LOCUS       NM_001015039            3980 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger, FYVE domain containing 28 (Zfyve28),
            mRNA.
ACCESSION   NM_001015039 XM_132032
VERSION     NM_001015039.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3980)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3980)
  AUTHORS   Yu,L., Xu,M., Yan,Y., Huang,S., Yuan,M., Cui,B., Lv,C., Zhang,Y.,
            Wang,H., Jin,X., Hui,R. and Wang,Y.
  TITLE     ZFYVE28 mediates insulin resistance by promoting phosphorylated
            insulin receptor degradation via increasing late endosomes
            production
  JOURNAL   Nat Commun 14 (1), 6833 (2023)
   PUBMED   37884540
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3980)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3980)
  AUTHORS   Zambrano,S., Rodriguez,P.Q., Guo,J., Moller-Hackbarth,K.,
            Schwarz,A. and Patrakka,J.
  TITLE     FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in
            podocytes but is not critical for the function of filtration
            barrier in mice
  JOURNAL   Sci Rep 8 (1), 4712 (2018)
   PUBMED   29549365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3980)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   6  (bases 1 to 3980)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 3980)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   8  (bases 1 to 3980)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   9  (bases 1 to 3980)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK129414.1.
            
            On May 17, 2005 this sequence version replaced XM_132032.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129414.1, AK036334.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.85 cM"
     gene            1..3980
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /note="zinc finger, FYVE domain containing 28"
                     /db_xref="GeneID:231125"
                     /db_xref="MGI:MGI:2684992"
     exon            1..226
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2905
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /note="zinc finger FYVE domain-containing protein 28"
                     /codon_start=1
                     /product="lateral signaling target protein 2 homolog"
                     /protein_id="NP_001015039.1"
                     /db_xref="CCDS:CCDS39068.1"
                     /db_xref="GeneID:231125"
                     /db_xref="MGI:MGI:2684992"
                     /translation="MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRK
                     EPQRCTLLVSQFRSCQDNVLNIINQIMEECIPQDRAPRDFCVKFPEEIRHDNLAGQLW
                     FGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGTLRDQALRDLNTYTEKMREA
                     LRRFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDD
                     YEPALMFTIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQALTE
                     EELHTLERSLCVSQDVELPIRADTQAPSALAPTFSASLPPEETLSASANNPEAELACS
                     MQYDDQELEELSRMVHRAGDEMSSLLSPPSACQSPAHRPGSEASPRGEASPARARLKS
                     GSDEEERVFFMDDVEVTESPARPESPGNTFELTQGNAQQRGQDGQSGEVGVEAPALVK
                     EEDWSNNNVEGDKIKLASLMGSTSCSCLDSQLYLDGWEVSAEDAETAEMIAHRTGGMK
                     LSATVIFNPKSPTSQDSAVAAQEAPGHGTSPLEPRAEGTGDNSHKLSTTATNCLLHSC
                     VCCGSCGDSRDDAVERLREKCGPGSVISASNPSVSLAKGGDKEPERIDEAQPSDVTLP
                     AEDASNRQEPKAPASSKCLAHTSGPQVDTASRLQGEGEVKGQPEPEARKQDPEKSPVV
                     SGDSPRGDVAQTEHQHLLGSSSTVGSCSLDNTRLDVATAAMPVTPMATREKIRSRFHG
                     SHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLKKVTQTLR
                     SAALEDCALCQETVSSSELAAKTRDGDFEDPPEWVPDEACGFCTSCKAPFTVIRRKHH
                     CRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKTGM"
     exon            227..367
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            368..505
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            506..708
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            709..798
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            799..888
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            889..990
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2295
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2447
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2564
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2669
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2773
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3980
                     /gene="Zfyve28"
                     /gene_synonym="9630058O20Rik; Gm146; mKIAA1643"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccggccg cgcacctgcc ccgcgcacct gcagccagct gctcggcgct aggcgccgcg
       61 cacacgatct gcttgctcaa gcaggtcccg gccctgcctg cgtgtccacc ccgcgccgca
      121 gccggacccg ggcgcagcgc tgcagagggc gagggccgcc cggagcgtgg ctcgggccgg
      181 cgcggcgatg atgaacagat tccgaaagtg gctgtacaaa cccaagaggt cagacccaca
      241 actgctggcc cagttctact atgctgatga ggagctgaac caggtggctg cagagctgga
      301 cagcctggat gggcggaagg agccccagag gtgcacactg cttgtcagcc agttccgctc
      361 ctgtcaggac aatgtattaa acatcattaa tcagatcatg gaggagtgta tccctcagga
      421 ccgtgcccct cgggatttct gcgtcaagtt tccagaggag atccggcatg acaacttggc
      481 tggccagctg tggttcgggg ctgagtgcct ggcagctggc tccatcatca tgaatcggga
      541 gctggagagc atggccatgc ggccactggc caaggagctg acacgcagcc tggaggacgt
      601 gcggggcact ctccgtgacc aggcactccg agacctcaac acttacacag agaagatgcg
      661 ggaggcactg aggcgctttg atgtcctgtt tgctgagttt gaactgagct atgtctcagc
      721 catggtgcca gtgaagtccc ccagggagta ctatgtgcag caggaggtca tcgtgctgtt
      781 ctgtgagaca gtggagagag ccttggattt tgggtatctg acccaggaca tgatcgacga
      841 ctacgaaccc gccctcatgt tcaccattcc tcggctggcc attgtgtgtg gccttgtggt
      901 ctatgcagat ggacccctga acttggaccg gaaggtggag gacatgtctg agctgttccg
      961 gcccttccac acgttgctgc ggaaaataag ggatctgctg caggcgctga cggaggagga
     1021 gctgcacaca ctggagcgga gcctctgtgt ttctcaggat gtggagctcc ccatccgggc
     1081 agacacccag gcacccagtg ccctggcacc caccttttct gcatctcttc ctcccgagga
     1141 gacactttca gccagtgcca acaacccaga ggcagaactg gcctgctcaa tgcagtatga
     1201 tgatcaggag ttggaggaac tcagccgcat ggtccacagg gctggggatg agatgtcttc
     1261 tctgctttca ccacccagtg cctgccagtc cccggcacat aggccaggct cagaggctag
     1321 ccctcgaggg gaggcctctc cagccagagc ccggctgaaa tcaggcagtg atgaggagga
     1381 aagggtgttc ttcatggatg atgtggaggt gacagagtct cctgccaggc ctgaatcccc
     1441 agggaacaca tttgagttga cgcagggtaa tgcccagcag agaggacaag atggccagag
     1501 tggagaggtg ggggtcgagg cacctgccct ggtaaaggag gaagactgga gcaacaataa
     1561 tgttgagggt gacaagataa agctggccag cctcatgggc tccacttcct gcagctgcct
     1621 agactcacag ctctacctgg acggctggga ggtgagtgca gaggatgctg agactgcaga
     1681 gatgattgca caccggaccg ggggaatgaa actgtcagcc acagtcatct tcaaccccaa
     1741 gtctcccact tcccaggact cagctgtggc agcccaagaa gccccaggcc atggtacttc
     1801 ccctttggag cccagggcag aggggacagg ggacaattca cacaaactca gcactacagc
     1861 caccaactgc ctcctccatt cctgtgtgtg ctgtgggagc tgtggggaca gcagggacga
     1921 tgctgtagag cgcctgcggg agaagtgtgg cccaggaagt gtcatcagtg cctctaaccc
     1981 ttctgtaagc ttagccaagg gtggtgacaa agagcccgag agaatagatg aggcccagcc
     2041 ttctgatgtc accctgcctg cagaagatgc ctccaacagg caggagccca aagcccctgc
     2101 ttccagcaag tgcctggcac acacctcagg gcctcaggtg gacacagcga gcaggttgca
     2161 aggagagggt gaggtcaaag gccagccaga gccagaggcc agaaagcagg accctgagaa
     2221 gtcccctgtg gtcagcgggg acagtccaag aggggatgtg gcccagacag aacaccagca
     2281 cctgttgggc tccagctcca cggttggttc ctgctcctta gacaacacca ggttggatgt
     2341 ggccactgct gccatgcctg tcacccccat ggccaccaga gagaagatcc ggtccaggtt
     2401 ccatggcagc catgacctga tccaccgcct gtttgtctgc atttcaggtg tagcagacca
     2461 gctacagacg aactatgcta gcgacctgag aagtattctc aaaacactgt ttgaggtcat
     2521 ggccaccaag ccagaaacag atgacaaaga gaagctaaag aaggtaactc agaccctgcg
     2581 gagtgcagcc ttggaggact gtgcactgtg ccaggagact gtgtcatcct cagaactggc
     2641 agccaagacc cgagatgggg actttgaaga ccctcctgag tgggtgccag atgaggcctg
     2701 tggcttctgc acctcctgta aagctccctt caccgtcatc cgcaggaagc accactgtcg
     2761 cagctgtggt aagatcttct gttcccgctg ctcatcccac tcggcgccgc ttccgcgcta
     2821 cggacaggtg aagcccgtcc gtgtgtgtac acactgctac atgttccacg tcacaccctt
     2881 ctacagtgac aagacgggca tgtgatgctg tgcctggcat gtcccagctg agcaggctgt
     2941 ctagagtcct atccagggtc tccgggaagg aggtgctgtg cctgctgtgt gccctgtcca
     3001 ggctgtgctg caggagggcc tcatttcatc tcatcatgcc acagctgctg caggcctgac
     3061 caggttccag aaggcccaga gtctctgtct actactctcc tttgcctctc cactgtggag
     3121 acaccagtcc tggcatgggc caatgagagg tcagctttat tcagaggagg gacccaggga
     3181 tgcccagttg ctgcttccag gtctagttac ttggttaggc agggttgaac tttcttctct
     3241 tgcccatcta cagcattttg ctccagctgt gcatagcaag gcaggagagg gccaattctg
     3301 tgtgttctct tctgtagcca agaatctgga aacagaagcc agggggtgtt gggcctcaac
     3361 atcatagcag aactccctgc ctgttcacca cactcctcat cccctagatg aggaacctcc
     3421 ccgcctcaga acctcctcaa caacatacat ctcatttcct tttgaagggg ggaatgtagg
     3481 aagcagacat agtggtctcc aggggaagta agcatgctct tggcatctac gccattgcca
     3541 cttgctggtg gagcaggggc tgaccactca ctgatattgt aggctgagct ctcaggtgtt
     3601 tggcctggac ccatcaggca gcttagctac tattcccttc ttccactgca cccgctggga
     3661 ctctaaccca cttcctcaga cctcagtgcg gcctagacag gctgagatgc acagacacct
     3721 cctcaggctt caatctcagg cttcacgttg caatgatgat tacagtttta tttttagaga
     3781 gatgacacac ctactgcttc ttttatagga taaaatccaa ccgctgctca gcagtggaag
     3841 acacaaaatg cacaaaaatg gcttctgtgt gggggaggtg gggagagtgt ataacagagg
     3901 gaatattatg tattgagatg atttttattt tctaaatgct gtaattcaaa accatttcca
     3961 taaatctatt taaggattgc
//
