LOCUS       NM_177319               5636 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger, FYVE domain containing 27 (Zfyve27),
            transcript variant 1, mRNA.
ACCESSION   NM_177319
VERSION     NM_177319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5636)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5636)
  AUTHORS   Arora,A., Kivela,A.M., Wang,L., Minkeviciene,R., Taskinen,J.H.,
            Zhang,B., Koponen,A., Sun,J., Shirane,M., Zhou,Y., Hotulainen,P.,
            Raiborg,C. and Olkkonen,V.M.
  TITLE     Protrudin regulates FAK activation, endothelial cell migration and
            angiogenesis
  JOURNAL   Cell Mol Life Sci 79 (4), 220 (2022)
   PUBMED   35368213
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5636)
  AUTHORS   Shirane,M., Shoji,H., Hashimoto,Y., Katagiri,H., Kobayashi,S.,
            Manabe,T., Miyakawa,T. and Nakayama,K.I.
  TITLE     Protrudin-deficient mice manifest depression-like behavior with
            abnormalities in activity, attention, and cued fear-conditioning
  JOURNAL   Mol Brain 13 (1), 146 (2020)
   PUBMED   33172474
  REMARK    GeneRIF: Protrudin-deficient mice manifest depression-like behavior
            with abnormalities in activity, attention, and cued
            fear-conditioning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5636)
  AUTHORS   Shirane,M., Wada,M., Morita,K., Hayashi,N., Kunimatsu,R.,
            Matsumoto,Y., Matsuzaki,F., Nakatsumi,H., Ohta,K., Tamura,Y. and
            Nakayama,K.I.
  TITLE     Protrudin and PDZD8 contribute to neuronal integrity by promoting
            lipid extraction required for endosome maturation
  JOURNAL   Nat Commun 11 (1), 4576 (2020)
   PUBMED   32917905
  REMARK    GeneRIF: Protrudin and PDZD8 contribute to neuronal integrity by
            promoting lipid extraction required for endosome maturation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5636)
  AUTHORS   Lu,X., Yang,Y., Zhou,R., Li,Y., Yang,Y. and Wang,X.
  TITLE     Protrudin modulates seizure activity through GABAA receptor
            regulation
  JOURNAL   Cell Death Dis 10 (12), 897 (2019)
   PUBMED   31772151
  REMARK    GeneRIF: Protrudin modulates seizure activity through GABAA
            receptor regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5636)
  AUTHORS   Matsuzaki,F., Shirane,M., Matsumoto,M. and Nakayama,K.I.
  TITLE     Protrudin serves as an adaptor molecule that connects KIF5 and its
            cargoes in vesicular transport during process formation
  JOURNAL   Mol Biol Cell 22 (23), 4602-4620 (2011)
   PUBMED   21976701
  REMARK    GeneRIF: Protrudin and KIF5 interact in mouse brain.Protrudin-KIF5
            complex contributes to the vesicular transport in neurons.
REFERENCE   7  (bases 1 to 5636)
  AUTHORS   Shirane,M., Ogawa,M., Motoyama,J. and Nakayama,K.I.
  TITLE     Regulation of apoptosis and neurite extension by FKBP38 is required
            for neural tube formation in the mouse
  JOURNAL   Genes Cells 13 (6), 635-651 (2008)
   PUBMED   18459960
REFERENCE   8  (bases 1 to 5636)
  AUTHORS   Shirane,M. and Nakayama,K.I.
  TITLE     Protrudin induces neurite formation by directional membrane
            trafficking
  JOURNAL   Science 314 (5800), 818-821 (2006)
   PUBMED   17082457
  REMARK    GeneRIF: protrudin regulates Rab11-dependent membrane recycling to
            promote the directional membrane trafficking required for neurite
            formation [protrudin]
REFERENCE   9  (bases 1 to 5636)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5636)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK781433.1 and BC042595.1.
            
            On Sep 1, 2009 this sequence version replaced NM_177319.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042595.1, SRR1660817.176936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CK781433.1         1-54
            55-5636             BC042595.1         1-5582
FEATURES             Location/Qualifiers
     source          1..5636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.87 cM"
     gene            1..5636
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /note="zinc finger, FYVE domain containing 27"
                     /db_xref="GeneID:319740"
                     /db_xref="MGI:MGI:1919602"
     exon            1..219
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            220..417
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1468
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger FYVE domain-containing protein 27; protrudin"
                     /codon_start=1
                     /product="protrudin isoform 1"
                     /protein_id="NP_796293.2"
                     /db_xref="CCDS:CCDS29825.2"
                     /db_xref="GeneID:319740"
                     /db_xref="MGI:MGI:1919602"
                     /translation="MQTSDRDLSGPEASPSGMPEVLSECPPAPTKSAAFDLFNLVLSY
                     KRLEIYLEPLKDAGDGVRYLLRWQMPLCSLLTCLGLNILFLTLNEGAWYSMGALMISV
                     PALLGYLQEVCRGQLPESELMRRKYHSIRQEDLQRVRLSRVHLSRPEAVAEVKSFLIQ
                     LEAFLARLCYTCESAYRVLHWENPVVSSQFYGALLGMVCMLYLLPLCWVLALLNSTLF
                     LGNGDFFRVVCEYRACLQRRMNPRQEECACESSALQGAGGRGLLDSSPAPTPTEDLTP
                     GSVEEAEEAEPDEEFKDAIEETHLVVLEDEEGTPCPAEDELTLQDNGFLSKNEVLRSK
                     VSRLTERLRKRYPTNNFGNCAGCAATFSVLKKRRSCSNCGNSFCSRCCSFKVPRSSMG
                     ATAPEAQRETVCVCASCNQTLSK"
     exon            418..488
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..690
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..786
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..899
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1036
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1108
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1129
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1274
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1321
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1403
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..5614
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2739
                     /gene="Zfyve27"
                     /gene_synonym="2210011N02Rik; 9530077C24Rik"
                     /note="major polyA site"
ORIGIN      
        1 cacgggcgcg ccaccgcaga gtgagtcgcg tcccggaagc gacggcggtg gaggggcaga
       61 cggttcccgg gtggacctgc gacttcggag cgtcggtggg aggtggcgtg gcgtggcgtg
      121 gggtggggcg ggcctggcct gagggaccgc tccggggctt ggtggccctt ctgtccccct
      181 ggccgttcct gtctcttcct ttcctgggac agcgtccgga atgcagactt cggatcggga
      241 cctgagtggg ccggaggcga gccccagcgg gatgcctgag gttctctctg agtgtccacc
      301 tgcccctacc aagtcagcag cgtttgatct cttcaacctg gtcctgtcct acaagaggct
      361 ggagatctac ctggaacccc tgaaggatgc aggggacggt gttcgatact tgctaaggtg
      421 gcagatgcct ttgtgttcct tgctgacttg cctgggcctc aacatcttgt tcctcacttt
      481 gaacgagggt gcgtggtact ccatgggtgc cttgatgatc tcggtgcctg ccctactggg
      541 ctaccttcag gaggtgtgcc ggggacagct gccagagtcg gagctgatgc ggaggaagta
      601 ccacagcata aggcaggaag acctgcagag agttcgcctt tcccgagtgc acctttcccg
      661 ccctgaggct gttgctgagg tgaagagctt cttgatccaa ctggaagcct tcttggcccg
      721 cctgtgctat acctgcgagt cagcctaccg tgtacttcac tgggagaacc ccgtggtgtc
      781 ctcacagttc tatggcgctc ttctgggcat ggtgtgcatg ctctacctgc taccgctctg
      841 ctgggtcctc gccctgttaa atagcacact cttcctggga aatggggact tcttccgagt
      901 ggtgtgtgag tacagggcct gcctgcagcg gaggatgaac ccccggcagg aagagtgtgc
      961 ctgtgagagc tcagcactgc agggggccgg agggaggggc ctgctggaca gctcgcctgc
     1021 ccccacaccc accgaggacc tcacgccagg cagtgtggag gaagctgagg aggctgagcc
     1081 agatgaggag ttcaaagatg caattgagga gacccacctg gtggtgctgg aggatgaaga
     1141 gggcaccccg tgcccagcag aggatgagct gaccctgcag gacaatggat tcctcagcaa
     1201 gaatgaggtg ctgcgcagca aggtgtcccg gcttacagag cggcttcgca agcgttaccc
     1261 aaccaataac ttcgggaatt gtgcaggctg tgccgctacg ttctccgtgc tgaagaagag
     1321 gcggagctgc agcaactgtg ggaacagctt ctgctcgcgg tgttgctcct tcaaggtgcc
     1381 caggtcctct atgggagcca cagctcctga agcccagaga gagactgtgt gtgtgtgcgc
     1441 ctcctgcaat cagaccctga gcaaatgaga agagaagcca ggctccaact gtcctggggc
     1501 cagcagtgac cctactgtcc caactctggg cctctgaggc ctgtgctggg caaacgtagc
     1561 ctgacagcta ggtccttcct gcccttcccc tgctgcctcc agctgggctg gtgatgctct
     1621 aaggcccagg gggagaggag cccctggggt cccggctctt ggttctgctc tatcctatac
     1681 cctgttaact cagggctagc gagggagtgt ccaccagagg gcagaattga gcacagcctg
     1741 ctctcatctg ggctctggtc gtcaaggtca ggctggctag accttaggat ccaagagact
     1801 tgaggttgga aaagaggttc ttccctgttg ggtacttgtc agtctctcag ccccagagag
     1861 cctgcgaggg gacttagagc tccatggcct gcctttgcct tttgaatagc ctcaggactg
     1921 gcgttcccag gtgtcccaag gagagggaag gtgagggtgc tgctcaagtc cttcagtgtc
     1981 aagtggatgg caggatgggg aagctctgct tacagaatct taactcccat ggttctctgg
     2041 tgtcctcagc cctgctgggg tggctacagg accctcacat cactcttcca tcctgctctg
     2101 agtctagggc accccacctt tctcccactg ccacatatct ctagccctta tctcatggaa
     2161 catgcggcca ggtgagtgga gcagagagac tgcaagcctt tgaggtccag ggacgtgtag
     2221 gactgcccgg atttcagggc tgttcctgga gtagagatag cattgtagga tagggtcagt
     2281 cacatggcca gttttatgtt ccctctgacc tgccaagggt gctgtgcctc ttcttaagcc
     2341 atgagctggc tcaggcccct tcccctggag ctttttcaga gtatttattt atttatttca
     2401 tggttcctga gagcacgcag cacagggtag gatgaagaag acaaggggct tctgcctgag
     2461 acccttctgc agtcatggac tgcccttgga gctgatcttc aggaactgtt tctgctgccc
     2521 agtcatgggt gtggtgccca cacctgaacc atttgaggtc ctccttgctg ataggccaca
     2581 cacacacagc agtagagcac tgagggtttg gcagtgggga ccaagcaggt gaggtgtact
     2641 cctttgtcct ggtgagagat gctcacctct gcgtatttat actgtagagc agtagacagg
     2701 aacgctgtgg agaattgtca ataaaaggcc ccatgcttat ggttttgtca ggtctcctag
     2761 tgctgttcag gtctttcatg ttgcccaggg tgggctgtag gtgggctttg cacacctcct
     2821 gtggcaattc gtgagccagc caggcccagt ggaaagctgt gccttatcaa caggaggggt
     2881 gggctttatc ttgtgaccag acccacggtc ttggattgag gttgggacca gaacttaact
     2941 ataaataatg caggcttcag aatggaaagg ttttagctaa tcctctggga aagacagaaa
     3001 ggccagcgct gcaggaggct gagagctggt aagcaggttt ctggtggggt gaggtgcaag
     3061 ttggccctgt gatcaggcta ggctggagct gggcactgca cacattatgt tagcgctggc
     3121 accaagctca tgaggtaggc tctgttttcc acatggtaag gccggcagtg cacagcagca
     3181 gcactgtgag ccagctctga gctcagcccc acctaccaag gacccatgtg ctatcatcct
     3241 gtagccttta gaaagaatgc acatctgtcc tgtgtcctta tagcaaaagc cactgctgcc
     3301 tcctcttcct cctctccctc ctcttcttcc accacctcct tcaacaaaga atgattttaa
     3361 cttttttttt tttttttttt ttttaaggta tcaggccatc ttattgaaag gtgactgtgt
     3421 agccgggcgt ggtagcgcat gcctttaatc ccaggatttg ggaggcagag gcaggcggat
     3481 ttctgagttc aaggtcagcc tggtctacaa agtgagttcc aggacagcca gggctacaga
     3541 gaaaccctgt cttgaaaaac cgaaaaacaa aacaaagcaa aaggtgactg tcactgctga
     3601 aaaaggctgg ctgtagtcac agatgtgaga cagggggctt gccttttttg tttcctggag
     3661 gtccctgtga gaacaggtgg ggaggctgtc ttcagatgca ggttcctctt aagagagcag
     3721 agctaacagg gttcagcaag gttggtgatg gtgtcaccat ggagcctgtg gtacagagat
     3781 ctcaatgtgg aatgatagac agcttgcacg ttgtagaatt ggatgtctgt gtcaaaatac
     3841 accttccaat ttgctggtac ccaggaacag agacagagag ccaggttgtg ttagagtcct
     3901 ggcatgtggc agggcaggtt tggaactctg gcatctagcc tgacttgggc tcaggtctgt
     3961 tgagtctttt gtggtctagt atgtggatgt cttcagaagg tcttggcaga cctggaatag
     4021 gtgatgattt tggggtgttt tctgtagccc ctggggctga agccaaatga atctcctttt
     4081 tcagagatct gtgtctcttc tcacagctgg ccctgttcac aggtcatcct gccagggact
     4141 atacctagcc agtagctcat gtcttacagt gtcacagttt gtctagttct tggatattct
     4201 aaataggtaa atagaggtac tggggtgggg ggtgttaagt tccccaccca aagtggagtg
     4261 ggaaacactt gtgttacaag tgttcatagc agctatggtc taagaagcct tgggtaaagg
     4321 ccatgttctg gtccccactc tctaaggagc tagccactga gctaacagac tggtctgccc
     4381 cacccccacc ctcttagcac catccccctt cagtctctac cagaacagaa gtggccttgt
     4441 ggctggagcc cccaccttcc ctagctccca gtgaccccac ctcctgccag caacacccca
     4501 gcagcacatt ccattctctg gcactgctgg tggctgggga ttccgggctc ctttggcggt
     4561 gagccttctt tggggctcca gcagaggctg tttgggctgg gacactaggc tccagccaca
     4621 cacattccag caacaaacac cccccacatt agatttccca aggagtgaac tttagccagg
     4681 attacagatg gctgcacagt tgtgggatgt gagcttgctt tgtgcagacc tgaggctgga
     4741 tgctagtagg ggtgaaaagg aatgggtggg agcggcaggc ttctctgctg ctgcctgggc
     4801 tcttgtagca tcacggaagc agctgaaggc agcctttgag attgcctgtc ccgtcctatc
     4861 tcacctctgt agaaggtggt aatagtcctc agacttttaa gctgtaggct gtgattccgt
     4921 gtggtatccc gtaactgcat gtgaggattg ggaaaagttt ggtgacagta aaaggctatc
     4981 agacaccgag caactaaaaa acaattcaaa accaaacttg aaaatcagtt ggaggtgttt
     5041 gtggagtcct gtcctgagca tcgcagtctt ggttctgaac acacaacagg caccctgtgc
     5101 cctctgcctc ccctcctgcc acacagccag tgaacactcc ttgaatcaca cagatgtgag
     5161 accactgcat attgtgaact gcagtgtttt tactgtccag tcagctcctg cttttacagg
     5221 aacacaatgg cttacagaaa ataaggacat actattgccc tgcttgcatg taaatatcaa
     5281 aaaagtacat ctttgcatca cattatattg gaatacttga ttttaaaaat taatgtttgt
     5341 ggactagtga gatgactcat taggtaagtc ctggtcacat gggctggacc cctgaatttg
     5401 atccctggaa cctgtgttaa aaagcctgat gtgttgcgtc tgtagtctca gtgttcctat
     5461 agcaagatgg gaagagacaa gaggattgct ctggagtgtg caggaggctg gcataaaccg
     5521 gagactgcct caagaagatt gaaggacaga agcagttcct ctggcatcta cactgtagca
     5581 caagtaataa caaaaattaa aaaagaagtg gaaaaaaaaa aaaaaaaaaa aaaaaa
//
