LOCUS       NM_183149               3359 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger protein 598 (Zfp598), transcript variant
            1, mRNA.
ACCESSION   NM_183149
VERSION     NM_183149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Fu,X., Zang,K., Zhou,Z., Reichardt,L.F. and Xu,B.
  TITLE     Retrograde neurotrophic signaling requires a protein interacting
            with receptor tyrosine kinases via C2H2 zinc fingers
  JOURNAL   Mol Biol Cell 21 (1), 36-49 (2010)
   PUBMED   19864463
  REMARK    GeneRIF: NTRAP regulates retrograde neurotrophic signaling by
            controlling the formation of signaling endosomes.
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF537189.1, BC050859.1 and AC154566.2.
            
            On Feb 8, 2017 this sequence version replaced NM_183149.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050859.1, SRR7974084.3215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CF537189.1         1-65
            66-3352             BC050859.1         1-3287
            3353-3359           AC154566.2         81098-81104         c
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.46 cM"
     gene            1..3359
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /note="zinc finger protein 598"
                     /db_xref="GeneID:213753"
                     /db_xref="MGI:MGI:2670965"
     exon            1..287
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2798
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase ZNF598"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNF598 isoform 1"
                     /protein_id="NP_898972.1"
                     /db_xref="CCDS:CCDS28490.1"
                     /db_xref="GeneID:213753"
                     /db_xref="MGI:MGI:2670965"
                     /translation="MAAAAGAEGRRAALEAVAAPERGGGSCVLCCGDLEATALGRCDH
                     PVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKKLPAFALIPIHQLQHEKKYDIYFAD
                     GKVFALYRQLLQHECPRCPHLPPFSLFGDLEQHMRKQHELFCCKLCLKHLKIFTYERK
                     WYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDG
                     AQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHKTACHSRSRAEAR
                     QNRQIDLQFSFAPRHSRRSEGVVSGEDYEEVDRYNRQGRAGRASGRGAQQNRRGSWRY
                     KREEEDREVAAAIRASVAAQQQEETQRVEDREEGSRPKKEEAAARVPEEPRGHRRLPR
                     AQGEGSGSKEASANGPVSQEAFPATGPGPVVALSNTLPPPSPELKEEDFPSLCASTSS
                     CCTAVTPGSVGLALAYPGPPRGKNTFQEEDFPALVSSAPKPSSAPSSLISAWNSGCSK
                     KGNLPTPGSQAVVGGSQPPRKAGKGSRGGRKGGPAPVDEEDSGGLTVQGLRSVPTTVA
                     VSSLLAPATNQSSAKVGKKKKVGSEKPGATSSPLLPPDHTPKPSGAEQVLEAPLSKAE
                     VPVTIVVNGHSEGSALVRSAPKEPPGLPRPLGPLPCPIPQEDFPALGGPCPPRMPPPP
                     GFSTVVLLKGTPPPPPPPPGLVPPISKPPPGFSSLLPSSHSACAPSPTTTTTTTTTTK
                     TPGLAPTPQAYLVPENFRERNLQLIQSIKDFLQSDEACFSKFKSHSGEFRQGMISAAQ
                     YYKSCRDLLGESFQKIFSELLALLPDTAKQQELLSAHTDFCSREKPPNSRSKRNKKNV
                     WQTSTQQLGLDCCVCPTCQQVLAHGDVSSHQALHAARDDDFPSLQAIARIIT"
     exon            288..400
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            401..530
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            531..742
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            743..960
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1078
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1266
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1351
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..2118
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2293
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2444
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..3359
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /note="hexamer: AATAAA"
     polyA_site      3352
                     /gene="Zfp598"
                     /gene_synonym="Ntrap; Znf598"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggggcg ggtccgccgg gagccaggcc gcgctgtgcc gcgccggcca ggagggggcc
       61 ggagcccggc catggcggcg gcggcgggcg ccgaggggcg gcgcgcggct ctggaggcgg
      121 tggcagcgcc ggagcggggc ggcgggagct gcgtgctgtg ctgcggtgac ctggaggcta
      181 cggcgctggg ccgctgcgat cacccggtgt gctaccggtg ctctaccaag atgcgggtgc
      241 tgtgcgagca gcgctactgc gccgtgtgcc gcgaggagct gcgccaggtg gtctttggga
      301 agaaactccc tgcttttgcc ctgatcccca tccatcagct ccaacacgag aagaaatatg
      361 acatctattt tgcagatgga aaggtgtttg cattgtacag gcagctgctg cagcatgagt
      421 gcccacggtg ccctcacctg ccacccttca gcctcttcgg ggacttggag cagcacatgc
      481 gcaagcagca tgagctcttc tgctgcaagt tgtgcctcaa gcacctcaag atcttcacct
      541 atgaacgcaa gtggtactca cgcaaggacc tggctcgaca ccgtatgcag ggtgaccctg
      601 atgatacatc ccatcgggga catccactct gtaagttctg tgacgagcgc tacctggaca
      661 atgacgagct gctcaagcac ctgcgccgag accactactt ctgccacttc tgtgactctg
      721 atggggccca ggactactat agtgactatg cctacctgcg tgagcacttc cgggagaagc
      781 acttcctgtg tgaggagggc cgctgcagca ctgagcagtt cacccatgcc ttccgcaccg
      841 agatcgacct caaggctcat aaaacagctt gccacagccg cagccgggcc gaggcacgcc
      901 agaaccggca gattgacctt cagtttagct ttgcaccacg gcactcacgc cggagtgagg
      961 gagtcgtcag tggtgaggac tacgaggagg tggacaggta caatcgccag ggccgagctg
     1021 gccgggccag cgggcgtgga gcccagcaga accgccgggg aagctggagg tacaagaggg
     1081 aagaagaaga ccgagaagtg gcagctgcta tccgggcctc tgtggctgct caacagcaag
     1141 aggagactca gagggttgag gaccgggagg agggtagcag gcccaagaaa gaggaagccg
     1201 cagccagggt gcctgaggaa ccccgtggcc accggcgtct gcctcgggct cagggtgaag
     1261 gctcaggctc caaggaagcc tcagcaaatg gtcctgtaag ccaagaagcc ttcccagcca
     1321 caggcccagg cccagtggtt gccctctcaa ataccctccc accacccagc cctgagctca
     1381 aggaggaaga cttccccagt ctctgtgcct ccacctcctc ctgctgcaca gcggttaccc
     1441 caggctctgt aggcttggca ctggcttatc ctggtcctcc caggggcaag aacaccttcc
     1501 aggaagagga ctttcctgcc ttggtttcct ccgcacccaa gcccagcagt gccccttcca
     1561 gtctcatctc agcttggaat agcggctgca gcaagaaagg gaacctaccc accccggggt
     1621 cccaggctgt ggttggtggc agccagcctc cccggaaggc aggaaagggg agcaggggtg
     1681 gcagaaaggg tggcccagcc ccagtggatg aggaggatag cggtggcctc actgtgcagg
     1741 ggctgcggag tgtgcccacc acggtagctg tgtcttcttt gctggcacca gccaccaacc
     1801 agagttcagc caaggttggc aagaagaaga aggtgggctc tgagaagcct ggggccacat
     1861 catccccact gttgccccct gatcataccc caaagccctc tggggctgag caggtcctgg
     1921 aagccccttt gagcaaagct gaagtgccag taaccatcgt tgtcaatgga cattccgaag
     1981 ggtcagccct ggtacggagt gccccaaagg aacctccagg gcttccaagg cccctcggtc
     2041 ccctcccctg ccccatacca caggaggact ttccagctct cggaggccct tgtccaccca
     2101 ggatgcctcc tcccccaggc ttcagcaccg tggtactctt gaagggcaca ccacctccac
     2161 ccccaccccc acccggcctg gtgcctccca tcagcaagcc accccctggc ttctctagtc
     2221 ttctgcccag ctcccactca gcctgtgctc ctagtcccac caccacaacc accaccacca
     2281 ccaccacgaa aacacccggg ctagcaccca caccacaagc ctacttagtt cctgagaatt
     2341 tccgggagag aaacctgcag cttatccagt ctatcaagga ctttctgcaa agcgatgagg
     2401 cctgcttcag caagtttaaa agccattcgg gggagttcag acaggggatg atctctgcgg
     2461 ctcagtacta caagagctgc agggacctgc ttggagagag cttccagaag atcttcagtg
     2521 agctgctggc gctcctgcca gacacagcca aacagcagga gctgctgtct gcacacacag
     2581 acttctgcag tcgtgagaag cctcccaact ccagatctaa gaggaacaag aagaatgtgt
     2641 ggcagaccag cacccaacag ttgggcctgg actgctgtgt gtgccccacc tgccagcagg
     2701 tactggcaca cggtgacgtc agcagccacc aggcactgca cgctgcccgg gacgatgact
     2761 tcccctccct tcaagccatt gccaggatca ttacgtagct gctgctggtg agggcaggag
     2821 ctgtcacacc ctagcgcctc ctttctcctt cctccctctt cccagctgct tggccctggt
     2881 agggccctgg gaaggccgaa ggccaggcct cctggttagc caggcctgcc aggtggacat
     2941 caggaaaggt ctaccctgtg caccgtcact cataagttct gtcccatgct tggctgaggg
     3001 tcagtcttgg tttgtgatct tgtgattttg gaatgtgcca ggggagggaa aggctaggat
     3061 gctgggacct gagctagagg cctcagtggc ctgaagagag ttctcgtgag gcaagtccat
     3121 agccccagag ctgacagctt cgggtccact ggtgctggag tcagatgtca agtgtgttgt
     3181 gtaaacaatt ggctgtttca tagagaatgt tccagattaa aaacagacac aaaattgtgc
     3241 tacttgaagt tcaatctttt tacaagacaa gttaaatcta agatctcaaa ttgcctctga
     3301 cattttataa aagacagttt atcttcaaat aaatttattt tgcagtactg cacatagct
//
