LOCUS       NM_053009               5624 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 91 (Zfp91), mRNA.
ACCESSION   NM_053009 XM_909506
VERSION     NM_053009.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5624)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5624)
  AUTHORS   Xing,Y., Wang,J.Y., Li,M.Y., Zhang,Z.H., Jin,H.L., Zuo,H.X., Ma,J.
            and Jin,X.
  TITLE     Convallatoxin inhibits IL-1beta production by suppressing zinc
            finger protein 91 (ZFP91)-mediated pro-IL-1beta ubiquitination and
            caspase-8 inflammasome activity
  JOURNAL   Br J Pharmacol 179 (9), 1887-1907 (2022)
   PUBMED   34825365
  REMARK    GeneRIF: Convallatoxin inhibits IL-1beta production by suppressing
            zinc finger protein 91 (ZFP91)-mediated pro-IL-1beta ubiquitination
            and caspase-8 inflammasome activity.
REFERENCE   3  (bases 1 to 5624)
  AUTHORS   Wang,F., Zhang,Y., Yu,X., Teng,X.L., Ding,R., Hu,Z., Wang,A.,
            Wang,Z., Ye,Y. and Zou,Q.
  TITLE     ZFP91 disturbs metabolic fitness and antitumor activity of
            tumor-infiltrating T cells
  JOURNAL   J Clin Invest 131 (19) (2021)
   PUBMED   34403361
REFERENCE   4  (bases 1 to 5624)
  AUTHORS   Wang,A., Ding,L., Wu,Z., Ding,R., Teng,X.L., Wang,F., Hu,Z.,
            Chen,L., Yu,X. and Zou,Q.
  TITLE     ZFP91 is required for the maintenance of regulatory T cell
            homeostasis and function
  JOURNAL   J Exp Med 218 (2) (2021)
   PUBMED   33355624
REFERENCE   5  (bases 1 to 5624)
  AUTHORS   Wu,X., You,W., Wu,Z., Ye,F. and Chen,S.
  TITLE     Zinc finger protein 91 loss induces cardiac hypertrophy through
            adenosine A1 receptor down-regulation under pressure overload
            status
  JOURNAL   J Cell Mol Med 24 (17), 10189-10201 (2020)
   PUBMED   32677376
REFERENCE   6  (bases 1 to 5624)
  AUTHORS   Jin,H.R., Jin,X. and Lee,J.J.
  TITLE     Zinc-finger protein 91 plays a key role in LIGHT-induced activation
            of non-canonical NF-kappaB pathway
  JOURNAL   Biochem Biophys Res Commun 400 (4), 581-586 (2010)
   PUBMED   20804734
  REMARK    GeneRIF: Functional analysis of the human ZFP91 protein.
REFERENCE   7  (bases 1 to 5624)
  AUTHORS   Tompkins,V., Hagen,J., Zediak,V.P. and Quelle,D.E.
  TITLE     Identification of novel ARF binding proteins by two-hybrid
            screening
  JOURNAL   Cell Cycle 5 (6), 641-646 (2006)
   PUBMED   16582619
REFERENCE   8  (bases 1 to 5624)
  AUTHORS   Saotome,Y., Winter,C.G. and Hirsh,D.
  TITLE     A widely expressed novel C2H2 zinc-finger protein with multiple
            consensus phosphorylation sites is conserved in mouse and man
  JOURNAL   Gene 152 (2), 233-238 (1995)
   PUBMED   7835706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ113470.1, AK147560.1,
            AK147502.1 and BE947731.1.
            
            On Oct 2, 2010 this sequence version replaced NM_053009.2.
            
            Summary: The protein encoded by this gene is a member of the zinc
            finger family of proteins. The gene product contains C2H2-type
            domains, which are the classical zinc finger domains found in
            numerous nucleic acid-binding proteins. The homologous human
            protein has been shown to function as a regulator of the
            non-canonical NF-kappaB pathway in lymphotoxin-beta receptor
            signaling. A read-through transcript variant composed of Zfp91 and
            the downstream Cntf gene sequence has been identified, but it is
            thought to be non-coding. Read-through transcription of Zfp91 and
            Cntf has been observed in both human and mouse. A Zfp91-related
            pseudogene has also been identified on chromosome 17. [provided by
            RefSeq, Oct 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147560.1, AK147502.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               CJ113470.1         1-411
            412-699             AK147560.1         416-703
            700-1272            AK147502.1         15-587
            1273-5528           AK147560.1         1277-5532
            5529-5624           BE947731.1         1-96                c
FEATURES             Location/Qualifiers
     source          1..5624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.73 cM"
     gene            1..5624
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="zinc finger protein 91"
                     /db_xref="GeneID:109910"
                     /db_xref="MGI:MGI:104854"
     exon            1..1140
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1169
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1376
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1413
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1518
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1653
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1704
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1783
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1898
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1998
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..5609
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="hexamer: AGTAAA"
     polyA_site      2619
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="major polyA site"
     regulatory      5506..5511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="hexamer: AATAAA"
     polyA_site      5532
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="major polyA site"
     regulatory      5588..5593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="hexamer: AATAAA"
     polyA_site      5609
                     /gene="Zfp91"
                     /gene_synonym="9130014I08Rik; A530054C17Rik; Pzf; Zfp-91"
                     /note="major polyA site"
ORIGIN      
        1 attttttcag agactttcat ccggcaacgg acagggcctt ttttttctta aaggagaagc
       61 tgcaactcaa ataatttacc acttctcccc tcgagagctg gcggcgctgg ggacagaaag
      121 gccagagcag gaaggtgggg gtctgggtgg aggcgggata acgtccaggc tacttcttag
      181 gctagtaaga acccttgagg ggacagcggc gcctccggga ggcaggtgcg cgcgcagccg
      241 gcaggggggt gcgcgcgcgg ctgagaacgg tgcgttttgt cctcgcctcc gccctcgcca
      301 gccctgcccc tcccaccgcc cctagcttga gccgaactcc aaagtggggg gggagaaagg
      361 tcactttggg attgtcgcga gacgcagccg tttaacggtg agaacgggcg cgcgggcaag
      421 gaaacctcgc gctctccctc ggagccgttt cctgattggt tggaggaagg ggtgggggag
      481 ggcaccgagt gcgctgctgc gtgtgagacc gcgaggggcc gggccagggg ggccgatcct
      541 cccctccgat tggcccgctg cgtgtccgtc cgggtgcgcg cgtgcgcgcc gccggcggtc
      601 gctggcttga gtggcagggg gcgggtgggg gggggcgccc tcggaacggg cggaggggcg
      661 ggggggagag aggcgctccg gagtgaggga gccggacgct ccgggagccg aggggggcgg
      721 ggggagctgc gccgcgggcg ccgccgcctc caccgcctgg gacgcagggg tgggggacgg
      781 acgagccccg atgccggggg agacggagga gccgcgatcc ccggagcagc aggaccagga
      841 agggggccca gcagcggcgg ccgacgcggc ttcggaggag ctccggcccg gcgcggcggc
      901 ggcgccggcg gcgcctgcag agaccgcgag cagccgcgtg ctgaggggag gtcgggaccg
      961 cggccggacc gctgcggccg ccgccgccgc cgctgccgct gtgtcccgcc ggagaaaggc
     1021 cgagtatccc cgccggcgga ggagcagccc cagcaacagg cctcccgacg gcccagggca
     1081 tcagcccgcg gccgcgaagc ccccgtctcc tgctcagggc aagaagagtc cgcgactcca
     1141 gtgtatagaa aaactaacaa ctgataaaga tcccaaggaa gagaaagaag atgattctgt
     1201 cctccctcag gaagtttcca ttactacaac tagagctagc cggagctggc gcagtagtag
     1261 caggacctct atctctcgcc ttcgagacag tgagaatact cggagctcta ggtccaagac
     1321 tggctccttg caactcgtct gcaagacaga accaattact gatcaacttg attatgatgt
     1381 tccagaagaa catcagtctc ccggtggcat tagtagtgat gaggaagagg aggaggaaga
     1441 agaaatgtta atcagtgaag aggaaatacc attcaaagat gacccaagag atgagactta
     1501 caagccccac cttgaaaggg aaaccccaaa gccacggaga aaatcaggga aggtgaaaga
     1561 agagaaagaa aagaaagaaa ttaaagtgga agtagaagta gaggtgaaag aagaagagaa
     1621 tgaaattagg gaagatgagg agcctcccag gaagagaggg agaaggcgaa aagatgacaa
     1681 aagtccgcgg ttacccaaaa ggagaaaaaa gcctccaatc caatatgtcc gttgtgagat
     1741 ggaaggatgt ggaactgttc ttgctcaccc tcgctatttg cagcaccaca ttaaatacca
     1801 gcatttgctg aaaaaaaaat atgtatgtcc ccacccctcc tgtgggcgac tcttcaggct
     1861 ccagaaacaa cttctgcggc atgcaaagca tcatacagac cagagggatt atatctgtga
     1921 atattgtgct cgggccttca agagttccca caatctggca gtacaccgga tgattcatac
     1981 gggcgagaag ccattacaat gtgagatctg tggatttact tgtcgacaaa aagcatctct
     2041 taattggcac atgaagaaac atgatgcaga ctccttctac cagttttctt gcaatatctg
     2101 tggcaaaaaa tttgagaaga aggacagtgt agtggcacac aaagcaaaaa gccaccctga
     2161 ggtgctgatt gcagaagctc tggcagccaa tgcgggcgcc ctcatcacca gcacagatat
     2221 cttgggcact aacccagagc ccctgacaca gcctgcagat ggtcaggggc ttcctcttct
     2281 tcctgagccc ttgggaaact caacagctgg agagtgccta ctgctagaag ctgaagggat
     2341 gtcaaagtca tactgcagtg ggacagaacg ggtgagcctt atggctgacg ggaagatctt
     2401 tgtgggaagt ggcagcagtg ggggcactga agggctggtc atgaactcgg atatactcgg
     2461 tgctaccaca gaggttctga ttgaagatac agactctact ggaccctagt gcaaaggaag
     2521 actttgggca ctgggacagt gcagactttg tatttaaaag ataaaaagga caaaaaaaat
     2581 ttaaagcatt taaaaatcta gtaaaataac tgaagggcct gctctttgca ttgtggatca
     2641 caacacacac acacaccatc cccattccct gaactcccct tcctcatcct taaaatattg
     2701 atgtagcctt taccagaaag gttgatgaaa aagcagcaac atgctaggtt ccagccagca
     2761 gcagacttcc tgctcattgg caaatctcct ttttctcagc ctataactct gatgtgctct
     2821 ggatcagctt tgaactcata atagtatatt actatcatct aaatcttttc tcctctacta
     2881 ctgccctatg gctctggctt cttcccactg caacaaccaa cacttaccct caaatattat
     2941 ataattctat tttccggagg ctggcagctt gacttggcac tttagggctc cttggcagga
     3001 tgctgttaaa acagcacaca tctctcaccc ctcttccatt actcactggg tttggggaag
     3061 gaaggataca tggggaccac ctccctccct ttcaatggat cccagcacct cagttccccc
     3121 cactcctgaa cctccataat gctcttaatg gtgctcactt gcttggaagc aggctcccaa
     3181 gagaggggac tgacctctgt ttctggctga aagatagggc tctgtgtcag tgagaaaagt
     3241 cccaggctaa tggcagaaat ttgcactttg aacatgtgtg ttttgtgttg tggaacctga
     3301 gattccttat ttattaatgg aaagtctgat tttttggggg ggagggtctt tgttgctatg
     3361 ttttgtgggg ctgggagagt agattattct gacatgggat ccttcctaca agaggtactt
     3421 tgaaggcaag gcttagagtt gaagaagcac agccagcctc taaaatcata gttctccagt
     3481 ggcctttaaa gtaagctggt ccccagcact aacagaatca ctacaatagc ctagtgcttt
     3541 tttggaagcc ttagggaagt ttgataggtt tgtggtaact agtgtgctct ttgagatttt
     3601 taagagcatt tgagatacaa gaattttgag gggatgagga atgttggtca aggtctaaat
     3661 cacacataaa aaattttctt ctgtgaattt atcttctttg catatatatc cctgctggcc
     3721 ccttgttttg attttgttat tggtcattcc agctctcagt ggaagaccgg accctgtcat
     3781 tcatgaagga acacaatcta aaagttctag agatttggtt aagagtaaac tcttctgtct
     3841 tatctcctct ttagaagaga caaagcttca atagacaaaa acaaaagtaa aaatctatac
     3901 gataatgttt tttggctttc cccagaatta tctgttttcc tctgagtaga gattttaatg
     3961 ccctgtggca ttaaaattac tgtcactggg agacacggat catattttta catgcttcta
     4021 cctctcaaaa gactaaaacc ctaattcagc tcattttttg aaaattagga gtgcagttct
     4081 tccctgtgta cttcagaatc agccattgaa gactgggcca gttgttgtca gcaacacatg
     4141 atgactattg ggaaaaataa gagtttgaga acaaaataag gaacagcttg tttttcacaa
     4201 acactaaaac tgtggagttt atcaaatttt ctctgcttga tttttttttc cccccaaaag
     4261 gagaatagca aaatgtcatc tctgaaagac gcttactata cacccaccta tgtcggtggt
     4321 tgggatgcca gggagaggga ggaagacacc tacaggaaca atcttaaaca cattattgtt
     4381 tcctctagag tgttgcagac ttagccaccc ctccatgtga ggggagaaaa ggcatgaaga
     4441 caggcttttc tgccctgcag agttgcagtt gaccttggta cattgcatag atttgaaaac
     4501 actttaagag gaattaaaaa tggatctgca gcaaactttg ctcctcttga cgctgtttat
     4561 ctagtatctg tgtcctacac ttaccctttg tttttcacat ttagaatgtc tccaataaat
     4621 tagatagagc cacccacaga aaaacaaact gcattgaaaa catctcactt ttctgggatg
     4681 gggaaaaata tgttcttttc tgtacttcgc tctcctcccc ataaaagcaa ctagttctaa
     4741 aacttagaaa cttcctgtcc tctcatgggg ttggggtggg gctgaaaggg ggctcggtca
     4801 tcttagctgc tctctgttgg caataagttt ttttagcagt ttgcaataaa tttttcatga
     4861 acttcctatt ccttttgaga gctagtgcta gtataataaa agtgtatgag caaactaagc
     4921 ccctaccctt ttcttttttc ccatgccagt catttaattg tccttcgaag gagtcctttt
     4981 agttttgaaa atagttaatt catactgatg gtttgttatc ttttaagtca tacctccatc
     5041 ttcaattggc aattctaaat tcttaggtat atagttatga taattacttg gtatttctgg
     5101 gagttgtgta ccctccttgc ttgcattgct agcgtatttt gcataattag accctaacac
     5161 attttacagg gtttagtcag acactggctg ggagtcctgg gaatgagcag agaaaacatc
     5221 agcatagagc acttggacct cccttgtacc tgttcagagg aagaaaatca actaactata
     5281 taccaacaac ctaagtgagg tcttacagcc ttgctgcagg gctagtttcc tgcctttctt
     5341 tctatcaatt ttccagtata ctcaagaaaa tcgggaaatt gtaatggggc agttatatct
     5401 cctgagactt tttgcctgtt gaaatgtgca ggaccctttt cctgtgatga gagatagctg
     5461 gttacttgat ctaggtttaa aagttatgta aaagaaaaaa attataataa aagggatact
     5521 ttgcttttaa aatcttgttt ccttttaatc taggtaatca tttcaaaata agtatgtaaa
     5581 gaagaaaaat aaaagttgtc ttcctggaaa aaaaaaaaaa aaaa
//
