LOCUS       NM_177622               3909 bp    mRNA    linear   ROD 05-MAR-2025
DEFINITION  Mus musculus zinc finger protein 595 (Zfp595), transcript variant
            1, mRNA.
ACCESSION   NM_177622
VERSION     NM_177622.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3909)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3909)
  AUTHORS   Krebs,C.J., Larkins,L.K., Price,R., Tullis,K.M., Miller,R.D. and
            Robins,D.M.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB632383.1, AK136304.1 and BK001632.1.
            
            On Jul 28, 2006 this sequence version replaced NM_177622.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136304.1, AK154058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BB632383.1         2-14
            14-667              AK136304.1         2-655
            668-2261            BK001632.1         668-2261
            2262-3909           AK136304.1         2251-3898
FEATURES             Location/Qualifiers
     source          1..3909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..3909
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="zinc finger protein 595"
                     /db_xref="GeneID:218314"
                     /db_xref="MGI:MGI:3040707"
     exon            1..94
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1966
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="isoform 1 is encoded by transcript variant 1; KRAB
                     zinc finger protein; regulator of sex-limitation candidate
                     23; zin finger protein 595"
                     /codon_start=1
                     /product="zin finger protein 595 isoform 1"
                     /protein_id="NP_808290.1"
                     /db_xref="CCDS:CCDS36712.1"
                     /db_xref="GeneID:218314"
                     /db_xref="MGI:MGI:3040707"
                     /translation="MEDMLSFWDVAMYFSAEEWEYLGPAQWKMYRDVMLENYSNLVFL
                     GLASTKPYLVTFLEQRQELSDVKRQAATAKYSGGKSYTCKECGKVFEAEKGFQNHQII
                     HLGVKSCKCEECGKSFHFSSLLSEHKRIHTGEKPYKCEIHSKAFHVPSKLFQHRIIHT
                     GEKPYNCEVCGKAFCTSLFLSKHKIIHMGKNPCKCEVCGKAFEYPSRLSKHKKIHTGE
                     KPYKCKVCGKAYRSPSSLCEHKRTHTGGKPYKCEVCGKAFHYPSLLSKHKIIHTEEKP
                     YKCEVCGKAFHYLSRLSNHKTIHTGEKPYKCEVCGKAFHVPSSLSEHKRTHTGKKPYK
                     CEVCGKEFRCPSLFSNHKRIHTGEKPYSCEVCGKAFHTTTLCSIHKRIHTGEKPYKCE
                     VCGKAFHYSSRLSNHKKIHAGEKPYKCEVCGKAFHYPSILSKHKTIHTEDNPYKCEVC
                     GKAFDYPSRLSNHKKVHTEEKPYQCDICGKAFHYASLLSKHKIIHIGEKPYKCEVCDK
                     AFHYPSRLSNHKKIHTGEKPYKCEICGNVFRFPSSLSEHKRIHTGDKPYKCQICGKAF
                     HYPSLLSKHKIIHTGENPYKCEVCGKFFNYSSRLYKHKKIHTREKSYKYKECGLAFYC
                     Q"
     exon            95..221
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /inference="alignment:Splign:2.1.0"
     exon            222..317
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /inference="alignment:Splign:2.1.0"
     exon            318..1997
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..3909
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="major polyA site"
     regulatory      3815..3820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="hexamer: ATTAAA"
     polyA_site      3834
                     /gene="Zfp595"
                     /gene_synonym="A230042K10Rik; Rslcan23"
                     /note="major polyA site"
ORIGIN      
        1 atcaaacttc cgcatttgat tttcaaactt aagcttctcc ccaaagttag gcgtctgtcc
       61 tgttgagcac tgcgtttgga tctctgacat ggaggatatg ctgtcattct gggatgtggc
      121 tatgtatttc tctgcagagg agtgggaata cctgggtcct gctcagtgga aaatgtacag
      181 agatgtgatg ctggagaatt acagcaacct tgtgttcctg ggtcttgctt ccactaagcc
      241 atatctagtc acatttctgg agcaaagaca agagctttca gatgtgaaga gacaagcggc
      301 cactgctaag tactcagggg ggaaaagcta tacgtgtaaa gaatgtggca aagtctttga
      361 ggcggaaaaa ggatttcaaa atcatcagat aattcattta ggagtgaagt cctgcaagtg
      421 tgaagagtgt ggcaagtcct tccatttttc atcactactt tctgaacaca aaaggattca
      481 tacaggagaa aaaccctaca agtgtgaaat acatagcaag gcctttcatg ttccatcaaa
      541 actttttcaa cacaggataa ttcacacagg agaaaaaccc tacaactgtg aagtatgtgg
      601 caaggccttc tgcacttcat tattcctttc taaacacaag ataattcata tgggaaagaa
      661 tccttgcaag tgtgaagtat gtggcaaggc cttcgaatat ccatcaagac tttcaaaaca
      721 taagaaaatt catacaggag agaaaccata caagtgtaaa gtatgtggaa aggcctaccg
      781 ctctccatca tcactttgtg aacacaagag aactcataca ggagggaaac cctacaagtg
      841 tgaagtatgt ggcaaggcct tccactatcc atcattactt tcaaaacaca agataattca
      901 tacagaagaa aaaccctaca agtgtgaagt atgtggtaag gccttccatt atctgtcaag
      961 actttctaac cataagacaa ttcatacagg agagaaaccg tacaagtgtg aagtatgtgg
     1021 gaaggccttt catgttccat catcactttc tgaacacaag agaactcata caggaaagaa
     1081 accttacaaa tgtgaagtgt gtggcaagga gtttcgttgt ccatcattat tttctaacca
     1141 caagagaata catacaggtg aaaaacccta tagttgtgaa gtatgtggca aggccttcca
     1201 tactacaact ttatgttcta tacacaagag aattcacaca ggagagaaac cttacaagtg
     1261 tgaagtatgt ggcaaggcct tccattattc atcaagactt tccaaccata agaaaattca
     1321 tgccggagag aaaccataca agtgtgaagt atgtggcaag gccttccatt atccatccat
     1381 actttctaaa cacaagacaa ttcatacaga agataatccc tacaagtgtg aagtatgtgg
     1441 caaagcattt gattatccat caagactttc caaccataag aaagttcata cagaagagaa
     1501 accataccag tgtgacatat gtggcaaggc cttccattat gcatcattac tttctaaaca
     1561 caagataatt catattggag aaaagcccta taagtgtgaa gtatgtgaca aggcctttca
     1621 ttacccatca agactttcca accataagaa aattcataca ggagagaaac catacaagtg
     1681 tgaaatatgt ggaaatgtct tccgttttcc atcatccctt tctgaacata agagaattca
     1741 cactggagac aaaccataca agtgccaaat atgtggcaag gccttccatt atccatcatt
     1801 actttctaaa cacaagataa ttcatacagg agaaaatccc tacaagtgtg aagtatgtgg
     1861 caagttcttt aattattcat caagacttta caaacataag aaaattcata cacgagagaa
     1921 gtcctacaaa tataaagaat gtggcctagc tttctattgt caataagtac tttctgaaaa
     1981 aaagagaatc catacaggag gtctgttgat tgcagttgga agcatctgtt tgactgagat
     2041 gctgcagtat cagagaatac cctgagacca gctattcatc catcttctgc ttcctgactg
     2101 tagaagaaac gtgaccagct gcttatgttc ctgttgtttt acctttctca ccatgtgctg
     2161 tggttggaat aagaattgcc ccaagggctc ataggcttga atgcttagtc tgaaggtagt
     2221 agcactgctg gaaaaagatt aaggagtgcg gcgtcattag tgtaagtgtg taactggggg
     2281 tcatatttga ggtttcaaag tttcagaccc agtatctccc tcttttaaaa actttagtca
     2341 atacgtataa ttctcagcta ctcttcaagt accatgtcta tctgcattcc accatgctcc
     2401 caagctagtt tcccacaata ataacttaca agcctctgaa actgtaaaca cgctccaatt
     2461 aaatgctttt taaaataggg attgtcatgg tttgatgtct cttcatagca accggacact
     2521 gagtaagtct ccatggtaga caatggaatt gaactatgat ccaaattaag cccttctact
     2581 tgtgcttgtg tgcatatatt attgccatga gaatacttac taaatcttca tgccaaatgc
     2641 aagtttcaat gtgatgttta atacgtatga atcatgtgtg ttttcccttt ccccattatt
     2701 gccctccctt ttgctccctt ctctgaaaag tgtttccact cttctttatt tacataccta
     2761 cacacatatc tacattaaca aacacagatg tagagcaagc agtgtctaaa actagagaaa
     2821 tattagtgac tgctggctgc ctgccagtca cacgggtgcc cctgcaacac tggagcattt
     2881 atctcttcaa cctattggcc cagaacatct gacagatttt tctctgcagc agcaaatatg
     2941 aaggagttat ctcccttgac ctggcagagt ttggctgttg actttctatg ttttctgctt
     3001 ctccacagct tgcaggtcag catttgaggt aagggcagtt tcctgtctag tggcagcttg
     3061 tcacattttt aacaaacttc gtaaggaagt tcttcaatgc tcatcatcat ctttgaagga
     3121 cttgcagatt ctgccaagag ctgggatttc tcattgtcaa acattaataa aatatctttc
     3181 aatgccatat tttatagatt tctgatgttt ctgaagacca tctaacattc tcaggatatt
     3241 tgaataggaa tatattgttt gtctctagct atttactatc tcattaactt agaaaacgtc
     3301 tgtgatataa ctaaacaaga atgtgttgag attttgtctt ttactgtcta ttctaatcat
     3361 aagtgcagga ctcccaagat ctggagtctg catttagtcc cttggaccct gctccatgtt
     3421 atttttgatt ggtaaataaa gatgccagca actaatagtt gggtagaaga tacgtaagtg
     3481 ccgattaggt ttcctgggct tggggtcaga ggagaaccag gagaagaaga acatgtagga
     3541 gggagaagga aaggctgctg tgggttaggt gcaccataaa aaatgtggcc ctgtgagctg
     3601 gctaattgga attaagagta gcccagatga caaatattaa atatgaaata ataatttgag
     3661 gtaaatatat caatagggat gtagattctg atagcatgaa tgcttggtat ctacccatca
     3721 tttgtactgt ataggcttat tgtaaatatg aaatttgtgt ttgtttttat ttcatatcta
     3781 aatggtaaaa gtgggataga aaccctgtgc cggcattaaa atagttctac aacatatggt
     3841 gcctcaacgt ctgccccgtt ttgggtgcca atttgttgca gtaaatgtca aaccccaata
     3901 aacctgtgt
//
