LOCUS       NM_001289691            4249 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus zinc finger protein 740 (Zfp740), transcript variant
            2, mRNA.
ACCESSION   NM_001289691
VERSION     NM_001289691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4249)
  AUTHORS   Nabekura,T., Deborah,E.A., Tahara,S., Arai,Y., Love,P.E., Kako,K.,
            Fukamizu,A., Muratani,M. and Shibuya,A.
  TITLE     Themis2 regulates natural killer cell memory function and formation
  JOURNAL   Nat Commun 14 (1), 7200 (2023)
   PUBMED   37938555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4249)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 4249)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple differences in the 5' coding region compared to variant 1.
            These differences cause translation initiation at a downstream
            start codon compared to variant 1. The encoded isoform (2) has a
            shorter N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC123791.4         96617-96774
            159-674             AC123791.4         97543-98058
            675-751             AC123791.4         98201-98277
            752-901             AC123791.4         100743-100892
            902-991             AC123791.4         101244-101333
            992-1115            AC123791.4         101725-101848
            1116-1234           AC123791.4         102127-102245
            1235-4249           AC123791.4         105568-108582
FEATURES             Location/Qualifiers
     source          1..4249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.37 cM"
     gene            1..4249
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="zinc finger protein 740"
                     /db_xref="GeneID:68744"
                     /db_xref="MGI:MGI:1915994"
     exon            1..158
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            159..674
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            675..751
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            752..901
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     CDS             818..1324
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 740 isoform 2"
                     /protein_id="NP_001276620.1"
                     /db_xref="CCDS:CCDS79416.1"
                     /db_xref="GeneID:68744"
                     /db_xref="MGI:MGI:1915994"
                     /translation="MMLSQIASKQAENGERAGSPDVLRCSSQGHRKDSDKSRNRKEDD
                     SLAEASHSKKTVKKVVVVEQNGSFQVKIPKNFICEHCFGAFRSSYHLKRHVLIHTGEK
                     PFECDVCDMRFIQKYHLERHKRVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGCQSK
                     TSEGQFSL"
     exon            902..991
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1115
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1234
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..4249
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4169..4174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="hexamer: ATTAAA"
     polyA_site      4174
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="major polyA site"
     regulatory      4215..4220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="hexamer: AATAAA"
     polyA_site      4245
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /note="major polyA site"
ORIGIN      
        1 ggagaagtgc ttccggggaa acgggccccg ggttggtgtt tgtaaacttg cctcggtccc
       61 gacgcgggga gcggcggccg cgggcttggc acggggtgcc tggggcctgg agggggcgcc
      121 gcgcggcgga ggagacggcg ggaggccgcg ccaggcaggt ttctggaaca gacctagagc
      181 ttcaccaaga gaattcaact tggaaaccaa gactggtaga ctctcgtttc ttccgacaag
      241 aggcagaagt cagagagaga ctgcggattc ttgggacacc tgttttcctt ttggaggaca
      301 ccgagttctt tgagaagaca gttcaatatg gcaaaggaac tgaaagaacg gggaggagcc
      361 gttactgtga tttggtgacg gttcttcaga caaccagtgt cttaaggaaa actgggacag
      421 agaacttctg aactttttgg gttcgttaag tgagaagtca gcatggctca ggtaaaaagc
      481 tctcgagtcc tccttcaaga ccgttcactg ggaagcctct ttgcagtgtc acccttgaat
      541 tctgccttag ccaacagtat tgaccatccc cagtgagccg agctctgtat taagcgccag
      601 ggggagatct agaggaagga aaggagacag gccacagccc ctgccttcag ggagcttcca
      661 gtcaaatgaa ggaggaattt tattgagctc ctgttacatg cacggcattg tgtttggaat
      721 acaaagatga ataagattgc ccttgtcccc agcaagtctt ctggcttgtg aaggcctagc
      781 aggtgtgagt ttggttccca ctgcagccag caagaagatg atgctgagcc agattgccag
      841 caagcaggct gaaaacggcg agcgggcagg tagccctgat gtgctgaggt gctccagtca
      901 gggccaccga aaagacagtg ataaatcccg caaccgcaaa gaggatgaca gcttggctga
      961 ggcctctcat tcaaaaaaga ctgttaaaaa ggtggtggta gtggaacaaa atggctcttt
     1021 tcaagtaaag attcccaaaa attttatttg tgaacactgc tttggagcct ttcggagcag
     1081 ttaccacctc aagaggcacg tcctaatcca cactggtgag aaaccatttg agtgtgatgt
     1141 ctgtgatatg cgtttcatcc agaagtacca tctcgaacgc cacaagcggg tacacagtgg
     1201 cgaaaagcct taccagtgtg aacgatgtca tcagtgtttt tctcggacag accgattact
     1261 cagacacaaa cggatgtgcc aaggatgcca gtccaagact tctgaagggc agttttctct
     1321 ataggcacaa ggggccctag gtggtgggag tgctgaggag agtctctgga agagcatagc
     1381 cctgtgttct gacggtccca ccaccactcc ctctgaacct gtcccccttc ctagaggacc
     1441 agccccaggt tagcagaaga gcgtctgagg acatcggctc caaagcccca actctgtaac
     1501 cagtctgagg ctatgagtat cccagggaca cctgcagcat tcttgggcaa gggagctggt
     1561 ccttgaacct cagctgagat gaggtgggga ctcaaaggtg caggaccaag actgaaatgt
     1621 tcccacaacc ttggactgga actggcagct aaaatggaaa ggaccgggga ggggtttttg
     1681 ttggttctgc ttttgttttt gtttatccaa aagcaattta aacaggtaaa ccggggatac
     1741 aggtaatgtg gaggggacag tcctgaagca catcaaggac tgtggctggc ctggccatgt
     1801 ctgtcaccac agtccctcgg tgttccacag cccgcctatt tgaaagcaaa taggaagggg
     1861 gctggcagct gggcttcctt ggacttctta tacactgtga agacaaaagg agaaactggg
     1921 aaggacagac gtgggctgga caagaagcgt aggcatacct tttcttatct cctcaagaag
     1981 agcggtgttg tgtcacgggt gttcccatgg tttgtgtggc actggggcct gatgggatca
     2041 gctcaagtgc cttgtggagg acttgggttc cgtagcccat ttggctcttt tttctgggaa
     2101 gttggtcttg gttgtggttt gtggctacct cgcttgtcct tgactctaga acccaggcac
     2161 agttgagcag ggggttgtgg gtatcagagt atgctgtcct tttgtgtcct cttagaacaa
     2221 ggatagtcca aagttttgtt aactatgaga aaaacagaaa ttgggacagt ccttatggga
     2281 cttgtgtgat ggagccctct ccctgtcaga atcctctgcc tgttcaagta gaggagatgg
     2341 aggtctggtc tggtctggtc ttcagtctca gagaaccgac cttggctccc tcctgatagc
     2401 atccctgcag agtggggggg ggggggtgct tcagaggaag gattgcagga agacacctaa
     2461 tgtctgcttt attcttgacc ttactctgtt ataacaccct tctatcttgt ctacccctgg
     2521 aaaggtgatt ggattagtgt gtgtgtctga tttgtgaatg cttgtgtttc tttgcttgga
     2581 aggggtgaaa attgttgact gaaattcatt cggccaccaa cttggaggac agaaaaacgt
     2641 agggcagcct tcccacccag acctgaagga cgtctgcctc ccttgttctt gctgagaaca
     2701 ggggaacaga ggggcttgtt tcagaagaat gttgagggtt ttttctcatt gttgttaggt
     2761 tgatttaacc gtgtactgat cagagtgttt ctaagccagg gcttctgaac atgtactttc
     2821 taaagtgaga taacttctgc taaagaaagg attcttaagg gagaccttgg ggtttcattg
     2881 agcactccag gacccctgag gcctacttca ggtgtaatct ttgggttaca cctgagcaca
     2941 caactccagc tgtgggtagg aatctgagct ggccgcctcc aggaagaagt tttgacttgc
     3001 aaatgagagc caggcagcaa cctaccttaa gacctcttcc agtgtattgg gagatggtcc
     3061 accacaactt aaggggagaa gggagaatgt ctcagccttc agttttcctc tgatagcacc
     3121 tgagaggagg tctgaagagg acagcctgcc gtgtgttctg gctccctgct gtccctctaa
     3181 cgtgctgtaa agcctgcgcc tctgaccttc gtccgccgtg tggcccctgg gcatccatgt
     3241 tcgtgatgca cagacccttt gctgttagag ggttctgctg ggctgggatt tttctgtcac
     3301 tgggaaagag gatacgctga gaaagatatc ctcccagaaa tgcttttgaa agtggaatcc
     3361 ctccctgcca ctcgtagatg atctgttcgt gctgaaagtt ggcagagtgg cctgtgcctc
     3421 tgcaagtatg aatgtgtttc ctgggtcaga gcaggccctg cagacagtgg cgttctgcct
     3481 aggtgggagc tgagagaagt gagagagaac tggatgtgta cagacagccc acccagaacc
     3541 acactgccaa ggccaggtgt gagaggctca gaagctggca gtgggtaagg acagacaggc
     3601 tctggggtgg agagtaatac aacagccaag agcctgggca gaagccacat ctctaccctg
     3661 ggggaatgca cagacagctg caaaggctcc tgagcctgat gcccccctct gctggggtgg
     3721 gttgttagca ctggacagat gtctcaggtg tgtgtagaag gggaaatgag aaggtgggtg
     3781 ctcagacatc agaatgtgga tgtgggtttg gtagggagag taataccggt ccttggatgg
     3841 actcctgcac caggccgtcc catcccaccc ttgctggtgc ctgcccttcc catccgtccc
     3901 tgacagcctc ttgtcattta gctactgatt gtacttcatg gcttgacata gagggttaga
     3961 gaagtggggt gaccacactt tgagccctct ccccaggttc cttctgcccc tgctgtggcc
     4021 ctgggctttt atcttcaatt cccctcctac cgtgctccat ttttttttaa atatacttat
     4081 tttgctatgg gggaggggaa ctatcaaatg gacaagatta cttttaatgt agtttttata
     4141 agatgttata aacttgtatc tttttaccat taaagtgcag tgtatgttcc ttcgtgacat
     4201 atttaggata tttaaataaa aaggatggcg cttttctaca ttccatgtc
//
