LOCUS       NM_009571               2816 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus zinc finger protein 2, Y-linked (Zfy2), mRNA.
ACCESSION   NM_009571
VERSION     NM_009571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Yamauchi,Y., Matsumura,T., Bakse,J., Holmlund,H., Blanchet,G.,
            Carrot,E., Ikawa,M. and Ward,M.A.
  TITLE     Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to
            spermatogenesis impairment, sperm defects, and infertility
  JOURNAL   Biol Reprod 106 (6), 1312-1326 (2022)
   PUBMED   35293998
  REMARK    GeneRIF: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to
            spermatogenesis impairment, sperm defects, and infertility.
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Kuroki,S., Okashita,N., Baba,S., Maeda,R., Miyawaki,S., Yano,M.,
            Yamaguchi,M., Kitano,S., Miyachi,H., Itoh,A., Yoshida,M. and
            Tachibana,M.
  TITLE     Rescuing the aberrant sex development of H3K9 demethylase
            Jmjd1a-deficient mice by modulating H3K9 methylation balance
  JOURNAL   PLoS Genet 13 (9), e1007034 (2017)
   PUBMED   28949961
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Nakasuji,T., Ogonuki,N., Chiba,T., Kato,T., Shiozawa,K.,
            Yamatoya,K., Tanaka,H., Kondo,T., Miyado,K., Miyasaka,N.,
            Kubota,T., Ogura,A. and Asahara,H.
  TITLE     Complementary Critical Functions of Zfy1 and Zfy2 in Mouse
            Spermatogenesis and Reproduction
  JOURNAL   PLoS Genet 13 (1), e1006578 (2017)
   PUBMED   28114340
  REMARK    GeneRIF: Zfy2-KO mice did not show any significant phenotypic
            alterations.  Zfy1/2-DKO mice were infertile and displayed abnormal
            sperm morphology and fertilization failure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Vernet,N., Mahadevaiah,S.K., de Rooij,D.G., Burgoyne,P.S. and
            Ellis,P.J.I.
  TITLE     Zfy genes are required for efficient meiotic sex chromosome
            inactivation (MSCI) in spermatocytes
  JOURNAL   Hum Mol Genet 25 (24), 5300-5310 (2016)
   PUBMED   27742779
  REMARK    GeneRIF: we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also
            necessary for efficient meiotic sex chrand the sex chromosomes are
            not correctly silenced in Zfy-deficient spermatocytes.
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Vernet,N., Mahadevaiah,S.K., Decarpentrie,F., Longepied,G., de
            Rooij,D.G., Burgoyne,P.S. and Mitchell,M.J.
  TITLE     Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm
            Head Remodelling and Sperm Tail Development
  JOURNAL   PLoS One 11 (1), e0145398 (2016)
   PUBMED   26765744
  REMARK    GeneRIF: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for
            Sperm Head Remodelling and Sperm Tail Development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Su,H. and Lau,Y.F.
  TITLE     Demonstration of a stage-specific expression of the ZFY protein in
            fetal mouse testis using anti-peptide antibodies
  JOURNAL   Mol Reprod Dev 33 (3), 252-258 (1992)
   PUBMED   1449792
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Simpson,E.M. and Page,D.C.
  TITLE     An interstitial deletion in mouse Y chromosomal DNA created a
            transcribed Zfy fusion gene
  JOURNAL   Genomics 11 (3), 601-608 (1991)
   PUBMED   1774064
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Ashworth,A. and Denny,P.
  TITLE     Zinc finger protein genes in the mouse genome
  JOURNAL   Mamm Genome 1 (3), 196-200 (1991)
   PUBMED   1797234
  REMARK    Review article
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Gubbay,J., Koopman,P., Collignon,J., Burgoyne,P. and
            Lovell-Badge,R.
  TITLE     Normal structure and expression of Zfy genes in XY female mice
            mutant in Tdy
  JOURNAL   Development 109 (3), 647-653 (1990)
   PUBMED   1698142
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Ashworth,A., Skene,B., Swift,S. and Lovell-Badge,R.
  TITLE     Zfa is an expressed retroposon derived from an alternative
            transcript of the Zfx gene
  JOURNAL   EMBO J 9 (5), 1529-1534 (1990)
   PUBMED   1691708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK133222.1.
            
            On Jan 5, 2007 this sequence version replaced NM_009571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133222.1, M24401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2816              AK133222.1         2-2817
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..2816
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /note="zinc finger protein 2, Y-linked"
                     /db_xref="GeneID:22768"
                     /db_xref="MGI:MGI:99213"
     exon            1..261
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..331
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..419
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2692
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /note="Y-linked zinc finger protein 2"
                     /codon_start=1
                     /product="zinc finger Y-chromosomal protein 2"
                     /protein_id="NP_033597.2"
                     /db_xref="CCDS:CCDS41217.1"
                     /db_xref="GeneID:22768"
                     /db_xref="MGI:MGI:99213"
                     /translation="MDEDEIELTPEEEKSLFDGIGADAVHMDSDQISVEVQETVFLSN
                     SDVTVHNFVPDDPDSVIIQDVIENVLIEDVHCSHILEETDISDNVIIPEQVLDLDTAE
                     EVSLAQFLIPDILTSSITSTSLTMPEHVLMSEAIHVSNVGHFEQVIHDSLVEREIITD
                     PLTADISDILVADWASEAVLDSSGMPLEQQDDARINCEDYLMMSLDEPSKTDHEGSSE
                     VTMNAESETDSSKLDEASPEVIKVCILKADSEVDDVGETIQAVESETDNGNEAEVTDQ
                     RTSIHVPRVNIYMLASDSQKEEEDTKVIVGDEDAGGTAADTPEHEQQMDVSEIKAAFL
                     PIAWTAAYDNNSDEIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQSAIF
                     VAPDGQTLRVYPCMFCGKKFKTKRFLKRHIKNHPEYLANKKYHCTECDYSTNKKISLH
                     NHMESHKLTIKTEKTTECDDCRKNLSHAGTMHTEKGVNKTCKCKFCDYETAEQTLLNH
                     HLLVVHRKKFPHICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADSSNLKTH
                     IKSKHSKEIPLKCGICLLTFSDTKEAQQHAVLHQESRTHQCSHCNHKSSNSSDLKRHI
                     ISVHTKAYPHKCDMCSKGFHRPSELKKHVATHKSKKMHQCRHCDFKSPDPFLLSHHIL
                     SAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRKVYQCEYCEYSTKDASGFKRHVIS
                     IHTKDYPHRCDFCKKGFRRPSEKNQHIMRHHKEVGLA"
     exon            420..971
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1121
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1262
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1385
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1526
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..2816
                     /gene="Zfy2"
                     /gene_synonym="Zfy-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactatgg ggccagtctc tggagagctc tgctattgct ccagtggcca agaaagtcca
       61 ctggtctaga gcagcaacag gagcagccac cgccaccaaa gccaaaagat ctaagcttaa
      121 gacctccagc aaaagattca agcttaataa gaagcgaaac cctagattta gcttcccaag
      181 agatcttgtc cctctttaat tcgttccagt tctcgttcct gttgttgctg ttgtggttct
      241 cgtagcagaa atacattaaa gccagagacc ggcccagtac tctgaagtct gcagtacttg
      301 tcgtcattgc ctacccctct acactggtct ggagctgact tagtaagaac taaaggccat
      361 ggatgaagat gaaattgaat tgaccccaga agaagaaaag tcgttatttg atggaatagg
      421 agctgatgca gtacacatgg atagtgacca gatttctgta gaagtacaag aaactgtttt
      481 tttatctaat tcagatgtaa ctgtgcacaa ttttgttcct gatgatccag actcagttat
      541 aattcaagat gttattgaaa atgttcttat tgaagatgtt cactgttcac atattttaga
      601 agaaacagat atatctgaca atgtcattat tcctgagcaa gttctcgatt tagatacagc
      661 tgaagaagtg tctttagcac agttcttaat tccagacatt ttaacttcca gtattacatc
      721 aacctcattg actatgcctg aacatgtctt gatgagtgaa gctatacatg tgtctaatgt
      781 aggacatttt gaacaagtga ttcatgatag cctagtagaa agagaaatca tcactgatcc
      841 tttgacagcc gacatttcag atatactggt agcagattgg gcttctgaag cagtcttaga
      901 ttccagtggg atgcctctgg agcagcaaga tgatgccaga atcaactgtg aggattatct
      961 aatgatgtct ttggatgagc ctagcaaaac agatcatgaa ggttcctctg aagttaccat
     1021 gaatgcagag tcagaaactg attcttctaa attggatgaa gcatctccag aagttatcaa
     1081 ggtgtgcatt cttaaagctg actcagaagt ggatgatgta ggagaaacta tacaagcagt
     1141 agagagtgag accgacaatg gcaatgaagc tgaagtcact gatcagagga ctagcattca
     1201 tgttcccaga gtcaacattt atatgttagc cagtgattct caaaaggaag aagaagatac
     1261 taaagtaatt gtaggagatg aagatgctgg tggcacagct gcagatactc ctgagcatga
     1321 gcaacagatg gatgtcagtg aaataaaagc agctttccta cctattgcat ggacagcagc
     1381 ttatgataat aattctgatg aaattgaagt gcagaatgcc actgccagtg ctatgttaca
     1441 ccatgatgaa tctggtggcc ttgacagagt accaaaacaa aaatcaaaaa agaaaaaaag
     1501 acctgaatcc aaacagtacc agtcagcaat atttgttgct cctgatggac aaactttacg
     1561 tgtctatcct tgcatgtttt gtgggaaaaa atttaagacc aaaaggtttt tgaaaagaca
     1621 cataaaaaac catcctgaat accttgctaa taaaaaatat cactgtactg agtgtgatta
     1681 cagtaccaac aagaagataa gcttacataa tcacatggag agccacaagc taaccattaa
     1741 gacagaaaag accaccgaat gtgatgactg taggaagaat ctttctcatg ctgggacaat
     1801 gcatacagaa aaaggagtca acaaaacatg taagtgtaag ttctgtgact atgaaacagc
     1861 tgaacagaca ttattgaatc accacctttt ggtggtccac aggaagaaat ttcctcacat
     1921 ttgtggagaa tgtggtaaag gtttccgtca cccatcagca ctcaaaaagc acatacgagt
     1981 tcacacagga gagaagccct atgaatgtca gtattgtgag tacaagtctg cagactcttc
     2041 caacttgaaa actcatataa aatctaagca tagtaaagag ataccactga agtgtggcat
     2101 ctgtctcctg actttctcag ataccaaaga ggctcagcaa catgccgttc tgcaccaaga
     2161 aagcagaaca catcaatgtt cacattgcaa ccataagagt tcaaactcaa gtgatttaaa
     2221 gcgacacata atttccgttc acacaaaggc gtatcctcat aaatgtgaca tgtgcagcaa
     2281 aggatttcat aggccttcag aactcaagaa gcatgtggct acccataaaa gtaaaaaaat
     2341 gcaccaatgt agacactgtg actttaagag tccagatcca tttctgctta gtcaccatat
     2401 tctctcagct cacacaaaga atgttccatt caagtgtaag agatgtaaaa aggaatttca
     2461 acaacagtgt gagcttcaaa cgcatatgaa gacccacagt agccgaaaag tctatcagtg
     2521 tgagtactgt gaatatagca ccaaagatgc ctcaggtttt aagcgccatg ttatctccat
     2581 tcatacgaaa gactatcctc accgctgtga cttctgcaag aaaggattcc ggagaccctc
     2641 ggaaaagaat caacacataa tgcgacatca taaagaagtt ggcctggcct aagtgtgtaa
     2701 tcctaacgta tggggacatt ggcattcagg caggaaattc attttaaaag taggcatcct
     2761 tgttcacatt caatgtcatg aatttgtcaa gtgaatataa atatgatatt gcttcg
//
