LOCUS       NM_145492               6152 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus zinc finger protein 521 (Zfp521), transcript variant
            1, mRNA.
ACCESSION   NM_145492 NM_181326
VERSION     NM_145492.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 6152)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   3  (bases 1 to 6152)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6152)
  AUTHORS   Li,Z., Fu,X., Wu,W., Liu,Z., Chen,Z., Zhou,C., Liu,Y., Kuang,M.,
            Sun,F., Xiao,F., Huang,Y., Zhang,X., Fan,S., Huang,X., Zheng,G.,
            Chen,J. and Hou,Y.
  TITLE     Zfp521 is essential for the quiescence and maintenance of adult
            hematopoietic stem cells under stress
  JOURNAL   iScience 24 (2), 102039 (2021)
   PUBMED   33532716
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6152)
  AUTHORS   Dang,T.N., Taylor,J.L., Kilroy,G., Yu,Y., Burk,D.H. and Floyd,Z.E.
  TITLE     SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with
            EBF1 and ZFP521 to Promote Adipogenesis
  JOURNAL   Obesity (Silver Spring) 29 (1), 98-107 (2021)
   PUBMED   33155406
  REMARK    GeneRIF: SIAH2 is Expressed in Adipocyte Precursor Cells and
            Interacts with EBF1 and ZFP521 to Promote Adipogenesis.
REFERENCE   6  (bases 1 to 6152)
  AUTHORS   Pataer,A., Kamoto,T., Lu,L.M., Yamada,Y. and Hiai,H.
  TITLE     Two dominant host resistance genes to pre-B lymphoma in
            wild-derived inbred mouse strain MSM/Ms
  JOURNAL   Cancer Res 56 (16), 3716-3720 (1996)
   PUBMED   8706013
REFERENCE   7  (bases 1 to 6152)
  AUTHORS   Griffith,A.J., Radice,G.L., Burgess,D.L., Kohrman,D.C.,
            Hansen,G.M., Justice,M.J., Johnson,K.R., Davisson,M.T. and
            Meisler,M.H.
  TITLE     Location of the 9257 and ataxia mutations on mouse chromosome 18
  JOURNAL   Mamm Genome 7 (6), 417-419 (1996)
   PUBMED   8662222
REFERENCE   8  (bases 1 to 6152)
  AUTHORS   Nakamura,T., Largaespada,D.A., Shaughnessy,J.D. Jr., Jenkins,N.A.
            and Copeland,N.G.
  TITLE     Cooperative activation of Hoxa and Pbx1-related genes in murine
            myeloid leukaemias
  JOURNAL   Nat Genet 12 (2), 149-153 (1996)
   PUBMED   8563752
REFERENCE   9  (bases 1 to 6152)
  AUTHORS   Justice,M.J., Morse,H.C. 3rd, Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of Evi-3, a novel common site of retroviral
            integration in mouse AKXD B-cell lymphomas
  JOURNAL   J Virol 68 (3), 1293-1300 (1994)
   PUBMED   8107195
REFERENCE   10 (bases 1 to 6152)
  AUTHORS   Davisson,M.T. and Johnson,K.R.
  TITLE     Encyclopedia of the mouse genome III. October 1993. Mouse
            chromosome 18
  JOURNAL   Mamm Genome 4 Spec No, S253-S260 (1993)
   PUBMED   8268679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101651.6, AC104328.10, AC108404.8 and AC101682.8.
            
            On or before Apr 7, 2010 this sequence version replaced
            NM_181326.3, NM_145492.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY147406.1, BC021376.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC101651.6         28198-28430         c
            234-274             AC101651.6         27061-27101         c
            275-454             AC104328.10        25354-25533
            455-3807            AC104328.10        117361-120713
            3808-3892           AC108404.8         187497-187581       c
            3893-4024           AC101682.8         58245-58376
            4025-4140           AC101682.8         60736-60851
            4141-6152           AC101682.8         86968-88979
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 7.68 cM"
     gene            1..6152
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /note="zinc finger protein 521"
                     /db_xref="GeneID:225207"
                     /db_xref="MGI:MGI:95459"
     exon            1..233
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            234..274
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..4170
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ecotropic viral integration site 3 protein"
                     /codon_start=1
                     /product="zinc finger protein 521 isoform 1"
                     /protein_id="NP_663467.1"
                     /db_xref="CCDS:CCDS37740.1"
                     /db_xref="GeneID:225207"
                     /db_xref="MGI:MGI:95459"
                     /translation="MSRRKQAKPRSLKDPNCKLEDKIEDGEAVDCKKRPEDGEELEED
                     AVHSCDSCLQVFESLSDITEHKIHQCQLTDGVDVEDDPSCSWPASSPSSKDQTSPSHG
                     EGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRS
                     RDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLH
                     GHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNE
                     DRAALQCMYCHELFVEETSLMNHIEQVHGGEKKNSCSICSESFLTVEELYSHMDSHQQ
                     PESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTSD
                     MTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLY
                     NLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAK
                     DSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCT
                     NSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTTLKMMQTVG
                     GGPARASGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKH
                     VTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLH
                     LAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVEL
                     QCHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEA
                     ELQTLLTNSQESHNSHDGSEEDVDSSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPG
                     ESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLL
                     TLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
                     STLELKIHGTFHMQKTGNGSSVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGL
                     PYGLCAGCVNLSKSSSPGLSLPPGASRPGLGQNESLSAMEGKGKAGGLKTRCSSCNVK
                     FESESELQNHIQTVHRELVPDANSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVF
                     YNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCF
                     TVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS"
     exon            275..454
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            455..3807
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3892
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4024
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4140
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..6152
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4930..4935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /note="hexamer: AATAAA"
     polyA_site      4950
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /note="major polyA site"
     regulatory      6133..6138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
                     /note="hexamer: AATAAA"
     polyA_site      6152
                     /gene="Zfp521"
                     /gene_synonym="B930086A16Rik; Evi3; Znf521"
ORIGIN      
        1 cgggaccccc tcctccctcc cgctccccgc gctctcgcct tttaatcatg cccctctgtc
       61 tgtgtgtgag tgcaggcagg ctgacaatga tttcctcagt gattacgtac agagcgagtc
      121 cctgcgggtt aggggccccc tctggagcca tcctgatggc tttgggggcc ttgcttccat
      181 tttccattat tatgtggact accggagcga cagcgcagtc caagaccttg caggatgtct
      241 cgccgcaagc aagcgaaacc gagatccctc aaagacccca actgtaaact tgaagacaag
      301 attgaagatg gggaggcagt agactgcaag aagaggccag aagacgggga ggagttggag
      361 gaggacgctg tgcacagctg tgacagctgc ctccaggtgt ttgagtcact gagcgacatc
      421 acagagcaca agatccatca gtgccagctg acagatggcg ttgacgttga ggacgacccc
      481 agctgctctt ggccagcctc ctcgccttcc agtaaggacc agacttcccc cagccatgga
      541 gaagggtgtg atttcggaga ggaagaaggt ggccctggac tgccttaccc atgccagttc
      601 tgtgacaagt cctttagccg cctcagctac ctaaagcacc atgaacagag ccacagtgac
      661 aagctgccct tcaagtgcac ctactgcagt cggctgttca aacacaagcg gagccgtgac
      721 cgccacataa agctccacac tggggataag aagtatcact gtagcgagtg tgacgcagcc
      781 ttctcccgga gcgatcatct caagatccac ttaaagactc acacctccaa caagccatat
      841 aaatgtgccg tctgccgcag agggttcctc tcctctagct ccttgcacgg acatatgcag
      901 gttcatgagc ggaacaagga cggctcccag tctggctcca ggatggagga ctggaagatg
      961 aaggacactc agaagtgcag ccagtgcgag gaaggctttg acttcccgga agacctccag
     1021 aagcacattg cagaatgcca ccccgagtgc tcccctaatg aggaccgagc agccctccag
     1081 tgcatgtact gccacgagct gtttgtggag gagacgtccc tcatgaacca catcgagcag
     1141 gtacacgggg gtgagaagaa gaactcttgc agcatttgct cagagagctt cctcacggtc
     1201 gaggagctgt atagccacat ggacagtcac cagcagccag agtcctgcaa tcacagcaac
     1261 agcccttccc tggtcactgt gggttacacc tcagtgtcca gcacgactcc agactcgaac
     1321 ctctcagtgg acagctcgac catggtagag gctgcaccac cgattccaaa gagccgcggg
     1381 aggaagcgag ctgctcagca gacctccgat atgactggcc cctctagtaa gcaggcgaaa
     1441 gtcacctaca gctgtattta ctgcaacaag cagttatttt ccagtctcgc ggttctgcag
     1501 attcacttga aaactatgca tttagataag cctgagcagg ctcatatctg tcagtattgc
     1561 ttggaggtct taccctcact ctataaccta aatgaacatc ttaaacaagt gcacgaagct
     1621 caggaccccg gcctgattgt ttcggccatg cctgccattg tttaccagtg caacttctgt
     1681 tccgaagttg tcaatgacct caacaccctt caggagcaca tccgatgttc tcatgggttt
     1741 gccaatcccg cggccaagga cagcaatgcg ttcttttgtc cccattgtta catggggttt
     1801 ctcactgact cttcacttga agagcatata agacaggtcc attgtgacct cagtggctcc
     1861 cggtttgggt ctcctgtgct tgggactcca aaagaaccgg tggttgaagt ctactcctgt
     1921 tcctattgta caaattcgcc aatattcaac agtgttctta aactgaataa gcatattaaa
     1981 gagaatcata aaaacattcc cttggccctg aattatattc acaatgggaa gaaatcccgg
     2041 gccttgagcc ctttgtcccc tgtggctata gaacaaacaa ctcttaagat gatgcagact
     2101 gtgggaggcg ggcctgcccg cgcctctgga gagtatatct gtaatcagtg tggtgctaag
     2161 tacacgtccc tagacagctt tcagactcac ctcaaaaccc atttggacac cgtgctgcca
     2221 aaactgacct gccctcagtg taacaaagaa ttccccaacc aagagtcctt gctaaagcac
     2281 gtgaccatcc actttatgat cacctcaacc tactacatct gtgagagctg tgacaagcag
     2341 ttcacctccg tggatgacct ccagaagcac ctgctggaca tgcacacctt cgtcttcttc
     2401 cgctgcacac tctgccagga agtgttcgac tccaaggtct ctatccagct gcacttggcc
     2461 gtgaagcaca gtaacgagaa gaaggtgtac cgctgcacgt cctgcaactg ggacttccgc
     2521 aacgagaccg acctgcagct gcacgtgaag cacaaccact tggagaacca aggcaaagtg
     2581 cacaagtgca tcttctgcgg cgagtcgttt ggcaccgagg tggagctgca gtgccacatc
     2641 accacccaca gcaagaagta caactgcagg ttctgcagca aagccttcca cgccgtcatc
     2701 ctgctggaga agcacctgcg ggagaaacac tgtgtgtttg aaaccaagac ccccaactgt
     2761 ggcaccaacg gggcctcgga gcaagtgcag aaggaggagg ctgagctgca gaccttgctc
     2821 accaacagcc aggagtccca taacagccat gatgggagtg aggaggacgt ggacagctct
     2881 gaacccatgt atggctgtga catctgcggg gcggcctaca ccatggagac gttgctgcag
     2941 aaccaccagc tccgagacca caacatcagg cccggagaaa gcgccatcgt gaagaagaag
     3001 gcggagctca ttaaagggaa ttacaagtgt aacgtttgct cgagaacctt cttctccgaa
     3061 aacgggctcc gtgaacacat gcagacccac ttaggcccgg tcaaacacta catgtgccct
     3121 atctgtggag agcgcttccc ttccctgtta actctcacag agcacaaagt cacacacagc
     3181 aagagcctgg ataccggaaa ctgtcgtatt tgtaagatgc ccctgcagag cgaagaggag
     3241 tttttggagc actgccagat gcaccctgac ctgaggaatt ccctgactgg gtttcgttgt
     3301 gtggtgtgta tgcagactgt gacctccacc ttggaactca aaatccacgg gaccttccac
     3361 atgcagaaga cggggaatgg gtcctccgtg cagaccaccg ggcgtggcca gcacgttcag
     3421 aaactgtata agtgcgcatc ttgcctcaaa gagttccgtt ccaagcaaga tctggtgaaa
     3481 ctcgacatca acggcctgcc atatggtctg tgtgccggct gtgtgaatct cagtaagagc
     3541 agtagcccgg gcctcagtct ccctcctggt gccagcaggc caggcttggg ccagaatgag
     3601 agtctgagcg ccatggaagg aaaaggcaag gcggggggac tgaagacgcg ctgttcaagc
     3661 tgcaatgtca agtttgagtc tgaaagcgaa ctgcagaacc acatccagac ggtgcaccgg
     3721 gagcttgtgc cagacgccaa cagcacacag ttgaaaacgc cccaagtgtc acccatgccc
     3781 agaatcagtc cctcccagtc cgatgagaag aagacctacc agtgtatcaa gtgtcagatg
     3841 gttttctaca acgagtggga catccaggtt catgtggcaa atcacatgat tgatgaaggg
     3901 ctgaaccatg agtgcaaact ctgcagccag acctttgact cccccgccaa acttcagtgt
     3961 cacctgatag agcacagctt cgaagggatg ggtggtacct tcaagtgccc cgtctgtttc
     4021 acagtgtttg ttcaagctaa caagttgcaa cagcatatat tctctgccca tggacaagaa
     4081 gacaagatct atgactgcac acaatgccca cagaagtttt tcttccaaac agagctacag
     4141 aatcatacga tgactcagca cagcagttag ttcatgtatg cacggcctct caaggagaag
     4201 gacttttgtg gcacaaaaag ggaacatgtt ttactctttg cacgaaactc ccattgttaa
     4261 tgtatactct tcagaagcat tgtattgtat catacaacgt gtactatcaa aactgttgga
     4321 tgttcatgtg ttggaacttt tgagcaccag atagacagac tccttgtata taaagtgttg
     4381 cacatgtatt atgtcgtcga tgctaaaatg gtcttataaa gacaagtgga cttgggccct
     4441 attcaggcaa gattttcaaa gtgaacaaaa tggcttaaga gaaaatgttt tcaaggaaga
     4501 cagaacttaa atgaactgtt ctcatgtgac tatggttgga cttcctttta tgtacactta
     4561 agcctagaat ttctcttttg gtatatcaat ggttaaaacc caagactatt ttttactgct
     4621 ggagattctc gtgaactatg aagagacatt ctcacagaac agaaccccac atctggatac
     4681 ggcccatata tatatttgta agccttgcag tgtgacaggt agcctcacca tatatgcaat
     4741 agttgttatg tagactgtca aagatttttt tttcctggct acatttgaag ctttgagtgt
     4801 tcaaggtttt ccttaatgat ttcacacagc caaattcttg aatcagttga actaacctgt
     4861 atgttactgc tctcaatgtt taccctgcgg cctgaacctg gagattactg gaattgtttt
     4921 ccaagaggaa ataaattcag tttaccatca gctgtgagtg tatttgtgtg ttttcctttt
     4981 ctagttagtc ttaccattaa gaaagaaagc aagaaaagga aatctaatgc ctgcaccctt
     5041 ggctatgaaa cttgctccag agctgattgc aggcatagcc tcaatcatat ttaaccttag
     5101 cacaccgggc cagatgcagc tgggaagaga tccatcatgc ggcacaggaa gaaagcagac
     5161 ccagtctatt tgaactgtct tagatctacc aggtcacatt gtacttgaag agtctgacat
     5221 cacagatgga tgtgatggct gttttctgca taatttgcag cccaattcac atcatgctgt
     5281 gcagatctga actcgtggtg gatgactgca attggagcgg ctgtttggct tatgtgtact
     5341 taagaagcag cgtcgttcca aagacaaagt gcagagcatc atcgagtcag agggctgtta
     5401 gttctgcttc tgctgccgac tcccagtgga gccttctcca aatggcttca tctcctggcc
     5461 tgggatcacc cgaccaggga aggtaatgga acttggtcat cagcctttcg acagggagga
     5521 gatggctcta tgagatgcct tccgcagcct accacaaaat gctgaaaaag agaagcccct
     5581 gatttcagag ctttttgtgc aattttttaa agatgagaag ggtggcattg tgtgccctgg
     5641 accttgatag acgtcattag tctgagtagt gtaagtatga actccacact cacggagcgc
     5701 attcatggca tcgtgcttaa aatggttacc acactctgag tcctatgacc tcttttaaac
     5761 ttggaagatc tcaagcaaat agcaataatc accacagaac tttgaggtaa gaaaaatgca
     5821 acctggactg atggatgtgt gaccccttgt caccaatgga ctagcctgtg acagccacat
     5881 ctccagcatc acaacgcagg gtcactgccc catggttcta acccttaacc tccttgacat
     5941 tcccttgcag gacttgcttg ttacatcttg gcgtgctggt ccctgaagcc tcaagcttgg
     6001 gctctcctaa gaatttctgg gtaatgctgg ttgcagacca cactttgaga accactaccc
     6061 tacctcattc acaagtcatg gaatgaacca agtgtgaata accaagcaca tgatattatt
     6121 tgttgtgttt tcaataaaaa aattttttta aa
//
