LOCUS       NP_001012450             529 aa            linear   ROD 04-AUG-2023
DEFINITION  zinc finger protein 708 isoform b [Mus musculus].
ACCESSION   NP_001012450
VERSION     NP_001012450.2
DBSOURCE    REFSEQ: accession NM_001012448.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Seah MKY, Wang Y, Goy PA, Loh HM, Peh WJ, Low DHP, Han BY, Wong E,
            Leong EL, Wolf G, Mzoughi S, Wollmann H, Macfarlan TS, Guccione E
            and Messerschmidt DM.
  TITLE     The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression
            at RMER19B retrotransposons
  JOURNAL   Development 146 (19) (2019)
   PUBMED   30846446
  REMARK    GeneRIF: ZFP708 recruits the repressive TRIM28 complex to RMER19B
            retrotransposons to evoke regional heterochromatin formation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Krebs CJ, Larkins LK, Khan SM and Robins DM.
  TITLE     Expansion and diversification of KRAB zinc-finger genes within a
            cluster including Regulator of sex-limitation 1 and 2
  JOURNAL   Genomics 85 (6), 752-761 (2005)
   PUBMED   15885501
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Krebs CJ, Larkins LK, Price R, Tullis KM, Miller RD and Robins DM.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB612019.1 and BC089368.1.
            
            On Mar 21, 2007 this sequence version replaced NP_001012450.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (b) has a
            shorter and distinct N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089368.1, SRR1660813.130541.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     Protein         1..529
                     /product="zinc finger protein 708 isoform b"
                     /note="regulator of sex-limitation candidate 11"
                     /calculated_mol_wt=61371
     Region          5..65
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          83..103
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(88,90,92,94..95,98..99,102,116,118,122..123,
                     126..127,130,144,146,148,150..151,154..155,158)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          107..528
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          111..131
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          139..159
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          167..187
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          195..215
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          223..243
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          251..271
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          279..299
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(284,286,288,290..291,294..295,298,312,314,318..319,
                     322..323,326,340,342,344,346..347,350..351,354)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          307..327
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          335..355
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          363..383
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          391..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..439
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          447..467
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(452,454,456,458..459,462..463,466,480,482,486..487,
                     490..491,494,508,510,512,514..515,518..519,522)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          475..495
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          503..523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..529
                     /gene="Zfp708"
                     /gene_synonym="Rslcan11"
                     /coded_by="NM_001012448.2:91..1680"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS49298.1"
                     /db_xref="GeneID:432769"
                     /db_xref="MGI:MGI:3040674"
ORIGIN      
        1 medplsftdv aidfsadece cldsaqwnly kevmlenysn lvflglafsk pylvtfleqs
       61 sdlwsvkrka svaihlgska hkckecgksf drnsvliqhq rihtgerpyk ceecgmaftg
      121 rcilskhqri htgekpykck ecgkafscss nlhqhqqihr eekpykcddc gkafscssyl
      181 ykhqrihtgm kpykckecgk afncsanliy hqrihtgekp ykcgecgkaf tiystfmnhq
      241 rthsgekpye ckdcgkaftn cynliqhqri htgekpyace ecgksfnyss hlkqhkriht
      301 gekpykcevc gkafncsdyl vkhqrihtge kpykcevcgk afsfstylhk hqrihtgekr
      361 yrceecgkaf tnysglivhr rvhtgekpyk ceecgkafsv htslskhqri htreqpykcd
      421 ecgktfsvhs tfskhqimht rekpykckhc dktfkypspl vqherihtge rpykcevcgk
      481 aftsssnlky hwrlhtgekp ykceqcgkaf knssnvtrhy kihtrenpd
//
