LOCUS       NM_001406073            6367 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger protein 638 (Zfp638), transcript variant
            6, mRNA.
ACCESSION   NM_001406073 XM_006505706
VERSION     NM_001406073.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6367)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6367)
  AUTHORS   Meng,M., Cao,Y., Qiu,J., Shan,G., Wang,Y., Zheng,Y., Guo,M., Yu,J.,
            Ma,Y., Xie,C., Hu,C., Xu,L., Mueller,E. and Ma,X.
  TITLE     Zinc finger protein ZNF638 regulates triglyceride metabolism via
            ANGPTL8 in an estrogen dependent manner
  JOURNAL   Metabolism 152, 155784 (2024)
   PUBMED   38211696
  REMARK    GeneRIF: Zinc finger protein ZNF638 regulates triglyceride
            metabolism via ANGPTL8 in an estrogen dependent manner.
REFERENCE   3  (bases 1 to 6367)
  AUTHORS   Ni,W., Lin,S., Bian,S., Zheng,W., Qu,L., Fan,Y., Lu,C., Xiao,M. and
            Zhou,P.
  TITLE     USP7 mediates pathological hepatic de novo lipogenesis through
            promoting stabilization and transcription of ZNF638
  JOURNAL   Cell Death Dis 11 (10), 843 (2020)
   PUBMED   33040080
  REMARK    GeneRIF: USP7 mediates pathological hepatic de novo lipogenesis
            through promoting stabilization and transcription of ZNF638.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6367)
  AUTHORS   Du,C., Ma,X., Meruvu,S., Hugendubler,L. and Mueller,E.
  TITLE     The adipogenic transcriptional cofactor ZNF638 interacts with
            splicing regulators and influences alternative splicing
  JOURNAL   J Lipid Res 55 (9), 1886-1896 (2014)
   PUBMED   25024404
  REMARK    GeneRIF: ZNF638 participates in splicing decisions and that it may
            control adipogenesis through regulation of the relative amounts of
            differentiation-specific isoforms.
REFERENCE   5  (bases 1 to 6367)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6367)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 6367)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6367)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6367)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 6367)
  AUTHORS   Matsushima,Y., Ohshima,M., Sonoda,M. and Kitagawa,Y.
  TITLE     A family of novel DNA-binding nuclear proteins having
            polypyrimidine tract-binding motif and arginine/serine-rich motif
  JOURNAL   Biochem Biophys Res Commun 223 (2), 427-433 (1996)
   PUBMED   8670298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156283.6 and AC153607.15.
            
            On May 10, 2022 this sequence version replaced XM_006505706.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.8745.1,
                                           SRR10223971.6969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC156283.6         78988-79121         c
            135-1647            AC156283.6         16065-17577         c
            1648-1709           AC156283.6         11220-11281         c
            1710-1748           AC156283.6         4947-4985           c
            1749-2056           AC156283.6         3089-3396           c
            2057-2331           AC156283.6         1343-1617           c
            2332-2344           AC156283.6         1-13                c
            2345-2478           AC153607.15        205469-205602       c
            2479-2601           AC153607.15        203891-204013       c
            2602-2660           AC153607.15        198690-198748       c
            2661-2713           AC153607.15        198445-198497       c
            2714-2764           AC153607.15        197071-197121       c
            2765-2833           AC153607.15        195070-195138       c
            2834-2917           AC153607.15        194240-194323       c
            2918-2986           AC153607.15        193580-193648       c
            2987-3024           AC153607.15        191864-191901       c
            3025-3156           AC153607.15        189724-189855       c
            3157-3285           AC153607.15        186175-186303       c
            3286-3327           AC153607.15        185344-185385       c
            3328-3462           AC153607.15        184405-184539       c
            3463-3585           AC153607.15        182593-182715       c
            3586-3623           AC153607.15        179549-179586       c
            3624-4851           AC153607.15        174403-175630       c
            4852-4917           AC153607.15        173745-173810       c
            4918-5833           AC153607.15        171923-172838       c
            5834-5932           AC153607.15        167758-167856       c
            5933-6051           AC153607.15        166937-167055       c
            6052-6367           AC153607.15        164959-165274       c
FEATURES             Location/Qualifiers
     source          1..6367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 36.06 cM"
     gene            1..6367
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /note="zinc finger protein 638"
                     /db_xref="GeneID:18139"
                     /db_xref="MGI:MGI:1203484"
     exon            1..134
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..6117
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /note="isoform 5 is encoded by transcript variant 6;
                     nuclear protein 220; zinc finger matrin-like protein; zinc
                     finger, matrin-like"
                     /codon_start=1
                     /product="zinc finger protein 638 isoform 5"
                     /protein_id="NP_001393002.1"
                     /db_xref="GeneID:18139"
                     /db_xref="MGI:MGI:1203484"
                     /translation="MPGAGVPAAASSPKSGASGSSQVSDSLRRFVLFLENFAPLVNSL
                     SLGIASPLLLGPSPLRFAQIETQLALQQLNAVASHGSTPPYTFLNQAFLKVAMSRPRF
                     NPRGTFPLQRPRAPNPPGMRPPGPFVRPGSMGLPRFYPAGRARGIPHRFPGHGSYQNM
                     GPQRMNVQVTQHRTDPRLTKEKLDFPEAQQKKGKPHGSRWDDESHITPPVEVKQSSVT
                     QVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMR
                     KMSRRLPNLPSHSRNKETLSNETVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEV
                     KNEFQPQQSISATVSTPNVICNSVFPGGDMFRQMDFPGESSSQSFFPVESGTKMSGLH
                     ISGQSVLEPVKSISQSISQTVSQTTSQSLNPPSMNQVPFTFELDAVLRQQERISQKSV
                     ISSADAHGGPTESKKDYQSEADLPIRSPFGIVKASWLPKFTQAGAQKMKRLPTPSMMN
                     DYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSR
                     RNESNRKENETPRRRSHSPSPRHSRRSSSGHRIRRSRSPVRYIYRPRSRSPRICHRFI
                     SKYRSRSRSRSRSRSPYRSRNLLRRSPKSYRSASPERTSRKSVRSDRKKALEDGGQRS
                     VHGTEVTKQKHTETVDKGLSPAQKPKLASGTKPSAKSLSSVKSDSHLGAYSAHKSENL
                     EDDTLPEGKQESGKSALAQRKPQKDQSLSSNSILLVSELPEDGFTEEDIRKAFLPFGK
                     ISDVLLVPCRNEAYLEMELRKAVTSIMKYIETMPLVIKGKSVKVCVPGKKKPQNKEMK
                     KKPSDIKKSSASALKKETDASKTMETVSSSSSAKSGQIKSSTVKVNKCAGKSAGSVKS
                     VVTVAAKGKASIKTAKSGKKSLEAKKSGNIKNKDSNKPVTVPANSEIKASSEDKATGK
                     SAEESPSGTLEATEKEPVNKESEEMSVVFISNLPNKGYSTEEIYNLAKPFGALKDILV
                     LSSHKKAYIEINKKSADSMVKFYTCFPISMDGNQLSISMAPEHVDLKDEEALFTTLIQ
                     ENDPEANIDKIYNRFVHLDNLPEDGLQCVLCVGHQFGKVDRYMFMSNKNKVILQLESP
                     ESALSMYNFLKQNPQNIGEHVLTCTLSPKTDSEVQRKNDLELGKGSTFSPDLKNSPVD
                     ESEVQTAADSSSVKPSEVEEETTSNIGTETSVHQEELGKEEPKQALCESDFAIQTLEL
                     EAQGAEVSIEIPLVASTPANIELFSENIDESALNQQMYTSDFEKEEAEVTNPETELAV
                     SDSVFIEERNIKGIIEDSPSETEDIFSGIVQPMVDAIAEVDKHETVSEVLPSACNVTQ
                     APGSYIEDEKVVSKKDIAEKVILDEKEEDEFNVKETRMDLQVKTEKAEKNEAIIFKEK
                     LEKIIAAIREKPIESSVIKADPTKGVDQTSKPDETGKSSVLTVSNVYSSKSSIKATVV
                     SSPKAKSTPSKTESHSTFPKPVLREQIKAEKKVSAKEFGLLKNTRSGLAESNSKSKPT
                     QIGVNRGCSGRISALQCKDSKVDYKDITKQSQETETKPPIMKRDDSNNKALALQNTKN
                     SKSTTDRSSKSKEEPLFTFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKEALKISPSP
                     ELNLKKKKGKTSVPHSVEGELSFVTLDEIGEEEDATVQALVTVDEVIDEEELNMEEMV
                     KNSNSLLTLDELIDQDDCIPHSGPKDVTVLSMAEEQDLQQERLVTVDEIGEVEESADI
                     TFATLNAKRDKRDSIGFISSQMPEDPSTLVTVDEIQDDSSDFHLMTLDEVTEEDENSL
                     ADFNNLKEELNFVTVDEVGDEEDGDNDSKVELARGKIEHHTDKKGNRKRRAVDPKKSK
                     LDSFSQVGPGSETVTQKDLKTMPERHLAVDDAELKDSEPDEKRRKTQDSSVGKSMTSD
                     VPGDLDFLVPKAGFFCPICSLFYSGEKAMANHCKSTRHKQNTEKFMAKQRKEKEQNET
                     EERSSR"
     exon            135..1647
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1709
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1748
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..2056
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2331
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2478
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2601
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2660
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2713
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2764
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2833
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2917
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..2986
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3024
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3156
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3285
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3327
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3462
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3585
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3623
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..4851
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..4917
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5833
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..5932
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            5933..6051
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     exon            6052..6367
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6098..6103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /note="hexamer: AAGAAA"
     polyA_site      6134
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
     regulatory      6339..6344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /note="hexamer: AATAAA"
     polyA_site      6367
                     /gene="Zfp638"
                     /gene_synonym="mNP220; Np220; Zfml; Znf638"
                     /note="major polyA site"
ORIGIN      
        1 agaagcgaat tgaggtgagg gaggagctca gagctgtgca ggtcggcgat gcccggggct
       61 ggcgttcccg cagcggcatc gagccccaag tccggggcct ccgggtcgtc gcaggtgtcg
      121 gactccctga ggcgctttgt gttattcttg gaaaatttcg caccacttgt gaattccttg
      181 agcctgggca ttgcgagccc acttctgttg ggcccgtctc ctttgcgctt tgctcagatt
      241 gagactcagt tggcgcttca gcagctgaat gccgttgcct cccatggttc aacaccacct
      301 tatacttttt taaatcaggc attcttgaaa gtagccatgt cgagacccag gtttaatcct
      361 cgagggacct ttccacttca aaggccacga gcacctaatc ctcctgggat gaggcctcca
      421 ggaccatttg tgaggcctgg ctctatgggt cttccaagat tttacccagc agggagagcc
      481 cgtggaattc cacacagatt tcctggccac ggatcttatc agaacatggg accacaaaga
      541 atgaatgttc aggtaactca acaccgaacc gatccaagat taaccaaaga aaaattggat
      601 tttcctgaag cacaacaaaa gaaggggaag cctcatggta gtcggtggga tgatgagtct
      661 catataactc caccggtaga agtgaaacag agctctgtaa cccaggttac agagcaaagt
      721 cctaaagtac agagccgcta cacaaaagag agtgcttcaa gtattttagc aagttttgga
      781 ttatcaaatg aagatctaga agaacttagc cgctatcctg atgaacagct aactcctgaa
      841 aatatgccat taatattgag ggatataaga atgcgaaaaa tgagccgccg attacctaat
      901 ttaccttctc acagcagaaa taaggaaaca cttagtaatg aaacagtttc aagtaatgtg
      961 attgattatg ggcatgcaag caaatatggt tatacagaag atccacttga agtacgtatt
     1021 tatgatcctg aaattccaac tgatgaagta aagaatgaat ttcagcccca gcagagcatt
     1081 tctgcaactg tttcaactcc aaatgtgata tgtaattctg tgtttcctgg tggagatatg
     1141 tttcgtcaga tggacttccc tggtgagtcc tccagtcagt cttttttccc agttgagagt
     1201 ggaaccaaga tgtcaggctt acacatttca ggacagtcag tccttgaacc tgtaaaatcc
     1261 atcagccagt ctattagcca aacagttagc cagacaacga gccagtctct gaatcctcca
     1321 tctatgaacc aggtaccctt tacatttgaa ttagatgcag ttttacgcca acaagagcgg
     1381 atctcacaga agtctgtgat cagttcagct gatgcacatg gtggacctac agaaagtaaa
     1441 aaggattacc aatcagaggc tgacttgcct attcggtctc cctttgggat tgtgaaagct
     1501 tcgtggctac caaagtttac acaagctggt gcccagaaaa tgaagagact gccaacccct
     1561 tctatgatga atgattatta tgcagcatct ccaagaatat ttccacattt gtgttctctg
     1621 tgtaacgtag aatgtagtca tttgaaggac tggattcagc atcaaaatac ctccacccac
     1681 attgagagct gtcggcagtt aaggcaacaa taccctgatt ggaatcctga gatcctccca
     1741 tccagaagaa atgagagcaa taggaaagaa aatgaaactc caagaagacg ttctcattcc
     1801 cccagcccca gacattctag gagatcaagc tcaggtcaca gaatccgtcg ctctcgaagt
     1861 ccagtccgtt atatctatag accaaggagt cgaagtccaa gaatttgcca ccgtttcatt
     1921 tctaaatata gatccagatc caggtccaga tccaggtccc gttctccata tcgtagtcgg
     1981 aatctcctta gaagaagtcc gaagtcctat cggtcagcta gcccagagag gacatcaaga
     2041 aaatcagtga gatcagatag gaaaaaggca ttagaagatg gaggacaacg ttctgtgcat
     2101 gggacagaag ttactaaaca gaaacatact gaaacagttg ataaagggct ctcaccagca
     2161 caaaagccaa aacttgccag tggaacaaag ccatcagcga aatctctaag ctctgtaaag
     2221 agtgattcac atttaggagc atattctgct cacaagtctg agaatctgga agatgacact
     2281 ttaccagaag gtaaacagga gtctggtaaa agtgctttgg cccagcggaa gccacagaag
     2341 gatcagtctt tgagttccaa ctcaattctt cttgtatctg aacttccaga ggatggcttt
     2401 actgaagaag atattagaaa agcatttctg ccatttggaa aaattagtga tgttctcctt
     2461 gttccttgta gaaatgaggc ttacttggaa atggagctta gaaaagcagt tacttcaatc
     2521 atgaagtaca ttgaaacaat gcctcttgtg ataaaaggaa aaagtgtgaa agtatgtgtt
     2581 ccaggaaaga aaaagccaca gaacaaagaa atgaagaaga aaccttcaga tattaagaaa
     2641 tcatctgcat ctgctttaaa aaaagagaca gatgcttcaa aaaccatgga aactgtcagt
     2701 tcaagctctt ctgccaaatc tggacaaata aagtcatcta cggtcaaggt gaacaaatgt
     2761 gcagggaaat cagcgggttc tgtaaaatct gtggttacgg tagctgcgaa aggtaaagct
     2821 tctatcaaaa cagcaaaatc tggaaagaag tctctagaag ctaaaaagtc tgggaatatc
     2881 aaaaacaaag actccaataa acccgtgact gtaccagcaa actctgaaat caaggctagt
     2941 tcagaagaca aagccactgg aaagagtgct gaagaaagtc cttcaggtac tttggaggcc
     3001 acagaaaagg aaccagtgaa caaggaatcg gaggaaatga gtgtagtatt tatttctaat
     3061 ttgcctaaca aaggatattc tacagaagaa atttacaact tagcaaaacc atttggtgct
     3121 ttgaaggaca ttttggtttt atcatctcat aaaaaggcat atatagaaat aaacaaaaaa
     3181 tctgcagatt ctatggtaaa attttacacc tgcttcccaa tatccatgga tggaaatcag
     3241 ctctccataa gtatggctcc tgagcatgtg gacttaaaag atgaggaagc tctctttaca
     3301 actttgattc aagaaaatga cccagaggca aatattgata aaatttacaa ccgatttgta
     3361 catcttgaca atttacctga agatggactt cagtgtgtgc tttgtgttgg gcatcagttt
     3421 ggaaaagtgg atcgctatat gttcatgagt aacaaaaaca aggtgatcct tcagttagaa
     3481 agtcctgaat ctgctctgtc aatgtacaat tttttgaaac aaaatccaca aaacataggt
     3541 gagcacgtgt tgacctgcac tttatctcca aagactgact cagaggttca aaggaagaat
     3601 gatctggaac taggaaaagg aagtactttt agccctgact tgaaaaacag tcctgttgat
     3661 gaaagtgagg tacaaacagc agctgatagt tcctctgtta aacctagtga ggttgaagaa
     3721 gaaactactt ccaatattgg aacagaaact tcagtgcatc aggaagaact tggtaaggaa
     3781 gaacccaaac aagcattgtg tgagtctgac tttgcaattc aaacactaga acttgaagct
     3841 caaggagcag aggtcagcat agaaattcct cttgtagcat ccactccagc caatattgag
     3901 ttattcagtg aaaatataga tgagtctgct ttaaaccagc agatgtacac cagtgacttt
     3961 gaaaaggaag aggcagaagt tacaaaccct gaaactgaat tagcagtatc tgacagtgtc
     4021 ttcatagaag aaaggaacat caagggaatt atagaagatt ctccatctga aacagaagat
     4081 atattttctg gaattgtaca gcctatggta gatgccatag ctgaagtgga taaacatgaa
     4141 actgtttcag aagtactgcc atctgcttgt aatgtgaccc aagcaccagg aagttacatt
     4201 gaagatgaga aggttgtgag caaaaaggat attgctgaaa aagttatctt ggatgaaaag
     4261 gaggaagatg aatttaatgt taaggagacc agaatggatt tacaagtaaa aacagagaag
     4321 gctgagaaga atgaagctat catatttaaa gaaaaattgg agaagattat agcagcaata
     4381 agagaaaagc caattgaaag ttctgtaatc aaggcagacc caactaaagg agtggatcag
     4441 accagtaagc ctgatgaaac tggtaaaagt agtgtgctga ctgtatcaaa tgtatatagt
     4501 agtaaatcaa gcatcaaggc tactgtggtc tcttctccta aagcaaaaag tacaccttca
     4561 aaaactgaaa gtcacagcac cttcccaaaa cctgtgctta gagagcaaat aaaggctgaa
     4621 aagaaagttt cagccaagga atttggtctg cttaaaaata ccagatcagg cttggcagaa
     4681 agcaacagta aatccaaacc cactcagatt ggtgttaaca gagggtgcag tggaaggatc
     4741 tcagcccttc agtgcaagga ttctaaagtg gattacaagg acataacaaa acagtctcag
     4801 gaaacagaga ctaaacctcc catcatgaaa cgggatgaca gcaacaataa ggcattggct
     4861 ttgcagaaca ctaagaattc taaaagtact acagatagaa gttccaaatc gaaagaggaa
     4921 ccattattta catttaattt ggatgaattt gttactgtgg atgaagtcat agaagaagta
     4981 aatccttctc aagccaagca gaatccatta aaaggaaaaa gaaaggaagc cctcaaaatt
     5041 tctccttccc ctgaacttaa cttaaaaaag aaaaagggga aaacttctgt ccctcacagt
     5101 gttgagggag aattgtcctt tgtaacatta gatgaaatag gggaggaaga agatgcaact
     5161 gtgcaagctc tagtcactgt ggatgaagtc attgatgaag aagagctcaa tatggaagaa
     5221 atggtaaaaa attccaactc ccttcttacc ttagatgaac taattgacca agatgattgc
     5281 attccccaca gtggacctaa agatgttact gtcctgtcga tggctgaaga acaagatcta
     5341 caacaggaac gcttggtaac tgtggatgaa attggagaag tagaagagtc agcagacata
     5401 acttttgcta ctttgaatgc taaaagagat aaaagggatt ctattgggtt catttcttcc
     5461 cagatgcctg aagacccttc cactttagtt actgtagatg aaatacagga tgacagcagt
     5521 gattttcact taatgacttt ggatgaagta actgaagagg atgaaaactc tctggctgat
     5581 tttaacaacc ttaaagaaga gctgaatttt gttactgtgg atgaagttgg agatgaggaa
     5641 gatggagaca atgattcaaa agttgagtta gcacgaggca aaattgagca ccatacagat
     5701 aaaaaaggaa atagaaagag gagagctgtg gacccaaaga agtcaaagct tgattctttc
     5761 tcccaagtag gtccaggaag tgaaactgtt acacaaaaag atctgaaaac catgcctgaa
     5821 agacatttgg cagttgatga cgctgaacta aaggattcag aacctgatga aaaacgcagg
     5881 aagactcaag actcttctgt aggcaaatca atgacatctg atgtccctgg agatttggac
     5941 tttcttgttc cgaaggctgg atttttctgt ccaatttgct ccctcttcta ctcaggtgaa
     6001 aaagcaatgg caaatcactg caagagcaca cgtcataaac aaaatacaga gaagttcatg
     6061 gccaagcaaa gaaaggaaaa ggagcagaat gagactgaag aaagaagctc taggtgatgg
     6121 aggaaaggag aaaagaattc attagaaatt catttagggt ccagttgatt tgtgtatttt
     6181 tgttatcatt taatttgtaa tttttttgtt tcaaaagcat attcatgttg tacaaatttc
     6241 tgattgccct tgatgtagag aaactgatgg gaaaatatga tgggtttgat ttttatatca
     6301 aatcatcagg catggataat accttttaga agtgtttaaa taaatgttcc tactgtatat
     6361 ttcaaca
//
