LOCUS       NM_173392               5451 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger, FYVE domain containing 16 (Zfyve16),
            mRNA.
ACCESSION   NM_173392
VERSION     NM_173392.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5451)
  AUTHORS   Zhao,X., Li,D., Qiu,Q., Jiao,B., Zhang,R., Liu,P. and Ren,R.
  TITLE     Zfyve16 regulates the proliferation of B-lymphoid cells
  JOURNAL   Front Med 12 (5), 559-565 (2018)
   PUBMED   29247407
  REMARK    GeneRIF: The proportion of T cells in the peripheral blood of
            Zfyve16(KO) mice increases compared with that in wild-type mice. B
            cell proliferation is inhibited in Zfyve16(KO) mice. The
            proliferation potential of Zfyve16(KO) B-lymphoid cells also
            significantly decreases in vitro. Zfyve16 inhibits the
            proliferation of T cells, possibly through the TGF-beta signaling,
            but upregulates the proliferation of B-lymphoid cells.
REFERENCE   2  (bases 1 to 5451)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154363.2.
            
            On Oct 19, 2007 this sequence version replaced NM_173392.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042669.1, AK122241.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC154363.2         48399-48510
            113-221             AC154363.2         54871-54979
            222-2437            AC154363.2         55878-58093
            2438-2534           AC154363.2         59646-59742
            2535-2696           AC154363.2         62517-62678
            2697-2839           AC154363.2         65280-65422
            2840-3218           AC154363.2         67353-67731
            3219-3341           AC154363.2         69086-69208
            3342-3497           AC154363.2         70163-70318
            3498-3722           AC154363.2         70863-71087
            3723-3805           AC154363.2         73467-73549
            3806-3910           AC154363.2         74629-74733
            3911-4058           AC154363.2         75123-75270
            4059-4139           AC154363.2         78916-78996
            4140-4302           AC154363.2         84112-84274
            4303-4408           AC154363.2         85246-85351
            4409-4576           AC154363.2         86539-86706
            4577-5451           AC154363.2         90586-91460
FEATURES             Location/Qualifiers
     source          1..5451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.72 cM"
     gene            1..5451
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="zinc finger, FYVE domain containing 16"
                     /db_xref="GeneID:218441"
                     /db_xref="MGI:MGI:2145181"
     exon            1..112
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            113..221
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4738
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="endofin; endosomal-associated FYVE domain protein"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 16"
                     /protein_id="NP_775568.1"
                     /db_xref="CCDS:CCDS26682.1"
                     /db_xref="GeneID:218441"
                     /db_xref="MGI:MGI:2145181"
                     /translation="MDSYFKAAVSGLDKLLDDFEQNPDKQDYLPDAYAFNQCSVSSES
                     ASPQLALLSKDQRCISTCASSEACCEDANETFLEGKIHEGLTSRPNEKNVAGLDLLSS
                     VDASTSDEIQPSCMRRCSKPVCDLISDMGNLVHATNSEEDIKQLLPDDPKSSADTLIT
                     LDSSSVSEALTVSSVDCGSNAVREEQNNINAGIKNRDISIKELGVKVDMALFDSCKYN
                     RTENLKDKIISNELETVDFDMPSVLMEQSSEMSNTKDNPQYKRLPCELLKDDGCLAEE
                     KVAVAVNNTECLEEGGGSNTIAMPCKLPENEGISPSDPASKDENFKLPDFPLQENRTS
                     VFMKQTVKEDSRNLDLKDNNDIVHVSGDDVPPSLSCLSLSGSLCGSLIHNNEHSDILP
                     PNESEGQNNDAVTIHEEIQKSDVLDGETDLSKKETCRSIFLQPVNEKKGEGKVEVEEM
                     VISGESLESPEDASSAAAAGSPVALSAASVPEAPGPCEGLTFPSSDMDGQELDYFNID
                     ESMRSGILISDAELDAFLKEQCLSNSNTMSAGENVNDSQLQMNQITMKGLHDENAGDI
                     YFNAEAGAAGENGGVGNCETSDKENTENNGLSIGEKGAIPTERELSACQPDIRDELPV
                     PSIKTQAVGGARPKQLLSLPPGTRSSKELNKPDVVDVPESEPCTANATAVSTCSADHI
                     PDSQVSFNSNYIDIESNFEDGSSFVTANKDSLPENKRKESLVLGQKQPTWVPDSEAPN
                     CMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVICYETINKAQAF
                     ERMMSPGGSCLKSNHSNECATDQPLQETQTSSTPSPTTLPISALKQPNVEGPCSKEQK
                     RVWFADGILPNGEVADTTKLSSGSKRCSDDFSPVLPDVPTMINKVDRTHSPTVEKPNN
                     GLGDIIRSEISQSPTCHTAPVERLPGNTGTEGLPMPGPFTLEDDVFVDSEEPSTPTVV
                     PANSGLPVASISDYRLLCSVAKCVCNNISLLPDDDIGLPPLLATSGEDGSVPVVQERP
                     SHEQIILLLEGEGFPPATFVLNANLLVNVKLVLYSSEKYWYFSTNGLHGLGQAEIIVL
                     LQCLPNEDTVPKDIFRLFITIYKDALKGKYIENLDNLTFTESFLNSKDHGGFLFITPT
                     FQNLDGLPVPRSPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSVRGRKP
                     LFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVIHSSN
                     EHVISIGASFSTEADSHLVCVQSDGVYQTQANSATGQPRKVTGASFVVFNGALKTSSG
                     FLAKSSIVEDGLMVQITPETMEGLRLALREQKDFRIQCGKVDAVDLREYVDICWVDSE
                     ERKNKGVISSVDGMSVEGFPSEKIKLETDFETEEKTVKCTEVFYFLKDQDISILSSSY
                     QFAKEIAVACSAALCPHLRTLKSNRMNKIGLRVSIDTDMVEFQAGCEGQLLPQHYLND
                     LDSALIPVIHGGTSNSSLPLEIELAFFILENLSE"
     exon            222..2437
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2534
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2696
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2839
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3218
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3341
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3497
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..3722
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3805
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3910
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4058
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4139
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4302
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4408
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            4409..4576
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..5451
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5242..5247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="hexamer: ATTAAA"
     polyA_site      5265
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="major polyA site"
     regulatory      5331..5336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="hexamer: ATTAAA"
     polyA_site      5362
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
     regulatory      5433..5438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
                     /note="hexamer: AATATA"
     polyA_site      5451
                     /gene="Zfyve16"
                     /gene_synonym="B130024H06Rik; B130031L15; mKIAA0305"
ORIGIN      
        1 ggacgagctc taggctggcg tcgcgctgtc ctgggtgtcg tggccgggtt actcttcacg
       61 cctcactgcg gcgtcgcgtc gagtccccga gagctcggcg gggtgtgggg agacatagaa
      121 gaattgagtt ctgagtaagc ccacagggag gatggacagt tactttaaag cagctgtcag
      181 tggcttggac aaacttcttg atgattttga gcagaatcca gataagcaag attatctccc
      241 agatgcatat gcttttaacc agtgctcagt ttcctcagag tcggcctctc cacagctagc
      301 tttactgtca aaggaccaaa gatgcatcag tacttgtgcc tcatcagaag catgctgtga
      361 agatgcaaat gagacttttc ttgaaggaaa gatacacgag ggcttaacct ctagaccgaa
      421 tgaaaaaaac gtagcgggac ttgatcttct ttcttctgtg gatgcgagta cttcagatga
      481 gatccagcct tcctgtatga gacggtgtag taagcctgtc tgtgacctga taagtgacat
      541 gggtaactta gtgcatgcca ccaatagtga ggaagacatt aagcagttat tgccagatga
      601 ccctaagtct tctgcagata ctttgatcac attggactcg tcttcagttt cagaggctct
      661 cactgtctct tcagtagact gtggtagtaa tgctgtcaga gaagagcaga ataacatcaa
      721 cgctggtata aaaaacagag atattagtat caaagaattg ggtgtaaaag tagacatggc
      781 actttttgat tcttgtaaat ataatagaac agaaaattta aaggataaaa ttatttctaa
      841 tgagttagaa acagttgatt ttgacatgcc atctgttttg atggaacaaa gttctgaaat
      901 gtctaatacc aaagataacc cacaatacaa gaggctgcca tgtgaattgt taaaagatga
      961 tggctgtttg gcagaagaga aagtagctgt ggcagtcaat aatacagagt gtttagaaga
     1021 aggaggagga agtaacacaa ttgctatgcc ttgcaagctt ccagaaaatg aagggatatc
     1081 cccaagtgac ccagcttcaa aagatgaaaa tttcaagtta cctgactttc ccctccagga
     1141 aaatagaact tctgtgttca tgaaacagac tgtaaaagaa gactcaagaa atttagacct
     1201 taaagataat aatgatatag tccatgtttc aggtgatgat gtgccccctt cactgtcctg
     1261 tctttcattg tctgggtctt tgtgtggatc gttaattcac aataatgaac acagtgatat
     1321 tttacctcct aatgagtctg aaggccagaa caatgatgca gtgactatac atgaagagat
     1381 acagaagagt gatgttttag atggggagac agatctttca aagaaggaaa cgtgtaggag
     1441 catatttctt cagccagtaa atgaaaagaa aggggaggga aaggttgagg ttgaggagat
     1501 ggtaatcagt ggtgagtctt tggagtcccc tgaggacgcc agctctgctg cagcagctgg
     1561 gtctccggtg gcactttctg ctgcaagtgt cccagaggct cctggtccat gtgaaggtct
     1621 cacttttccc agcagtgata tggatgggca agagttagat tactttaata ttgatgaaag
     1681 catgagaagt ggcatactaa ttagcgatgc tgaactcgat gcttttctga aggaacagtg
     1741 tctttcgaac tctaacacaa tgtctgctgg agaaaatgta aatgattccc agttgcagat
     1801 gaatcagatc actatgaaag gactacatga tgaaaatgct ggggatatat acttcaatgc
     1861 tgaagcagga gctgctggag aaaatggagg tgttggcaac tgtgaaacaa gtgataaaga
     1921 aaacacagaa aataatggtc tttccatagg agaaaaaggc gcaattccaa ctgaaagaga
     1981 gttatctgcc tgtcagcctg acataaggga tgaattgcca gtccccagta ttaaaaccca
     2041 agctgttgga ggggctcgac ctaagcagct gctgagtctt ccaccaggaa caaggagttc
     2101 aaaggaactg aataagccag atgttgtgga tgtgccagaa agtgagccat gcacagcaaa
     2161 tgctactgct gtatccactt gctctgcaga tcatatacct gattctcagg ttagcttcaa
     2221 ctccaattac attgacatag aaagtaattt tgaagatgga tccagttttg taactgcaaa
     2281 caaggattct ctgcctgaaa ataagcgcaa agaaagcttg gttttgggcc agaaacaacc
     2341 tacatgggtt cctgattcag aagctccaaa ctgtatgaac tgccaagtca aattcacctt
     2401 tacaaaacgg cgacaccact gccgagcatg tgggaaggta ttttgtggtg tctgttgtaa
     2461 caggaaatgt aagcttcagt atctagagaa ggaagcaaga gtatgtgtaa tctgctatga
     2521 gactataaat aaagctcagg catttgaaag gatgatgagt ccaggtggtt cttgtcttaa
     2581 gtctaatcat tctaatgaat gtgccactga tcagccactt caggagaccc aaacatccag
     2641 tacaccttca cctacaactt tgcccatctc agcactgaaa caaccaaatg ttgaaggacc
     2701 atgttccaaa gaacagaaga gagtatggtt tgcagatggc atactgccga atggtgaagt
     2761 tgcagatact acgaaattat catctggaag taaaagatgt tctgatgact ttagtcctgt
     2821 cttacctgat gtgcccacaa tgataaataa agtggatcgt acccattctc ctacagtgga
     2881 aaaaccaaac aatggtttag gagacattat aagaagtgag ataagccaga gtccaacttg
     2941 tcatactgca cctgtggaaa gactgccggg gaacacaggc acggaaggct tgcccatgcc
     3001 tggccctttc acactagaag atgatgtttt tgtggacagc gaggagccgt ctactcctac
     3061 tgttgtccct gctaatagtg gtttgcctgt tgctagcatt tcagactaca ggttattgtg
     3121 tagtgttgcc aaatgtgtct gcaacaacat tagtcttcta ccagacgatg acattggttt
     3181 gcctcccctt ctggccacat ctggagaaga tggatcagtg cctgttgtgc aagaacgtcc
     3241 ctctcatgag cagatcattt tacttcttga aggggaagga tttcctcctg ctacatttgt
     3301 tctaaatgca aacctccttg tgaatgtcaa gttggtgctt tattcctcag agaagtattg
     3361 gtacttctca accaatggat tgcatggctt gggacaggca gaaattattg tcctgttgca
     3421 atgtttgcca aatgaggata cggttcctaa ggacatcttc agactgttca tcaccatata
     3481 taaggatgct ttaaaaggaa aatacataga aaatttggac aatctgacct ttactgagag
     3541 ttttctcaac agcaaggatc atggagggtt cctgtttatt acacctacct tccagaacct
     3601 tgatggtctc cccgtgccaa ggagtccttt tctctgcggc attcttatcc agaagctgga
     3661 gattccctgg gcaaaggttt ttcctatgcg gctaatgttg cgattgggag cagaatacaa
     3721 agcataccct gctcctctaa caagtgtcag aggcaggaaa cctctttttg gagaaatagg
     3781 acatactatt atgaacttac ttgttgatct tcgaaattac cagtatacat tgcataacat
     3841 cgatcagcta ttgattcata tggaaatggg aaaaagctgt ataaaaatac ctcgaaaaaa
     3901 gtacagtgat gtaatgaagg taatacattc ctctaacgag cacgtcatca gtattggagc
     3961 tagttttagt acagaagcag attctcatct ggtctgtgta cagagtgatg gagtttatca
     4021 gactcaggcc aacagtgcca ctggtcagcc aaggaaagtg acaggtgcaa gttttgtggt
     4081 gtttaatggt gctctgaaaa catcttcagg atttcttgcc aaatccagca tagtcgaaga
     4141 tggcttaatg gtacaaataa ctccagagac catggagggc ttgcggctgg ctttacgaga
     4201 gcaaaaggac tttagaatcc agtgtggaaa agttgatgcg gtagacctga gagagtatgt
     4261 ggacatctgt tgggtggatt cagaagagag gaagaacaaa ggtgttatca gttcagtaga
     4321 tggaatgtca gtggaaggat ttccaagtga aaaaataaaa ctggaaacag attttgaaac
     4381 tgaggagaag actgtgaaat gcactgaggt gttctacttc ctaaaggacc aagatatatc
     4441 tattttatca agtagttacc agtttgcaaa ggagattgct gtggcttgta gtgctgccct
     4501 gtgccctcac ctgagaactc taaagagtaa cagaatgaac aaaattggac tcagagtgtc
     4561 cattgacact gatatggttg agttccaggc aggctgtgaa ggccagcttc tgcctcagca
     4621 ttacctgaat gatctggata gtgccctgat ccctgtgatc cacggcggga cctccaactc
     4681 tagtctgcca ctagaaatag agttagcatt tttcattcta gaaaaccttt ctgagtgaaa
     4741 ccgtgtactg tgctgtatct tgcaaactga tcggttaaaa cgaatcccag cactaaaacg
     4801 gaaatgccac caacactaaa tgtttgataa ttgaaatata taattttgct ttttaggtag
     4861 gaatgatttt taaaaatcat tagcacagta tttaagttcc taaaaattta aggaatcatc
     4921 atttttatag ctttatgctt attataagaa ctaagaggaa atatttctaa cttacaattt
     4981 acagtattta ctgtgtacct taactgttaa gccaaagcat ctgcgcttag ccctactcct
     5041 catagatgac gagaatgaag gagagacctg cgttgtgtgg atgctagtga gaacactggt
     5101 tttgaagtct gtttaaaaat gtatctcagt aaggaagacc agtttcaaga ttctagactt
     5161 ataattcttt gaataaagct gataacttat ttgtataaat ggaatgaaga cctacctcca
     5221 tgattacata caaactgttt gattaaattt agaattttgc ctttatttct tctcaaattt
     5281 catgtatcta tatatatata tacacacata taaatatatc attttttctg attaaaataa
     5341 ttgcgggtgc tttaggactt tatgcttctc tatttaagtc tgttgtttcc atagcaacat
     5401 atgatttgga atgtgtttta taaatctttg ctaatatata aatagataat a
//
