LOCUS       NM_026752               1310 bp    mRNA    linear   ROD 04-SEP-2024
DEFINITION  Mus musculus zinc finger, FYVE domain containing 21 (Zfyve21),
            transcript variant 1, mRNA.
ACCESSION   NM_026752
VERSION     NM_026752.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Jiang,Q., Song,G., He,L., Li,X., Jiang,B., Wang,Q., Wang,S.,
            Kim,C., Barkestani,M.N., Lopez,R., Fan,M., Wanniarachchi,K.,
            Quaranta,M., Tian,X., Mani,A., Gonzalez,A., Goodwin,J.E.,
            Sessa,W.C., Ishibe,S. and Jane-Wit,D.
  TITLE     ZFYVE21 promotes endothelial nitric oxide signaling and vascular
            barrier function in the kidney during aging
  JOURNAL   Kidney Int 106 (3), 419-432 (2024)
   PUBMED   38797325
  REMARK    GeneRIF: ZFYVE21 promotes endothelial nitric oxide signaling and
            vascular barrier function in the kidney during aging.
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Jiang,B., Wang,S., Song,G., Jiang,Q., Fan,M., Fang,C., Li,X.,
            Soh,C.L., Manes,T.D., Cheru,N., Qin,L., Ren,P., Jortner,B.,
            Wang,Q., Quaranta,E., Yoo,P., Geirsson,A., Davis,R.P., Tellides,G.,
            Pober,J.S. and Jane-Wit,D.
  TITLE     Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by
            activating NLRP3 inflammasomes in T cells
  JOURNAL   Sci Signal 16 (777), eabo3406 (2023)
   PUBMED   36943921
  REMARK    GeneRIF: Hedgehog-induced ZFYVE21 promotes chronic vascular
            inflammation by activating NLRP3 inflammasomes in T cells.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Nagano,M., Hoshino,D., Koshiba,S., Shuo,T., Koshikawa,N.,
            Tomizawa,T., Hayashi,F., Tochio,N., Harada,T., Akizawa,T.,
            Watanabe,S., Handa,N., Shirouzu,M., Kigawa,T., Yokoyama,S. and
            Seiki,M.
  TITLE     ZF21 protein, a regulator of the disassembly of focal adhesions and
            cancer metastasis, contains a novel noncanonical pleckstrin
            homology domain
  JOURNAL   J Biol Chem 286 (36), 31598-31609 (2011)
   PUBMED   21768110
  REMARK    GeneRIF: the C-terminal region is important for the ability of ZF21
            to induce disassembly of FAs and cell migration, and to promote an
            early step of experimental metastasis to the lung
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152065.4 and BC132248.1.
            
            On Mar 26, 2011 this sequence version replaced NM_026752.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155300.1, BC019521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC152065.4         93032-93131         c
            101-998             BC132248.1         1-898
            999-1310            AC152065.4         78913-79224         c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.14 cM"
     gene            1..1310
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /note="zinc finger, FYVE domain containing 21"
                     /db_xref="GeneID:68520"
                     /db_xref="MGI:MGI:1915770"
     exon            1..208
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..775
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger FYVE domain-containing protein 21"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 21
                     isoform 1"
                     /protein_id="NP_081028.3"
                     /db_xref="CCDS:CCDS56865.1"
                     /db_xref="GeneID:68520"
                     /db_xref="MGI:MGI:1915770"
                     /translation="MSSGVAARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPD
                     KECPRCMQCDAKFDFITRKHHCRRCGKCFCDRCCSQKVPLRRMCFVDPVRQCADCALV
                     SHREAEFYDKQLKVLLSGATFLVTFGDSEKPETMVCRLSNNQRCLVLDGDSHREIEIA
                     HVCTVQILTEGFTPGAGSTRATGMLLQYTVPGAEAAAQLRLMAGEDASGSKRQAAAWL
                     AAMHKATKLLYESRDQ"
     exon            209..259
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            260..428
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..504
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            505..596
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            597..739
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1310
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1308
                     /gene="Zfyve21"
                     /gene_synonym="1110013H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgggg cggggtggcg ccttgtgtgg gctcagcgcg ggcggtggcg tgaggggctc
       61 aggcggagac atgtcctcgg gggtggccgc gcgtcgcgac gccaagaagc ttgtgcgctc
      121 gccaagtggc ctgcgcatgg tgccggagca ccgcgccttc ggaagccctt tcggcttgga
      181 ggagccgcag tgggttccgg acaaggagtg cccaagatgt atgcagtgtg atgccaagtt
      241 tgacttcatc accagaaagc atcactgccg ccgctgtggg aagtgcttct gcgacaggtg
      301 ctgcagccag aaggtgccac ttcggcgcat gtgcttcgtg gacccagtgc gccagtgtgc
      361 tgactgtgcc ctggtgtccc accgagaggc ggagttttat gacaagcagc tgaaggtgct
      421 cctaagtgga gctaccttcc ttgttacttt tggggactca gagaagcccg agaccatggt
      481 ttgtcgtctt tccaacaacc agaggtgctt ggttctggat ggggacagtc atcgtgaaat
      541 cgagattgca catgtctgta ctgttcagat tctcacagaa ggcttcactc ctggagcagg
      601 cagcacccga gccactggca tgctcctgca gtacacagtg ccaggggcag aggctgcagc
      661 acagctgagg ctgatggccg gagaggacgc gagcggcagc aagaggcagg cagcagcgtg
      721 gctggcagcc atgcacaagg ctaccaagct cctctatgaa tcacgagacc agtaactgca
      781 agggaactga actcggagca cgtcgggtta cataaccaag ctgcttgccc ctgcctgcac
      841 tctcagggtc ttccctgtgt gtgcttggaa atgcaattca agtgtctgga agcagagtat
      901 cacttaccta gtgcaatatg tacaccgctg attaatgctg taaagagctt atgttgttgt
      961 gcattgtggt ccttcagtag ggttgggaga agctgcacta cattactgct aaagcaggct
     1021 tctgtaaact tccaggttca ttagaggctt gtggctctgt tcccacagat acattcgggg
     1081 gtgaccactc aggcccttcc actctcaata gcccattcac aatgccttag ctgttcctag
     1141 actctggtca ctctgtcact aaccggggcg atgaacagtc ctgttgctgc ctctaagagg
     1201 aaggcgtcag ctttctgttt tctactttca cttactattt cactttatta aaatgactgt
     1261 acagtaattt gtatataaag tgtataatta aaacttattt tgaaagtaca
//
