LOCUS       NM_001033355            7195 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus zinc finger protein 568 (Zfp568), transcript variant
            2, mRNA.
ACCESSION   NM_001033355 XM_145503 XM_899356 XM_899361 XM_899368 XM_899375
            XM_899378 XM_899382 XM_899389 XM_899395
VERSION     NM_001033355.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7195)
  AUTHORS   Yang,P., Wang,Y., Hoang,D., Tinkham,M., Patel,A., Sun,M.A.,
            Wolf,G., Baker,M., Chien,H.C., Lai,K.N., Cheng,X., Shen,C.J. and
            Macfarlan,T.S.
  TITLE     A placental growth factor is silenced in mouse embryos by the zinc
            finger protein ZFP568
  JOURNAL   Science 356 (6339), 757-759 (2017)
   PUBMED   28522536
  REMARK    GeneRIF: A placental growth factor is silenced in mouse embryos by
            the zinc finger protein ZFP568
REFERENCE   2  (bases 1 to 7195)
  AUTHORS   Murphy,K.E., Shylo,N.A., Alexander,K.A., Churchill,A.J.,
            Copperman,C. and Garcia-Garcia,M.J.
  TITLE     The Transcriptional Repressive Activity of KRAB Zinc Finger
            Proteins Does Not Correlate with Their Ability to Recruit TRIM28
  JOURNAL   PLoS One 11 (9), e0163555 (2016)
   PUBMED   27658112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7195)
  AUTHORS   Chien,H.C., Wang,H.Y., Su,Y.N., Lai,K.Y., Lu,L.C., Chen,P.C.,
            Tsai,S.F., Wu,C.I., Hsieh,W.S. and Shen,C.K.
  TITLE     Targeted disruption in mice of a neural stem cell-maintaining,
            KRAB-Zn finger-encoding gene that has rapidly evolved in the human
            lineage
  JOURNAL   PLoS One 7 (10), e47481 (2012)
   PUBMED   23071813
  REMARK    GeneRIF: Zfp568 is both a neural stem cell-maintaining and a brain
            size-regulating gene.
REFERENCE   4  (bases 1 to 7195)
  AUTHORS   Shibata,M., Blauvelt,K.E., Liem,K.F. Jr. and Garcia-Garcia,M.J.
  TITLE     TRIM28 is required by the mouse KRAB domain protein ZFP568 to
            control convergent extension and morphogenesis of extra-embryonic
            tissues
  JOURNAL   Development 138 (24), 5333-5343 (2011)
   PUBMED   22110054
  REMARK    GeneRIF: The results revealed that TRIM28 is differentially
            required by ZFP568 and other factors during the early stages of
            mouse embryogenesis.
REFERENCE   5  (bases 1 to 7195)
  AUTHORS   Shibata,M. and Garcia-Garcia,M.J.
  TITLE     The mouse KRAB zinc-finger protein CHATO is required in
            embryonic-derived tissues to control yolk sac and placenta
            morphogenesis
  JOURNAL   Dev Biol 349 (2), 331-341 (2011)
   PUBMED   21094155
  REMARK    GeneRIF: ZFP568 controls the production of secreted factors
            required to promote morphogenesis of extraembryonic tissues.
REFERENCE   6  (bases 1 to 7195)
  AUTHORS   Garcia-Garcia,M.J., Shibata,M. and Anderson,K.V.
  TITLE     Chato, a KRAB zinc-finger protein, regulates convergent extension
            in the mouse embryo
  JOURNAL   Development 135 (18), 3053-3062 (2008)
   PUBMED   18701545
  REMARK    GeneRIF: Chato regulates convergent extension in the mouse embryo.
REFERENCE   7  (bases 1 to 7195)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   8  (bases 1 to 7195)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7195)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148548.1, AK143471.1, BC082606.1 and BE456949.1.
            
            On Nov 18, 2009 this sequence version replaced NM_001033355.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1, and encodes isoform (1). Variants 1 and 2
            encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK148548.1         2-3
            3-2229              AK143471.1         2-2228
            2230-3190           BC082606.1         1921-2881
            3191-4200           AK148548.1         3198-4207
            4201-7172           BC082606.1         3892-6863
            7173-7195           BE456949.1         44-66               c
FEATURES             Location/Qualifiers
     source          1..7195
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.26 cM"
     gene            1..7195
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="zinc finger protein 568"
                     /db_xref="GeneID:243905"
                     /db_xref="MGI:MGI:2142347"
     exon            1..274
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            275..341
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            342..559
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..2541
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 568 isoform 1"
                     /protein_id="NP_001028527.2"
                     /db_xref="CCDS:CCDS21077.1"
                     /db_xref="GeneID:243905"
                     /db_xref="MGI:MGI:2142347"
                     /translation="MERLSQMAGRRAWCAEDSVPRQEEEDRTRPSKTVTFKDVAVDLT
                     QEEWQQMKPAQRALYRDVMLETYSNLVTVGCQVTKPDVIFKLEQAEEPWVLEEEMFWR
                     RSPEAARGRMKSFAFKDMAKDLRFEDVVIYFSLEEWECLRHSHRNLYRAVMLDNYSNL
                     LSLSLADTKPRVVSLLEQGKEPWMVMRNETKIWHPDWVSRTEAKDSSKIKTLQEKMAK
                     KHTCPTLEDSKTRGDREVTRELEGQQVHQEGHLRQAAVTSVERPDSVQCTAHREAHPG
                     GKPCSSEKSQKTSLCQPPPIEREQLHSKAKASEHAQHGKVFNSCTSDTAVHPRPQESR
                     KDSERKKSALAGGPDTSKPQSAQGSERPHKCKECGKAFHTPSQLSHHQKLHVGEKPYK
                     CQECGKAFPSNAQLSLHHRVHTDEKCFECKECGKAFMRPSHLLRHQRIHTGEKPHKCK
                     ECGKAFRYDTQLSLHLLTHAGARRFECKDCDKVYSCASQLALHQMSHTGEKPHKCKEC
                     GKGFISDSHLLRHQSVHTGETPYKCKECGKGFRRGSELARHQRAHSGDKPYKCKECGK
                     SFTCTTELFRHQKVHTGDRPHKCKECGKAFIRRSELTHHERSHSGEKPYECKECGKTF
                     GRGSELSRHQKIHTGEKPYKCQQCGKAFIRGSHLTQHQRIHTGRRSE"
     exon            560..618
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            619..745
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            746..841
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            842..891
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1015
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1111
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..7176
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7155..7160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="hexamer: AGTAAA"
     polyA_site      7176
                     /gene="Zfp568"
                     /gene_synonym="chato; Gm1691; Znf568"
                     /note="major polyA site"
ORIGIN      
        1 ataacgggcg cgcgctgccg cccgagtgga ggggctggcc gtgcgtggcc cgcatgccgc
       61 gtctctgagg ttgcgtctcg ggaggttttg gctggtggcg ctgcggggac ctctccacgg
      121 gagaggcacg ggtggtccgg tttgcgccgg ccgtgggctt cgggctgggc gcgggctctc
      181 ggggggctcg gagtatcccg ggtcacagct ttgcggagag ctccgggcca gaaggcggga
      241 ctcaagcctg ttcggagctg caaccaaaaa cctggtttct catgagcaac atatcagctg
      301 agtgtttttt aaactcattt gtctggcctg actgttaata ggtcctgcct cccaacacta
      361 agactgtgct gtgcatggag atggctgagg acagatgtct gtcatggaag gagaccttct
      421 gacctgatac ccagagcaca ggctgcaggg tcctgggaaa gggtggactc tggacccgca
      481 gatcgtcttg acccagcctt gaaataccag caacagctgc agggcatgga gcgcttgtcc
      541 cagatggcag gaagaagagc ttggtgtgcc gaggattctg tacctcgcca ggaagaagaa
      601 gacaggacca ggccttcaaa aacagtgaca ttcaaggatg tggctgtgga cctcacacag
      661 gaggaatggc agcaaatgaa gcctgctcag agggctttgt accgagatgt gatgctggag
      721 acctacagca acctagtaac cgtgggttgt caagtcacca aaccagatgt gatcttcaag
      781 ttggaacaag cagaggagcc atgggtactg gaggaagaga tgttttggag acgctctcca
      841 gaagccgcaa gaggaagaat gaagagtttt gcctttaagg acatggccaa ggatctgagg
      901 ttcgaggatg tggtcattta cttctctctg gaggagtggg agtgcttgcg ccattcccac
      961 aggaatctgt accgagctgt gatgttggat aactacagca acctgctgtc actgagtctt
     1021 gctgatacta agccacgggt ggtctccctt ctagaacagg gcaaagagcc ctggatggtt
     1081 atgaggaatg agacaaaaat ttggcatcct gattgggtgt ctaggacaga agccaaggac
     1141 agttccaaaa ttaaaacatt gcaagaaaag atggcaaaaa aacacacatg ccccactctt
     1201 gaggacagca agaccagagg ggacagagaa gtcacacgtg agctggaggg tcaacaggtc
     1261 catcaggagg gacacttgag gcaagctgca gtaacctctg tcgagaggcc tgattctgtc
     1321 cagtgcacag cccataggga ggctcaccct ggaggaaaac cctgcagctc tgagaaaagt
     1381 cagaaaacgt ccctgtgcca gccacctccc attgaacgtg agcaacttca cagtaaggca
     1441 aaggccagtg agcatgcaca gcatggcaag gtctttaata gctgcacgtc agacacggct
     1501 gtgcatccga gaccccagga aagcagaaaa gacagtgaga ggaagaaaag tgcccttgct
     1561 ggtggtcctg acacctcgaa acctcagagc gctcagggga gtgagaggcc acataagtgt
     1621 aaggaatgcg ggaaggcctt ccacactccc tcccagctca gtcaccatca aaagctgcat
     1681 gtgggtgaga agccctacaa gtgccaagag tgtggaaagg ctttcccgtc taacgcccag
     1741 cttagtcttc accatagagt tcacactgat gagaagtgct ttgaatgcaa ggagtgcggg
     1801 aaagccttca tgcgcccatc acacctgctc cggcaccagc gcatccacac tggggagaag
     1861 cctcacaagt gtaaggagtg cgggaaggcc ttccgctacg acacacagct cagcctgcac
     1921 ctgctcacgc atgctggggc acggcgcttt gagtgtaagg actgtgacaa ggtgtatagc
     1981 tgtgcctccc agctcgctct ccaccagatg tcacacactg gggagaagcc ccacaagtgt
     2041 aaggagtgtg ggaaaggctt catctctgac tcacaccttc ttcgccatca gagtgttcac
     2101 actggcgaga cgccctataa gtgtaaggag tgtggcaaag gcttccgtcg tggttcagaa
     2161 cttgcccggc atcagagagc ccattctggc gataaaccct acaagtgtaa ggaatgtgga
     2221 aagtccttca cttgcaccac agagctcttt agacatcaga aagttcacac tggtgataga
     2281 ccccacaaat gtaaggagtg tgggaaggcc ttcatccgaa gatcagagct gacacatcat
     2341 gaaagaagcc acagcggtga gaaaccctat gagtgcaaag agtgtggaaa gaccttcggc
     2401 cgaggctcag agctcagtcg acaccagaaa atccacaccg gtgagaagcc ctataagtgc
     2461 cagcaatgtg ggaaggcctt tattcgtggc tctcacctta cccaacatca gaggattcat
     2521 acaggacgga ggagtgaatg agttgccatc agaaaatcca tacagtttaa aaaccctgtg
     2581 gtggataaca atgtgggaag acaacgagat acagggtttc tcattggtgc tagaattcat
     2641 actcaaaaga cccgttaggt ccagaagtga tggaacacgt gttacaagaa agaaacctta
     2701 taactccaga aattggaggg ggctacttgt ttcagaattt atcataaggc ttttgttgat
     2761 gaaaaactct taagttccat gaatgtaaag gaaggaggaa tgcctctcag tggcctggag
     2821 ccaaacaagc aggcctcggg attcatagca gggacaagct gaggagggca gtgtgtgtgt
     2881 ccgagagatt agcagttgga acctttccac acccacaccc gggccagccc tccgaggaga
     2941 gaagtcagtc gttatactgc ataatctctg tgatacctca ggctgcactt ctgctaaaac
     3001 acagcacact cgccattcat cccactctac gctcatggaa tgtttgctac tttataaagc
     3061 catttggact gcggagtgtg gaaaggacat gctaactttt tacatgtcct catgattcag
     3121 ggcaggttat ttaccaacta ttcttttctt ctgtggggta gcagtgttag ccccgtgttt
     3181 ctagttacgc tttgaggttg tgtgtagatt gtggaatagc atccagctag tatctaaagt
     3241 gtgccaagtg cagcaggcat gctgttccac gcaatatgag catctgaagc caaaggtagg
     3301 agggaggatc acaagttgag gctagcttgg agactctcta gtaaaacaaa caaacaaaca
     3361 aaaattataa caaatatagc tgctttcttt gttattttca taatagtgaa cttttacata
     3421 aactttaaca gtcttaaaga ggaaagcctt atatgtccag taactggagg gacatcttgc
     3481 cttgtccctt tgactgttac agaattctta tgaagaaaga cttaaagctt tcgttcttag
     3541 tttacccttc tgctggtcag aagcgtcaga actggaatgt ggtgaggtca gtatgagaag
     3601 gggctggagg aattgctaaa gcctctgagt gaggagtggt gctacacaca gcctgtaatc
     3661 ccagccctcg ggaggggagc acaggacagg gattcaagtc catcctggtc tacctagtta
     3721 gttagggggt agcctggaca acatgtgttg cagtctcaga actttcataa gcaaaagcca
     3781 tgccatggat ctgtgcacta gagaactgga aaacagtaaa gctttagcta agacccaagc
     3841 ctccatagag agtgttaaat gcctatataa agacatctat atctaaaggt ccaataggtg
     3901 tggtagcgca taccttttat cccagcactt gggaggcaga ggcaggcaga tttctgagtt
     3961 cgaagccagc tagggctata tagagaaacc ctgtcttgaa aaaccaaaaa agaaatttgt
     4021 acactgtgac tgaaactata ctctgagaaa aatgaccttc ccttcatctt tgtaaacagt
     4081 gggggttgga aggtctagga ctctgtattt attgtttata cagtactgtt acagtgccta
     4141 gtcctggtaa ttcccagtga gtattctaag taacagaaga gcaaataact actcagctcc
     4201 aacagaaaag aaactaacaa aattcaactt ggcaaaacta aaccttggaa taggtgagac
     4261 gcacacagtg ttgtacagga gatgaggctc ttatgaaaca aggcttgaat gagcagagca
     4321 taggttctac ctgtcgacag atgttagcca tgctcctgca gtgttatggc cctgtgattg
     4381 gttctggctg tgcccttggt ctcatgtgtg actgactggg cagtagacca tcatgggctt
     4441 agtaacaaga tccaggggca tggtcttccc ggctgcaggg agcacatctg tgccaccagg
     4501 tggtgcctgc tttctgaggc tgagactgcc atagaacaca cattgtcacc gacattgtgg
     4561 tgtcatggaa ccatgacctc gccttctcct ggacctacag aataagaaat gcagacactg
     4621 aaaattaata ctcaactctt tacagtatac ataacactga gaaatttagc atttaaaaat
     4681 atttttactc agatgtattc agcttcagga acatatttta tgtttgtatt ctgcctttta
     4741 tagtatatct gacaatgaaa agcattattt tccaaattat tttcttagcc atattattga
     4801 aatatatatt caacttcaat ttagtaagat gtagtatatt ttcttagagt atttgatagt
     4861 gtgtttttat attctgcttt tatagtgtat cttaaatcct agaaaagtat tttcctgaat
     4921 gaagttagag ccaaggagaa gctgcttaag gaactacact cgttccccta acactgagcc
     4981 acttgacagc tgagacacct tctacctctt caatgtggaa aagggcggca gcatctaaag
     5041 tcacgtcggt tagttgccag tccacggcct tagaggactt tgtgattaca gcagcgtgta
     5101 gtatcagcag cccagtaatt gagcggtgtg gtgctttgtg caaaggactt tggttgaagt
     5161 gctaatgagt gagtgagaga ggactctgca gtcactggag actagcagag cctgctgtga
     5221 aggtccttgt ccttcctctt ggtctgctct ctcctggagc tcatctgccc cgccctgccc
     5281 atcatctcaa tgaggaggga aagctgctaa ttactaaaca ggctccggca gagcagttgt
     5341 gacagaggtc aggcagcatg tgggcatggg tgcaacttgt gtggaggcca ggccagcggt
     5401 caggctaagg ggtcctgcct caggagcctt tggcttcagt tttctgatgc agggtctcac
     5461 aggagctggg atttaccaat taggctcagc taactggcca gtgaacccca gggatccact
     5521 tgcctgtctc cgtagcactg aattaaacgc aggtgcacac atcacctggc tttattttcg
     5581 tgtgggtttt gggggtgttt ggaggtcagg ccctcggctt gcacagcagg tgccttactg
     5641 actggtccag catcccactg gccaaagact ttttaaaagg cagaaatgat aactgagttt
     5701 taatctgcac tggtatatta ataaacctat atagaaattt taactattct tctaagagga
     5761 gaacttgcac attttatagg aattaaataa atagaagttt tttagagggt gcttttagta
     5821 ctgatttcag acttggaagg atagcttttt aatgttctgc tcctatatac atatttgtta
     5881 gacttgacgg tcctctgacg agtgtatgca tcaggatgca cctcaaacca aaaatatcct
     5941 acaggggttt atttagagaa tgacatgtgt acactgttaa gtgctgatag tggatgctgc
     6001 aattccgctc tctggttgag atgcacacgc aagcttagac atcttggtaa cgggttgggt
     6061 gaggaagagt gtattgagtg ggattgtgcg cacacaggga tgcaggctcc tttcctcacg
     6121 tggtaatgtc ctaagggggg tgttctcgtc actactcacc gctctaacga tctcaccata
     6181 gacaagccat gtgtgtgcag cctcttcttc ccagcaaatg ttagcttcac catcagcaat
     6241 gtgagttcgg gacacaagca ttacctcagg ttgctgcctg tttctatagg gcagctactt
     6301 tcctgcctta gcatagtaga attaaaatgt acttggtgct ttattgtttc catgtggagc
     6361 tcaccgccat ctcagcagga accagtgtgt gtttctcaac tgtgttagcc agggctgaaa
     6421 atgtgccttc tgtttgcact tcctcgactg ctagggaggt ggagcatctc cctggcctgc
     6481 aggtcatttg agctttgttt ctgtgaattg tacattgcta tccgtctcac tttgtagcac
     6541 acctaggaga tcatattaca catgggcaat ttgttgtctt catctagaat atgtcatttg
     6601 ccctttttct gtcaaaatac ttagccagtg ttgttttatg aagggccaga ccgagtattt
     6661 caggttgggc ttttatgcag cctttgctgc gtagaagcct cctgtatacg ccagtggtcc
     6721 tcagccactt ctgccacatc cccaggaggc atttgccaat gtccacaggc atttttttgt
     6781 cactttaaaa tgactgctgc ttatgtctag tgggcagagg ccagagaggc ttctcagtgt
     6841 cctggggtgc acagcacagc cccccaaaaa tgatgtcaca ctccaaaatg tcattaggtt
     6901 tctggccaga acagaatggg ataccactgt gtagcaataa aacattcaca gagacaagca
     6961 gctggccaca tcgagcctgc aagtgtgcct tcccacctgg ttttagtagc atttatctgt
     7021 attattagtt ttgtttctga aatctctttt acctcaagta gttttccagc ccatgtgtaa
     7081 cccattattt cagcccatta tttctaaagt gtgggtttgt gtttgcttgg tttgggttga
     7141 gttttataaa ataaagtaaa tcatttcaga aacgtaaaaa aaaaaaaaaa aaaaa
//
