LOCUS       NM_001164624            1603 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger protein 809 (Zfp809), transcript variant
            2, mRNA.
ACCESSION   NM_001164624
VERSION     NM_001164624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Wang,C. and Goff,S.P.
  TITLE     Differential control of retrovirus silencing in embryonic cells by
            proteasomal regulation of the ZFP809 retroviral repressor
  JOURNAL   Proc Natl Acad Sci U S A 114 (6), E922-E930 (2017)
   PUBMED   28115710
  REMARK    GeneRIF: Data indicate that ZFP809 protein is the key mouse
            embryonic stem (ES) cell-specific component of the silencing
            complex for transcriptionally silencing of proviral DNA.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Ichida,Y., Utsunomiya,Y. and Onodera,M.
  TITLE     The third to fifth zinc fingers play an essential role in the
            binding of ZFP809 to the MLV-derived PBS
  JOURNAL   Biochem Biophys Res Commun 469 (3), 490-494 (2016)
   PUBMED   26692479
  REMARK    GeneRIF: Furthermore, the results of the present study indicate
            that other zinc fingers, which were not directly involved in
            binding to MLV PBS, may function in potentiating binding and stable
            protein expression.
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Ichida,Y., Utsunomiya,Y., Yasuda,T., Nakabayashi,K., Sato,T. and
            Onodera,M.
  TITLE     Functional Domains of ZFP809 Essential for Nuclear Localization and
            Gene Silencing
  JOURNAL   PLoS One 10 (9), e0139274 (2015)
   PUBMED   26417948
  REMARK    GeneRIF: Data suggest that interaction between KAP1 and the KRAB A
            box of zinc finger protein 809 (ZFP809) is critical in
            KAP1-dependent control of gene silencing for ZFP809 targets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Wolf,G., Yang,P., Fuchtbauer,A.C., Fuchtbauer,E.M., Silva,A.M.,
            Park,C., Wu,W., Nielsen,A.L., Pedersen,F.S. and Macfarlan,T.S.
  TITLE     The KRAB zinc finger protein ZFP809 is required to initiate
            epigenetic silencing of endogenous retroviruses
  JOURNAL   Genes Dev 29 (5), 538-554 (2015)
   PUBMED   25737282
  REMARK    GeneRIF: ZFP809 evolved to recognize foreign DNA and establish
            histone modification-based epigenetic silencing of endogenous
            retroviruses.
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Wolf,D. and Goff,S.P.
  TITLE     Embryonic stem cells use ZFP809 to silence retroviral DNAs
  JOURNAL   Nature 458 (7242), 1201-1204 (2009)
   PUBMED   19270682
  REMARK    GeneRIF: ZFP809 appears to be a stem-cell-specific retroviral
            restriction factor, and therefore may constitute a new component of
            the intrinsic immune system of stem cells
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729060.1, AK049344.1 and BY764604.1.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 3' coding region and 3' UTR, compared to variant 1. The
            resulting protein (isoform 2) has a shorter and distinct C-terminus
            when it is compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD555584.1, AK049344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY729060.1         11-50
            41-1353             AK049344.1         2-1314
            1354-1603           BY764604.1         457-706
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 8.65 cM"
     gene            1..1603
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /note="zinc finger protein 809"
                     /db_xref="GeneID:235047"
                     /db_xref="MGI:MGI:2143362"
     exon            1..121
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /inference="alignment:Splign:2.1.0"
     exon            122..248
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /inference="alignment:Splign:2.1.0"
     exon            249..341
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /inference="alignment:Splign:2.1.0"
     exon            342..451
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /inference="alignment:Splign:2.1.0"
     exon            452..1603
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /note="hexamer: AATAAA"
     polyA_site      1367
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /note="major polyA site"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /note="hexamer: AATAAA"
     polyA_site      1598
                     /gene="Zfp809"
                     /gene_synonym="C330026E23"
                     /note="major polyA site"
ORIGIN      
        1 ttagaaagtt cagaggaggt ctgagcctgc catcttgggt cctgtggtcc ccaggcgtcc
       61 gttgcgggaa gttgtgctgg tggcggagac cgagtcacag gacgctccca gtcccatcat
      121 ggggttggtg tcctttgagg atgtagccgt ggacttcacc ttggaggagt ggcaggacct
      181 ggacgctgct cagaggaccc tgtacaggga tgtgatgctg gaaacctaca gcagcctggt
      241 gttcctggac ccctgcattg ccaaacctaa gttgatcttc aatttggagc gtggatttgg
      301 gccatggagc ctagcagaag cttcaagcag gagcctccca ggtgtccata acgtgagtac
      361 tctgagtgac accagcaaga aaattcctaa gacacgtttg cggcaactca gaaaaactaa
      421 ccaaaagaca ccaagtgaag acacgattga agcagaacta aaggctcgac aggaagtctc
      481 caaagggaca acatcccgtc atagaagagc ccccgtaaaa tctttgtgcc gcaagtcaca
      541 gagaaccaag aatcagacat catacaatga tgggaatctc tatgaatgta aggactgcga
      601 gaaagttttc tgtaataatt caaccctaat taagcattac agaagaactc ataatgtgta
      661 caagccctat gagtgtgatg aatgcagtaa aatgtactat tggaagtcag acctcacgtc
      721 tcatcagaaa acgcacagac agaggaagag gatctatgag tgtagcgaat gtggaaaggc
      781 tttcttccgc aagtctcacc tcaatgcaca tgaaagaacc cattcaggtg agaagcctta
      841 tgaatgcaca gagtgcagga aagctttcta ttacaagtct gacctcactc gacataagaa
      901 gactcacctg ggtgaaaaac cttttaaatg tgaagagtgc aagaaagctt tttctcgaaa
      961 gtccaaactc gctatacatc agaagaaaca tacgggcgag aaaccatatg aatgtacaga
     1021 atgcaagaag gctttctccc atcagtcaca actcactgca catcggattg ctcattcatc
     1081 tgagaatcct tatgaatgta aagaatgcaa taaatcattc cactggaagt gtcaactcac
     1141 agcacatcag aaaagacaca caggtcagta tggggatagc tgaataaatt aaaactaaca
     1201 acactcctgc atatgtatcc aatcaaatga ggcaaatcgt tgcatatttc aacataaagc
     1261 atgtaaccgg tataccacac aatcccacag gacgagcagt tacgaaaaga gccaattgat
     1321 gcttattaaa caaaaagagt aataaaaacc tccagggaca gactaaataa tgctttttta
     1381 attctaaatt ttcttactgt tggtgaaaag agaacaagag caactgagag acactgggct
     1441 attgaaaaaa ctgaggaact aggccaacca atagactaca aggatgtgtt gacattagga
     1501 tggaaacctg caatagtttt aagatgggga catggttatg tgttgtggga aataataaaa
     1561 gaaccagcgc attccctcgt cttgtgctgg caactcaagc tct
//
