LOCUS       NM_001103168            1010 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus zinc finger, GATA-like protein 1 (Zglp1), mRNA.
ACCESSION   NM_001103168 XM_001475156 XM_001475715
VERSION     NM_001103168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1010)
  AUTHORS   Maiseyeu,A., Di,L., Ravodina,A., Barajas-Espinosa,A., Sakamoto,A.,
            Chaplin,A., Zhong,J., Gao,H., Mignery,M., Narula,N., Finn,A.V. and
            Rajagopalan,S.
  TITLE     Plaque-targeted, proteolysis-resistant, activatable and MRI-visible
            nano-GLP-1 receptor agonist targets smooth muscle cell
            differentiation in atherosclerosis
  JOURNAL   Theranostics 12 (6), 2741-2757 (2022)
   PUBMED   35401813
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1010)
  AUTHORS   Nagaoka,S.I., Nakaki,F., Miyauchi,H., Nosaka,Y., Ohta,H.,
            Yabuta,Y., Kurimoto,K., Hayashi,K., Nakamura,T., Yamamoto,T. and
            Saitou,M.
  TITLE     ZGLP1 is a determinant for the oogenic fate in mice
  JOURNAL   Science 367 (6482) (2020)
   PUBMED   32054698
  REMARK    GeneRIF: this study shows that ZGLP1, a conserved transcriptional
            regulator with GATA-like zinc fingers, determines the oogenic fate
            in mice.
REFERENCE   3  (bases 1 to 1010)
  AUTHORS   Liu,J., Conde,K., Zhang,P., Lilascharoen,V., Xu,Z., Lim,B.K.,
            Seeley,R.J., Zhu,J.J., Scott,M.M. and Pang,Z.P.
  TITLE     Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect
            of Endogenous Glucagon-like Peptide-1 in the Paraventricular
            Hypothalamus
  JOURNAL   Neuron 96 (4), 897-909 (2017)
   PUBMED   29056294
  REMARK    GeneRIF: study provides a comprehensive multi-level (circuit,
            synaptic, and molecular) explanation of how food intake behavior
            and body weight are regulated by endogenous central GLP-1.
REFERENCE   4  (bases 1 to 1010)
  AUTHORS   Huang,C., Yuan,L. and Cao,S.
  TITLE     Endogenous GLP-1 as a key self-defense molecule against
            lipotoxicity in pancreatic islets
  JOURNAL   Int J Mol Med 36 (1), 173-185 (2015)
   PUBMED   25976560
  REMARK    GeneRIF: data demonstrate an increase in number of pro-alpha cells
            and activation of the intra-islet GLP-1 system comprise a
            self-defense mechanism for enhancing beta cell survival to combat
            lipid overload, which is in part mediated by oxidative stress and
            inflammation.
REFERENCE   5  (bases 1 to 1010)
  AUTHORS   Kim,N., Min,K.W., Kang,K.H., Lee,E.J., Kim,H.T., Moon,K., Choi,J.,
            Le,D., Lee,S.H. and Kim,J.W.
  TITLE     Regulation of retinal axon growth by secreted Vax1 homeodomain
            protein
  JOURNAL   Elife 3, e02671 (2014)
   PUBMED   25201875
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1010)
  AUTHORS   Li,S.K., Zhu,D., Gaisano,H.Y. and Brubaker,P.L.
  TITLE     Role of vesicle-associated membrane protein 2 in exocytosis of
            glucagon-like peptide-1 from the murine intestinal L cell
  JOURNAL   Diabetologia 57 (4), 809-818 (2014)
   PUBMED   24356748
  REMARK    GeneRIF: Findings indicate an essential role for VAMP2 in GLP-1
            exocytosis from the GLUTag L cell in response to a variety of
            established secretagogues.
REFERENCE   7  (bases 1 to 1010)
  AUTHORS   Li,Y., Chigurupati,S., Holloway,H.W., Mughal,M., Tweedie,D.,
            Bruestle,D.A., Mattson,M.P., Wang,Y., Harvey,B.K., Ray,B.,
            Lahiri,D.K. and Greig,N.H.
  TITLE     Exendin-4 ameliorates motor neuron degeneration in cellular and
            animal models of amyotrophic lateral sclerosis
  JOURNAL   PLoS One 7 (2), e32008 (2012)
   PUBMED   22384126
  REMARK    GeneRIF: GLP-1 and analogues may provide neuroprotective actions in
            ALS
REFERENCE   8  (bases 1 to 1010)
  AUTHORS   Strauss,T.J., Castrillon,D.H. and Hammes,S.R.
  TITLE     GATA-like protein-1 (GLP-1) is required for normal germ cell
            development during embryonic oogenesis
  JOURNAL   Reproduction 141 (2), 173-181 (2011)
   PUBMED   21123517
  REMARK    GeneRIF: Loss of GLP-1 is associated with germ cell development
            during embryonic oogenesis.
REFERENCE   9  (bases 1 to 1010)
  AUTHORS   Quoyer,J., Longuet,C., Broca,C., Linck,N., Costes,S., Varin,E.,
            Bockaert,J., Bertrand,G. and Dalle,S.
  TITLE     GLP-1 mediates antiapoptotic effect by phosphorylating Bad through
            a beta-arrestin 1-mediated ERK1/2 activation in pancreatic
            beta-cells
  JOURNAL   J Biol Chem 285 (3), 1989-2002 (2010)
   PUBMED   19915011
REFERENCE   10 (bases 1 to 1010)
  AUTHORS   Li,S., Lu,M.M., Zhou,D., Hammes,S.R. and Morrisey,E.E.
  TITLE     GLP-1: a novel zinc finger protein required in somatic cells of the
            gonad for germ cell development
  JOURNAL   Dev Biol 301 (1), 106-116 (2007)
   PUBMED   16982049
  REMARK    GeneRIF: data identify GLP-1 as a critical nuclear repressor in
            somatic cells of the gonad that is required for germ cell
            development, and highlight the importance of somatic-germ cell
            interactions in the regulation of this critical process
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ286956.1.
            
            On or before Sep 15, 2007 this sequence version replaced
            XM_001475156.1, XM_001475715.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ286956.1, SRR1660811.396105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1010              DQ286956.1         1-1010
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.7 cM"
     gene            1..1010
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /note="zinc finger, GATA-like protein 1"
                     /db_xref="GeneID:100009600"
                     /db_xref="MGI:MGI:3696042"
     exon            1..154
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..815
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /note="GATA-like protein 1; GLP-1; GATA-like 1"
                     /codon_start=1
                     /product="GATA-type zinc finger protein 1"
                     /protein_id="NP_001096638.1"
                     /db_xref="CCDS:CCDS40549.1"
                     /db_xref="GeneID:100009600"
                     /db_xref="MGI:MGI:3696042"
                     /translation="MEAAQAGDLTRRQELLAPPCLDTESLRKSRPPALEPGALRCLTP
                     NIRSLWPTCQDSVSTALPFLQEKEKGLPGSPSPATQVLGSCWELMVIGMSDHLSMARN
                     PRGTQCPNLEISSATSPASLQRRPRKQLNPRMGIEKVDPRFKGVTLEFQIQPDSSLQI
                     VPTYSLPGRSCSQKLPASPSKALASPGSSEALGPRRCASCRTQRTPLWRDAEDGTPLC
                     NACGIRYKKYGTRCSSCWLVPRKSIQPKRLCGRCGMSQDPHLSPTQEL"
     exon            155..508
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..591
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..685
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1010
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zglp1"
                     /gene_synonym="Glp1"
ORIGIN      
        1 ggcccacagt gggcatggag gcggcacagg ctggagactt gacgcgccgg caggaacttc
       61 tggcgccacc ttgtctggac accgagtcgc tccggaagag tcgacccccc gcgctggagc
      121 ctggagccct gagatgcctc actcccaata tcaggtctct gtggcctaca tgccaggact
      181 cggtcagcac tgcattgcct ttcctccaag agaaagaaaa gggactgccg ggttcccctt
      241 cgccggccac ccaggtcctg gggtcgtgct gggagctgat ggtcatagga atgtcagacc
      301 acctgagtat ggccaggaat cccaggggca cacagtgccc taacctggaa atttccagtg
      361 ctacttctcc tgcctcactc cagagaagac cacggaagca gctaaacccg cgaatgggta
      421 ttgagaaggt ggaccccagg ttcaaggggg taactctgga gttccagatc cagccggatt
      481 ctagcctcca gattgtaccc acctacagct tgcctggaag aagttgttca caaaagcttc
      541 ctgcaagccc ttccaaggct ctggccagcc caggaagcag tgaggccctt gggcccaggc
      601 ggtgtgcttc ttgtagaacc cagaggactc cactatggag agacgctgaa gatgggacac
      661 ccctctgcaa tgcctgtggc atcaggtaca agaaatatgg cacccgttgt tccagttgct
      721 ggctggtccc aaggaaaagc atccagccca aaaggctctg tggcaggtgt gggatgtccc
      781 aggaccccca cctcagccca acccaggaac tgtaagccct tctttaccta gccaagtcag
      841 ctttgtctca gtttctctat tggagacaat ggaggctgac agggatccca gtgggagagt
      901 caggcctcag gcccagagtc ccacctgtgg ggggtcacct accctctggc ttccccttcc
      961 ccactcagtc ctggatgaac cccaaataaa agaaaatcat ttcagaaatg
//
