LOCUS       NM_011762               3813 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus zinc finger protein 59 (Zfp59), mRNA.
ACCESSION   NM_011762
VERSION     NM_011762.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Peng,H., Begg,G.E., Harper,S.L., Friedman,J.R., Speicher,D.W. and
            Rauscher,F.J. 3rd.
  TITLE     Biochemical analysis of the Kruppel-associated box (KRAB)
            transcriptional repression domain
  JOURNAL   J Biol Chem 275 (24), 18000-18010 (2000)
   PUBMED   10748030
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Passananti,C., Corbi,N., Paggi,M.G., Russo,M.A., Perez,M.,
            Cotelli,F., Stefanini,M. and Amati,P.
  TITLE     The product of Zfp59 (Mfg2), a mouse gene expressed at the
            spermatid stage of spermatogenesis, accumulates in spermatozoa
            nuclei
  JOURNAL   Cell Growth Differ 6 (8), 1037-1044 (1995)
   PUBMED   8547218
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Passananti,C., Felsani,A., Caruso,M. and Amati,P.
  TITLE     Mouse genes coding for 'zinc-finger'-containing proteins:
            characterization and expression in differentiated cells
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9417-9421 (1989)
   PUBMED   2512579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164532.4 and AC139063.11.
            
            On May 3, 2022 this sequence version replaced NM_011762.3.
            
            Summary: The Krueppel-associated box (KRAB) is a domain of around
            75 amino acids found in the N-terminal portion of about one third
            of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The
            KRAB domain functions as a transcriptional repressor when tethered
            to the template DNA by a DNA-binding domain. Although the function
            of KRAB-ZFPs is largely unknown, they appear to play important
            roles during cell differentiation and development. This gene
            encodes a protein belonging to the Krueppel family of C2H2-type
            zinc finger proteins and has been shown to accumulate in the nuclei
            of mature sperm in association with the nuclear matrix. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142951.1, SRR17784648.738206.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC164532.4         202186-202309
            125-177             AC164532.4         206435-206487
            178-304             AC139063.11        58036-58162
            305-403             AC139063.11        60155-60253
            404-3813            AC139063.11        67135-70544
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.97 cM"
     gene            1..3813
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /note="zinc finger protein 59"
                     /db_xref="GeneID:22717"
                     /db_xref="MGI:MGI:99206"
     exon            1..124
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..177
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2106
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /note="zinc finger protein Mfg-2; zfp-59"
                     /codon_start=1
                     /product="zinc finger protein 59"
                     /protein_id="NP_035892.2"
                     /db_xref="CCDS:CCDS39851.1"
                     /db_xref="GeneID:22717"
                     /db_xref="MGI:MGI:99206"
                     /translation="MASTNSQDMVCGSVTFRDVAVDFSQEEWACLDATQKVLYRNIML
                     ETYSNLVAVVGSCISKPDLIVLLEQEKEPWMAVNEETGRPSPDLEADYDAENISPQNR
                     IYNRKFSKQSIKQLSRTFDPKGSWFSNGPNYSTFHGLRDCQSDAGQQITNKEGVPPHT
                     CQTLAHNTEKPYECKECGKCFGCRSTLTQHQSVHTGEKPYECKECGKAFRLPQQLTRH
                     QKCHSGEKPFSHNEGRQAFQHPNLLKYPKAIHTGAKAFACRECGKSFNRVSSLVEHGL
                     IHADVKPYECNECGKAFKRHRSFVRHQKIHSGERPFQCKDCGKGFIVLAHLTRHQSSH
                     SEEKPFECEECGKKFRTARHLVKHQRIHSGEKPFECNVCGSAFRLQLYLSEHQKTHME
                     EKYLECNVCGKAFRLQVYLSEHLKTHTEENPFKCKLCGSAFPNKYQLNKHLTVHTDGK
                     PYQCKECGKCFRQRSKLTEHESIHTGKKPFQCEECGKFFRLNTLLIHHQKSHSGERPF
                     ECKECGKAFLLPSQLNSHKIVHTSKRPFECKVCGKSFKRESNLIQHGAVHAGVKSYEC
                     SECGKGFIHRSSLFHHRKIHSDEKPFKCQECGKAFVVLAYLIQHQSIHTGEKPFECEL
                     CGSAFRCRSQLNKHLRIHTDVKLFQCVED"
     exon            178..304
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..403
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..3813
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /note="major polyA site"
     regulatory      3770..3775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
                     /note="hexamer: AATAAA"
     polyA_site      3813
                     /gene="Zfp59"
                     /gene_synonym="Mfg-2; Mfg2"
ORIGIN      
        1 gagttgcacg ccgggatctc cgggacgctc caggcttctc cagggctttg cttgtgacaa
       61 ctgtgttttc cgggaccacc gcgccggaag tagcgcatag gcttttggtt tatgtctccc
      121 cagagggagg aagcctgaag aagaatggcc agcactaatt ctcaagacat ggtttgtggg
      181 tcagtgacat ttagggatgt ggctgttgac ttctctcagg aggagtgggc ctgcctggat
      241 gctactcaga aggtcttata caggaacata atgttggaga cctacagcaa cctggtcgca
      301 gtggtgggaa gttgcatttc caagccagat ctgatcgtct tactagagca ggagaaagag
      361 ccctggatgg ctgtgaatga agaaacaggc aggccgagcc cagatttgga ggcagattat
      421 gatgctgaaa atatatcccc ccaaaatcgt atttataata gaaaattttc caaacagagc
      481 ataaagcaat taagtagaac ttttgacccc aagggctcct ggtttagtaa tggccccaac
      541 tatagtacat tccatggact acgggattgt cagagtgatg ctggccaaca gattactaac
      601 aaggaaggag tgcctcctca cacctgccag actcttgctc acaatacaga aaaaccatat
      661 gaatgtaaag agtgtgggaa gtgctttggt tgcaggtcaa ctcttactca gcatcagagt
      721 gttcacactg gagagaagcc ctatgaatgt aaggagtgtg ggaaggcctt cagactcccc
      781 caacagctca caaggcatca gaagtgtcac agtggtgaga agcctttcag tcataatgaa
      841 ggcagacagg cttttcaaca tcccaaccta ctcaagtacc ctaaagccat tcatacaggt
      901 gccaaagcat ttgcatgcag ggaatgtggg aagtccttca accgtgtctc cagccttgtt
      961 gaacatgggc ttattcatgc tgatgtgaaa ccatatgaat gtaatgagtg tgggaaagcc
     1021 tttaaacgac acagaagttt tgtgcgccat cagaaaatcc attctggtga gagacccttt
     1081 cagtgtaagg attgtgggaa gggcttcatt gttctggctc acctcactcg gcaccagagc
     1141 agtcatagtg aagagaagcc atttgaatgt gaggaatgtg gcaagaaatt tagaactgcc
     1201 agacaccttg ttaagcacca gcgcattcat agcggcgaga aaccctttga atgcaatgta
     1261 tgtgggagtg ctttccggct tcaactatac ctttctgagc atcagaaaac tcacatggaa
     1321 gagaaatact tggaatgcaa tgtgtgtggg aaggcttttc ggcttcaggt atacctttct
     1381 gagcatctga aaactcacac tgaagagaat cctttcaagt gtaagctctg tgggtcagcc
     1441 ttcccaaata agtaccaact taataagcat ctcacagttc acactgatgg gaaaccctat
     1501 cagtgcaagg aatgtggcaa atgctttcgt caaaggtcaa aactaacgga acatgagagt
     1561 attcacactg gcaagaaacc cttccagtgt gaagaatgtg ggaagttctt tagacttaac
     1621 acacttctca ttcatcatca gaagtctcac agtggtgaga gaccttttga atgtaaagaa
     1681 tgcggaaagg ctttccttct tcccagtcaa cttaatagcc ataaaattgt tcatacaagt
     1741 aaaagaccct ttgaatgcaa ggtatgtggg aagtccttca agcgtgaatc caatctcatt
     1801 caacatggcg ctgttcatgc tggtgtgaaa tcatatgaat gcagtgagtg tgggaaaggt
     1861 tttattcacc gctcaagcct gttccaccat cggaaaattc attctgatga gaaaccattt
     1921 aagtgtcagg agtgtggaaa ggccttcgtt gttctggcgt atctcattca gcatcagagc
     1981 atccacactg gagagaaacc atttgaatgt gagctgtgtg ggtcagcctt cagatgtaga
     2041 tcccaactca ataaacatct gagaattcat actgatgtga aactctttca gtgtgtggaa
     2101 gattgaacag acattgttcg tggaacagag cttagggagt ccacactggt gagaagctcg
     2161 ttcagtgtaa tggatatggg gaagctcttt gatatcttta caaaattctt agacatgtta
     2221 gaattcatac tggcaagaat catcatgaat ataaagaatg tgggaagtac tttatgtgtg
     2281 gtggagacct taaagtacat ccaagaattc acactgtaag aaacattacc actgttaaga
     2341 atgtaggaag acctttagtt gaatatgaaa cttgttttga catcctaaat ataatagtaa
     2401 taagaagtct tatgatgtaa ggagtatgga aaggcctaca gtaattctaa gttccctgta
     2461 tatcagagaa gttctactgg tgagaaagcc tatgaataaa agtaaggtgg gaacatgttt
     2521 agacttcgtg cagccttcat gcatagtggc aaattcatac aggtaggaca ccctatcagt
     2581 ataaagaatg tgcaaagacc tccaagtgga gctggggcct tcttcaacat aaaaaaatgt
     2641 ttgcttgtgt cgaacactat gaatgcaagg aatgtgggaa tatttacaga attagctcag
     2701 ctcttaaagc tcatcagagg gtccatataa gtctcgagat gctgtgactg tgaggactcg
     2761 gtaagaaagc tttgattgta aatggtgacc ttacacaaca tcagaaaatc cataatcacc
     2821 aggagtcatg tgcatgtgaa agaggacaag ccactgtatg aaaatcttcc tgaacatcag
     2881 agaactcaca ttgggaagac catgacgtca cataaaatga gaactttaat ctgccctggg
     2941 atttggtgaa cataagagta ttcatatacg gttgatgcca agaaatcctt tggaacgaga
     3001 atttgggaag tcggttcaga gaagatactc tgttgaaaat gtctcttatc ctcagaaatc
     3061 taggaagtct cctgacaacc ttttcccagc attctaacag tctagattga ctgtcccagg
     3121 atgctgccaa acgtgactgg aaacaaagtt gttctatcct ccctacaggg tcaggacaca
     3181 gaatactgat agttaaactg tgaggggccc tacatgaaga acctgactct gccattgttc
     3241 cattggcagc aacaacaaag ccctggtggc tctaatgtct aggagaaaaa gctggatgcc
     3301 tacaattcag agtcctttgc tttaaggatt gaagctaggt gtggtgactt ttgcctgtaa
     3361 ttccagaata tgagaggatg aggtaggaga attaccaggc atttaaggca agcccgggtt
     3421 tcatgtatga aatccaggat atcttggaaa agaaaagcaa aataaataca caagcctaaa
     3481 ggctcaggga tctacagaca agagaaggca ggaagattgc aagagccaaa gggtgtcttc
     3541 aaggaaatac tgacttccag acacaacaga tgcacattat gaactctcaa gagtccatgc
     3601 agtgtgtgca ggttcaagga agacagtctc aacaatgggg ggtgggggga accatgggct
     3661 cccaccccta accagtgaac tatctgtaat tgacacctgc tagcaaataa aaatcaggtg
     3721 tctccaatgc tgtctcactg ggtgtatcaa cacctcaggg cccacacaaa ataaacttgg
     3781 tggtattttt gtgacctttt tgtttatttt gca
//
