LOCUS       NM_011767               4612 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger RNA binding protein (Zfr), transcript
            variant 1, mRNA.
ACCESSION   NM_011767 XM_976662
VERSION     NM_011767.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4612)
  AUTHORS   Long,Y., Marian,T.A. and Wei,Z.
  TITLE     ZFR promotes cell proliferation and tumor development in colorectal
            and liver cancers
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1027-1034 (2019)
   PUBMED   31010678
  REMARK    GeneRIF: ZFR overexpression also promoted tumor development of
            immortalized mouse liver cells.
REFERENCE   2  (bases 1 to 4612)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4612)
  AUTHORS   Doganli,C., Kjaergaard,T., Olsen,A., Oxvig,C., Fuchtbauer,E.M. and
            Lykke-Hartmann,K.
  TITLE     Early developmental expression of Mus musculus zinc finger
            RNA-binding protein compared to orthologs in Caenorhabditis elegans
            and Danio rerio and subcellular localization of Mus musculus and
            Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell
            Mus musculus embryos
  JOURNAL   DNA Cell Biol 29 (12), 713-727 (2010)
   PUBMED   21091219
  REMARK    GeneRIF: Mouse Zfr mRNA was detected in all stages tested during
            mouse preimplantation, with higher levels at the 1-cell stage that
            includes the maternal contribution of Zfr mRNA.
REFERENCE   4  (bases 1 to 4612)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 4612)
  AUTHORS   Elvira,G., Massie,B. and DesGroseillers,L.
  TITLE     The zinc-finger protein ZFR is critical for Staufen 2 isoform
            specific nucleocytoplasmic shuttling in neurons
  JOURNAL   J Neurochem 96 (1), 105-117 (2006)
   PUBMED   16277607
  REMARK    GeneRIF: ZFR is a native component of Staufen2-containing granules
            and likely plays its role during early steps of RNA transport and
            localization
REFERENCE   6  (bases 1 to 4612)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4612)
  AUTHORS   Kleines,M., Gartner,A., Ritter,K. and Schaade,L.
  TITLE     Cloning and expression of the human single copy homologue of the
            mouse zinc finger protein zfr
  JOURNAL   Gene 275 (1), 157-162 (2001)
   PUBMED   11574164
REFERENCE   8  (bases 1 to 4612)
  AUTHORS   Meagher,M.J. and Braun,R.E.
  TITLE     Requirement for the murine zinc finger protein ZFR in
            perigastrulation growth and survival
  JOURNAL   Mol Cell Biol 21 (8), 2880-2890 (2001)
   PUBMED   11283266
REFERENCE   9  (bases 1 to 4612)
  AUTHORS   Meagher,M.J., Schumacher,J.M., Lee,K., Holdcraft,R.W., Edelhoff,S.,
            Disteche,C. and Braun,R.E.
  TITLE     Identification of ZFR, an ancient and highly conserved murine
            chromosome-associated zinc finger protein
  JOURNAL   Gene 228 (1-2), 197-211 (1999)
   PUBMED   10072773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058570.1, AF071059.1, AK034963.1, AK041429.1 and BU757317.1.
            
            On Feb 22, 2008 this sequence version replaced NM_011767.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.9705.1,
                                           SRR1660811.184033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1092              BC058570.1         1-1092
            1093-1432           AF071059.1         1091-1430
            1433-4036           AK034963.1         2-2605
            4037-4325           AK041429.1         1291-1579
            4326-4612           BU757317.1         1-287               c
FEATURES             Location/Qualifiers
     source          1..4612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.9 cM"
     gene            1..4612
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /note="zinc finger RNA binding protein"
                     /db_xref="GeneID:22763"
                     /db_xref="MGI:MGI:1341890"
     exon            1..97
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..3285
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger RNA-binding protein isoform 1"
                     /protein_id="NP_035897.2"
                     /db_xref="CCDS:CCDS37044.2"
                     /db_xref="GeneID:22763"
                     /db_xref="MGI:MGI:1341890"
                     /translation="MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQ
                     YSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAAT
                     AAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQY
                     YQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQARQVTAIKPATP
                     SPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAA
                     SSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKTPFQNKQLKPKQPPKPPQIHYCD
                     VCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTSSSNNSTRGTQNQLRCELCDVSCT
                     GADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAASASKPTASPSSIG
                     ASNCTLNTSSIATSSVKGLSTTGNSSLNSTSNTKVSAIPTNMAAKKTSTPKINFVGGN
                     KLQSTGNKTEDLKGIDCVKNTPAASAVQIPEVKQDAGSEPVTPASLAALQSDVQPVGH
                     DYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKP
                     SIRARKIQEEKMRKQMQKEEYWRRREEEERWRMEIRRYEEDMYWRRMEEEQHHWDDRR
                     RMPDGGYPHGPPGPLGLLGVRPGMPPQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEE
                     LQAVQKIVSITERALKLVSDSLSEHEKSKNKEGDDKKEGGKDRALKGVLRVGVLAKGL
                     LLRGDRNVNLVLLCSEKPSKSLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSC
                     VEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQA
                     RANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVF
                     ECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVL
                     GMDPLPQMNQRFNIHNNRKRRRDSDGVDGFEAEGKKDKKDYDNF"
     exon            98..197
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            198..480
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            481..625
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..844
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1092
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1284
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1576
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1773
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1893
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2039
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2202
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2408
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2559
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2701
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2799
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2895
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3007
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3105
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..4596
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4574..4579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4591
                     /gene="Zfr"
                     /gene_synonym="C920030H05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagagg agggaggcag cgggtgagag ttcagagttc agcagcagca gcccgagccc
       61 atgattccca tatgccctgt agtttctttc acctatgtgc ccagccggct gggggaagat
      121 gccaaaatgg cgaccggcaa ctactttgga ttcacccaca gcggggcggc ggcggcggcg
      181 gctgcggccc agtatagcca gcagccagct tcgggtgtag cctattccca tccaactaca
      241 gttgctagct acactgtcca tcaggctcca gtagctgctc acacagttac tgctgcttac
      301 gcaccagcag ccgccacagt tgcagttgcc aggcctgctc cagttgctgt tgcagctgct
      361 gcaacagctg ctgcatatgg aggctacccc actgcacaca cagcaaccga ctatggttac
      421 acccagaggc aacaagaagc accaccacca ccacccccag ctactacaca gaactaccag
      481 gactcatatt cgtatgtaag atccacagcc cctgctgtag cttatgatag taagcagtac
      541 taccaacagc caacagcaac tgctgctgct gtagctgctg ctgcccagcc tcagccttct
      601 gttgctgaaa cctactatca gacagcccct aaagcaggtt atagccaagg tgcaacacag
      661 tatactcaag cgcagcaagc tcggcaagtg acagccataa aaccagccac accaagtcca
      721 gctaccacta ctttctccat ttatcctgtg tcctccactg tacaaccggt ggcagctgca
      781 gctactgtgg taccatccta tactcagagt gctacttaca gtaccacagc agttacttat
      841 tctggtacat cttattcagg ttatgaagca gccgtatatt cagctgcgtc ttcctactac
      901 caacagcagc agcaacaaca gaagcaagca gcagcagcag ctgctgctgc agcagcaaca
      961 gctgcctgga cagggaccac ctttactaaa aaaacaccat tccaaaataa acaactgaaa
     1021 ccaaaacagc ctcccaaacc accccagatt cattattgtg atgtttgtaa gatcagctgt
     1081 gctggaccac agacttataa agagcactta gaaggacaga aacataaaaa aaaggaagcc
     1141 gcattgaaag cctctcaaaa taccagcagc agcaacaact caactcgtgg gacacaaaat
     1201 cagctacgtt gcgagctctg tgatgtgtct tgtacaggag cagatgcata tgctgcccac
     1261 attcgtggtg ctaagcatca gaaagtggtt aaattacaca caaaacttgg taaacctatt
     1321 ccttcaacgg aaccaaatgt tgttagccaa gctacttctt caacagctgc atctgcttca
     1381 aaaccaactg cctctccttc aagtattggc gcaagcaatt gtactctgaa cacgtcatca
     1441 attgcaactt cttcagtgaa aggtctttca actacaggaa actcgtctct taatagtaca
     1501 tccaacacta aagtgtcagc gatacctacc aatatggctg ccaagaaaac atctacaccc
     1561 aaaataaact ttgttggtgg aaataagcta cagtcaacag gaaataaaac ggaagactta
     1621 aaaggaattg actgtgttaa gaatactcct gctgcctctg ctgtgcagat tccagaagta
     1681 aagcaagatg cagggtcaga accagtcaca cctgcgtccc ttgctgctct gcagagtgat
     1741 gtacaaccag tgggacatga ttatgttgaa gaggtacgaa atgatgaagg aaaagtcatt
     1801 cgcttccatt gtaaattatg tgaatgcagc tttaatgacc ccaatgctaa agagatgcac
     1861 ctaaaaggac gaagacatag acttcagtat aaaaaaaaag taaatccaga tttgcaagta
     1921 gaagtgaagc ccagtattcg tgccagaaaa attcaagaag agaaaatgag aaagcaaatg
     1981 cagaaggagg aatattggcg gagacgagaa gaggaggaac gctggaggat ggagataaga
     2041 cgttatgaag aagacatgta ctggagaaga atggaggaag agcagcatca ttgggatgat
     2101 cgcagacgaa tgcctgatgg cggctatcct catggtcctc ccggcccact aggtcttttg
     2161 ggagtccgac caggcatgcc tccccagccg cagggtcctg cccccttacg gcgtcctgac
     2221 tcatctgatg atcgttatgt aatgacaaag catgcaacta tttatccaac tgaagaagag
     2281 ttacaagccg tccagaaaat tgtttctatc actgagcgtg ctttaaagct tgtttcagac
     2341 agtttgtcgg aacatgagaa gagcaagaac aaagagggag atgataagaa agagggaggt
     2401 aaagacagag ctctgaaagg ggtgttgcga gtaggcgtgc tggcaaaagg attacttctc
     2461 cgaggagaca ggaatgtcaa ccttgttttg ctgtgctcag aaaaaccttc aaagtcgtta
     2521 ttaagccgta ttgcagaaaa cctacccaaa cagcttgctg ttataagtcc tgagaagtat
     2581 gacataaaat gtgccgtgtc tgaggcagcg ataattttga actcgtgtgt ggagcccaaa
     2641 atgcaagtca ctatcaccct gacatctcca attattcgag aagagaacat gagggaagga
     2701 gatgtaacct cgggtatggt gaaagaccca ccggacgtct tggacaggca aaaatgcctt
     2761 gacgctctgg ctgctctacg ccacgctaag tggttccagg ctagagctaa tggcctacag
     2821 tcgtgtgtga ttatcatacg tattctccga gacctttgtc aacgagttcc aacgtggtct
     2881 gattttccta gctgggctat ggagttactg gtggagaagg caattagcag tgcttctagt
     2941 cctcaaagcc ctggagatgc cctgagaaga gtatttgagt gcatttcttc agggattatt
     3001 ctcaaaggca gccctggact tctggaccct tgtgaaaagg atccctttga cactttggca
     3061 acaatgactg accaacagcg tgaagacatt acatccagtg cacagtttgc attgagactc
     3121 cttgcattcc gtcagataca caaagttctg gggatggatc cattaccaca aatgaatcag
     3181 cgctttaaca tccacaacaa caggaaacga agaagggata gtgatggagt ggatggattt
     3241 gaagctgagg ggaagaaaga caaaaaggat tatgataact tttaaaaagt ttgtgtaaat
     3301 cttcagtgtt acagtaggtg ccggtttatt ggctgttttc cattcatatt aatctctact
     3361 ttaaaagttt atcaagagta taaagagttt catggaagaa ccaagttttt ctatgattaa
     3421 aaacttattg tacagtgtca ggtattatat ggatggaaag aaagagattt gactaggggg
     3481 aatatattgg tctttccccc cccccaccct ttttcattat tttgatttta ttgactggtt
     3541 gcccttactc cctgtatttt tgtgtctttt attaactagt gcattgtgtt attaaatctt
     3601 ttctgtatgt aatacaggat ttgtgcttca gttgctctgt gtattttgat acttttattg
     3661 agaagttctg tttgctttga cacagttgta agttactttg tgttatagat ggcacccttt
     3721 acccttacta ctttatagca gtgcggtttt tttgtaacgt gaaactgcag gagttttcct
     3781 ttgttattct gtatgtgaag gattacaata taaaagctac cctgccatct aagtgctcag
     3841 aaatagctgt ttctgcagat cttgtggcat ttgtctatct agtgtgatat ataaaggtgt
     3901 aattaagaca aattccttaa tctaatcaag tttgctgtta gttgtgcatt agcagtataa
     3961 aagctaatat atattatatg gtcttgcaac agttttaaag cctctgcata attgataaaa
     4021 aaatgcatga catttttgtt tttaatagac atttaaagta ataattttag gtttaacacg
     4081 tagatctttg tacagttgac tttttgacat agcaaggcca aaaataactt tctgaatact
     4141 ttttcttctg tacaagtgga aagggaattt ttcacatcta agtgggctat tgttttcaaa
     4201 agaactttat cattgtgcaa ctaacaataa ctagccctga ctatgtgaca gttccctgtt
     4261 gatgtgtgca attactctag cggcttctac agtcttaaca cagttgaatg atccccacat
     4321 cctgtcaccc agatcattta taggtctatt aactgtgaga ttgataaagt attactgatt
     4381 taaaaaaata agagtatcta agaaaaaaaa aaaacagaaa attatttggt gtggccatcc
     4441 aacatgctta tgtcttatac agaatgctaa tcccctggca gtggtgtaat gagaggtcac
     4501 accttactgt gatgtgtgtg tgctctggtg cacagatgtc attttgttgt cacagcacta
     4561 cagtgagata cagaataaac acttaaattc atgtaaaaaa aaaaaaaaaa aa
//
