LOCUS       NM_028054               1941 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus zinc finger, FYVE domain containing 19 (Zfyve19),
            transcript variant 1, mRNA.
ACCESSION   NM_028054
VERSION     NM_028054.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Yang,J., Zhang,Y.N., Wang,R.X., Hao,C.Z., Qiu,Y., Chi,H.,
            Luan,W.S., Tang,H., Zhang,X.J., Sun,X., Sheps,J.A., Ling,V., Cao,M.
            and Wang,J.S.
  TITLE     ZFYVE19 deficiency: a ciliopathy involving failure of cell
            division, with cell death
  JOURNAL   J Med Genet 61 (8), 750-758 (2024)
   PUBMED   38816193
  REMARK    GeneRIF: ZFYVE19 deficiency: a ciliopathy involving failure of cell
            division, with cell death.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Zhang,Y., Tang,D., Wang,L., Yang,J., Wu,X., Xiao,X. and Wang,J.S.
  TITLE     Prevention of Portal-Tract Fibrosis in Zfyve19-/- Mouse Model with
            Adeno-Associated Virus Vector Delivering ZFYVE19
  JOURNAL   Hum Gene Ther 34 (23-24), 1219-1229 (2023)
   PUBMED   37672510
  REMARK    GeneRIF: Prevention of Portal-Tract Fibrosis in Zfyve19[-/-] Mouse
            Model with Adeno-Associated Virus Vector Delivering ZFYVE19.
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772264.8, BC099429.1, AK005386.1 and CO038937.1.
            
            On Sep 19, 2009 this sequence version replaced NM_028054.2.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005386.1, BC018420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AL772264.8         3165-3471           c
            308-879             BC099429.1         1-572
            880-1922            AK005386.1         644-1686
            1923-1941           CO038937.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..1941
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /note="zinc finger, FYVE domain containing 19"
                     /db_xref="GeneID:72008"
                     /db_xref="MGI:MGI:1919258"
     exon            1..464
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1580
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger FYVE domain-containing protein 19; abscission/NoCut
                     checkpoint regulator"
                     /codon_start=1
                     /product="abscission/NoCut checkpoint regulator isoform 1"
                     /protein_id="NP_082330.2"
                     /db_xref="CCDS:CCDS16595.1"
                     /db_xref="GeneID:72008"
                     /db_xref="MGI:MGI:1919258"
                     /translation="MESRCYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAGN
                     TQQKVCKQCHTILTRGSSDNASKWSPPQNYKKRVAALEAKKKSSTSHSQSLTHKDQAI
                     AERLARLRQENKPKSVPSQAEIEARLAALKDEVQGPIPSTQEMEDRLAALQGRVPPSH
                     TVRPAHQAPDTRTQAQQTQDLLTQLTAEVAIDENCQPRASASLQNDLNKGAARSQRTN
                     SQGQASQSLEEEKYKLLAEAAVELQEENTRQERILALAKRLAVLKGQDPSRVTLQDYH
                     LPDSDEDEETAIQRVMQQLTEEAALDEASGFNIPEKPAPGSRAQPCKAEMEGPQAEEE
                     ELPWCCICNEDATLRCAGCDGDLYCARCFREGHDNFDLKEHQTSPYHPRRPCQEH"
     exon            465..586
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            587..637
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            638..756
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            757..902
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1011
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1218
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1292
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1391
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1501
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1923
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /note="hexamer: AATAAA"
     polyA_site      1921
                     /gene="Zfyve19"
                     /gene_synonym="1500041L05Rik; ANCHR"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgcgta cagatccatt tgtaagagct ctttggtcac cgccatggtt ctagtccaaa
       61 cttgaattga tactacaact cccaggagtc tgagcgtgtg cgtgggcgcg gggcttactc
      121 gctccgagcc ggcccaaaag cgcgctaagc ctcctgggat gatgccttcc gattctcgtc
      181 tgactggctg tggaggagcg cgctgcggag aatgaactac gactcccagc atgccccact
      241 ccgctgccgc cccgccttgg tgagtgcaaa gtcagaattc tccgcgctgg gccgcccctg
      301 gacagcgccg atgggcgtgt gggactgggc tgcacaacct gagggtctga gaggcctacc
      361 ctgcgctggt gagaggctaa cctaccaatt ctgcagcgcc gagaactgct atggagagca
      421 ggtgctacgg ctgtgctgtc aagttcaccc tcttcaagaa ggagtatggc tgtaagaatt
      481 gtggccgagc cttctgtaac ggctgtctta gcttcagcgc tctggtaccc cgggctggca
      541 acacacaaca gaaagtctgc aagcagtgcc acacaatcct gaccagaggg tcttctgaca
      601 atgcttccaa gtggtcacca cctcagaact ataagaagcg tgtggcagcc ttggaagcca
      661 agaaaaagtc cagcacttcc catagccaaa gcctgaccca caaagaccaa gccatcgctg
      721 agcgcctagc acggcttcgt caggaaaaca agcctaagtc agtaccctca caagccgaga
      781 tagaggcacg gctagccgca ctgaaggatg aagtccaggg ccccattcct tccacgcagg
      841 agatggagga tcggcttgca gccttgcagg gcagagtccc accttctcac accgtgagac
      901 cggcacacca ggcaccagat accaggaccc aggcccagca gacgcaggat ctgctaacac
      961 agttgacagc tgaggtggct attgatgaaa actgccaacc aagagcctca gcctctctcc
     1021 agaatgacct caacaaggga gctgcgagaa gccagcgcac aaattcccag ggccaggcca
     1081 gccagtctct ggaggaagag aagtacaagc tgctggctga ggcagctgtt gagctacagg
     1141 aggagaacac caggcaggaa cggatcctgg ctcttgccaa aagattggct gtactgaagg
     1201 gacaggaccc cagcagagtg accctccagg actatcacct cccagacagt gatgaggatg
     1261 aagagacagc catccagaga gtcatgcagc agctcactga agaagctgcc ctggatgagg
     1321 caagtggctt taacatccct gagaaaccag ctccaggatc ccgggcccaa ccctgcaagg
     1381 cagagatgga ggggccccag gctgaggagg aggaactccc ctggtgctgt atctgcaatg
     1441 aggatgctac tttgcgctgt gctggctgtg atggggacct ctactgtgcc cggtgcttcc
     1501 gggagggcca tgataacttt gatcttaaag aacatcagac ttctccctac cacccccgac
     1561 ggccttgcca agaacactga ggataaccta atgatctcct gaggtggctg tgccacaggc
     1621 aaccagcagg ctgggaagac tcctgggcca agtctcaggg catccagggg gacagaagac
     1681 cctgctctac tgatggtaaa cacacccttt tgtgagcttc ccagtccctg gaaggaagaa
     1741 acataataag tctgagaggg gccaggtgag aggaggagtc atggccctcc cctaagaggc
     1801 tggcctcaaa cagagacaga tggagaagac accatactga agctaaaagt gatacctgaa
     1861 atctgcttcc caggcccaat cctggctata ctgggatcta ataaaatgtg ttgagccatt
     1921 ggcaaaaaaa aaaaaaaaaa a
//
