LOCUS       NM_175311               2290 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 513 (Zfp513), transcript variant
            1, mRNA.
ACCESSION   NM_175311
VERSION     NM_175311.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Li,L., Nakaya,N., Chavali,V.R., Ma,Z., Jiao,X., Sieving,P.A.,
            Riazuddin,S., Tomarev,S.I., Ayyagari,R., Riazuddin,S.A. and
            Hejtmancik,J.F.
  TITLE     A mutation in ZNF513, a putative regulator of photoreceptor
            development, causes autosomal-recessive retinitis pigmentosa
  JOURNAL   Am J Hum Genet 87 (3), 400-409 (2010)
   PUBMED   20797688
  REMARK    GeneRIF: These results suggest that the ZNF513 p.C339R mutation is
            responsible for retinitis pigmentosa and that ZNF513 plays a key
            role in the regulation of photoreceptor-specific genes in retinal
            development and photoreceptor maintenance.
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ076079.1 and BC058976.1.
            
            On May 1, 2010 this sequence version replaced NM_175311.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus based on the presence of a well-conserved in-frame uAUG.
            The update changes the protein length from 479 aa to 541 aa, but
            the splice sites are unaffected.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058976.1, SRR7345562.67686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CJ076079.1         1-70
            71-2290             BC058976.1         1-2220
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..2290
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /note="zinc finger protein 513"
                     /db_xref="GeneID:101023"
                     /db_xref="MGI:MGI:2141255"
     exon            1..317
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1888
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 513 isoform 1"
                     /protein_id="NP_780520.3"
                     /db_xref="CCDS:CCDS19178.2"
                     /db_xref="GeneID:101023"
                     /db_xref="MGI:MGI:2141255"
                     /translation="MPRRKQSHPQPVKCEGVKVDTEDSFDEGPGALVLESDLLLGQDL
                     EFEEEEEEDEGDGHNDQLMGFERDSEGDSQGARPGLPYGLSDDESGGGRALSAESEVE
                     EPARGPGEARGERPGPACQLCGGPTGEGPCCGAGGPGGGPPLPPRLLYSCRLCAFVSH
                     YSSHLKRHMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSL
                     GNLRRHQRTHTGPPTPPCPTCGFRCCAPRPTRPPSPTEQEGTMPRRSEDALILPDLSL
                     HVPPGGASFLPDCGQLRGEGESLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAA
                     MCGRCMRGEAGGVATGGPQGPGDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCAR
                     CPYASAHLDNLKRHQRVHTGEKPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCN
                     YSCNQSMNLKRHMLRHTGEKPFRCATCAYTTGHWDNYKRHQKVHGHGGAGGPGLSAPE
                     GWAPPHSPPSVLSTRGPAALGATGSRALHSDSP"
     exon            318..473
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1061
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..2228
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2208..2213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /note="hexamer: AATAAA"
     polyA_site      2228
                     /gene="Zfp513"
                     /gene_synonym="D430028M17Rik; Znf513"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcggaa gcggaagcgg gtacggaggt accagctggt cttcggaggg gggtaggggg
       61 ctccatgaat ggaagcggcg gcggcggcgg gagcgacctg agctggattc cggggccggg
      121 gccaggggct gcccagggcc cgcaccggtg tatgggggcg gttcgtggat cctaagagca
      181 aggaccgacg gcagggccga actgggaggg gcggggccgg gaggcctcgg gccggaggcg
      241 cgtcgggctg gagccggtca cgatgccccg aaggaagcaa agccatccac agcccgtgaa
      301 atgcgagggg gtcaaagtgg atactgaaga ttccttcgac gaaggtcctg gggccctggt
      361 gttggagagc gatttgctac taggccaaga tctggagttt gaagaggaag aggaagagga
      421 tgaaggtgac ggccacaacg accagctcat gggctttgag agagactctg aaggagactc
      481 tcagggggcc agacctggac ttccctatgg gctgagtgac gacgagtctg ggggcggccg
      541 cgcactaagt gcggagagtg aagttgagga accagccagg ggtccagggg aggccagggg
      601 tgagaggcca ggcccagcct gtcagctgtg tggggggccg acaggtgagg ggccgtgttg
      661 tggggcagga gggccgggtg gggggccccc gctgccccca cggctactgt actcatgccg
      721 gctgtgcgcc ttcgtgtccc actactcgag ccacctgaag cggcacatgc agacacacag
      781 cggggagaag ccgttccgct gtggccgctg cccctacgcc tcagcccagc tcgtcaacct
      841 gacgcgacat acccgcaccc atactggcga gaagccctac cgctgtcccc actgcccctt
      901 tgcctgcagc agcctgggca acctgaggcg gcatcagcgc acccacacag ggcctcccac
      961 tcctccctgc ccaacctgtg gctttcgatg ctgtgctcca cgaccaaccc ggcctcccag
     1021 tcccacagag caggagggga caatgccccg acgatcagaa gatgcgctga tcctgccaga
     1081 cttgagtctt catgtgccac caggtggtgc cagtttcctg ccagactgtg ggcagctgcg
     1141 gggtgaaggg gagagcttgt gtggaactgg atccgaacca ctgccagagc tactgttccc
     1201 ttggacctgc cggggctgtg gacaggaact ggaggagggt gagggcagca ggctgggagc
     1261 tgccatgtgt gggcgctgca tgcgaggaga ggctggaggg gttgccactg ggggacccca
     1321 gggccctggt gacaaaggct ttgcctgtag tttatgcccc tttgccactc actaccccaa
     1381 ccacctggct cggcacatga agactcacag tggtgagaaa cccttccgct gtgcccgctg
     1441 tccatacgcc tctgctcatc tggataacct gaaacggcac cagcgcgtcc acacaggaga
     1501 aaagccctac aagtgccccc tctgtccgta tgcctgtggc aacctggcca acctcaagcg
     1561 tcatggtcgc atccactctg gtgacaaacc ttttcggtgt agcctttgca actacagctg
     1621 caaccagagt atgaacctca aacgtcatat gctgcgacac acgggcgaga agcccttccg
     1681 ctgtgccacc tgcgcctata ccacaggcca ctgggacaac tacaagcgtc atcagaaggt
     1741 gcatggccat ggtggagcag gagggcctgg tctctctgcc cctgagggct gggccccacc
     1801 tcatagccca ccctctgttt tgagcactcg gggtccagca gccctgggtg ctactggtag
     1861 cagggctctt cattcagact caccttgaac taactaggtt cttttacctg gggctctagg
     1921 aattagccct atgcctcctg cattttatac aaatgaacta gaaaccacct ttccctttct
     1981 cccccgctgg tcaggggctc cacacagact aacctaggca ctatatggac cagcctgaat
     2041 cccatggtca gggggccata tagaccaggg gacttgtctt agctcacgta ccagatgagc
     2101 taagtgatta gggccttgga ttcaccgcca ctgctcccag aggctatgga tgaactggtt
     2161 gggagctgcc cagcctttta ctgttttaac ttatttcagt gctttataat aaaggaaaca
     2221 ctaacagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa
//
