LOCUS       NM_020589               3629 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein 467 (Zfp467), transcript variant
            1, mRNA.
ACCESSION   NM_020589 XM_001005295
VERSION     NM_020589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Liu,H., Wada,A., Le,I., Le,P.T., Lee,A.W.F., Zhou,J., Gori,F.,
            Baron,R. and Rosen,C.J.
  TITLE     PTH regulates osteogenesis and suppresses adipogenesis through
            Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
  JOURNAL   Elife 12, e83345 (2023)
   PUBMED   37159501
  REMARK    GeneRIF: PTH regulates osteogenesis and suppresses adipogenesis
            through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Le,P.T., Liu,H., Alabdulaaly,L., Vegting,Y., Calle,I.L., Gori,F.,
            Lanske,B., Baron,R. and Rosen,C.J.
  TITLE     The role of Zfp467 in mediating the pro-osteogenic and
            anti-adipogenic effects on bone and bone marrow niche
  JOURNAL   Bone 144, 115832 (2021)
   PUBMED   33359894
REFERENCE   3  (bases 1 to 3629)
  AUTHORS   You,L., Chen,L., Pan,L., Gu,W.S. and Chen,J.Y.
  TITLE     Zinc finger protein 467 regulates Wnt signaling by modulating the
            expression of sclerostin in adipose derived stem cells
  JOURNAL   Biochem Biophys Res Commun 456 (2), 598-604 (2015)
   PUBMED   25490389
  REMARK    GeneRIF: these results indicate that Zfp467 regulates the
            differentiation of adipose-derived stem cells via a mechanism
            involving Sost-mediated inhibition of Wnt signaling, suggesting
            potential therapeutic targets for the treatment of osteoporosis.
REFERENCE   4  (bases 1 to 3629)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3629)
  AUTHORS   You,L., Pan,L., Chen,L., Chen,J.Y., Zhang,X., Lv,Z. and Fu,D.
  TITLE     Suppression of zinc finger protein 467 alleviates osteoporosis
            through promoting differentiation of adipose derived stem cells to
            osteoblasts
  JOURNAL   J Transl Med 10, 11 (2012)
   PUBMED   22252242
  REMARK    GeneRIF: Zfp467 play an important role in adipose derived stem
            cells differentiation to adipocyte and osteoblast.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3629)
  AUTHORS   Quach,J.M., Walker,E.C., Allan,E., Solano,M., Yokoyama,A., Kato,S.,
            Sims,N.A., Gillespie,M.T. and Martin,T.J.
  TITLE     Zinc finger protein 467 is a novel regulator of osteoblast and
            adipocyte commitment
  JOURNAL   J Biol Chem 286 (6), 4186-4198 (2011)
   PUBMED   21123171
  REMARK    GeneRIF: Zfp467 is a novel co-factor that promotes adipocyte
            differentiation and suppresses osteoblast differentiation
REFERENCE   7  (bases 1 to 3629)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3629)
  AUTHORS   Saijou,E., Itoh,T., Kim,K.W., Iemura,S., Natsume,T. and Miyajima,A.
  TITLE     Nucleocytoplasmic shuttling of the zinc finger protein EZI Is
            mediated by importin-7-dependent nuclear import and
            CRM1-independent export mechanisms
  JOURNAL   J Biol Chem 282 (44), 32327-32337 (2007)
   PUBMED   17848547
REFERENCE   9  (bases 1 to 3629)
  AUTHORS   Nakayama,K., Kim,K.W. and Miyajima,A.
  TITLE     A novel nuclear zinc finger protein EZI enhances nuclear retention
            and transactivation of STAT3
  JOURNAL   EMBO J 21 (22), 6174-6184 (2002)
   PUBMED   12426389
  REMARK    GeneRIF: EZI. EZI is a novel nuclear zinc finger protein that
            augments STAT3 activity by keeping it in the nucleus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI552311.1, BE448817.1, CK791410.1, BQ571818.1, AK033146.1,
            AK032551.1 and BY661825.1.
            
            On Apr 28, 2007 this sequence version replaced NM_020589.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076746.1, AB041616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AI552311.1         1-50
            51-396              BE448817.1         13-358
            397-1034            CK791410.1         6-643
            1035-1566           BQ571818.1         77-608
            1567-2644           AK033146.1         1215-2292
            2645-3616           AK032551.1         2189-3160
            3617-3629           BY661825.1         359-371
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.39 cM"
     gene            1..3629
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="zinc finger protein 467"
                     /db_xref="GeneID:68910"
                     /db_xref="MGI:MGI:1916160"
     exon            1..473
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /inference="alignment:Splign:2.1.0"
     exon            474..549
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2300
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein EZI; endothelial cell-derived zinc finger
                     protein"
                     /codon_start=1
                     /product="zinc finger protein 467 isoform a"
                     /protein_id="NP_065614.2"
                     /db_xref="CCDS:CCDS51764.1"
                     /db_xref="GeneID:68910"
                     /db_xref="MGI:MGI:1916160"
                     /translation="MRETLEALNSLGFSVGQPEMAPQSEPRDGFSNAQEKMSSRGEST
                     LHSCSGHETPGQKEGIHTEQAEAPCMGSQASTPQKAEPAGSVPGEEWMIRKVKVEDED
                     QEAEEEVEWPQHLSFLPSPFPTPDLGQLAVTYKLEPGTPGALGGIALSGWAPIPEKPY
                     GCEECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPC
                     SECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTE
                     CEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSFTHKQHLVRHQRVHDAASRTRSSPDI
                     PVAPHSPTASLTPSPPGPKPFACSHCGQSFGWKKNLATHQSLHLTEGRPFGCDECALG
                     TNVDPAAEPSACTPHAPDCGPGSGPAAPQRTTSSERSFFCPDCGRGFAHGQHLARHRR
                     VHTGERPFACAQCGRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVH
                     TGSRPHACAVCARCFSSKTNLVRHQAIHTGSRPFSCPQCAKSFSRKTHLVRHQRIHGD
                     AALPAPASNLSAPAWSNPSEVVPPPIFF"
     exon            550..663
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /inference="alignment:Splign:2.1.0"
     exon            664..777
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /inference="alignment:Splign:2.1.0"
     exon            778..3619
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="hexamer: ATTAAA"
     polyA_site      2667
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="major polyA site"
     polyA_site      2682
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="hexamer: AATAAA"
     polyA_site      3607
                     /gene="Zfp467"
                     /gene_synonym="1190001I08Rik; EZI; MNCb-3350; Znf467"
                     /note="major polyA site"
ORIGIN      
        1 ctccctccta ggctgtgagc accctccctt ctagcccgag tgcccttcct tctagcctct
       61 tcttctcctt cctctcccct ctgcccttcc tcggtcctaa gctcccactt tccatctcca
      121 cactccgggc atcttgccct cagaccgtca cctgcaccca agcccattag tgcaccctcc
      181 cgcggcaggt ctctcgaaga ccctccgctt tagcctgtgc cccggagcag tgttcccgct
      241 tcccgggttc ctccccccga tcacccgcaa cgctgcccca caccctctcc ctccgcgtct
      301 ttccttcccc tccccgcgaa gtttcagggc tgtcagtccc ggagtctttc gggcagcccg
      361 cacccaagct gcaggcagcc ggcgccattg tgcaaacggc cgcccgggac cggaggcccg
      421 agcgcctggg tccccgaagc gggccgcggc acgtagccgc aggagcccgc cagggtctgt
      481 ggcctgatca cctaggagag ccactcctgg tggccatgag agagaccctg gaggccctga
      541 actccttggg attctcagtg ggacagccag agatggctcc ccagagtgag cccagggatg
      601 ggttcagtaa tgcccaggag aagatgtcat ccagaggaga gagcacactg cactcctgct
      661 cagggcatga gactcctggc cagaaagaag gcatccacac agaacaagct gaagctcctt
      721 gtatgggcag ccaggccagt accccacaga aggccgaacc tgcaggctct gtcccagggg
      781 aggaatggat gattcggaag gtgaaggtag aggatgagga tcaggaggca gaggaggagg
      841 tggaatggcc ccagcatctc tccttccttc ccagtccttt tcccactcct gacttgggtc
      901 agttggctgt tacgtacaaa ctggagccag ggactccggg agcactaggt ggaatcgcgc
      961 tgtccgggtg ggccccgatc cctgagaagc cttatggctg cgaggaatgc gagcggcgtt
     1021 tccgggatca gctaactctg cggctccacc agaggttgca ccggggtgag ggtccttgtg
     1081 cctgcccgga ctgtggccgc agcttcacgc agcgtgctca tatgctcctg caccaacgca
     1141 gccaccgcgg agagcgtccc ttcccgtgct cagagtgcga caagcgcttc agcaagaagg
     1201 cccacctgac ccgccacctg cgcacgcaca ctggcgagcg tccctacccg tgcgctgagt
     1261 gcggcaaacg cttcagccag aagattcacc taggctcgca tcagaagacc cacaccggag
     1321 agcggccctt cccctgcacc gaatgcgaga aacgtttccg caagaagacg catctgatcc
     1381 gccaccagcg tatccacacc ggcgagaggc cctaccagtg cacccagtgc acgcgcagct
     1441 tcacacacaa gcaacacctg gtgcggcacc agagggtgca cgatgctgct agccgcaccc
     1501 ggtcctctcc agacattcct gttgctcccc attcccccac cgcgtctctt accccgtccc
     1561 ctcctgggcc caagcctttc gcttgttccc actgcgggca gagcttcggc tggaaaaaga
     1621 acctcgctac gcaccagagt ctgcatctca ccgagggtcg tccttttggg tgcgatgaat
     1681 gtgcactcgg caccaacgtg gaccccgccg ccgagccctc ggcctgcact ccccatgcgc
     1741 ctgactgtgg accgggttcg gggcccgcgg caccccagcg caccacctcc agcgagcgct
     1801 ccttcttctg cccggactgc gggcgaggct ttgcccacgg gcagcacctg gcccgccacc
     1861 ggcgggtgca cacgggcgaa aggccatttg cctgtgctca gtgtggccgc cgcttcggct
     1921 cacgacccaa tctagtcgcc cactcccggg cccatagcgg cgccagacct tttgcctgtg
     1981 cgcaatgtgg ccgccgcttc agtcgcaaat ctcacctggg ccgccaccag gcagtgcaca
     2041 ctggtagtcg cccccacgcc tgcgccgtct gcgcccgctg cttcagctct aaaaccaacc
     2101 tggtccgcca tcaggcaatc catacaggtt cccgcccctt ttcctgccct cagtgcgcca
     2161 agagcttcag ccgcaagacc catctggtgc ggcaccaacg catccatggg gacgcggccc
     2221 tcccagcccc agcctcgaac ctctctgctc cagcctggtc caatccctcc gaggtggtac
     2281 cacctccaat ctttttctaa gcgaagttct gaccctcatc ctgcctttcc tgacagattt
     2341 gggagactca tatctggaga cttagtgggt tttcaacatt cacacctaag ttgctgccaa
     2401 agcaccagga cacttgggcc atttctttaa ttgtcctttc tttaatgtta gttgagaagt
     2461 ccagaaaaac ttagctcttg acagttgtga caacacacag agactatcct tgcagatacc
     2521 acgctgagaa acagacattt atggggatca gccaggtcaa ggggagattg actgagcaag
     2581 agacctctaa atagaggata agaatagtta tttatgtact tgaagttcat taaagttcag
     2641 atctgaggtt ctggagctgt taactgagcc actgaaggaa aacctgactc tttattcgct
     2701 gccacttcca tccacaggaa aaagaccttt tctgtcagtc cagggacgta aacttagcta
     2761 ggtggttttt cccaacaaag tgcaagatgc acacaggcca aacaactacc atggtcccgc
     2821 aagtgcgcgc gcgcgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgacagaaa
     2881 tttggctcag agggagtagg tgaggaccag aggggacagg ctgctcttgg gcgctcccag
     2941 gggaccagca ctgttactct aggtgctgct gcggctccat accacctgtt tccaggcctt
     3001 caagaggctt cccagaagca tccttaccta tctctgccta ggaggtacag aaggaggcag
     3061 tgcgtgaaca ggccataaag gttgtttgtg tatcactttt cccaccagtt gtctcctttt
     3121 gaggactgct tgagcctgca ggcactgcaa ctgtacaccc cgctgtgact gaagcacagg
     3181 ggctgggctg cctgacagtg aaggagcagt cagggcatgg ggtgtgagtt tagagagaac
     3241 tattttgggt tcaacctcac agaggacttg gagggaatcc tttactctcc cggaacttca
     3301 atttctcatt aaaatgagag ctggtgttga tgaaagctga gagtactttc tatcctattg
     3361 ttagattact aacaacaaaa atacccaagg caatggtctc ctgggtgcta agcactggga
     3421 aggatcagga gccatcacag cttaagtagg tttcctggtt tgtgttactg ttgctgggat
     3481 aaaatactga ccttggcttt ccaagggtgg ctttcacgtc tacattgatg cccctggagt
     3541 gatagtcaac gttttctttg ctgttcattg ttgaaccaat aaagtctgtg aaccctaaag
     3601 aaaaaaatac tgaccttgaa aaaaaaaaa
//
