LOCUS       NM_026918                682 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus zymogen granule protein 16 (Zg16), mRNA.
ACCESSION   NM_026918 XM_006508175
VERSION     NM_026918.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Chen,X., Chen,Y., Zhang,Y., Zhang,Y., Wang,Y., Li,Y., Sun,Y.,
            Meng,G., Yang,G. and Li,H.
  TITLE     ZG16 impacts gut microbiota-associated intestinal inflammation and
            pulmonary mucosal function through bacterial metabolites
  JOURNAL   Int Immunopharmacol 141, 112995 (2024)
   PUBMED   39191121
  REMARK    GeneRIF: ZG16 impacts gut microbiota-associated intestinal
            inflammation and pulmonary mucosal function through bacterial
            metabolites.
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Mufazalov,I.A., Schelmbauer,C., Regen,T., Kuschmann,J., Wanke,F.,
            Gabriel,L.A., Hauptmann,J., Muller,W., Pinteaux,E., Kurschus,F.C.
            and Waisman,A.
  TITLE     IL-1 signaling is critical for expansion but not generation of
            autoreactive GM-CSF+ Th17 cells
  JOURNAL   EMBO J 36 (1), 102-115 (2017)
   PUBMED   27827809
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Bergstrom,J.H., Birchenough,G.M., Katona,G., Schroeder,B.O.,
            Schutte,A., Ermund,A., Johansson,M.E. and Hansson,G.C.
  TITLE     Gram-positive bacteria are held at a distance in the colon mucus by
            the lectin-like protein ZG16
  JOURNAL   Proc Natl Acad Sci U S A 113 (48), 13833-13838 (2016)
   PUBMED   27849619
  REMARK    GeneRIF: The more penetrable Zg16(-/-) mucus allowed Gram-positive
            bacteria to translocate to systemic tissues. Viable bacteria were
            found in spleen and were associated with increased abdominal fat
            pad mass in Zg16(-/-) animals. The function of ZG16 reveals a
            mechanism for keeping bacteria further away from the host colon
            epithelium.
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Neuschwander-Tetri,B.A., Fimmel,C.J., Kladney,R.D., Wells,L.D. and
            Talkad,V.
  TITLE     Differential expression of the trypsin inhibitor SPINK3 mRNA and
            the mouse ortholog of secretory granule protein ZG-16p mRNA in the
            mouse pancreas after repetitive injury
  JOURNAL   Pancreas 28 (4), e104-e111 (2004)
   PUBMED   15097871
  REMARK    GeneRIF: ZG16p mRNA is downregulated in chronic pancreatitis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122863.4.
            
            On or before Sep 6, 2017 this sequence version replaced
            XM_006508175.3, NM_026918.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG967428.1, BQ947379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC122863.4         193367-193409       c
            44-105              AC122863.4         192653-192714       c
            106-238             AC122863.4         192361-192493       c
            239-682             AC122863.4         190890-191333       c
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.3 cM"
     gene            1..682
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /note="zymogen granule protein 16"
                     /db_xref="GeneID:69036"
                     /db_xref="MGI:MGI:1916286"
     exon            1..43
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /inference="alignment:Splign:2.1.0"
     exon            44..105
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..554
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /note="zymogen granule membrane protein 16; secretory
                     lectin ZG16"
                     /codon_start=1
                     /product="zymogen granule membrane protein 16 precursor"
                     /protein_id="NP_081194.1"
                     /db_xref="CCDS:CCDS21856.1"
                     /db_xref="GeneID:69036"
                     /db_xref="MGI:MGI:1916286"
                     /translation="MLAVALLVLLCASASANSIQSRTSSYSGEYGGKGGKRFSHSGNQ
                     LDGPITAFRIRVNRYYIVGLQVRYGTVWSDYVGGTQGDLEEIFLHPGESVIQVSGKYK
                     SYVKQMIFVTDKGRYLPFGKASGTSFNAVPLHPNTVLRFISGRSGSAIDSISLHWDTY
                     PSHCNTC"
     exon            106..238
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /inference="alignment:Splign:2.1.0"
     exon            239..682
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      659..664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /note="hexamer: AATAAA"
     polyA_site      682
                     /gene="Zg16"
                     /gene_synonym="1810010M01Rik; ZG16p"
                     /note="major polyA site"
ORIGIN      
        1 ggaaatttct agaagactag catctgcaac ttctagggga aagcctcaga atgttggccg
       61 tcgccctctt agtccttctt tgtgcctcgg cctctgctaa ttccattcag tccaggacat
      121 cctcttacag tggagagtat ggaggtaaag gaggaaagcg attctctcat tctggcaacc
      181 agctggacgg ccccatcacc gccttccgta tccgggtcaa cagatactac atagtaggtc
      241 tccaggtgcg ctatggcaca gtgtggagtg actatgtagg tggcacacag ggagacctgg
      301 aggagatctt tctgcacccc ggggaatctg tgatccaggt gtctggcaag tacaaatcat
      361 acgtgaagca gatgatcttc gtgacggaca agggccgcta cctgcctttt ggaaaagcct
      421 caggcacaag tttcaacgct gttcccttgc atcccaacac tgtcctccgt ttcattagtg
      481 ggcgatctgg ctctgccata gattctatta gcctgcactg ggatacctac cctagccact
      541 gcaacacttg ctgaatgaaa cccaccttcc tttctgtcag gggtgctgtg tgtgtatggg
      601 ggtggtggtg gtgagaactc ccttatcacc aagccccatg aaagtatgca aatagcttaa
      661 taaaaggata tggttaaaga ca
//
