LOCUS       NP_001347982            1304 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger protein 532 isoform 1 [Mus musculus].
ACCESSION   NP_001347982 XP_011245252
VERSION     NP_001347982.1
DBSOURCE    REFSEQ: accession NM_001361053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1304)
  AUTHORS   Liang,G.H., Luo,Y.N., Wei,R.Z., Yin,J.Y., Qin,Z.L., Lu,L.L. and
            Ma,W.H.
  TITLE     CircZNF532 knockdown protects retinal pigment epithelial cells
            against high glucose-induced apoptosis and pyroptosis by regulating
            the miR-20b-5p/STAT3 axis
  JOURNAL   J Diabetes Investig 13 (5), 781-795 (2022)
   PUBMED   34839589
  REMARK    GeneRIF: CircZNF532 knockdown protects retinal pigment epithelial
            cells against high glucose-induced apoptosis and pyroptosis by
            regulating the miR-20b-5p/STAT3 axis.
REFERENCE   3  (residues 1 to 1304)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1304)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   5  (residues 1 to 1304)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132307.5 and AC124578.4.
            
            On Feb 27, 2018 this sequence version replaced XP_011245252.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.78507.1,
                                           SRR9219382.1489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 38.91 cM"
     Protein         1..1304
                     /product="zinc finger protein 532 isoform 1"
                     /calculated_mol_wt=141250
     Region          <136..371
                     /region_name="PTZ00108"
                     /note="DNA topoisomerase 2-like protein; Provisional"
                     /db_xref="CDD:240271"
     Region          753..772
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          781..816
                     /region_name="zf-RING_7"
                     /note="C4-type zinc ribbon domain; pfam02591"
                     /db_xref="CDD:426857"
     Region          782..802
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(787,789,791,793..794,797..798,801,816,820..821,
                     824..825,831,846,848,850,852..853,856..857)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          810..832
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          841..858
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          869..890
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          904..924
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1024..1044
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1029,1031,1033,1035..1036,1039..1040,1043,1059,1061,
                     1065..1066,1069..1070,1073,1092,1094,1096,1098..1099,
                     1102..1103)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1054..1075
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1084..1104
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1179..1199
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1184,1186,1188,1190..1191,1194..1195,1198,1213,1215,
                     1219..1220,1223..1224,1228,1274,1276,1278,1280..1281,
                     1284..1285,1288)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1204..1230
                     /region_name="zf-C2H2_11"
                     /note="zinc-finger C2H2-type; pfam16622"
                     /db_xref="CDD:465205"
     Region          1208..1229
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1268..1289
                     /region_name="zf-C2H2_6"
                     /note="C2H2-type zinc finger; pfam13912"
                     /db_xref="CDD:433576"
     Region          1269..1289
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1304
                     /gene="Zfp532"
                     /gene_synonym="C530030I18Rik; mKIAA1629; Znf532"
                     /coded_by="NM_001361053.1:517..4431"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS89265.1"
                     /db_xref="GeneID:328977"
                     /db_xref="MGI:MGI:3036282"
ORIGIN      
        1 mtmgdmktpd fddllaafdi pdmvdpkaai esghddhesh ikqnahvddd shtpsssdvg
       61 vsvivknvrn idssegvekd ghnptgnglh ngfltassld sygkdgaksl kgdtpasevt
      121 lkdpafsqfs pissaeefed dekievddpp dkeearagfr snvltgsapq qdfdklkalg
      181 genssktgvs tsghtdknkv kreaesnsit lsvyepfkvr kaedklkens ekmlesrvld
      241 gkpsseksds giaaaasskt kpssklssci aaiaalsakk aasdsckepv ansreasplp
      301 kevndspkaa dkspesqnli dgtkkaslkp sdsprsvsse nsskgspssp vgstpaipkv
      361 riktiktssg eikrtvtrvl pevdldsgkk pseqaasvma svtsllsssa satvlssppr
      421 aplqtamvts avssaeltpk qvtikpvata flpvsavkta gsqvinlkla nnttvkatvi
      481 saasvqsass aiikaanaiq qqtvvvpass lanaklvpkt vhlanlnllp qgaqatselr
      541 qvltkpqqqi kqaiinaaas qppkkvsrvq vvsslqssvv eafnkvlssv npvpvytpnl
      601 sppanagitl pmrgykclec gdafaleksl sqhydrrsvr ievtcnhctk nlvfynkcsl
      661 lsharghkek gvvmqcshli lkpvpadqmi vppssntaas tlqssvgaat htvpkvqpgi
      721 agavisapas tpmspampld edpsklcrhs lkclecnevf qdepslathf qhaadtsgqk
      781 tctvcqmllp nqcsyashqr ihqhkspytc pecgaicrsv hfqnhitknc lhytrrvgfr
      841 cvhcnvvysd vaalkshiqg shcevfykcp icpmafksap sthshaytqh pgvkigepki
      901 iykcsmcdtv ftlqtllyrh fdqhtdnqkv svfkcpdcsl lyaqkqlmmd hiksmhgtlk
      961 siegppnlgi nlplsvkpat qnsanhsred aksvngkekl ekkspspakk stepkkmasl
     1021 gwtcwecdrl ftqrdvylsh mrkehgkqmk khpcrqcdks fssshslcrh nrikhkgirk
     1081 vyacshcpds rrtftkrlml erhiqlmhgi kdpdvkelsd dagdvtndee eeaeikedak
     1141 vpspkrklee pvlefrpprg aitqplkklk invfkvhkca vcgfttenll qfhehipqhr
     1201 sdgsshqcre cglcytshgs larhlfivhk lkepqpvskq ngagedsqqe nkpspedeaa
     1261 egaasdrkck vcaktfetea alnthmrthg mafikskrms saek
//
