LOCUS       NM_001384119            2348 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger protein 69 (Zfp69), transcript variant 2,
            mRNA.
ACCESSION   NM_001384119 XM_011240568
VERSION     NM_001384119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2348)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2348)
  AUTHORS   Chung,B., Stadion,M., Schulz,N., Jain,D., Scherneck,S., Joost,H.G.
            and Schurmann,A.
  TITLE     The diabetes gene Zfp69 modulates hepatic insulin sensitivity in
            mice
  JOURNAL   Diabetologia 58 (10), 2403-2413 (2015)
   PUBMED   26232096
  REMARK    GeneRIF: Zfp69 mediates hyperlipidaemia, liver fat accumulation and
            mild insulin resistance. However, it does not induce type 2
            diabetes, suggesting that the diabetogenic effect of the Zfp69
            locus requires synergy with other as yet unidentified genes.
REFERENCE   3  (bases 1 to 2348)
  AUTHORS   Suto,J. and Satou,K.
  TITLE     Genetic background (DDD/Sgn versus C57BL/6J) strongly influences
            postnatal growth of male mice carrying the A(y) allele at the
            agouti locus: identification of quantitative trait loci associated
            with diabetes and body weight loss
  JOURNAL   BMC Genet 14, 35 (2013)
   PUBMED   23641944
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2348)
  AUTHORS   Scherneck,S., Vogel,H., Nestler,M., Kluge,R., Schurmann,A. and
            Joost,H.G.
  TITLE     Role of zinc finger transcription factor zfp69 in body fat storage
            and diabetes susceptibility of mice
  JOURNAL   Results Probl Cell Differ 52, 57-68 (2010)
   PUBMED   20865372
  REMARK    GeneRIF: Zfp69 mRNA-expression was significantly higher in diabetic
            subjects than in unaffected controls.
            Review article
REFERENCE   5  (bases 1 to 2348)
  AUTHORS   Malcuit,C., Trask,M.C., Santiago,L., Beaudoin,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Identification of novel oocyte and granulosa cell markers
  JOURNAL   Gene Expr Patterns 9 (6), 404-410 (2009)
   PUBMED   19539053
REFERENCE   6  (bases 1 to 2348)
  AUTHORS   Scherneck,S., Nestler,M., Vogel,H., Bluher,M., Block,M.D., Berriel
            Diaz,M., Herzig,S., Schulz,N., Teichert,M., Tischer,S.,
            Al-Hasani,H., Kluge,R., Schurmann,A. and Joost,H.G.
  TITLE     Positional cloning of zinc finger domain transcription factor
            Zfp69, a candidate gene for obesity-associated diabetes contributed
            by mouse locus Nidd/SJL
  JOURNAL   PLoS Genet 5 (7), e1000541 (2009)
   PUBMED   19578398
  REMARK    GeneRIF: Zfp69 is the most likely candidate for the diabetogenic
            effect of Nidd/SJL locus.
REFERENCE   7  (bases 1 to 2348)
  AUTHORS   Christoforou,N., Miller,R.A., Hill,C.M., Jie,C.C., McCallion,A.S.
            and Gearhart,J.D.
  TITLE     Mouse ES cell-derived cardiac precursor cells are multipotent and
            facilitate identification of novel cardiac genes
  JOURNAL   J Clin Invest 118 (3), 894-903 (2008)
   PUBMED   18246200
REFERENCE   8  (bases 1 to 2348)
  AUTHORS   Marine,J.C., Gilbert,D.J., Bellefroid,E.J., Martial,J.A.,
            Ihle,J.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   9  (bases 1 to 2348)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Matera,A.G., Bourguignon,C.,
            Desai,T., Healy,K.C., Bray-Ward,P., Martial,J.A., Ihle,J.N. and
            Ward,D.C.
  TITLE     Emergence of the ZNF91 Kruppel-associated box-containing zinc
            finger gene family in the last common ancestor of anthropoidea
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10757-10761 (1995)
   PUBMED   7479878
REFERENCE   10 (bases 1 to 2348)
  AUTHORS   Ihle,J.N., Smith-White,B., Sisson,B., Parker,D., Blair,D.G.,
            Schultz,A., Kozak,C., Lunsford,R.D., Askew,D., Weinstein,Y. et al.
  TITLE     Activation of the c-H-ras proto-oncogene by retrovirus insertion
            and chromosomal rearrangement in a Moloney leukemia virus-induced
            T-cell leukemia
  JOURNAL   J Virol 63 (7), 2959-2966 (1989)
   PUBMED   2542606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731722.19 and AL606904.12.
            
            On May 30, 2020 this sequence version replaced XM_011240568.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1381779.1,
                                           SRR11927935.2725667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AL731722.19        20045-20289         c
            246-474             AL731722.19        17933-18161         c
            475-755             AL731722.19        15890-16170         c
            756-882             AL731722.19        3668-3794           c
            883-978             AL731722.19        2934-3029           c
            979-2348            AL606904.12        168762-170131       c
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.66 cM"
     gene            1..2348
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /note="zinc finger protein 69"
                     /db_xref="GeneID:381549"
                     /db_xref="MGI:MGI:107794"
     exon            1..245
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     exon            246..474
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2132
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Zfp63p; zinc finger protein 642"
                     /codon_start=1
                     /product="zinc finger protein 69 isoform 2"
                     /protein_id="NP_001371048.1"
                     /db_xref="GeneID:381549"
                     /db_xref="MGI:MGI:107794"
                     /translation="MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGT
                     QQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSH
                     DGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVM
                     LENYRNLVSVGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDD
                     ISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQE
                     GNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQ
                     PIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRS
                     SLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHL
                     SEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSN
                     HRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQ
                     KIHRRNTFRDDPGHENKRQL"
     exon            475..755
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     exon            756..882
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     exon            883..978
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     exon            979..2348
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /note="hexamer: AATAAA"
     polyA_site      2348
                     /gene="Zfp69"
                     /gene_synonym="Gm1029; Krab2; Zfp63"
                     /note="major polyA site"
ORIGIN      
        1 gaaacggcgg agctcgggca tctgagccgc agccggcgcc gcaggtcctg ggctgggaca
       61 gaaggccggg caggacgcct gtgcgcgcgg agctccgctc ccgggtgcgg cgggtgagaa
      121 gcgggagagg ccggtgtcca gcccggaggc cgacggtgtc ctgtgtccct cggaagccac
      181 gctgcgcact gggcgccgcg gtgtgagcgt ggaaggctgg cgggaacgga tccggagatc
      241 ctccggggct caacaactct tccagggtaa aagattatgg cctgaggacg atacaaccag
      301 gaagcctctc atcgaaagtt ccagcagttt ccccacccga agctgccacc cccagtcagg
      361 ccggcgccat catgcctcag cagctcctga tcaccccggc cactgaggcg acctgggtga
      421 agttgaagga ggtgtccctg tgggaggatg tgacaaaaat gtttggagga gaagctctgc
      481 tatcccatga tgctaatggg acacaacaag aaagcttagc tgatggaacg acccctggca
      541 cccctgcagc aggatcccat gatggagcga cccctggcac cactgcaaca ggatcccatg
      601 atgaagcgac ccctggcacc cctgcagcag gatcccatga tggagagacc cctggcatcc
      661 ctgcagcagg atcccatgat ggagagaccc ctggcacccc tacagcagga tcccatgatg
      721 gagtgacccc tggcaccact gcagcaggat cccaggaatc gttgactttc aaggacattg
      781 ccgtggactt atcccaggag gagtggggac agctggctcc tgcataccag gatttgtatc
      841 gggaggtgat gctggagaac tacagaaacc tggtgtcagt gggatatcaa ctttccaagc
      901 ctactgtgat ttcccagttg gaaaaaggag agggaccatg catggcagag agtcaaggcc
      961 cagaggatcc cattttagat gtgaagaata aactagaaac caaggagtca actgcagagg
     1021 atgacatttc tgtcaagctc gatcatggca tcacgagggg aaggctgata gaggatgata
     1081 tagtttgttc tccattgaaa aaagcctcca gctacagtga tacattagag agtcaccggg
     1141 caacctgtgg gaaaggcacg agacgagcca tttggaccca caaaaagaaa cgccaagaag
     1201 ggaacaaatt ggaaaaccca gagagttcca atgttatttt agaacagaag caccgtaaac
     1261 acaaaccagc cagaaagagg aacaagtata aattagattc aattgatcac ccagtgagct
     1321 gtatgagagc cagaaggtac ccatgtaatg tgtgtgagaa aatgtttaag caacccattc
     1381 accttgtcga gcacatgaga actcacactg gcgagaaacc gttccggtgc aaggagtgtg
     1441 ggagggcctt tagtcagagc gcatctctca atacgcacca gaggatccac actggggaga
     1501 agcccttcgc atgtgaggag tgcggcaaag ccttccggca tcgctcgtcg cttaaccagc
     1561 atcaccggac tcacactgga gagaaaccgt tcacgtgtga caaatgtcag aaagccttta
     1621 gccagaacat cagcttggtc cagcatctga ggactcattc gggagagaaa ccctttagct
     1681 gcagtgaatg tgggaaaccc tttcgacaga ttagacacct tagcgaacat gtaagaatcc
     1741 acactgggga gaagccctac aaatgcacct cctgctgtaa aacattcagt catagagcat
     1801 atctcacaca tcaccagcga atccacaccg gggagagacc ctacaaatgt aaggagtgcg
     1861 ggaaagcctt caggcagagg atacacctta gcaaccacag gactgttcac acaggggtga
     1921 aagcctacga gtgtaaccgc tgtgggaaag cctacaggca cgactcctcc tttaagaaac
     1981 accagcgaca tcacacggga gaaaagcctt acgaatgtac tgagtgtgga aagtccttca
     2041 gctataactc atccctgagc cgacaccaga aaatccacag gaggaacact ttccgagatg
     2101 atccgggaca tgagaacaaa aggcagctct aaattggtga ttctgagctt taaagtttca
     2161 ggactcgagt aaccttgaga aattaacaac aacggtggca acttttgatt ttgccaaaag
     2221 tgtaaataaa taccctgttg attactactg tctgacaatt acacaaaatg ataaattaag
     2281 cattatgaga atttcacaaa tattttttta ctcatttcat gatagatgaa taaattattt
     2341 cttatgaa
//
