LOCUS       NM_001035231            4603 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger protein 748 (Zfp748), transcript variant
            1, mRNA.
ACCESSION   NM_001035231 XM_893654 XM_900969 XM_900974 XM_900980 XM_900983
            XM_900984 XM_900991 XM_900994
VERSION     NM_001035231.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Peng,H., Ivanov,A.V., Oh,H.J., Lau,Y.F. and Rauscher,F.J. 3rd.
  TITLE     Epigenetic gene silencing by the SRY protein is mediated by a
            KRAB-O protein that recruits the KAP1 co-repressor machinery
  JOURNAL   J Biol Chem 284 (51), 35670-35680 (2009)
   PUBMED   19850934
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Polanco,J.C., Wilhelm,D., Mizusaki,H., Jackson,A., Browne,C.,
            Davidson,T., Harley,V., Sinclair,A. and Koopman,P.
  TITLE     Functional analysis of the SRY-KRAB interaction in mouse sex
            determination
  JOURNAL   Biol Cell 101 (1), 55-67 (2009)
   PUBMED   18588511
  REMARK    GeneRIF: Reduced Sox9 expression in KRAB-knockdown cells supports a
            role for KRAB-O and perhaps other KRAB genes in mediating SRY
            function
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Oh,H.J., Li,Y. and Lau,Y.F.
  TITLE     Sry associates with the heterochromatin protein 1 complex by
            interacting with a KRAB domain protein
  JOURNAL   Biol Reprod 72 (2), 407-415 (2005)
   PUBMED   15469996
REFERENCE   6  (bases 1 to 4603)
  AUTHORS   Krebs,C.J., Larkins,L.K., Price,R., Tullis,K.M., Miller,R.D. and
            Robins,D.M.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
REFERENCE   7  (bases 1 to 4603)
  AUTHORS   Agata,Y., Matsuda,E. and Shimizu,A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573016.5.
            
            On Feb 28, 2022 this sequence version replaced NM_001035231.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132196.1, BC055310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               CT573016.5         66372-66479
            109-235             CT573016.5         72759-72885
            236-331             CT573016.5         74091-74186
            332-4603            CT573016.5         76600-80871
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..4603
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="zinc finger protein 748"
                     /db_xref="GeneID:212276"
                     /db_xref="MGI:MGI:1916455"
     exon            1..108
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2769
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="isoform 1 is encoded by transcript variant 1; KRAB
                     zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 748 isoform 1"
                     /protein_id="NP_001030308.1"
                     /db_xref="CCDS:CCDS59589.1"
                     /db_xref="GeneID:212276"
                     /db_xref="MGI:MGI:1916455"
                     /translation="MEEMLSFRDVAVDFSAEEWECLEPAQWNLYRDVMLENYSHLVFL
                     GLAFSKPYLVTFLEQRQEPLNEKRQVATTMHPDIKPYKCKECGKACDWNSLLLEHQRT
                     NPGENAYKCEECGQASGSYSVIPEHHINDTEEKACKCEECGKVICTCSENSSYQRICI
                     GENPYKCEECGKAFSSHSCLAQHEVEHTGQQFYNCEECGKLFYCPSHLTEHQKIHSQE
                     NLFKIEVCSEVFCAPIELSKDQNFCTEEKPYRYEDYVKAFSACSVLSEHPTIHPGEKA
                     FKCEECGNAFCTLHSVSKMKIHYEVKSYKCEECGKAFATHLSLIQHKIGHTREKPYQC
                     EECGKMFYCSSNLKQHQITHSQEKPYKCEVCGKVFRTCWQLSKHLRIHSGEKPYKCEE
                     CGKAFYTLSYLTQHKLGHTGEKPYKCEECGKTFYYPSVLKEHLAIHSGEKPYRCDECG
                     KDFCTRSGRSRHQRIHTGEKPYKCEQCGKAFSTHSYLSHHKIVHTGHKPYKCEECGKK
                     FYYPSRLKEHQRIHSQENPYKCEICGKAFYTHSYFTQHKLGHTGEKPYKCEECGKTFY
                     YPSILKEHLAIHSGKKPYRCEECGKDFCTRSGRSRHQRIHTGEKPHKCEECGKVFSTH
                     SYLTQHKVVHSGEKPYKCEECGKKFYYPSRLKEHQRIHSQENPYKCEICGNVFCTPKG
                     LSKHQRFHTGEKPYKCEECGKMFYYPSRLKEHQRIHSQENPYKCEICGKAFYTHSYLT
                     QHKLGHTGEKPYKCEECGKTFYYPSILKEHLAIHSGKKPYRCEECGKDFCTRSGRSRH
                     QRIHTGEKPYKCEQCGKAFSTHSYLSQHKVVHSGEKPYKCEECGKMFYYSSRLKEHQR
                     IHSQENPYKCEVCGKVFSAHLELATHLSIHSG"
     exon            109..235
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /inference="alignment:Splign:2.1.0"
     exon            236..331
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /inference="alignment:Splign:2.1.0"
     exon            332..4603
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3979..3984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="major polyA site"
     regulatory      4288..4293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="hexamer: TATAAA"
     polyA_site      4310
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="Zfp748"
                     /gene_synonym="KRAB-O; mszf54; Rslcan20/21; Zfp208"
ORIGIN      
        1 attgtggaaa cggcacttcc gcattgcgac tgcactagtg cattttctct caaagttggg
       61 cgattctctg gtcctgctcc gcgctcggct tgcatcgctg acatggagga aatgctgtca
      121 ttcagggatg tggccgttga tttctctgca gaggagtggg agtgcctgga gcctgctcag
      181 tggaatctgt acagggacgt gatgctggag aattacagcc accttgtgtt cctgggtctt
      241 gctttctcta agccatacct ggtcacgttt ctggagcaaa gacaagagcc tttgaatgag
      301 aagagacaag tggccaccac catgcaccca gatataaaac catataaatg taaagaatgt
      361 ggcaaagcct gtgattggaa ctcactcctt ctcgaacacc agagaaccaa tccaggagag
      421 aatgcctaca agtgtgaaga atgtggtcag gcttctggct cttactcagt aattcctgaa
      481 caccatataa acgatacgga agagaaagcc tgcaagtgtg aagaatgtgg taaagtcatt
      541 tgtacttgct cagaaaattc tagctaccag agaatttgca ttggagaaaa cccctacaag
      601 tgtgaagaat gtggaaaagc cttttcttct cattcatgtc ttgctcaaca tgaggtagaa
      661 cacactggac agcaatttta taactgtgaa gaatgtggga aactgtttta ttgtccttct
      721 caccttacag aacatcaaaa aattcattct caagagaatc tctttaagat tgaggtatgt
      781 agcgaggtct tttgtgctcc catagaactt tctaaagacc agaacttttg tactgaagaa
      841 aaaccctaca ggtatgaaga ctatgttaag gcctttagcg cttgctcagt tctttctgaa
      901 cacccgacaa ttcatccagg agagaaagca ttcaagtgtg aagaatgtgg caatgccttt
      961 tgtacactcc attcagtctc taaaatgaaa attcattatg aagtgaaatc ctacaagtgt
     1021 gaagagtgtg ggaaagcctt tgctactcat ctttccctga ttcagcataa gataggtcat
     1081 actcgagaga aaccttatca atgtgaagaa tgtggcaaaa tgttttactg ttcttcaaac
     1141 cttaagcaac atcaaataac tcattctcaa gagaaaccct acaagtgtga agtatgtggc
     1201 aaggtcttta gaacttgctg gcaactttct aaacacctga gaatccattc tggagagaaa
     1261 ccatacaagt gtgaggaatg tggcaaagcc ttttatactc tctcctacct tactcagcac
     1321 aaattaggtc acactgggga gaaaccttac aaatgtgagg aatgtggcaa aaccttttac
     1381 tacccttcag tccttaagga acacctagca attcattctg gagagaaacc gtacaggtgt
     1441 gatgaatgtg gcaaggactt ttgtactcgc tcaggacgtt ccagacacca gagaatccat
     1501 actggagaga aaccgtacaa gtgtgagcaa tgtggaaagg ccttcagtac ccattcatac
     1561 ctttctcatc acaagatagt tcacactgga cataaaccct acaagtgtga agagtgtggc
     1621 aaaaaatttt attatccttc tcgacttaag gagcatcaaa ggattcattc tcaagagaat
     1681 ccctacaagt gtgaaatatg tggcaaagcc ttttatactc actcatactt tacccagcac
     1741 aaattaggtc acactgggga gaaaccttac aaatgtgagg aatgtggcaa aaccttttac
     1801 tacccttcaa tccttaagga acacctagca attcattctg gaaagaaacc gtacaggtgt
     1861 gaagaatgtg gcaaggactt ttgtactcgc tcaggacgtt ccagacacca aagaatccat
     1921 actggagaga aaccccacaa gtgtgaagaa tgcggaaaag tcttttctac tcattcatat
     1981 cttactcagc acaaagtagt ccactctgga gagaagccct acaagtgtga agagtgtggc
     2041 aaaaagtttt actatccttc tcgccttaag gagcatcaaa ggattcattc tcaagagaat
     2101 ccttacaagt gtgaaatatg tggcaatgta ttttgtactc ccaaaggact ttcgaaacac
     2161 cagagatttc atactggaga gaaaccctac aagtgtgaag aatgcgggaa aatgttttat
     2221 tatccttctc gacttaagga acatcaaaga attcattctc aagagaatcc ttacaagtgt
     2281 gaaatatgtg gcaaagcctt ttatactcac tcctacctta ctcagcacaa attaggtcat
     2341 actggggaga aaccttacaa atgtgaggaa tgtggcaaaa ccttttacta cccttcaatc
     2401 cttaaggaac acctagcaat tcattctgga aagaaaccgt acaggtgtga agaatgtggc
     2461 aaggactttt gtactcgctc aggacgttcc agacaccaga gaatccatac tggagagaaa
     2521 ccctacaagt gtgagcaatg tggaaaggcc ttcagtactc actcatacct ttctcaacac
     2581 aaggtagtcc actctggaga gaagccctac aagtgtgaag agtgtggcaa aatgttttac
     2641 tattcttctc gacttaagga gcatcaaagg attcattctc aagagaatcc ctacaagtgt
     2701 gaagtgtgtg gcaaagtctt tagtgctcac ttagaacttg ctacccacct aagtattcat
     2761 tccggataaa accgtacaag tgggaaggat atggaaatgc tttttaactc atccatcctt
     2821 acctcagaac agattcctga acagaattct taacaatgtg aagaatggca aaatgttttc
     2881 tatcctccaa accttaagcc tttggaggga aaccattctc acgtgtggac tgtagcaagg
     2941 tcttttgtac tcacttagga ctttctaaac atcaaaagaa ccatactggt aagaaagacc
     3001 acaaatgtag gaaagctact aaacttttta accttactca ccacgaggta gttctttctg
     3061 ttcagaaaca ctatagaaga ggaaatgctg gaaaattctt tactcttttt caatccttaa
     3121 agaatatcac agaggtcatt ctcaggagag accctacaag tatgaggatt gtacttttgg
     3181 ttattcagat cttatccaac acaattggat ccatactaaa aagaaaccaa acctttgtga
     3241 agaatgtgac aagtgcttta ctaatcaaca ctttctaacc ttaaaattta ttctggggag
     3301 aaacactaca aatgtgaaca aattgacaag gcttttaaat gttcttcata gattaacaca
     3361 aaagtattgg tactggtaaa atgtattatg aagatttcat tcatcattca gtatttgctg
     3421 aatgtcagaa tattcacact tgggagaatc tctataaatg tgcaaaatat agccaggtgt
     3481 ttagctgtaa tttgtcactg cattagcatg agagaattaa tactccaaaa atacaaagaa
     3541 tatagcaagg cctttacccg ttttttcata ctttatcctc agaaacttca tactgtagag
     3601 aaactgcaca tacaaataac atgtcaaact tttaataata tttcaaatct cagtcaacac
     3661 caaagaatga attcagtaag cttcactgtt tgactttaca tctcggcatc taaggaaagc
     3721 tcaaccgtat gcttgtttga atcggactaa cttacagatg tgtctatagg acatttttct
     3781 tggatgttga ttgatgccca gtctcacccc tggactggtg gtcctgagtg aatgagaatt
     3841 ctggccacca aaaatcagag ggagcaagcc agtaagcaga attcctcaat ggtttctact
     3901 ttagttcctg tctcaaggtt tttcccttga gttctcatcc tggctgaact ggttgactaa
     3961 ctgtaattcc taaactgaaa taaacccttt cctcttttaa gttatttctt agtcatggca
     4021 tttatcacag caacagaaat caaactcagg cagcaaagaa tatgggaaag ctttttactt
     4081 ttctttatat cttagttatt atcagagtct tcatactgag aatgtcacag tgttggtttg
     4141 gttttttgtt tttgaaatgg aaaattagac tgctagtgtc agctaagaac atatgagtcc
     4201 tttagcagag acttctgttt gccataatct accaatctat tctttcagac aatgtgtttt
     4261 tcaagagtca ttgattgttc tttgaactat aaatttttcc tgaaactgta gccatgttgt
     4321 cagactgtac ctgagtactc tcaatctgga tttctgagcc atgacttata tggcagattt
     4381 tgccctttgg gtcccccaat tgtaagtaac tcttaccctt tggtctgtaa gaaaacccaa
     4441 tacattcact tttctcatca acttgggctg tagtgaaatc ctaagatggt gtgttgtggg
     4501 gtccctttgt agtgactaga catttatttg tgtctataga tagctaacaa cacatgtcat
     4561 tcatatttgg ctccaaaata aacaaagtct tatttctctg tca
//
