LOCUS       NP_001345745             685 aa            linear   ROD 02-MAY-2024
DEFINITION  zinc finger protein 7 isoform 1 [Mus musculus].
ACCESSION   NP_001345745 XP_006520858
VERSION     NP_001345745.1
DBSOURCE    REFSEQ: accession NM_001358816.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 685)
  AUTHORS   Taib,S., Lamande,N., Martin,S., Coulpier,F., Topilko,P. and
            Brunet,I.
  TITLE     Myelinating Schwann cells and Netrin-1 control intra-nervous
            vascularization of the developing mouse sciatic nerve
  JOURNAL   Elife 11, e64773 (2022)
   PUBMED   35019839
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 685)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 685)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (residues 1 to 685)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (residues 1 to 685)
  AUTHORS   Agata,Y., Matsuda,E. and Shimizu,A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
REFERENCE   7  (residues 1 to 685)
  AUTHORS   Marine,J.C., Gilbert,D.J., Bellefroid,E.J., Martial,J.A.,
            Ihle,J.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   8  (residues 1 to 685)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Matera,A.G., Bourguignon,C.,
            Desai,T., Healy,K.C., Bray-Ward,P., Martial,J.A., Ihle,J.N. and
            Ward,D.C.
  TITLE     Emergence of the ZNF91 Kruppel-associated box-containing zinc
            finger gene family in the last common ancestor of anthropoidea
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10757-10761 (1995)
   PUBMED   7479878
REFERENCE   9  (residues 1 to 685)
  AUTHORS   Ihle,J.N., Smith-White,B., Sisson,B., Parker,D., Blair,D.G.,
            Schultz,A., Kozak,C., Lunsford,R.D., Askew,D., Weinstein,Y. et al.
  TITLE     Activation of the c-H-ras proto-oncogene by retrovirus insertion
            and chromosomal rearrangement in a Moloney leukemia virus-induced
            T-cell leukemia
  JOURNAL   J Virol 63 (7), 2959-2966 (1989)
   PUBMED   2542606
REFERENCE   10 (residues 1 to 685)
  AUTHORS   Chavrier,P., Lemaire,P., Revelant,O., Bravo,R. and Charnay,P.
  TITLE     Characterization of a mouse multigene family that encodes zinc
            finger structures
  JOURNAL   Mol Cell Biol 8 (3), 1319-1326 (1988)
   PUBMED   2452975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157554.7.
            
            On Dec 9, 2017 this sequence version replaced XP_006520858.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144887.1, SRR7345562.3745526.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.28 cM"
     Protein         1..685
                     /product="zinc finger protein 7 isoform 1"
                     /note="zinc finger protein 86, related sequence 1"
                     /calculated_mol_wt=78632
     Region          4..65
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          194..214
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          222..242
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          246..668
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          250..270
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          278..298
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(283,285,287,289..290,293..294,297,311,313,317..318,
                     321..322,325,339,341,343,345..346,349..350,353)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          306..326
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          334..354
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          362..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          414..434
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          442..462
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(447,449,451,453..454,457..458,461,475,477,481..482,
                     485..486,489,503,505,507,509..510,513..514,517)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          470..490
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          498..518
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          526..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          554..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          582..602
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          635..655
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          663..683
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..685
                     /gene="Zfp7"
                     /gene_synonym="KRAB20; KRAB7; Krox-2; mszf73-2; Zfp-7;
                     Zfp65; Zfp80; Zfp86-rs1"
                     /coded_by="NM_001358816.2:331..2388"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37124.1"
                     /db_xref="GeneID:223669"
                     /db_xref="MGI:MGI:99208"
ORIGIN      
        1 meavtfgdva vhfsreewqc ldsgqralyk evmlenhssv aglagflvfk pelisrleqg
       61 qepwvldlqg aegteapric qtdsairtdr kqtceytsll qrqipgfgdn ldskvwsenc
      121 prslglsvsg slfqkhrlns eavmpknstk davqerkelq atdvgyrpdd qrdhlsskli
      181 rrqsvptgen rypceecgka frwrsrlnqh klshtgeksy qcnkctkvfa sssrlirhqr
      241 ahtgekpfkc dqcgkrfvla svltqhqrih tgerpfkcae cgkgfhlsak lvqhqrihtg
      301 ekpyrceecg ktfgqssslv hhqrihtger pficqecgka fcqrsqlsrh rrthtgerpy
      361 scqecgkafc qratlaqhqk mmhtaeksqm prasespsli acqgntteek pfkceqcgka
      421 frwlsrlnqh qvvhsgekpy qcnkcskafg ctsrlirhqr thtgekpfkc decgkrfvqs
      481 shliqhqrih tgekpyvcdd cgraftqsss liyhqrihkg ekpykcsqcg kafsmstqlt
      541 shqrthtger pytcnecgkt frqnstlfqh qiihvrvkpy ecnecgkafs rssyliehqr
      601 ihtraqgghe fgdtpesptv lnhkkvhtvk klyqcddcdk vfrwrsylii hqrihtgerp
      661 ykcnacgkaf hqiakltqhq klhmr
//
