LOCUS       NM_001167872            7202 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus zinc finger protein 568 (Zfp568), transcript variant
            1, mRNA.
ACCESSION   NM_001167872
VERSION     NM_001167872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7202)
  AUTHORS   Yang,P., Wang,Y., Hoang,D., Tinkham,M., Patel,A., Sun,M.A.,
            Wolf,G., Baker,M., Chien,H.C., Lai,K.N., Cheng,X., Shen,C.J. and
            Macfarlan,T.S.
  TITLE     A placental growth factor is silenced in mouse embryos by the zinc
            finger protein ZFP568
  JOURNAL   Science 356 (6339), 757-759 (2017)
   PUBMED   28522536
  REMARK    GeneRIF: A placental growth factor is silenced in mouse embryos by
            the zinc finger protein ZFP568
REFERENCE   2  (bases 1 to 7202)
  AUTHORS   Murphy,K.E., Shylo,N.A., Alexander,K.A., Churchill,A.J.,
            Copperman,C. and Garcia-Garcia,M.J.
  TITLE     The Transcriptional Repressive Activity of KRAB Zinc Finger
            Proteins Does Not Correlate with Their Ability to Recruit TRIM28
  JOURNAL   PLoS One 11 (9), e0163555 (2016)
   PUBMED   27658112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7202)
  AUTHORS   Chien,H.C., Wang,H.Y., Su,Y.N., Lai,K.Y., Lu,L.C., Chen,P.C.,
            Tsai,S.F., Wu,C.I., Hsieh,W.S. and Shen,C.K.
  TITLE     Targeted disruption in mice of a neural stem cell-maintaining,
            KRAB-Zn finger-encoding gene that has rapidly evolved in the human
            lineage
  JOURNAL   PLoS One 7 (10), e47481 (2012)
   PUBMED   23071813
  REMARK    GeneRIF: Zfp568 is both a neural stem cell-maintaining and a brain
            size-regulating gene.
REFERENCE   4  (bases 1 to 7202)
  AUTHORS   Shibata,M., Blauvelt,K.E., Liem,K.F. Jr. and Garcia-Garcia,M.J.
  TITLE     TRIM28 is required by the mouse KRAB domain protein ZFP568 to
            control convergent extension and morphogenesis of extra-embryonic
            tissues
  JOURNAL   Development 138 (24), 5333-5343 (2011)
   PUBMED   22110054
  REMARK    GeneRIF: The results revealed that TRIM28 is differentially
            required by ZFP568 and other factors during the early stages of
            mouse embryogenesis.
REFERENCE   5  (bases 1 to 7202)
  AUTHORS   Shibata,M. and Garcia-Garcia,M.J.
  TITLE     The mouse KRAB zinc-finger protein CHATO is required in
            embryonic-derived tissues to control yolk sac and placenta
            morphogenesis
  JOURNAL   Dev Biol 349 (2), 331-341 (2011)
   PUBMED   21094155
  REMARK    GeneRIF: ZFP568 controls the production of secreted factors
            required to promote morphogenesis of extraembryonic tissues.
REFERENCE   6  (bases 1 to 7202)
  AUTHORS   Garcia-Garcia,M.J., Shibata,M. and Anderson,K.V.
  TITLE     Chato, a KRAB zinc-finger protein, regulates convergent extension
            in the mouse embryo
  JOURNAL   Development 135 (18), 3053-3062 (2008)
   PUBMED   18701545
  REMARK    GeneRIF: Chato regulates convergent extension in the mouse embryo.
REFERENCE   7  (bases 1 to 7202)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   8  (bases 1 to 7202)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7202)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148548.1, BC082606.1 and BE456949.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform (1). Variants 1 and 2 encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148548.1, SRR10223971.7455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1401              AK148548.1         2-1402
            1402-3197           BC082606.1         1086-2881
            3198-4207           AK148548.1         3198-4207
            4208-7179           BC082606.1         3892-6863
            7180-7202           BE456949.1         44-66               c
FEATURES             Location/Qualifiers
     source          1..7202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.26 cM"
     gene            1..7202
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="zinc finger protein 568"
                     /db_xref="GeneID:243905"
                     /db_xref="MGI:MGI:2142347"
     exon            1..274
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            275..341
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            342..566
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..2548
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 568 isoform 1"
                     /protein_id="NP_001161344.1"
                     /db_xref="CCDS:CCDS21077.1"
                     /db_xref="GeneID:243905"
                     /db_xref="MGI:MGI:2142347"
                     /translation="MERLSQMAGRRAWCAEDSVPRQEEEDRTRPSKTVTFKDVAVDLT
                     QEEWQQMKPAQRALYRDVMLETYSNLVTVGCQVTKPDVIFKLEQAEEPWVLEEEMFWR
                     RSPEAARGRMKSFAFKDMAKDLRFEDVVIYFSLEEWECLRHSHRNLYRAVMLDNYSNL
                     LSLSLADTKPRVVSLLEQGKEPWMVMRNETKIWHPDWVSRTEAKDSSKIKTLQEKMAK
                     KHTCPTLEDSKTRGDREVTRELEGQQVHQEGHLRQAAVTSVERPDSVQCTAHREAHPG
                     GKPCSSEKSQKTSLCQPPPIEREQLHSKAKASEHAQHGKVFNSCTSDTAVHPRPQESR
                     KDSERKKSALAGGPDTSKPQSAQGSERPHKCKECGKAFHTPSQLSHHQKLHVGEKPYK
                     CQECGKAFPSNAQLSLHHRVHTDEKCFECKECGKAFMRPSHLLRHQRIHTGEKPHKCK
                     ECGKAFRYDTQLSLHLLTHAGARRFECKDCDKVYSCASQLALHQMSHTGEKPHKCKEC
                     GKGFISDSHLLRHQSVHTGETPYKCKECGKGFRRGSELARHQRAHSGDKPYKCKECGK
                     SFTCTTELFRHQKVHTGDRPHKCKECGKAFIRRSELTHHERSHSGEKPYECKECGKTF
                     GRGSELSRHQKIHTGEKPYKCQQCGKAFIRGSHLTQHQRIHTGRRSE"
     exon            567..625
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            626..752
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            753..848
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            849..898
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1022
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1118
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..7183
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7162..7167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="hexamer: AGTAAA"
     polyA_site      7183
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="major polyA site"
ORIGIN      
        1 ataacgggcg cgcgctgccg cccgagtgga ggggctggcc gtgcgtggcc cgcatgccgc
       61 gtctctgagg ttgcgtctcg ggaggttttg gctggtggcg ctgcggggac ctctccacgg
      121 gagaggcacg ggtggtccgg tttgcgccgg ccgtgggctt cgggctgggc gcgggctctc
      181 ggggggctcg gagtatcccg ggtcacagct ttgcggagag ctccgggcca gaaggcggga
      241 ctcaagcctg ttcggagctg caaccaaaaa cctggtttct catgagcaac atatcagctg
      301 agtgtttttt aaactcattt gtctggcctg actgttaata gcccacaggt cctgcctccc
      361 aacactaaga ctgtgctgtg catggagatg gctgaggaca gatgtctgtc atggaaggag
      421 accttctgac ctgataccca gagcacaggc tgcagggtcc tgggaaaggg tggactctgg
      481 acccgcagat cgtcttgacc cagccttgaa ataccagcaa cagctgcagg gcatggagcg
      541 cttgtcccag atggcaggaa gaagagcttg gtgtgccgag gattctgtac ctcgccagga
      601 agaagaagac aggaccaggc cttcaaaaac agtgacattc aaggatgtgg ctgtggacct
      661 cacacaggag gaatggcagc aaatgaagcc tgctcagagg gctttgtacc gagatgtgat
      721 gctggagacc tacagcaacc tagtaaccgt gggttgtcaa gtcaccaaac cagatgtgat
      781 cttcaagttg gaacaagcag aggagccatg ggtactggag gaagagatgt tttggagacg
      841 ctctccagaa gccgcaagag gaagaatgaa gagttttgcc tttaaggaca tggccaagga
      901 tctgaggttc gaggatgtgg tcatttactt ctctctggag gagtgggagt gcttgcgcca
      961 ttcccacagg aatctgtacc gagctgtgat gttggataac tacagcaacc tgctgtcact
     1021 gagtcttgct gatactaagc cacgggtggt ctcccttcta gaacagggca aagagccctg
     1081 gatggttatg aggaatgaga caaaaatttg gcatcctgat tgggtgtcta ggacagaagc
     1141 caaggacagt tccaaaatta aaacattgca agaaaagatg gcaaaaaaac acacatgccc
     1201 cactcttgag gacagcaaga ccagagggga cagagaagtc acacgtgagc tggagggtca
     1261 acaggtccat caggagggac acttgaggca agctgcagta acctctgtcg agaggcctga
     1321 ttctgtccag tgcacagccc atagggaggc tcaccctgga ggaaaaccct gcagctctga
     1381 gaaaagtcag aaaacgtccc tgtgccagcc acctcccatt gaacgtgagc aacttcacag
     1441 taaggcaaag gccagtgagc atgcacagca tggcaaggtc tttaatagct gcacgtcaga
     1501 cacggctgtg catccgagac cccaggaaag cagaaaagac agtgagagga agaaaagtgc
     1561 ccttgctggt ggtcctgaca cctcgaaacc tcagagcgct caggggagtg agaggccaca
     1621 taagtgtaag gaatgcggga aggccttcca cactccctcc cagctcagtc accatcaaaa
     1681 gctgcatgtg ggtgagaagc cctacaagtg ccaagagtgt ggaaaggctt tcccgtctaa
     1741 cgcccagctt agtcttcacc atagagttca cactgatgag aagtgctttg aatgcaagga
     1801 gtgcgggaaa gccttcatgc gcccatcaca cctgctccgg caccagcgca tccacactgg
     1861 ggagaagcct cacaagtgta aggagtgcgg gaaggccttc cgctacgaca cacagctcag
     1921 cctgcacctg ctcacgcatg ctggggcacg gcgctttgag tgtaaggact gtgacaaggt
     1981 gtatagctgt gcctcccagc tcgctctcca ccagatgtca cacactgggg agaagcccca
     2041 caagtgtaag gagtgtggga aaggcttcat ctctgactca caccttcttc gccatcagag
     2101 tgttcacact ggcgagacgc cctataagtg taaggagtgt ggcaaaggct tccgtcgtgg
     2161 ttcagaactt gcccggcatc agagagccca ttctggcgat aaaccctaca agtgtaagga
     2221 atgtggaaag tccttcactt gcaccacaga gctctttaga catcagaaag ttcacactgg
     2281 tgatagaccc cacaaatgta aggagtgtgg gaaggccttc atccgaagat cagagctgac
     2341 acatcatgaa agaagccaca gcggtgagaa accctatgag tgcaaagagt gtggaaagac
     2401 cttcggccga ggctcagagc tcagtcgaca ccagaaaatc cacaccggtg agaagcccta
     2461 taagtgccag caatgtggga aggcctttat tcgtggctct caccttaccc aacatcagag
     2521 gattcataca ggacggagga gtgaatgagt tgccatcaga aaatccatac agtttaaaaa
     2581 ccctgtggtg gataacaatg tgggaagaca acgagataca gggtttctca ttggtgctag
     2641 aattcatact caaaagaccc gttaggtcca gaagtgatgg aacacgtgtt acaagaaaga
     2701 aaccttataa ctccagaaat tggagggggc tacttgtttc agaatttatc ataaggcttt
     2761 tgttgatgaa aaactcttaa gttccatgaa tgtaaaggaa ggaggaatgc ctctcagtgg
     2821 cctggagcca aacaagcagg cctcgggatt catagcaggg acaagctgag gagggcagtg
     2881 tgtgtgtccg agagattagc agttggaacc tttccacacc cacacccggg ccagccctcc
     2941 gaggagagaa gtcagtcgtt atactgcata atctctgtga tacctcaggc tgcacttctg
     3001 ctaaaacaca gcacactcgc cattcatccc actctacgct catggaatgt ttgctacttt
     3061 ataaagccat ttggactgcg gagtgtggaa aggacatgct aactttttac atgtcctcat
     3121 gattcagggc aggttattta ccaactattc ttttcttctg tggggtagca gtgttagccc
     3181 cgtgtttcta gttacgcttt gaggttgtgt gtagattgtg gaatagcatc cagctagtat
     3241 ctaaagtgtg ccaagtgcag caggcatgct gttccacgca atatgagcat ctgaagccaa
     3301 aggtaggagg gaggatcaca agttgaggct agcttggaga ctctctagta aaacaaacaa
     3361 acaaacaaaa attataacaa atatagctgc tttctttgtt attttcataa tagtgaactt
     3421 ttacataaac tttaacagtc ttaaagagga aagccttata tgtccagtaa ctggagggac
     3481 atcttgcctt gtccctttga ctgttacaga attcttatga agaaagactt aaagctttcg
     3541 ttcttagttt acccttctgc tggtcagaag cgtcagaact ggaatgtggt gaggtcagta
     3601 tgagaagggg ctggaggaat tgctaaagcc tctgagtgag gagtggtgct acacacagcc
     3661 tgtaatccca gccctcggga ggggagcaca ggacagggat tcaagtccat cctggtctac
     3721 ctagttagtt agggggtagc ctggacaaca tgtgttgcag tctcagaact ttcataagca
     3781 aaagccatgc catggatctg tgcactagag aactggaaaa cagtaaagct ttagctaaga
     3841 cccaagcctc catagagagt gttaaatgcc tatataaaga catctatatc taaaggtcca
     3901 ataggtgtgg tagcgcatac cttttatccc agcacttggg aggcagaggc aggcagattt
     3961 ctgagttcga agccagctag ggctatatag agaaaccctg tcttgaaaaa ccaaaaaaga
     4021 aatttgtaca ctgtgactga aactatactc tgagaaaaat gaccttccct tcatctttgt
     4081 aaacagtggg ggttggaagg tctaggactc tgtatttatt gtttatacag tactgttaca
     4141 gtgcctagtc ctggtaattc ccagtgagta ttctaagtaa cagaagagca aataactact
     4201 cagctccaac agaaaagaaa ctaacaaaat tcaacttggc aaaactaaac cttggaatag
     4261 gtgagacgca cacagtgttg tacaggagat gaggctctta tgaaacaagg cttgaatgag
     4321 cagagcatag gttctacctg tcgacagatg ttagccatgc tcctgcagtg ttatggccct
     4381 gtgattggtt ctggctgtgc ccttggtctc atgtgtgact gactgggcag tagaccatca
     4441 tgggcttagt aacaagatcc aggggcatgg tcttcccggc tgcagggagc acatctgtgc
     4501 caccaggtgg tgcctgcttt ctgaggctga gactgccata gaacacacat tgtcaccgac
     4561 attgtggtgt catggaacca tgacctcgcc ttctcctgga cctacagaat aagaaatgca
     4621 gacactgaaa attaatactc aactctttac agtatacata acactgagaa atttagcatt
     4681 taaaaatatt tttactcaga tgtattcagc ttcaggaaca tattttatgt ttgtattctg
     4741 ccttttatag tatatctgac aatgaaaagc attattttcc aaattatttt cttagccata
     4801 ttattgaaat atatattcaa cttcaattta gtaagatgta gtatattttc ttagagtatt
     4861 tgatagtgtg tttttatatt ctgcttttat agtgtatctt aaatcctaga aaagtatttt
     4921 cctgaatgaa gttagagcca aggagaagct gcttaaggaa ctacactcgt tcccctaaca
     4981 ctgagccact tgacagctga gacaccttct acctcttcaa tgtggaaaag ggcggcagca
     5041 tctaaagtca cgtcggttag ttgccagtcc acggccttag aggactttgt gattacagca
     5101 gcgtgtagta tcagcagccc agtaattgag cggtgtggtg ctttgtgcaa aggactttgg
     5161 ttgaagtgct aatgagtgag tgagagagga ctctgcagtc actggagact agcagagcct
     5221 gctgtgaagg tccttgtcct tcctcttggt ctgctctctc ctggagctca tctgccccgc
     5281 cctgcccatc atctcaatga ggagggaaag ctgctaatta ctaaacaggc tccggcagag
     5341 cagttgtgac agaggtcagg cagcatgtgg gcatgggtgc aacttgtgtg gaggccaggc
     5401 cagcggtcag gctaaggggt cctgcctcag gagcctttgg cttcagtttt ctgatgcagg
     5461 gtctcacagg agctgggatt taccaattag gctcagctaa ctggccagtg aaccccaggg
     5521 atccacttgc ctgtctccgt agcactgaat taaacgcagg tgcacacatc acctggcttt
     5581 attttcgtgt gggttttggg ggtgtttgga ggtcaggccc tcggcttgca cagcaggtgc
     5641 cttactgact ggtccagcat cccactggcc aaagactttt taaaaggcag aaatgataac
     5701 tgagttttaa tctgcactgg tatattaata aacctatata gaaattttaa ctattcttct
     5761 aagaggagaa cttgcacatt ttataggaat taaataaata gaagtttttt agagggtgct
     5821 tttagtactg atttcagact tggaaggata gctttttaat gttctgctcc tatatacata
     5881 tttgttagac ttgacggtcc tctgacgagt gtatgcatca ggatgcacct caaaccaaaa
     5941 atatcctaca ggggtttatt tagagaatga catgtgtaca ctgttaagtg ctgatagtgg
     6001 atgctgcaat tccgctctct ggttgagatg cacacgcaag cttagacatc ttggtaacgg
     6061 gttgggtgag gaagagtgta ttgagtggga ttgtgcgcac acagggatgc aggctccttt
     6121 cctcacgtgg taatgtccta aggggggtgt tctcgtcact actcaccgct ctaacgatct
     6181 caccatagac aagccatgtg tgtgcagcct cttcttccca gcaaatgtta gcttcaccat
     6241 cagcaatgtg agttcgggac acaagcatta cctcaggttg ctgcctgttt ctatagggca
     6301 gctactttcc tgccttagca tagtagaatt aaaatgtact tggtgcttta ttgtttccat
     6361 gtggagctca ccgccatctc agcaggaacc agtgtgtgtt tctcaactgt gttagccagg
     6421 gctgaaaatg tgccttctgt ttgcacttcc tcgactgcta gggaggtgga gcatctccct
     6481 ggcctgcagg tcatttgagc tttgtttctg tgaattgtac attgctatcc gtctcacttt
     6541 gtagcacacc taggagatca tattacacat gggcaatttg ttgtcttcat ctagaatatg
     6601 tcatttgccc tttttctgtc aaaatactta gccagtgttg ttttatgaag ggccagaccg
     6661 agtatttcag gttgggcttt tatgcagcct ttgctgcgta gaagcctcct gtatacgcca
     6721 gtggtcctca gccacttctg ccacatcccc aggaggcatt tgccaatgtc cacaggcatt
     6781 tttttgtcac tttaaaatga ctgctgctta tgtctagtgg gcagaggcca gagaggcttc
     6841 tcagtgtcct ggggtgcaca gcacagcccc ccaaaaatga tgtcacactc caaaatgtca
     6901 ttaggtttct ggccagaaca gaatgggata ccactgtgta gcaataaaac attcacagag
     6961 acaagcagct ggccacatcg agcctgcaag tgtgccttcc cacctggttt tagtagcatt
     7021 tatctgtatt attagttttg tttctgaaat ctcttttacc tcaagtagtt ttccagccca
     7081 tgtgtaaccc attatttcag cccattattt ctaaagtgtg ggtttgtgtt tgcttggttt
     7141 gggttgagtt ttataaaata aagtaaatca tttcagaaac gtaaaaaaaa aaaaaaaaaa
     7201 aa
//
