LOCUS       NM_024215               1991 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 593 (Zfp593), mRNA.
ACCESSION   NM_024215
VERSION     NM_024215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Lynch,S.A., McLeod,M.A., Orsech,H.C., Cirelli,A.M. and Waddell,D.S.
  TITLE     Zinc finger protein 593 is upregulated during skeletal muscle
            atrophy and modulates muscle cell differentiation
  JOURNAL   Exp Cell Res 383 (2), 111563 (2019)
   PUBMED   31442450
  REMARK    GeneRIF: Zfp593 overexpression in cultured muscle cells resulted in
            significant repression of muscle cell differentiation and
            attenuation of ERK1/2 and p38 phosphorylation, but did not vitiate
            protein synthesis. The discovery that Zfp593 is expressed in
            skeletal muscle combined with the observation that it is induced in
            response to neurogenic atrophy furthers our understanding of the
            molecular genetic events of muscle wasting.
REFERENCE   3  (bases 1 to 1991)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1991)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 1991)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1991)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005247.1, AK014081.1 and CO040973.1.
            
            On Aug 4, 2007 this sequence version replaced NM_024215.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003465.1, AK133585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               AK005247.1         3-629
            628-1879            AK014081.1         672-1923
            1880-1991           CO040973.1         1-112               c
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.5 cM"
     gene            1..1991
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /note="zinc finger protein 593"
                     /db_xref="GeneID:68040"
                     /db_xref="MGI:MGI:1915290"
     exon            1..288
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..493
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /note="zinc finger protein T86"
                     /codon_start=1
                     /product="zinc finger protein 593"
                     /protein_id="NP_077177.2"
                     /db_xref="CCDS:CCDS51325.1"
                     /db_xref="GeneID:68040"
                     /db_xref="MGI:MGI:1915290"
                     /translation="MGRSRRTGAHRAHSLARQMKAKKRRPDLDEIHRELRPQGLPRPK
                     PEPDAEPDPDLPGGGLHRCLACARYFIDSANLKTHFRSKDHKKRLKQLSVEPYSQEEA
                     ERAAGMGSYVQPQRLGVPTEVSTDIPEMDTST"
     exon            289..351
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /inference="alignment:Splign:2.1.0"
     exon            352..1976
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /inference="alignment:Splign:2.1.0"
     regulatory      614..619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /note="hexamer: AATAAA"
     polyA_site      633
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /note="major polyA site"
     polyA_site      1976
                     /gene="Zfp593"
                     /gene_synonym="3110024A21Rik; E130106C14Rik; ZNF593"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgggc ggcccggaag cgccaacacg tgtgggtctt ttccctactc cctgtttctt
       61 ggtcttgtgt gtgggtgtct ctctgatcat gggtcgctct cggcggaccg gcgcgcaccg
      121 agcacattcc ttagcccgcc agatgaaggc caagaagcgg cggccggacc tggatgagat
      181 tcatcgcgag ctgaggccgc aggggctccc gcggcccaag ccggagccgg acgcggagcc
      241 cgacccggac ctgccagggg gcggcctgca tcgctgtctg gcttgcgcga ggtacttcat
      301 cgattcagcc aacctgaaga cccatttccg atccaaagac cacaagaaaa ggctgaagca
      361 gctgagtgtc gaaccctaca gtcaggaaga agctgagagg gcagcgggca tgggctcgta
      421 tgttcaaccc cagcggctgg gcgtgcccac agaagtgtcc actgatatcc ctgagatgga
      481 cacgtccacc tgagtggcct aaggatgcag ggcagaggaa ctgcccatgg gcagtggttc
      541 atcagccaag ctgagagtgt gtattttgga tttccggttt gcggagatgc tctcttccgg
      601 gtgttctgcc caaaataaag gacctggaca agagggcaca cctccgatac taacttccct
      661 taccaggggt ttctgggcca agatgtctac tccctactag gtccagcttt ggaacgggta
      721 tcctccccct gcttctttgg atctaggctg gagtctggct aggtacagcg taaaacttgg
      781 gagtaggatc tagcgatggc tgagactaat ccccaagggg aaaaaagtgg gattcggata
      841 ttgcagcccc ctcccctgaa tcgcctacct ccaagcctgg gcgagaggct acccgcctca
      901 tcacggggcc tgtgatggtt gccgctgctt caccatcttc catactgcat agcaggagcc
      961 acctaacccg aggacagcca acaatgtagc cacaatccca accaggggac tccggggctc
     1021 tgccttcagc tccccagcca cctgcatctg ggagagcaca gagggtgcac gtgaagggtc
     1081 aactgaggct tctaggcagg aagaagggta taagatggcg cagctgggta aagaagatgc
     1141 aggcgccatt tctgccccag ggagattcca ccccaatcct tctcgcctca ctgcccatct
     1201 gggtcccggc tagtcaggca gcagggaacg tgacagcctg actgttgggg gtatcagacg
     1261 tgtcgttggg ggaagttggg aggaagaggt aggtagattt ccttacctgt agcacccgga
     1321 agtagccagg agtcaggcgt cgaaatctca tagtgggggc actgtcctcc ctgttggcct
     1381 gtgaaatggg aacagaaatg aagactgggt gtcgcccagg gtgccaagaa gtggacacca
     1441 gagcataggg gtccctgacc tatttgcctg ggcactgtat gctcagagga tgctcaccga
     1501 tgccggctta cccaagtctg gcagggggca gggcggctgg atctttaaat ctggtccctc
     1561 cccccctgcc tgctgctgcc ttgccagcct taggagcagc tgtcaggagg gatcagcatc
     1621 aggcctgaat atcagctcct cccccattta ccagagaggc caggccaggc atgtaggcca
     1681 agtcttggct gacagtgccc aggagtcccc gcatccatca ggtactaggc agcctccctc
     1741 ggccctggtc tgaactggat gtgagcattc agcaaaagag gccatacaac ctgttagcca
     1801 cttgaccatt gaggttctgt aaattcaact accttggtgg gagggtacac ttcatctcca
     1861 ccccccaacc aaagatggag ttctcacaag aacatctttt gtgggcttga gggtgacaaa
     1921 ggtttgcttg tgccattaag ctgtctataa tgttatgtta aaaaatttta actacaaaaa
     1981 aaaaaaaaaa a
//
