LOCUS       NM_183154               4342 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, FYVE domain containing 1 (Zfyve1),
            transcript variant 1, mRNA.
ACCESSION   NM_183154
VERSION     NM_183154.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Zhong,X., Feng,L., Xu,W.H., Wu,X., Ding,Y.D., Zhou,Y., Lei,C.Q. and
            Shu,H.B.
  TITLE     The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by
            facilitating TLR3 ligand binding
  JOURNAL   Cell Mol Immunol 17 (7), 741-752 (2020)
   PUBMED   31388100
  REMARK    GeneRIF: The zinc-finger protein ZFYVE1 modulates TLR3-mediated
            signaling by facilitating TLR3 ligand binding.
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Zhong,X., Feng,L., Zang,R., Lei,C.Q., Yang,Q. and Shu,H.B.
  TITLE     ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate
            antiviral response
  JOURNAL   PLoS Pathog 16 (4), e1008457 (2020)
   PUBMED   32251420
  REMARK    GeneRIF: ZFYVE1 acts as a specific negative regulator of
            MDA5-mediated innate immune responses by inhibiting its ligand
            binding and oligomerization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Gao,G., Sheng,Y., Yang,H., Chua,B.T. and Xu,L.
  TITLE     DFCP1 associates with lipid droplets
  JOURNAL   Cell Biol Int 43 (12), 1492-1504 (2019)
   PUBMED   31293035
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Dooley,H.C., Razi,M., Polson,H.E., Girardin,S.E., Wilson,M.I. and
            Tooze,S.A.
  TITLE     WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and
            pathogen clearance by recruiting Atg12-5-16L1
  JOURNAL   Mol Cell 55 (2), 238-252 (2014)
   PUBMED   24954904
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Hamasaki,M., Furuta,N., Matsuda,A., Nezu,A., Yamamoto,A.,
            Fujita,N., Oomori,H., Noda,T., Haraguchi,T., Hiraoka,Y., Amano,A.
            and Yoshimori,T.
  TITLE     Autophagosomes form at ER-mitochondria contact sites
  JOURNAL   Nature 495 (7441), 389-393 (2013)
   PUBMED   23455425
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Orsi,A., Razi,M., Dooley,H.C., Robinson,D., Weston,A.E.,
            Collinson,L.M. and Tooze,S.A.
  TITLE     Dynamic and transient interactions of Atg9 with autophagosomes, but
            not membrane integration, are required for autophagy
  JOURNAL   Mol Biol Cell 23 (10), 1860-1873 (2012)
   PUBMED   22456507
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055772.16, BC050015.1, AC139382.3 and AA422700.1.
            
            On Dec 22, 2017 this sequence version replaced NM_183154.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170954.1, AK129400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC055772.16        134962-135187
            227-1151            AC055772.16        136862-137786
            1152-1278           AC055772.16        157048-157174
            1279-2815           BC050015.1         625-2161
            2816-4326           AC139382.3         159634-161144       c
            4327-4342           AA422700.1         474-489
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.76 cM"
     gene            1..4342
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="zinc finger, FYVE domain containing 1"
                     /db_xref="GeneID:217695"
                     /db_xref="MGI:MGI:3026685"
     exon            1..226
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1151
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..3002
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger FYVE domain-containing protein 1"
                     /codon_start=1
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_898977.2"
                     /db_xref="CCDS:CCDS26028.1"
                     /db_xref="GeneID:217695"
                     /db_xref="MGI:MGI:3026685"
                     /translation="MSAQTSLAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLR
                     CEEELHRQERLRNHERIRLKAGHVPYCDPCKGPNGHSPGVRQRAAVRCQTCKINLCLE
                     CQKRTHSGGNKRRHPITVYLVSKVQESLEGEEMDEETKRKKMTERVVSFLLVDENEEI
                     QVTNEEDFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPAQESCT
                     VGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDL
                     FKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSE
                     APEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRH
                     PGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGAGCKNSMNHGKEG
                     VPHEAKSRCRYSHQYDNRVYTCKACYERGKEVSVVPKTSASTDSPWMGLAKYAWSGYV
                     IECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDAFLKDNNNAAQRLLDGMNF
                     MAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNQCATSFKDNDTKHHCRACG
                     EGFCDSCSSKTRPVPERGWGPAPVRVCDSCYDARNVQLDVTEAQADDEGGTLIARKVG
                     EAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSVKLSKHHCRAC
                     GQGFCDECSHDCRAVPSRGWDHPVRVCFNCNKKPGDL"
     exon            1152..1656
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1871
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1978
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2087
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2185
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2303
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2474
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2655
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2769
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..4329
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="hexamer: AATAAA"
     polyA_site      3007
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="major polyA site"
     regulatory      4307..4312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="hexamer: TATAAA"
     polyA_site      4329
                     /gene="Zfyve1"
                     /gene_synonym="DFCP1; G630053K23; mKIAA1589; TAFF1;
                     ZNFN2A1"
                     /note="major polyA site"
ORIGIN      
        1 agctgggctg cgctgttcat gccttcctgt tggtctgagc tgggagaagt tcactctgat
       61 cagctgattc caactgacaa caagagagga ggaagcctgg gaggcagcag aggaggaggg
      121 ggcggagatg gagctgagga tggatccgcc ggggccctag agcagcccgg gtcctgtcgg
      181 caatccgcgt cccccacacc gccttgcctt ggccgaactg ctccgggtag cccttgaaac
      241 attggcttga ggtccaagta aatcgaacag ctcctcacca ccttctgtca tcactctgac
      301 tttgtagctg agacccaaac caatgagctg acctttgtga acccagcaga cccctcagcg
      361 tgtggcagag actctgtcaa gttcacttcc accacatatt tctttgcact ttgcagagga
      421 tgagaccatc aaattcagtg gacactgctg ctgctgctga tacaagagac tgggaggcag
      481 agaattaaaa atctgaacat ttgtgagcgt gtgaaaatcc taagccagtc aggttttctt
      541 ttttaaaggg ctcagaaccc tgtgaagtgc tagccacctt cagcctcaaa gcatttgtct
      601 tccttcattc ctgggaaagt acagtagtga ctgttgcagg gtgggtggtt tccaaacgag
      661 tctaagttat gagtgcccag acttccctag cagagaaggg cctaaatccg gggctcatgt
      721 gccaggagag ttatgcatgc agtgggactg atgaagctat ctttgaatgt gatgagtgtt
      781 gtagtttgca gtgtctccgc tgtgaggagg aactccacag acaggagcgc cttcgaaacc
      841 atgagcggat aagactcaaa gctggccatg tcccttattg tgacccctgc aagggcccca
      901 atgggcattc gccaggtgtt aggcaaaggg cagccgtgag gtgccagact tgcaaaatca
      961 atctctgcct ggaatgccag aagaggactc attcaggggg taacaagaga agacacccca
     1021 ttaccgtgta ccttgtcagt aaggtccagg agtccctgga gggggaagag atggatgagg
     1081 agaccaagag gaagaagatg acagagaggg ttgtgagctt cctcctggta gacgaaaatg
     1141 aagagatcca ggtaacaaat gaagaggact ttatcaggaa attggactgt aagcctgacc
     1201 agcatctcaa ggtggtttcc atttttggaa atactggtga tggaaagtct cacacactca
     1261 accacacttt cttctatggc cgagaagtct tcaaaacctc ccctgctcag gagtcctgca
     1321 cagtgggagt gtgggcagcc tatgacccag tccataaggt agcagtgata gacacagaag
     1381 gactcttggg ggccaccgtg aatctgagcc agaggacacg gctgctgctg aaggtcctgg
     1441 ccatctcaga cttggtcatc tatcgaactc atgcagaccg gctgcataat gacctcttca
     1501 aattccttgg ggatgcctcg gaagcttacc tgaagcactt caccaaggaa ctcaaggcca
     1561 ccactgcacg atgtggcctg gatgtcccct tatccaccct gggccctgca gttattattt
     1621 tccatgagac tgtgcacact cagcttctgg gttctgatca cccctccgag gcgcccgaga
     1681 agctcatcca ggaccgcttc aggaagctgg gccgcttccc cgaagccttt agctccattc
     1741 actacaaggg aacgaggaca tacaatccgc ccacagactt ctctgggctt cggcgtgctc
     1801 tggaacagct actagagaac aacaccacca ggtctccccg gcacccaggg gtcatcttca
     1861 aagccctgaa ggcactaagt gaccgcttca gcggtgagat ccccgatgac cagatggcgc
     1921 acagttcatt ttttccagac gagtacttca cctgctcctc gctctgcctc agctgtgggg
     1981 cgggatgtaa gaacagcatg aaccacggca aggaaggggt gcctcatgaa gccaagagtc
     2041 gctgtaggta ctcacaccag tatgacaacc gcgtctatac ctgcaaggcc tgctatgaga
     2101 gaggcaagga agtcagcgtg gtgcccaaaa catctgcctc cactgactct ccctggatgg
     2161 ggctggcaaa gtatgcctgg tctgggtatg tgatcgagtg tcctaactgt ggggtggtct
     2221 atcggagccg ccagtactgg tttgggaacc aagatcctgt ggatacggtg gtgcggacag
     2281 agattgtcca cgtgtggcct ggaactgatg catttctgaa ggataacaac aatgccgccc
     2341 agcgtctctt ggatggaatg aactttatgg ctcagtcagt gtctgagctc agcctcggac
     2401 ccactaaggc tgtgacgtct tggctaacgg atcagattgc ccctgcctac tggaggccca
     2461 actcccagat cctgagctgc aaccagtgtg cgacatcctt caaggacaac gacacgaagc
     2521 atcactgccg ggcctgtggg gagggcttct gtgacagctg ttcatccaag acccggccgg
     2581 tgcctgagcg gggctgggga cctgcgcctg tccgcgtgtg tgacagctgc tacgatgcca
     2641 ggaatgtcca gttagatgtg actgaggcgc aggcagatga tgaaggtgga acgctgattg
     2701 cccggaaggt gggcgaggcc gtgcagaaca ccttgggagc cgtggtgaca gctattgaca
     2761 taccactagg cctggtaaaa gatgccgcca ggccggccta ctgggtgcct gaccatgaga
     2821 tcctgcactg ccacaactgc cgcaaggagt tcagcgtcaa gctctccaaa caccactgcc
     2881 gagcttgcgg acagggcttc tgcgatgagt gctcccatga ctgcagggct gtcccctctc
     2941 gtggctggga ccatccagtc cgagtctgct tcaactgcaa taaaaagccc ggtgaccttt
     3001 aaccccagtt ccctctccga ctgcttcaca attccttagg ttctcagggt tagaaacaga
     3061 agtctcactg aggtaggccc tcctcctggt cacctggtgt ggtgtgtggt gtgtgtaccc
     3121 cctctcacgt ccctcagtgg aggtgagcct ggcggtagat ccgaaggcat gaaccacgtc
     3181 agggcagggc atggagcagc tctcagtaaa gcagaatgga ccagagtcca ttgcatttat
     3241 ttcagttaaa aataataaat ctctctatat atatatatct ccatttatcc atctagaggg
     3301 gatttggagt gatcaagact gcttctgctt tgaagactta ccctggtgtg tccccagcac
     3361 agggataagg tggcactggg agtcagtctt gctcctgaag cgagccaggt tttgctgctt
     3421 cacccagagc ttggcagtgt ccttttctgt ccctcttccc tcctgcaccc ctgctgcctg
     3481 gatggctgtc taggtttgaa cctcttgctt gaagcagtca tggttccgac ctgtactggg
     3541 cagaggtctg gcttcgtgtg taagctactg gcgtatgtaa gggtcagagg gtagagtctt
     3601 gagacataaa aagtcaagat gcaggtactt gtggcccctg cagatgggga gtccagaagg
     3661 aattggtctc ccctgtaggc cgtgacgttt ctgtctcctc taggctttct tagaagccat
     3721 accctgctcc tcccctctgc ccctggactc caggctgccc cttcttagga tttttattgc
     3781 tcacagtgtc ttattctttg ttcccataca tacaacccct ctacttgggg gggtgggggg
     3841 gcgaccacaa gaaaccttcc agggaaacag cacagaatgg actgttagtt atgtttttta
     3901 aataaataaa tatatatata tatataaaat aaatatttca acagatcatg aggaaaaaaa
     3961 tctctttggt tcttacaaga gaaacgaagt gaacaaatat ttctcaaata aataaataaa
     4021 taaataattt taaaaagctt ggccatcgta tggatcatga ctggaaagac tgctgtgctg
     4081 aactcctggg agggagttca tcttcagtgg ccaaaaaaaa gaagaatcaa agcaacattg
     4141 ttacagattg aactgatggg tgggtggagc ctcagggaag gatatgggta gtcattcctg
     4201 gggcgggtct ccagcgatgt tagccctgga atggactggt ccttcttagc tctgcccttt
     4261 ctgcctccgg aggccctatt ctagaactgt atcatccatt caccactata aaggaatctt
     4321 cctgctgaaa aaaaaaaaaa aa
//
