LOCUS       NM_001101502            3186 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein 703 (Zfp703), transcript variant
            1, mRNA.
ACCESSION   NM_001101502 XM_001478406 XM_912161
VERSION     NM_001101502.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Cunningham,T.J., Colas,A. and Duester,G.
  TITLE     Early molecular events during retinoic acid induced differentiation
            of neuromesodermal progenitors
  JOURNAL   Biol Open 5 (12), 1821-1833 (2016)
   PUBMED   27793834
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Kumar,A., Chalamalasetty,R.B., Kennedy,M.W., Thomas,S., Inala,S.N.,
            Garriock,R.J. and Yamaguchi,T.P.
  TITLE     Zfp703 Is a Wnt/beta-Catenin Feedback Suppressor Targeting the
            beta-Catenin/Tcf1 Complex
  JOURNAL   Mol Cell Biol 36 (12), 1793-1802 (2016)
   PUBMED   27090637
  REMARK    GeneRIF: Results provide evidence that Zfp703 is a novel feedback
            suppressor of Wnt/beta-catenin signaling that functions by
            inhibiting the association of beta-catenin with Tcf1 on Wnt
            response elements in target gene enhancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Amin,S., Donaldson,I.J., Zannino,D.A., Hensman,J., Rattray,M.,
            Losa,M., Spitz,F., Ladam,F., Sagerstrom,C. and Bobola,N.
  TITLE     Hoxa2 selectively enhances Meis binding to change a branchial arch
            ground state
  JOURNAL   Dev Cell 32 (3), 265-277 (2015)
   PUBMED   25640223
REFERENCE   4  (bases 1 to 3186)
  AUTHORS   Pereira-Castro,I., Costa,A.M., Oliveira,M.J., Barbosa,I.,
            Rocha,A.S., Azevedo,L. and da Costa,L.T.
  TITLE     Characterization of human NLZ1/ZNF703 identifies conserved domains
            essential for proper subcellular localization and transcriptional
            repression
  JOURNAL   J Cell Biochem 114 (1), 120-133 (2013)
   PUBMED   22886885
  REMARK    GeneRIF: The conserved domains are essential for proper subcellular
            localization and transcriptional repression of the NLZ1/ZNF703
            protein.
REFERENCE   5  (bases 1 to 3186)
  AUTHORS   Slorach,E.M., Chou,J. and Werb,Z.
  TITLE     Zeppo1 is a novel metastasis promoter that represses E-cadherin
            expression and regulates p120-catenin isoform expression and
            localization
  JOURNAL   Genes Dev 25 (5), 471-484 (2011)
   PUBMED   21317240
  REMARK    GeneRIF: Zeppo1 is a key regulator of breast cancer progression
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   7  (bases 1 to 3186)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   8  (bases 1 to 3186)
  AUTHORS   Arlotta,P., Molyneaux,B.J., Chen,J., Inoue,J., Kominami,R. and
            Macklis,J.D.
  TITLE     Neuronal subtype-specific genes that control corticospinal motor
            neuron development in vivo
  JOURNAL   Neuron 45 (2), 207-221 (2005)
   PUBMED   15664173
REFERENCE   9  (bases 1 to 3186)
  AUTHORS   Bain,G., Mansergh,F.C., Wride,M.A., Hance,J.E., Isogawa,A.,
            Rancourt,S.L., Ray,W.J., Yoshimura,Y., Tsuzuki,T., Gottlieb,D.I.
            and Rancourt,D.E.
  TITLE     ES cell neural differentiation reveals a substantial number of
            novel ESTs
  JOURNAL   Funct Integr Genomics 1 (2), 127-139 (2000)
   PUBMED   11793228
  REMARK    Erratum:[Funct Integr Genomics 2000 Nov;1(3):218-9]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115820.11, AA008919.1, CF582327.1, BE981624.1, BF464968.1,
            BQ964921.1, BF323167.1, BE685996.1, CD352751.1 and BB609653.1.
            
            On or before Nov 16, 2007 this sequence version replaced
            XM_912161.3, XM_001478406.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript from the
            reference strain (C57BL/6J) was available for the full length of
            the gene. The extent of this transcript is supported by transcript
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF713461.1, AA008919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC115820.11        126141-126289       c
            150-422             AA008919.1         124-396
            423-442             CF582327.1         397-416
            443-953             BE981624.1         1-511
            954-978             BF464968.1         513-537
            979-1617            BQ964921.1         1-639
            1618-1915           BF323167.1         223-520
            1916-2323           BE685996.1         1-408               c
            2324-2885           CD352751.1         106-667
            2886-3186           BB609653.1         261-561
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     gene            1..3186
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /note="zinc finger protein 703"
                     /db_xref="GeneID:353310"
                     /db_xref="MGI:MGI:2662729"
     exon            1..276
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1803
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /note="isoform 1 is encoded by transcript variant 1; ES
                     neuronal differentiation 2; zinc finger elbow-related
                     proline domain protein 1"
                     /codon_start=1
                     /product="zinc finger protein 703 isoform 1"
                     /protein_id="NP_001094972.1"
                     /db_xref="CCDS:CCDS52532.1"
                     /db_xref="GeneID:353310"
                     /db_xref="MGI:MGI:2662729"
                     /translation="MSDSPAGSNPRTPESSGSGGGSSSGGGGGKRPAVPAVVSLLPPA
                     DPLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCS
                     QIGKPDPPPSSKLNSVAAAAANGLGSEKDPSRSAPGAASAAAALKQLGDSPAEDKSSF
                     KPYSKGSGGGDSRKDSGSSSVSSTTSSSSSSPGDKAGFRVPSAACPPFPPHGASVSTS
                     SNSSSPGGSRGGSPHHSDCKNGGGGAGELDKKEQEAKPSPEPAAGSRGSGGDSAHGGP
                     EATASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSIGYHGSIVGAYAGYPSQF
                     VPGLDPSKSGLVGGQLSGGLGLPPGKPPSSSPLTGASPPSFLQGLCRDPYCLGGYHSA
                     SHLGGSSCSTCSAHDPTGPSLKASGYPLVYPGHPLQPAALSSSAAQAALPGHPLYTYG
                     FMLQNEPLPHSCNWVAASGPCDKRFATSEELLSHLRTHTALPGAEKLLAAYPGASSLG
                     SAAAAAAAAASCHLHLPPPAAPGSPGSLSLRSPHTLGLSRYHPYGKSHLSTAGGLAVP
                     SLPTAGPYYSPYALYGQRLASASALGYQ"
     exon            277..3171
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3145..3150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /note="hexamer: AATAAA"
     polyA_site      3171
                     /gene="Zfp703"
                     /gene_synonym="1110032O19Rik; Csmn1; End2; Zeppo1; Znf703;
                     Zpo1"
                     /note="major polyA site"
ORIGIN      
        1 tggcactgcc tcctccaaat gagcgattcg cccgctggat ctaacccaag gacacccgaa
       61 agcagcggca gcggcggcgg cagcagcagc ggcggcggcg gcgggaagag gccggcggtg
      121 ccggcagtgg tgtccctcct gcccccggcg gaccccctgc gccaggcgaa ccggctccct
      181 atcagggtcc tgaagatgct gagcgctcac accggtcacc tcctgcaccc ggagtacctg
      241 caaccgctgt cctccacacc cgtcagccca attgagctgg acgccaagaa gagtcctttg
      301 gctctgctag cccagacctg ctcgcagatc ggcaagcccg acccgccgcc ctcatccaag
      361 ctcaactccg tagcggcggc ggcggccaac gggctgggat ccgagaaaga cccgagccgc
      421 tccgcccccg gcgccgcctc cgcggccgcg gcgctcaagc agctggggga ctcccccgcg
      481 gaggacaagt cgagcttcaa gccctactct aagggctccg gaggcggcga ctcccgcaaa
      541 gacagcggct cctcgtcggt gtcctccacc acctcttcgt cctcctcgtc ccccggagac
      601 aaggcgggct tcagggtccc cagcgccgcc tgccctccct ttcccccgca cggggcatcg
      661 gtctccacct catcaaactc gtcttctccc ggcggctccc gcggaggttc accacaccac
      721 tcagactgca agaacggcgg cggcggggcc ggcgaactgg acaagaaaga gcaggaagcc
      781 aaacccagtc ccgagccagc cgctgggagc cgaggtagcg gcggggactc ggctcacggt
      841 ggcccggaag ccaccgcatc ggggcgcaag tcagagccgc cctccgccct ggtgggggcg
      901 ggccacgtgg ctccagtgtc accctacaaa ccaggccact cggtgttccc actaccgccc
      961 tccagcatcg gttaccacgg ctccatcgtg ggcgcctacg ccggctaccc gtctcagttc
     1021 gttcctggcc tggatcctag caagtctggt ttggtgggag gtcagctgtc cgggggcctg
     1081 ggcctgccac caggcaagcc ccccagctcc agcccgctca cgggggcctc cccaccctcc
     1141 ttcctgcagg gattatgccg tgacccctac tgtctaggag gctaccacag cgcctcgcac
     1201 ctcggcggct caagctgttc cacttgcagc gcgcacgatc cgaccgggcc cagccttaag
     1261 gccagtggct accctctggt gtacccgggg caccccttgc aacctgcggc gctctcctcc
     1321 agcgccgccc aggccgctct cccgggccat cctctctaca cctatggctt catgctgcag
     1381 aacgaaccgc tgccacacag ctgcaattgg gtggcggcca gcgggccctg cgacaagcgc
     1441 tttgccacct ctgaggagct gctcagccat ctacggactc acacagccct gccgggcgca
     1501 gagaaacttc tggccgccta ccccggggcg tcgagcttgg gcagtgccgc tgcagccgct
     1561 gcagccgcag cctcttgtca cctgcatctc cccccgcccg ctgccccagg cagccccggg
     1621 tcgctgtcct tgcggagtcc acacactttg gggctaagcc gataccaccc ctatggcaag
     1681 agccacttat ctacagctgg gggcctggca gtgccgtccc ttcccacagc cggaccctac
     1741 tactcgccat acgcactgta tggacagaga ctagcctccg cctctgcgct tggataccag
     1801 taaccacagc tctggcccct cccagccctt ccccacccac cccttcctct cacgtcccac
     1861 tgccttcgac gctgcaagct ccactaccgc ttacccctac caggatccag cccagcccct
     1921 cccccaccgg actgtgtatt tatttactat aatgttagct tacaagctgg gaacataagt
     1981 gcattaatga ccacatgagt cagtggtatg caaaaagtct gtctccccca aataataata
     2041 ttaaccaccc aggtaactcc atgattcccc ccacccctct cccttctttt gcttattttc
     2101 ttcttcttgg gtatatgttt taaggctttg ggttgtttga ttttgactgg tttggtgtta
     2161 aggaatgaag gaagagttgg ggtcctacac tttcagtttc ccccatcttg ggaagtctct
     2221 tgcatgagtc ttaactgtta aaactgcata tcttcccttt tccttcccac cccatcttgt
     2281 ttcattccat gtgaagtttt aattcttttt tttccctttg tacaaaaaaa aaatgtaaca
     2341 atttgggggg gttcaagggg gaacaacttg gtggctggag gtcttgagct ctgatgaacc
     2401 agaattctgt tgggctgtgt ggtactacac aacaaacccc cctcccccca cttcccacat
     2461 gagcacttgg ttctaggccc tgagccccca aatcaaatca cagccttgac cctccagggt
     2521 gctcagttcg ggaagtccct gtgccaccag cagtgaccca atggcctcca actgagcctg
     2581 ccaagacttc taccttcctg gcccctcagg gacccacacc ttgcggtgca gtcaaattgc
     2641 cggctgacag ggacctgaca catccaatta aatgtcttag aaggccccgc tggcacgaaa
     2701 ttgctcttta tattttgtga agtactttat cgttactatt ttattttttc tctccctagt
     2761 tgggactgtg acccgccccc tcccctggcg ataggggtgg ggtcggggat ccttgatgga
     2821 tccctccaaa gcttaccagt cctcaagtca gcagaccaga caactttagg agctctgttg
     2881 ggggcaggct ggggactcag ggagccctag gatcagagca ctcccttcgc catgtcccag
     2941 acctgagcca gcaatcgcca aagctggcat taggtttccg tgggttcctg cggtggctag
     3001 gattaaagac ttaatacaag tcttctcccc aacaccttcc ctccctcccg gtcttacgca
     3061 gcagcgctgg ggcttcgggc cggcctcggc tgcggggcct cttgtggggt gaacagagct
     3121 ctcccttgct aagactattt tgttaataaa tggaatactt ggctatattc aaaaaaaaaa
     3181 aaaaaa
//
