LOCUS       NM_001012448            2479 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus zinc finger protein 708 (Zfp708), transcript variant
            2, mRNA.
ACCESSION   NM_001012448
VERSION     NM_001012448.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Seah MKY, Wang Y, Goy PA, Loh HM, Peh WJ, Low DHP, Han BY, Wong E,
            Leong EL, Wolf G, Mzoughi S, Wollmann H, Macfarlan TS, Guccione E
            and Messerschmidt DM.
  TITLE     The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression
            at RMER19B retrotransposons
  JOURNAL   Development 146 (19) (2019)
   PUBMED   30846446
  REMARK    GeneRIF: ZFP708 recruits the repressive TRIM28 complex to RMER19B
            retrotransposons to evoke regional heterochromatin formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Krebs CJ, Larkins LK, Khan SM and Robins DM.
  TITLE     Expansion and diversification of KRAB zinc-finger genes within a
            cluster including Regulator of sex-limitation 1 and 2
  JOURNAL   Genomics 85 (6), 752-761 (2005)
   PUBMED   15885501
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Krebs CJ, Larkins LK, Price R, Tullis KM, Miller RD and Robins DM.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB612019.1 and BC089368.1.
            
            On Mar 21, 2007 this sequence version replaced NM_001012448.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (b) has a
            shorter and distinct N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089368.1, SRR1660813.130541.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BB612019.1         3-35
            34-2479             BC089368.1         1-2446
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..2479
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /note="zinc finger protein 708"
                     /db_xref="GeneID:432769"
                     /db_xref="MGI:MGI:3040674"
     exon            1..96
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1680
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /note="isoform b is encoded by transcript variant 2;
                     regulator of sex-limitation candidate 11"
                     /codon_start=1
                     /product="zinc finger protein 708 isoform b"
                     /protein_id="NP_001012450.2"
                     /db_xref="CCDS:CCDS49298.1"
                     /db_xref="GeneID:432769"
                     /db_xref="MGI:MGI:3040674"
                     /translation="MEDPLSFTDVAIDFSADECECLDSAQWNLYKEVMLENYSNLVFL
                     GLAFSKPYLVTFLEQSSDLWSVKRKASVAIHLGSKAHKCKECGKSFDRNSVLIQHQRI
                     HTGERPYKCEECGMAFTGRCILSKHQRIHTGEKPYKCKECGKAFSCSSNLHQHQQIHR
                     EEKPYKCDDCGKAFSCSSYLYKHQRIHTGMKPYKCKECGKAFNCSANLIYHQRIHTGE
                     KPYKCGECGKAFTIYSTFMNHQRTHSGEKPYECKDCGKAFTNCYNLIQHQRIHTGEKP
                     YACEECGKSFNYSSHLKQHKRIHTGEKPYKCEVCGKAFNCSDYLVKHQRIHTGEKPYK
                     CEVCGKAFSFSTYLHKHQRIHTGEKRYRCEECGKAFTNYSGLIVHRRVHTGEKPYKCE
                     ECGKAFSVHTSLSKHQRIHTREQPYKCDECGKTFSVHSTFSKHQIMHTREKPYKCKHC
                     DKTFKYPSPLVQHERIHTGERPYKCEVCGKAFTSSSNLKYHWRLHTGEKPYKCEQCGK
                     AFKNSSNVTRHYKIHTRENPD"
     exon            97..223
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /inference="alignment:Splign:2.1.0"
     exon            224..319
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /inference="alignment:Splign:2.1.0"
     exon            320..2450
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgcttccg gttcattttg cttttgtgtt tctccaaact ctgcggcttt ctcaaagttg
       61 gaacagtgtg gcttgcgctc cgcgctcgac atggaggacc ctctgtcatt tacagatgtg
      121 gccattgatt tctctgcaga tgagtgtgaa tgtctggact ctgctcagtg gaatttgtat
      181 aaggaagtga tgttggagaa ttacagcaac cttgtgttcc tgggtcttgc tttctctaag
      241 ccatacctgg tcacatttct ggagcagagt tcagatctgt ggagtgtgaa gaggaaggca
      301 tcagtggcca tccatctagg atcaaaagcc cataaatgta aagaatgtgg gaaatccttt
      361 gataggaact cagtccttat tcaacatcaa agaattcata ctggagagag gccctacaaa
      421 tgtgaagaat gtggcatggc cttcaccggt cgctgcattc tttctaagca ccagcgaatc
      481 catactggag aaaaacccta caaatgtaaa gaatgtggca aagctttcag ctgttcttct
      541 aaccttcacc aacaccaaca aattcatagg gaagagaaac cctataaatg cgatgactgt
      601 gggaaggcct ttagctgttc ttcatatctg tataagcatc agcgaatcca tactggcatg
      661 aaaccctaca aatgcaagga atgtggcaag gcctttaact gttctgcaaa ccttatttac
      721 caccagagaa ttcatactgg agagaaacca tataagtgtg gtgaatgtgg gaaagccttt
      781 accatttatt caacatttat gaatcaccag cgaacacata gtggagaaaa accgtatgaa
      841 tgcaaagact gtgggaaagc ctttactaat tgttataatc taattcaaca ccaaagaatt
      901 catactggag agaaacccta tgcatgtgaa gaatgtggca aatcttttaa ctattcttcc
      961 catcttaaac aacacaaaag aatccatact ggagagaaac catataaatg tgaagtgtgt
     1021 ggcaaagctt ttaactgttc cgattatctt gttaagcatc aaagaattca tactggagag
     1081 aaaccctaca aatgtgaagt atgtggcaaa gcttttagct tttctacata tctgcataaa
     1141 catcaaagaa tccacactgg agagaaacgc tacagatgtg aagaatgtgg taaagctttt
     1201 actaattatt cagggcttat tgttcaccga agagtacata ctggagagaa accctacaaa
     1261 tgtgaagaat gtggcaaggc ctttagtgtt cacacatcac tctctaaaca tcagagaatt
     1321 catacgagag agcaacctta caaatgtgat gaatgtggaa agacctttag tgttcactca
     1381 acattctcta aacatcagat aatgcatact agagagaaac cctacaaatg caaacactgc
     1441 gacaagacct tcaaatatcc ttcacccctt gttcaacatg aaagaattca cactggagag
     1501 agaccctaca aatgtgaagt ttgtggcaag gcctttactt cttcttcaaa tcttaaatat
     1561 cattggagac ttcatactgg cgagaagccc tataaatgtg aacaatgtgg taaagccttt
     1621 aaaaatagtt caaatgtcac tcgacactac aaaattcata ctagagaaaa tccagattaa
     1681 tgcaaacact tttgtaaagc cttccacagt tgttcattga caattcagca ctaaagaatt
     1741 catataaaag aaaaacctta gaaatgaaag aaataaggaa aaacctttaa taatagttca
     1801 acccatattc aacatccacc attacatact ggagagatct tgtaatagtg aagaagatgg
     1861 ccgtgttgag cgttcaatac ttatggagca tcaaattttt tagagaaaca ctacaaatgc
     1921 aggtaataca ggaactgctc attaaccatg agtgatttat aaccagatgt tatacatgca
     1981 aaatgacttt ggaaggaaca ctgacaaata cataaaactg agaaaaccaa actggttcag
     2041 taaaaagcac tttgtaaaca gtgttgcaac actttgctca tcatgtaaat cttgagagat
     2101 tggagagaat tatctatcat aagagacaaa ttccaggagc tgtataggat ttagcaagcc
     2161 accaagtgct gctctgaatt cctaaagaat taatacagaa ctctgaactc actaagaaat
     2221 gtttggtgtg ctataaaaac tcattataga ctttggaatc atgcagataa gtttgtgagg
     2281 acatcaatgt gttataaatt gaaattataa gctcaatttt aaaaagtgat aagatcactc
     2341 aactagtgat ttttatcagt ttgttttttt ccccccaaag accatagata cattattgga
     2401 atatgaagtt tagtaacttc tgtaaataaa aataaactgt tttaatgtat aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaa
//
