LOCUS       NM_001163475            3651 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus zinc finger protein 746 (Zfp746), transcript variant
            1, mRNA.
ACCESSION   NM_001163475 XM_001474507 XM_904306 XM_973126
VERSION     NM_001163475.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   Hachiya,K., Deguchi,Y., Hirata,T., Arikawa,T., Fukai,H., Esashi,T.,
            Nagasawa,K., Mizunoe,Y., Nozaki,Y., Kobayashi,M. and Higami,Y.
  TITLE     Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor
            cells leads to attenuated mitochondrial biogenesis and impaired
            adipogenesis
  JOURNAL   Sci Rep 13 (1), 22990 (2023)
   PUBMED   38151567
  REMARK    GeneRIF: Obesity-induced PARIS (ZNF746) accumulation in adipose
            progenitor cells leads to attenuated mitochondrial biogenesis and
            impaired adipogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Kang,H., Park,S., Jo,A., Mao,X., Kumar,M., Park,C.H., Ahn,J.Y.,
            Lee,Y., Choi,J.Y., Lee,Y.S., Dawson,V.L., Dawson,T.M., Kam,T.I. and
            Shin,J.H.
  TITLE     PARIS undergoes liquid-liquid phase separation and
            poly(ADP-ribose)-mediated solidification
  JOURNAL   EMBO Rep 24 (11), e56166 (2023)
   PUBMED   37870275
  REMARK    GeneRIF: PARIS undergoes liquid-liquid phase separation and
            poly(ADP-ribose)-mediated solidification.
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Panicker,N., Kam,T.I., Wang,H., Neifert,S., Chou,S.C., Kumar,M.,
            Brahmachari,S., Jhaldiyal,A., Hinkle,J.T., Akkentli,F., Mao,X.,
            Xu,E., Karuppagounder,S.S., Hsu,E.T., Kang,S.U., Pletnikova,O.,
            Troncoso,J., Dawson,V.L. and Dawson,T.M.
  TITLE     Neuronal NLRP3 is a parkin substrate that drives neurodegeneration
            in Parkinson's disease
  JOURNAL   Neuron 110 (15), 2422-2437 (2022)
   PUBMED   35654037
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Jo,A., Lee,Y., Kam,T.I., Kang,S.U., Neifert,S.,
            Karuppagounder,S.S., Khang,R., Kang,H., Park,H., Chou,S.C., Oh,S.,
            Jiang,H., Swing,D.A., Ham,S., Pirooznia,S., Umanah,G.K.E., Mao,X.,
            Kumar,M., Ko,H.S., Kang,H.C., Lee,B.D., Lee,Y.I., Andrabi,S.A.,
            Park,C.H., Lee,J.Y., Kim,H., Kim,H., Kim,H., Cho,J.W., Paek,S.H.,
            Na,C.H., Tessarollo,L., Dawson,V.L., Dawson,T.M. and Shin,J.H.
  TITLE     PARIS farnesylation prevents neurodegeneration in models of
            Parkinson's disease
  JOURNAL   Sci Transl Med 13 (604) (2021)
   PUBMED   34321320
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Stevens,D.A., Lee,Y., Kang,H.C., Lee,B.D., Lee,Y.I., Bower,A.,
            Jiang,H., Kang,S.U., Andrabi,S.A., Dawson,V.L., Shin,J.H. and
            Dawson,T.M.
  TITLE     Parkin loss leads to PARIS-dependent declines in mitochondrial mass
            and respiration
  JOURNAL   Proc Natl Acad Sci U S A 112 (37), 11696-11701 (2015)
   PUBMED   26324925
  REMARK    GeneRIF: PARIS overexpression leads to reduced mitochondrial number
            and structural abnormalities
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Herriges,J.C., Yi,L., Hines,E.A., Harvey,J.F., Xu,G., Gray,P.A.,
            Ma,Q. and Sun,X.
  TITLE     Genome-scale study of transcription factor expression in the
            branching mouse lung
  JOURNAL   Dev Dyn 241 (9), 1432-1453 (2012)
   PUBMED   22711520
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Shin,J.H., Ko,H.S., Kang,H., Lee,Y., Lee,Y.I., Pletinkova,O.,
            Troconso,J.C., Dawson,V.L. and Dawson,T.M.
  TITLE     PARIS (ZNF746) repression of PGC-1alpha contributes to
            neurodegeneration in Parkinson's disease
  JOURNAL   Cell 144 (5), 689-702 (2011)
   PUBMED   21376232
  REMARK    GeneRIF: Conditional knockout of parkin in adult animals leads to
            progressive loss of dopamine neurons in a PARIS-dependent manner.
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166290.7.
            
            On or before Jul 23, 2009 this sequence version replaced
            XM_973126.2, XM_001474507.1, XM_904306.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156312.1, SRR13422590.277949.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC166290.7         46014-46292
            280-579             AC166290.7         49002-49301
            580-661             AC166290.7         49433-49514
            662-775             AC166290.7         50340-50453
            776-967             AC166290.7         65247-65438
            968-1093            AC166290.7         66053-66178
            1094-3651           AC166290.7         67655-70212
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.04 cM"
     gene            1..3651
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /note="zinc finger protein 746"
                     /db_xref="GeneID:69228"
                     /db_xref="MGI:MGI:1916478"
     exon            1..279
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            280..579
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            580..661
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            662..775
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            776..967
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1093
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..3651
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /note="hexamer: AATAAA"
     polyA_site      3651
                     /gene="Zfp746"
                     /gene_synonym="2810407L07Rik; Znf746"
                     /note="major polyA site"
ORIGIN      
        1 aggaagcctc acgggccttc gtcggcctgg ccgcggcacc ggctcccagg atgcagtgtg
       61 gagcggccgg gcgctgacgg cggcggtgcg gctgcgggcg gagcggcagc aggccggcct
      121 gcgaggagcg cggcggggaa ggtagcggca ggcccgggcg gcgctgccgg cggagaggac
      181 ccggcagccg ggcctgcgtg gggccgcgcg ccgcggcgtc gacttccttc gcgccgagca
      241 ggacagcgca gggccatggc cgaggcggcc gcggctccga tttctccatg gacaatggca
      301 gctacaattc aggctatgga gaggaagatt gaatcacagg ctgctcgact gctttctcta
      361 gaaggtcgaa ctgggatggc agagaagaag ctggctgact gtgagaagac agctgtggag
      421 ttcagcaacc agctggaggg caagtgggcc gtgctgggaa ccctgctgca ggaatatggg
      481 ctgctgcagc ggcggctgga aaatgtggag aatctgctac gcaaccggaa cttctggatt
      541 cttcggcttc ccccaggcag caagggcgag gtccccaagg agtggggcaa gctggaggac
      601 tggcagaagg agctctacaa gcatgtgatg aggggcaact acgagacact ggtctccctg
      661 gactatgcca tctccaaacc tgaggtcctc tcccagattg aacaaggcaa ggagccatgc
      721 acctggcgtc gcactgggcc caaggtcccg gaggttcctg tggacccaag tccaggctct
      781 ggagcaccag ttcctgcccc tgacctcctg atgcaaatca agcaagaggg ggagctgcag
      841 ctgcaggagc agcaggctct gggtgtggaa gcctgggcag ctggacagcc agatattggg
      901 gaagagccgt ggggcctcag ccagttggac tctggagcag gagacatctc cacagatgct
      961 acctctggtg tccattccaa cttttcaacc accatcccac ccacttcctg gcaagcagat
     1021 ctccctcccc accacccctc ttcagcatgc tcagatggga cactgaagct caacacagca
     1081 gcatccacag aagcagatgt aaaaattgtt atcaaaacag aagtccagga agaggaggtg
     1141 gtggccacac ctgttcatcc cacggacctg gaggctcatg ggactttgtt tgcaccaggc
     1201 caagccacaa gattcttccc tagccctgtc caggaaggag cctgggaaag tcaaggcagt
     1261 tccttcccca gccaggaccc agtgctaggc ctgcgggagc ccactcggcc agagagggac
     1321 attggtgagc tcagtcctgc catagcacag gaggaggctc ctgccgggga ttggctcttt
     1381 ggcggagtca ggtggggctg gaatttccgg tgtaaacctc cagtgggcct gaacccgagg
     1441 acggtgcccg aggggctccc tttctcatct ccagacaacg gagaggccat cttggacccc
     1501 agccaggccc caagaccctt caatgatccc tgcaaatacc ctggccggac aaaaggcttc
     1561 ggccacaaac cggggctgaa gaagcacccg gcggcaccac ccggaggccg gcccttcacc
     1621 tgtgccacct gcggaaagag cttccagctg caggtgagcc tgagtgccca ccagcgcagc
     1681 tgcggactgt ccgatggggc ggccacgggg gcagcttcca ccactactgg aggcggaggt
     1741 ggtggcagcg gcggaggagg aggcagcagc ggaggtggga gcagtgcacg ggacagcagc
     1801 gctctgaggt gtggggagtg tggtcgctgc ttcacacgcc ctgcacacct catccgccac
     1861 cgcatgctac acactggtga gaggcccttc ccctgcaccg agtgcgagaa gcgcttcaca
     1921 gagcgttcca agctcatcga ccactaccga acgcacacgg gcgtgcggcc attcacctgc
     1981 acagtgtgtg ggaagagctt catccgcaag gaccacctcc gcaagcacca gcgcaaccac
     2041 cctgcagtgg ccaaggcgcc cgcacacggt cagccactcc caccactgcc ggctcctccc
     2101 gaccctttca agagccccgc agccaaagga cccatggcct ccacagacct tgtgactgac
     2161 tggacttgtg gcctaagtgt tctgggaccc agtgatggtg gtggagacct gtaaggaccc
     2221 caatcctcct gtggcccttg caggccacga atgtacagtc ctgagtgcag atagcaggat
     2281 ggcctgaaag ctcagaagca aaaagggaga cttggcagag aaccaaattt ccatgttgct
     2341 gaactgatca ctggaaaaga ctatcgatgc agcctccacc ttaaagtaga attccaactg
     2401 tgaaactcaa caccgtatag gatcttaagt aatttaatta cccatttttt gttttttctc
     2461 tttaattctt gaggaaaaag ctggaaaaca gtagcaacaa ccagttagat tttgaggtgt
     2521 ggctttcaga ggtgtatgtt caccgtgtct taccagtgtt agaaagatgg tcagtgggag
     2581 aagggcactc ccagccatgg accacacagc cctatgggag gttgagttcc aggtctgtcc
     2641 aggcatgttg gggcttacac tcagcagtaa gaaccctact agaagcagcc cttaccttct
     2701 gaaaagaccc tttaagccaa ggcctgactt tttcctgttt tgagccatct gtggtacctg
     2761 tccaaggtgg taactccact atagtagtga ctccttggcc tggctaagaa gaatcatatg
     2821 gagctgtagt agtgttagat ctgaagtcac aggaagccag ggcctcccat cttgggctat
     2881 ctccattacc cacagatgct tctgttggct gcccgttgtg tagtatgttc attttcaaaa
     2941 tggcttcact ggttccacct cacatctcat cccaccatta accatgactt tggaaagcag
     3001 gcagacaggc agttcttctt agagaatagg aaataaaggg ctcagagggg acacagcctc
     3061 tctccatgag tactgtattg taggagctgg gaagagccgc agctgataac cagttctcct
     3121 ggaacaatgg tttagggaag gaaaggtttt gagatcttac cctctgaaaa gatttgtgcc
     3181 acacccatgg atcaggccat caagtcacag aactcctgca tcagcagctc gagctggaca
     3241 gcccctgtgt gtgcttatgc atcactagac atgcaggagg tagttggatt gccaggtaac
     3301 tgggtaaatg gctctcaggc ctgcctggag tatcttcaca gtggaattag agctaggtcc
     3361 aagtttctgt cataacagtg ctgtccccac cacacatagc cattcccatt ttgttaaagc
     3421 agccactggt ctcttgccca aatgggtaat gactccctga agagggcaga gaccatggca
     3481 cccattcagc tccttctgca tacttttatt agaaatagac tagttaagaa aattgtttct
     3541 atgtactgta tattttgtac ctgtttacac ttctaatatt gatataactg atattttgaa
     3601 aaacaaatga acagaagaca tcctgttaaa ataaaatcta accagcacca a
//
