LOCUS       NM_001099277            4664 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger protein 541 (Zfp541), transcript variant
            2, mRNA.
ACCESSION   NM_001099277 XM_001476680 XM_984387
VERSION     NM_001099277.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4664)
  AUTHORS   Zhou,X., Fang,K., Liu,Y., Li,W., Tan,Y., Zhang,J., Yu,X., Wang,G.,
            Zhang,Y., Shang,Y., Zhang,L., Chen,C.D. and Wang,S.
  TITLE     ZFP541 and KCTD19 regulate chromatin organization and transcription
            programs for male meiotic progression
  JOURNAL   Cell Prolif 57 (4), e13567 (2024)
   PUBMED   37921559
  REMARK    GeneRIF: ZFP541 and KCTD19 regulate chromatin organization and
            transcription programs for male meiotic progression.
REFERENCE   2  (bases 1 to 4664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4664)
  AUTHORS   Kuribayashi,S., Fukuhara,S., Tsujimura,G., Imanaka,T., Okada,K.,
            Ueda,N., Takezawa,K., Kiuchi,H., Saito,S., Takahashi,Y., Kioka,H.,
            Oura,S., Shimada,K., Ikawa,M. and Nonomura,N.
  TITLE     Evaluation of the efficacy of creatine chemical exchange saturation
            transfer imaging in assessing testicular maturity
  JOURNAL   Reprod Med Biol 22 (1), e12507 (2023)
   PUBMED   36845001
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4664)
  AUTHORS   Li,Y., Meng,R., Li,S., Gu,B., Xu,X., Zhang,H., Tan,X., Shao,T.,
            Wang,J., Xu,D. and Wang,F.
  TITLE     The ZFP541-KCTD19 complex is essential for pachytene progression by
            activating meiotic genes during mouse spermatogenesis
  JOURNAL   J Genet Genomics 49 (11), 1029-1041 (2022)
   PUBMED   35341968
REFERENCE   5  (bases 1 to 4664)
  AUTHORS   Xu,J., Gao,J., Liu,J., Huang,X., Zhang,H., Ma,A., Ye,J., Zhang,X.,
            Li,Y., Yang,G., Yin,H., Khan,R., Li,T., Fan,S., Jiang,X., Zhang,Y.,
            Jiang,H., Ma,H. and Shi,Q.
  TITLE     ZFP541 maintains the repression of pre-pachytene transcriptional
            programs and promotes male meiosis progression
  JOURNAL   Cell Rep 38 (12), 110540 (2022)
   PUBMED   35320728
  REMARK    GeneRIF: ZFP541 maintains the repression of pre-pachytene
            transcriptional programs and promotes male meiosis progression.
REFERENCE   6  (bases 1 to 4664)
  AUTHORS   Horisawa-Takada,Y., Kodera,C., Takemoto,K., Sakashita,A.,
            Horisawa,K., Maeda,R., Shimada,R., Usuki,S., Fujimura,S., Tani,N.,
            Matsuura,K., Akiyama,T., Suzuki,A., Niwa,H., Tachibana,M., Ohba,T.,
            Katabuchi,H., Namekawa,S.H., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-specific ZFP541 repressor complex promotes developmental
            progression of meiotic prophase towards completion during mouse
            spermatogenesis
  JOURNAL   Nat Commun 12 (1), 3184 (2021)
   PUBMED   34075040
  REMARK    GeneRIF: Meiosis-specific ZFP541 repressor complex promotes
            developmental progression of meiotic prophase towards completion
            during mouse spermatogenesis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4664)
  AUTHORS   Oura,S., Koyano,T., Kodera,C., Horisawa-Takada,Y., Matsuyama,M.,
            Ishiguro,K.I. and Ikawa,M.
  TITLE     KCTD19 and its associated protein ZFP541 are independently
            essential for meiosis in male mice
  JOURNAL   PLoS Genet 17 (5), e1009412 (2021)
   PUBMED   33961623
  REMARK    GeneRIF: KCTD19 and its associated protein ZFP541 are independently
            essential for meiosis in male mice.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4664)
  AUTHORS   Choi,E., Han,C., Park,I., Lee,B., Jin,S., Choi,H., Kim,D.H.,
            Park,Z.Y., Eddy,E.M. and Cho,C.
  TITLE     A novel germ cell-specific protein, SHIP1, forms a complex with
            chromatin remodeling activity during spermatogenesis
  JOURNAL   J Biol Chem 283 (50), 35283-35294 (2008)
   PUBMED   18849567
  REMARK    GeneRIF: the Mm.290718/ZFP541 complex is implicated in chromatin
            remodeling during spermatogenesis and is renamed SHIP1
REFERENCE   9  (bases 1 to 4664)
  AUTHORS   Choi,E., Lee,J., Oh,J., Park,I., Han,C., Yi,C., Kim,D.H., Cho,B.N.,
            Eddy,E.M. and Cho,C.
  TITLE     Integrative characterization of germ cell-specific genes from mouse
            spermatocyte UniGene library
  JOURNAL   BMC Genomics 8, 256 (2007)
   PUBMED   17662146
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151733.5.
            
            On Mar 1, 2018 this sequence version replaced NM_001099277.1.
            
            Transcript Variant: This variant (2) has two alternate exons in the
            5' coding region compared to variant 1. It encodes a longer protein
            (isoform 2) compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ864732.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849384 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AC151733.5         109407-109810
            405-645             AC151733.5         113909-114149
            646-2500            AC151733.5         115534-117388
            2501-2559           AC151733.5         119240-119298
            2560-2746           AC151733.5         119614-119800
            2747-2807           AC151733.5         120072-120132
            2808-2869           AC151733.5         120561-120622
            2870-3221           AC151733.5         120783-121134
            3222-3285           AC151733.5         127359-127422
            3286-3428           AC151733.5         127922-128064
            3429-3532           AC151733.5         128370-128473
            3533-3608           AC151733.5         129848-129923
            3609-3697           AC151733.5         130401-130489
            3698-3838           AC151733.5         132704-132844
            3839-4020           AC151733.5         132982-133163
            4021-4664           AC151733.5         133253-133896
FEATURES             Location/Qualifiers
     source          1..4664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.74 cM"
     gene            1..4664
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /note="zinc finger protein 541"
                     /db_xref="GeneID:666528"
                     /db_xref="MGI:MGI:3647699"
     exon            1..404
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..4189
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /note="isoform 2 is encoded by transcript variant 2;
                     spermatogenic cell HDAC-interacting protein 1"
                     /codon_start=1
                     /product="zinc finger protein 541 isoform 2"
                     /protein_id="NP_001092747.1"
                     /db_xref="CCDS:CCDS39781.1"
                     /db_xref="GeneID:666528"
                     /db_xref="MGI:MGI:3647699"
                     /translation="MEPYSLGEEGALPSEGHLPSFSESQVLNCSDTLNRDLGPSTRDL
                     LYAGLSGLDLDPSLSTSDMPSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQTSLQ
                     DLGLGALKVPKEADEGGRATGSTRKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYL
                     THSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYE
                     VQHGVCILKETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPNRDLLR
                     CIVSSIVHQKIPSPGPAVGPSDTEARSSACACPTSLGSSSCTPASTPVALGTLGSEIP
                     EETHPPRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRPSSLEGWPEGSSLP
                     ACLPLFRGHSVPSGSQPSSHNFQWLRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGG
                     SGPSSTPTSVEPSPSLGTTQEELLPFPPALLKAPGEASSEVRQAAGEDETWAPKKCKP
                     DCESFPWQSPTELGLQDAQNPGGLPSDATPLFRQLFMKSQESLVSHEQMQVLQMIAKS
                     QRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTVDSFQIGPGHSEPEG
                     SPVRRRKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSSLAKGT
                     LDLGDIIPNAGSRQSQLGGDEPAGTQLVGKQGQGENGLASGAMRGEKGPACPRGGGYR
                     LFSGHPRAQRFSGFRKEKVKMDVCCAASPSQVAMASFSSAGPLADPPRDMKSKLTIFN
                     RIQGGNIYRLPHPVKEESLAGGCHQPNGGPTDWMESKSTFVCKNCSQMFYTEKGLSSH
                     MCFHSDQWPSPRGKQEQQVKGQMVASVKRKAGREEGAVEDMKRHYDCSSSEPQDVTIL
                     SMLVSSGSCGVTPVVLSSLLQGQEKDGEERDSKESCQYRKRKKRPQPKALFAPPAPSA
                     LGEPGPGGCHQSCLHSPVFLVDHLLKGLFQCSPYTPPPMLSPIREGSGLYFNTLCSTS
                     RAGPHLISPVLDQVDSSFGICVVKDDTKISIEPHINVGSRFQAEIPELQERLLARVDE
                     NVASLVWKPWGDVMTNPETQDRVMELCNVACSSVMPGGGTNLELALHCLHDAQGSVQV
                     ALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFKKAFCAHKKDFYLIHKMIQTK
                     SVAQCVEYYYIWKKMVKFDCGRAPGLEKRGRRELDEVERTEDKVTCSPRERPTHRPTP
                     ELKIKTKSYRRESILHSSPSAAPKRTPEPPGSVESQGVFPCRECERVFDKIKSRNAHM
                     KRHRLQEHVEPVRVKWPVKPYPLKEEEEEEEEELGADMGPLQW"
     exon            405..645
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            646..2500
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2559
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2746
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2807
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2869
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3221
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3285
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3428
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3532
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3608
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3697
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3838
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..4020
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4664
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /note="hexamer: ATTAAA"
     polyA_site      4658
                     /gene="Zfp541"
                     /gene_synonym="EG666528; Znf541"
                     /note="major polyA site"
ORIGIN      
        1 gagctagctg ccagcgaggg ctcttccctt cctgactctg gacacggctt tgcttgtctg
       61 gagacgggct ctagccagga cctggcagtg gaaagccatg gagccataca gtcttgggga
      121 agagggagca cttccatcag aagggcacct cccatccttc tctgaaagtc aagtgctcaa
      181 ctgcagtgac acactcaacc gggacctggg ccccagcaca cgggacctgc tctacgctgg
      241 cttaagcggt ttggaccttg accccagtct ctccacatct gatatgccca gtgaagtgct
      301 agaggacaat ctggacaccc tgtccctata ctcggggaag gacagtgact ctgtgaagct
      361 gctggaagaa tatgcagact ctgagtcaca gacctcctta caagacctgg ggctgggcgc
      421 actcaaggtg cctaaagagg ctgatgaagg aggcagggcc actgggagta caaggaaagg
      481 caagcgacag cacagttccc ctcagaatcc actcctggac tgcagcctgt gtgggaaagt
      541 gttcagcagc gccagttccc tgagcaagca ttacctgacg cacagccagg agagaaaaca
      601 cgtgtgcaaa gtctgcagca aagccttcaa gcggcaggac cacctgactg ggcacatgct
      661 cacccaccag aagaccaagc cctttgtgtg cattgagcaa ggttgcagca agagctactg
      721 tgactaccgc tcgctgcgcc gccactatga agtccagcat ggagtatgca tcctgaagga
      781 gactccacca gaagaggagg cctatgggga cccaactcac aaccatgatg tggctaacca
      841 gcctccaccc agtggcctga ggtccctggg gcccccagaa gctaggtccc ctggctctgt
      901 cttgcccaac agagacctcc ttcgctgtat tgtgagcagc atcgtccacc agaagattcc
      961 ttctcctggc ccagcagtgg ggccttctga tactgaagca aggagctcag cctgtgcttg
     1021 ccccacctca ctgggatcat catcatgtac accagccagc accccagtgg ccctaggaac
     1081 cctgggctct gagattcctg aggaaactca tcccccacgg aaggaagctg ccaccgaagt
     1141 gttcacacct gtccagtcaa gggcagctga gaatggtgtc cccgatccac cagagtcaga
     1201 gttggagtca gagtctccac ggcttcaacg gccatcctcc ctggaaggct ggccagaggg
     1261 cagctctctg cctgcctgcc tgcctctctt cagaggccac tctgtcccct caggatccca
     1321 gccttccagc cacaacttcc agtggctccg gaacctgcct ggctgtccca agaacaaagg
     1381 cagcaatgtg tttatggtcc acaagccccc tgcagtggca tcccgggagg gctctgaggg
     1441 aggaggctct ggacccagca gcacccctac ctcagtggag ccttcaccca gcctgggcac
     1501 cacccaggag gaactcttgc catttcctcc tgcactacta aaggcccctg gtgaggcctc
     1561 cagtgaagtt cggcaggcag ctggggaaga tgaaacctgg gctcccaaaa agtgcaaacc
     1621 tgactgtgag tcattcccat ggcagagccc cactgagctt gggctccaag atgcacagaa
     1681 cccaggtggg ctcccctcag atgccacgcc cctcttccgg cagctgttca tgaagtcaca
     1741 ggagtctcta gtaagccatg agcagatgca ggtgctccag atgattgcca agtcccagcg
     1801 gatcttctcc catactcagg tggctacagc ctcagcccag agaccagggc ccgagggcaa
     1861 gcagtccact ctgaagccat tgcaggggcc atggccacca caaactctgc caccagcacc
     1921 cactgtagac tctttccaga taggccctgg acactcagag ccagaaggat ccccagtccg
     1981 caggaggaaa actatgcctg cggtgtccag agaaacatct cctggtggcc ctaggcgaga
     2041 cacaaaagga ggccccaaag tggcctctgc accaccatcc ctcacagggc caggcctgct
     2101 cccctcccgg aatccagaca gctcttcatt ggccaaaggg acattggacc tgggggacat
     2161 tatccccaat gcaggctcaa ggcagtccca gttaggtgga gatgagccag ctggaaccca
     2221 gctggttggg aaacaggggc aaggagaaaa tggcctggct tcaggggcca tgagaggtga
     2281 gaagggtcca gcctgccccc gaggtggagg ctacaggctc ttctcagggc accccagggc
     2341 ccagagattc tcaggtttcc ggaaggagaa agtgaagatg gatgtgtgct gtgcagcttc
     2401 tcccagccag gtggccatgg cctccttttc atcggctggg cctctggcag atccacccag
     2461 agacatgaag tccaagctga caatcttcaa cagaatccag ggtggaaaca tttacagact
     2521 cccccatcca gtgaaggaag agagcttggc aggcggatgc catcagccaa atgggggtcc
     2581 cacagactgg atggagtcaa agagcacttt tgtgtgcaag aattgcagcc agatgtttta
     2641 caccgagaaa gggctgagca gccacatgtg tttccatagt gaccagtggc catcacctcg
     2701 agggaagcag gagcaacagg tgaaggggca aatggtggct tctgtaaaaa ggaaggctgg
     2761 cagggaggaa ggagcagtag aagatatgaa acgtcattat gattgcagca gctctgagcc
     2821 tcaggatgtc accatactga gtatgttagt cagctctggc tcatgtgggg tgacacctgt
     2881 ggttctgtcc tctcttcttc agggacaaga aaaagatggg gaagagagag acagcaagga
     2941 gagctgccag tacagaaagc ggaagaagcg gccccagccc aaggccctgt ttgcccctcc
     3001 tgcaccctct gccctcgggg aaccaggccc aggagggtgc caccagagct gcctgcactc
     3061 tcctgtgttc ctggtggatc acctcctgaa gggcttgttt cagtgctctc cctacacacc
     3121 accgcctatg cttagcccga ttcgtgaggg ctctgggctg tacttcaata ccctctgctc
     3181 cacatccagg gctgggcccc accttatcag ccctgtactt gaccaagtgg acagctcctt
     3241 tggcatctgt gtggtgaagg atgacactaa aatcagcatc gaaccacata tcaacgtagg
     3301 aagcagattt caggcggaga tcccagaact gcaggagagg ctgctggcca gagtggatga
     3361 gaatgtagct tctctggtct ggaagccatg gggagatgtg atgaccaacc cagagaccca
     3421 ggacagagtg atggagctct gcaatgtagc atgctccagt gtgatgccag gagggggcac
     3481 caacctggag cttgccctgc actgcctgca tgatgcccag ggcagtgttc aggttgccct
     3541 ggagactctg ttactcagag gaccccagaa gccccggact cacccactgg ctgactatcg
     3601 atacacaggt tcagacatct ggacccccat ggagaagagg ctcttcaaga aggcattctg
     3661 tgcccacaag aaggactttt acctgataca caagatgatc cagactaaaa gtgtagcaca
     3721 gtgtgtcgag tactactaca tctggaaaaa gatggttaag tttgattgtg gccgagctcc
     3781 tgggctggag aagaggggca gaagagagct ggatgaagta gaaaggactg aagacaaggt
     3841 gacttgcagc cctcgagaga gacctaccca ccgtccaact cctgagttaa agataaagac
     3901 caagagttac aggagagagt ctatccttca ctccagccca agtgcagccc ccaagcgcac
     3961 tcctgagcct ccagggagtg tggagagcca gggcgtgttc ccttgcagag agtgtgagag
     4021 ggtgttcgac aagatcaaga gtcggaatgc ccacatgaag cgccaccgcc tccaggagca
     4081 tgtggaaccc gttagggtga agtggcctgt gaagccctac ccactgaagg aggaagagga
     4141 ggaggaagaa gaggagctgg gggccgacat gggccccttg cagtggtgac ttcttgctag
     4201 aatttggtct gcaaggagag gggaattcag ctctgaacca gtgccctggg cctctcagaa
     4261 gtgtttgggg ccctcttatc ctctctgtcc tctcacttcc agccttgcta gcatttggac
     4321 atgaacaggc agaagccctc caggtagctc tgcagtcatg tgggtcatca gaagctccat
     4381 tatctcctgg ttaatagttg cttacttgcc gtcccagtca cttggagggg accctgggag
     4441 gcagaaggtt tggtctaagt ggcatttaga tctgagctgg catgggactg acattggtta
     4501 gaaagaatca gtaaggacac ctgagacaca gtgagctggg ccctccttgg gcagggcctc
     4561 tctgcattcc caccatccct agtcttgcaa agactgtata ttgttaggtg tattttttac
     4621 gtgtctgctt atatcttatt aaattgggtt cttaaagagc tgtc
//
