca ggcaagatat gtaagaaaac
     2701 accagagcag ctgcacatgc ttaaaagtgc atttgtccga acacagtggc catcagcaga
     2761 agagtatgac aagctggctg aagagagtgg ccttgccaga acagatatag ttagttggtt
     2821 tggggatacc cgttatgctt ggaagaatgg aaacttgaaa tggtattact actatcaaag
     2881 ctccaattca agtagtttga atggtctatc ttcccttagg agaagaggga gaggcagacc
     2941 caaaggaagg ggcaggggca gaccacgtgg tcggcccaga ggtggaaaaa gaatgaacac
     3001 ctgggacagg gtaccatcgc ttataaagtt taaaactgga acagcaatac ttaaggatta
     3061 ttacctgaag cacaaatttc ttaatgagca agaccttgat gaacttgtca acagatcaca
     3121 catgggttat gagcaggtca gagagtggtt tgcagaaaga cagagaagat ctgagttagg
     3181 tatagaatta tttgaggaaa atgaggagga agatgaagtt gttgatgatc aggaagaaga
     3241 tgaagaagaa acagatgata gtgacacttg ggaaccccca cgacatgtga agcggaagct
     3301 ttctaaatcg gatgactgaa atctacttaa aattctgaag gagaataagt tcttcaactc
     3361 aagatctctg aattactgtg aatgggccca actaatcctg atgacactga aaatgctttg
     3421 gggcatacat actctcaaaa cagaatccaa tgtccaaaag aaatggaact tgatgttgtg
     3481 ccaaagtcaa actgctgcag tcgggggaag ttccgcaatg tatatagagc gctaattaaa
     3541 acacacctgt aaaaaatgaa attttaatac agtccatttt tattctgaca ggatggaaac
     3601 cttgtgaatc tttgactttc taaggggtta atgaccacta gagcttgtcc tcacatctag
     3661 tccagcttac tgctgtgtaa gatgggctgt attacctgta ttctttgacg tgattaagct
     3721 tacagctttg agtgaccaaa cattttacag agtaaaagtt gttagaaatg aaagaggaga
     3781 accaaaccct actttacttc tgtgtcttat ttatcaggtc ctacaccaaa attccacagt
     3841 ttgcagtgtg cctgtgcctg ttatgttagg acaggaagac ctgtggtctt gctggccttc
     3901 atgactagac cctccactga acactgtctc catttgtagc actgtgtgac tcctctgtca
     3961 gatccgactt gctttttact aaactgaaga tactacccca aagggagaaa gaacttagca
     4021 gagagactct taatactgtt ccaagtgtaa aacagtccac agtaaaatac atgtggtgcg
     4081 ctttctcacg ggcgccagac aggctcaggg cagagtttgc aggaatactt ttcatgaaat
     4141 tctaccttgt agtaacaatt tcagtgaaca gagaaaaaga attcggaacc taacatgtta
     4201 aaaattacct tttcgtgtaa gaatcggggc tttttaacgg taagtatgtc gcagcagaag
     4261 acagagttcc tactgacttg tcactagcct ggtgctgatg tcgtgttggg aaggaccctt
     4321 tctgttgtga tcataggacc acttttcaat ctgtgctttc ctcacaggac aaattgtcag
     4381 ttttattaga tttggactta aaaatttttt tttggatggt cacacatagt gggtttggcc
     4441 agttcatgtt ttgtctaact taatgaatac taaatactaa gctcttggtt aaatgtttgt
     4501 cagctaatga gaaatgttat gataaagcct tgactatgca tgctgctttc attttgataa
     4561 actttttatt ttttaactat agctttatta gcaattccca aatgctgcaa tttgctgatt
     4621 tcttcacaca gacagctggc tttgtgggtg gctttttcat actactgtta acttttttta
     4681 aaaaaagaag tgatgtaaag actgtaacaa ttgaatgcac taagctgttt ttcttttaca
     4741 catttaaaaa cttcttaaag tactctgtat tataatgatt aaattgctcc ctttttaaaa
     4801 ccattgctaa tgtggtctga gttttatttg acagtaattt taatgctctc aagattcaat
     4861 ccttgagatg tcaaggattg gagatgaagg atttgaatat atttacatta cgattccttt
     4921 gtgctatgct aactttgtat agctgcaaat aactttgtga tttttccatc tcactggtag
     4981 gctggatgaa agtctgctct gatgtttgct agcttttaaa tacatttatt cgacagtgca
     5041 aaagagcttt tctttcctgg ttgactatgt ctttgaatac aaaataaaag ttagcaataa
     5101 tgggc
//
