LOCUS       NM_009570               2785 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus zinc finger protein 1, Y-linked (Zfy1), mRNA.
ACCESSION   NM_009570 XM_905442
VERSION     NM_009570.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Yamauchi,Y., Matsumura,T., Bakse,J., Holmlund,H., Blanchet,G.,
            Carrot,E., Ikawa,M. and Ward,M.A.
  TITLE     Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to
            spermatogenesis impairment, sperm defects, and infertility
  JOURNAL   Biol Reprod 106 (6), 1312-1326 (2022)
   PUBMED   35293998
  REMARK    GeneRIF: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to
            spermatogenesis impairment, sperm defects, and infertility.
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Zhang,Y., Xi,J., Jia,B., Wang,X., Wang,X., Li,C., Li,Y., Zeng,X.,
            Ying,R., Li,X., Jiang,S. and Yuan,F.
  TITLE     RNAi as a tool to control the sex ratio of mouse offspring by
            interrupting Zfx/Zfy genes in the testis
  JOURNAL   Mamm Genome 28 (3-4), 100-105 (2017)
   PUBMED   28251288
  REMARK    GeneRIF: our findings show that RNAi-mediated disruption of Zfx/Zfy
            in mouse testis affected X/Y spermatogenesis. Additionally, results
            suggest that the paralogous genes Zfx/Zfy play an important role in
            the process of X and Y sperm development. The individual
            interference of Zfx/Zfy may predict the outcome of X and Y haploid
            sperms. Presented herein is an advanced method developed to control
            mouse X/Y spermatogenesis and sex rati
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Nakasuji,T., Ogonuki,N., Chiba,T., Kato,T., Shiozawa,K.,
            Yamatoya,K., Tanaka,H., Kondo,T., Miyado,K., Miyasaka,N.,
            Kubota,T., Ogura,A. and Asahara,H.
  TITLE     Complementary Critical Functions of Zfy1 and Zfy2 in Mouse
            Spermatogenesis and Reproduction
  JOURNAL   PLoS Genet 13 (1), e1006578 (2017)
   PUBMED   28114340
  REMARK    GeneRIF: Zfy1-KO mice did not show any significant phenotypic
            alterations.  Zfy1/2-DKO mice were infertile and displayed abnormal
            sperm morphology and fertilization failure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Vernet,N., Mahadevaiah,S.K., de Rooij,D.G., Burgoyne,P.S. and
            Ellis,P.J.I.
  TITLE     Zfy genes are required for efficient meiotic sex chromosome
            inactivation (MSCI) in spermatocytes
  JOURNAL   Hum Mol Genet 25 (24), 5300-5310 (2016)
   PUBMED   27742779
  REMARK    GeneRIF: we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also
            necessary for efficient meiotic sex chrand the sex chromosomes are
            not correctly silenced in Zfy-deficient spermatocytes.
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Koizumi,M., Oyama,K., Yamakami,Y., Kida,T., Satoh,R., Kato,S.,
            Hidema,S., Oe,T., Goto,T., Clevers,H., Nawa,A. and Nishimori,K.
  TITLE     Lgr4 controls specialization of female gonads in mice
  JOURNAL   Biol Reprod 93 (4), 90 (2015)
   PUBMED   26333992
REFERENCE   6  (bases 1 to 2785)
  AUTHORS   Su,H. and Lau,Y.F.
  TITLE     Demonstration of a stage-specific expression of the ZFY protein in
            fetal mouse testis using anti-peptide antibodies
  JOURNAL   Mol Reprod Dev 33 (3), 252-258 (1992)
   PUBMED   1449792
REFERENCE   7  (bases 1 to 2785)
  AUTHORS   Simpson,E.M. and Page,D.C.
  TITLE     An interstitial deletion in mouse Y chromosomal DNA created a
            transcribed Zfy fusion gene
  JOURNAL   Genomics 11 (3), 601-608 (1991)
   PUBMED   1774064
REFERENCE   8  (bases 1 to 2785)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   9  (bases 1 to 2785)
  AUTHORS   Gubbay,J., Koopman,P., Collignon,J., Burgoyne,P. and
            Lovell-Badge,R.
  TITLE     Normal structure and expression of Zfy genes in XY female mice
            mutant in Tdy
  JOURNAL   Development 109 (3), 647-653 (1990)
   PUBMED   1698142
REFERENCE   10 (bases 1 to 2785)
  AUTHORS   Ashworth,A., Skene,B., Swift,S. and Lovell-Badge,R.
  TITLE     Zfa is an expressed retroposon derived from an alternative
            transcript of the Zfx gene
  JOURNAL   EMBO J 9 (5), 1529-1534 (1990)
   PUBMED   1691708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076618.1 and X14382.1.
            
            On Sep 6, 2007 this sequence version replaced NM_009570.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14382.1, AK076618.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AK076618.1         2-561
            561-858             X14382.1           488-785
            859-2262            AK076618.1         860-2263
            2263-2580           X14382.1           2190-2507
            2581-2783           AK076618.1         2582-2784
            2784-2785           X14382.1           2712-2713
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="Y"
                     /map="Y"
     gene            1..2785
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /note="zinc finger protein 1, Y-linked"
                     /db_xref="GeneID:22767"
                     /db_xref="MGI:MGI:99212"
     exon            1..135
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..201
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..289
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2577
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /note="Y-linked zinc finger protein 1; Y-linked zinc
                     finger protein 2"
                     /codon_start=1
                     /product="zinc finger Y-chromosomal protein 1"
                     /protein_id="NP_033596.3"
                     /db_xref="CCDS:CCDS30539.1"
                     /db_xref="GeneID:22767"
                     /db_xref="MGI:MGI:99212"
                     /translation="MDEDEIELTPEEEKSFFDGIGADAVHMDSDQIVVEVQETVFLAN
                     SDVTVHNFVPDNPGSVIIQDVIENVLIEDVHCSHILEETDISDNVIIPEQVLNLGTAE
                     EVSLAQFLIPDILTSGITSTSLTMPEHVLMSEAIHVSDVGHFEQVIHDSLVETEVITD
                     PITADTSDILVADCVSEAVLDSSGMPLEQQDNDKINCEDYLMMSLDEPSKADLEGSSE
                     VTMNAESGTDSSKLDEASPEVIKVCILKADSEVDELGETIHAVESETKNGNEAEVTDQ
                     STSIRVPRVNIYMSASDSQKEEEDTEVIVGDEDAGGTAADTPEHEQQMDVSEIKAAFL
                     PIAWTAAYDNNSDEIEDQNVTASALLNQDESGGLDRVPKQKSKKKKRPESKQYQSAIF
                     VAPDGQTLRVYPCMFCGKKFKTKRFLKRHTKNHPEYLANKKYHCTECDYSTNKKISLH
                     NHMESHKLTIKTEKTTECDDCRKNLSHAGTLCTHKTMHTEKGVNKTCKCKFCDYETAE
                     QTLLNHHLLVVHRKKFPHICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADS
                     SNLKTHIKSKHSKEIPLKCGICLLTFSDNKEAQQHAVLHQESRTHQCSHCNHKSSNSS
                     DLKRHIISVHTKAYPHKCDMCSKGFHRPSELKKHVATHKSKKMHQCRHCDFNSPDPFL
                     LSHHILSAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRKVYQCEYCEYSTKDASGF
                     KRHVISIHTKDYPHSCDFCKKGFRRPSEKNQHIMRHHKVGLP"
     exon            290..841
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..991
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1132
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1255
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1396
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2785
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2768..2773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfy1"
                     /gene_synonym="Zfy-1; Zfy2"
                     /note="putative"
ORIGIN      
        1 gaacagaaag actggtgaac atcaaacggc cgttactcaa tttcaggcat tctgggaacg
       61 gaaagactgg tgagcatcaa acggtcgtta ctcattttca ggtgttctgg gttttcaggc
      121 gttctgggct gtaagagacc ggcccagtac tctgaagtct gcagtacttg tcgtcattgc
      181 ctacccctct acactggtct ggagctgact tagtaagaac tgaaggccat ggatgaagat
      241 gaaattgaat tgaccccaga agaagaaaag tcattctttg atggaatagg agctgatgca
      301 gtacacatgg atagtgacca gattgttgtg gaagtacaag aaactgtttt tttagctaat
      361 tcagatgtaa ctgtgcataa ttttgttcct gataatccag gctcagttat aattcaagat
      421 gttattgaaa atgttcttat tgaagatgtt cactgttcac atattttaga agaaacagat
      481 atatctgaca atgtcattat tcctgagcaa gttctcaatt taggtacagc agaagaagtg
      541 tctttagcac agttcttaat tccagacatt ttaacatctg gtattacgtc aacctcattg
      601 actatgcctg aacatgtctt gatgagtgaa gctatacatg tgtctgatgt aggacatttt
      661 gaacaagtga ttcatgatag ccttgtagaa acagaagtca tcactgatcc tataacagct
      721 gacacttcag atatactggt agcagattgt gtttctgaag cagtcttaga ttccagtggg
      781 atgcctctgg agcagcaaga taatgacaaa atcaactgtg aggattatct gatgatgtct
      841 ttggatgaac ctagcaaagc agatcttgaa ggttcctctg aagttaccat gaatgcagag
      901 tcaggaactg attcttctaa attggatgaa gcatctccag aagttatcaa ggtgtgcatt
      961 cttaaagctg actcagaagt ggatgaatta ggagaaacta tacacgcagt agagagtgag
     1021 accaaaaatg gcaatgaagc tgaagtcaca gatcagagca ctagcattcg tgttcccaga
     1081 gtcaacattt atatgtcagc cagtgattct caaaaggaag aagaagatac tgaagtaatt
     1141 gtaggagatg aagatgctgg tggcacagct gcagatactc ctgagcatga gcaacagatg
     1201 gatgtcagtg aaataaaagc agctttccta cctattgcat ggacagcagc ttatgataat
     1261 aattctgatg aaattgaaga ccagaatgtc actgccagtg ctctcttaaa ccaagatgag
     1321 tctggtggcc ttgacagagt accaaaacaa aaatcaaaaa agaaaaaaag acctgaatcc
     1381 aaacagtacc agtcagcaat atttgttgct cctgatggac aaactttacg tgtctatcct
     1441 tgcatgtttt gtgggaaaaa atttaagacc aaaaggtttt tgaaaagaca tacaaaaaac
     1501 catcctgaat accttgctaa taaaaaatat cactgtactg agtgtgatta cagtaccaac
     1561 aagaagataa gcttacataa tcacatggag agccacaagc taaccattaa gacagaaaag
     1621 accactgaat gtgatgactg taggaagaat ctttctcatg ctgggacttt gtgtactcac
     1681 aaaacaatgc atacagaaaa aggagtcaac aaaacatgta agtgtaagtt ctgtgactat
     1741 gaaacagctg aacagacatt attgaatcac caccttttgg tggtccacag gaagaaattt
     1801 cctcacattt gtggagaatg tggtaaaggt ttccgtcacc catcagcact caaaaagcac
     1861 atacgagttc acacaggaga gaagccctat gaatgtcagt attgtgagta caagtctgca
     1921 gactcttcca acttgaaaac tcatataaaa tctaagcata gtaaagagat accactgaag
     1981 tgtggcatct gtctcctgac tttctcagat aacaaagagg ctcagcaaca tgccgttctg
     2041 caccaagaaa gcagaacaca tcaatgttca cattgcaacc ataagagttc aaactcaagt
     2101 gatttaaagc gacacataat ttccgttcac acaaaggcgt atcctcataa atgtgacatg
     2161 tgcagcaaag gatttcatag gccttcagaa ctcaagaagc atgtggctac ccataaaagt
     2221 aaaaaaatgc accaatgtag acactgtgac tttaatagtc cagatccatt tctgcttagt
     2281 caccatattc tctcagctca cacaaagaat gttccattca agtgtaagag atgtaaaaag
     2341 gaatttcaac aacagtgtga gcttcaaacg catatgaaga cccacagtag ccgaaaagtc
     2401 tatcagtgtg agtactgtga atatagcacc aaagatgcct caggttttaa gcgccacgtt
     2461 atctccattc atacgaaaga ctatcctcac agctgtgact tctgcaagaa aggattccgg
     2521 agaccctcgg aaaagaatca acacataatg cgacatcata aagttggcct gccctaagtg
     2581 tataatccta acatataggg atattggcat tgagacagta aattcatttt aaaagcaggc
     2641 atccttgttc acatccaata tcatgaattt gtcaagtgaa tataaagatg atattgcgcc
     2701 tatttgactt tatgttttat taaatagggt attcaatata tcctttacag actgacaaag
     2761 tgtgagaaat aaattttaac aacac
//
