LOCUS       NP_001276620             168 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger protein 740 isoform 2 [Mus musculus].
ACCESSION   NP_001276620
VERSION     NP_001276620.1
DBSOURCE    REFSEQ: accession NM_001289691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 168)
  AUTHORS   Nabekura,T., Deborah,E.A., Tahara,S., Arai,Y., Love,P.E., Kako,K.,
            Fukamizu,A., Muratani,M. and Shibuya,A.
  TITLE     Themis2 regulates natural killer cell memory function and formation
  JOURNAL   Nat Commun 14 (1), 7200 (2023)
   PUBMED   37938555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 168)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (residues 1 to 168)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple differences in the 5' coding region compared to variant 1.
            These differences cause translation initiation at a downstream
            start codon compared to variant 1. The encoded isoform (2) has a
            shorter N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.37 cM"
     Protein         1..168
                     /product="zinc finger protein 740 isoform 2"
                     /calculated_mol_wt=19352
     Region          78..98
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(83,85,87,89..90,93..94,97,111,113,117..118,121..122,
                     125,139,141,143,145..146,149..150)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          90..115
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          106..126
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          118..143
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          134..152
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..168
                     /gene="Zfp740"
                     /gene_synonym="1110034O07Rik; Znf740"
                     /coded_by="NM_001289691.1:818..1324"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS79416.1"
                     /db_xref="GeneID:68744"
                     /db_xref="MGI:MGI:1915994"
ORIGIN      
        1 mmlsqiaskq aengeragsp dvlrcssqgh rkdsdksrnr keddslaeas hskktvkkvv
       61 vveqngsfqv kipknficeh cfgafrssyh lkrhvlihtg ekpfecdvcd mrfiqkyhle
      121 rhkrvhsgek pyqcerchqc fsrtdrllrh krmcqgcqsk tsegqfsl
//
