LOCUS       NP_001357580             470 aa            linear   ROD 14-JUN-2024
DEFINITION  zinc finger protein 436 isoform 2 [Mus musculus].
ACCESSION   NP_001357580 XP_006538792
VERSION     NP_001357580.1
DBSOURCE    REFSEQ: accession NM_001370651.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 470)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Zhang,D., Harry,G.J., Blackshear,P.J. and Zeldin,D.C.
  TITLE     G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
            factor X4 variant 3 (RFX4_v3) and functions as a transcriptional
            co-activator
  JOURNAL   J Biol Chem 283 (13), 8580-8590 (2008)
   PUBMED   18218630
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Garrett-Engele,C.M., Tasch,M.A., Hwang,H.C., Fero,M.L.,
            Perlmutter,R.M., Clurman,B.E. and Roberts,J.M.
  TITLE     A mechanism misregulating p27 in tumors discovered in a functional
            genomic screen
  JOURNAL   PLoS Genet 3 (12), e219 (2007)
   PUBMED   18069898
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (residues 1 to 470)
  AUTHORS   Denny,P. and Ashworth,A.
  TITLE     Mapping of two zinc finger protein genes to mouse chromosomes 4 and
            7
  JOURNAL   Mamm Genome 6 (9), 683 (1995)
   PUBMED   8535085
REFERENCE   7  (residues 1 to 470)
  AUTHORS   Danciger,M., Brady,J., Adamson,M.C., Farber,D.B., Piatigorsky,J.
            and Kozak,C.A.
  TITLE     Chromosomal localization of the genes for five zinc finger proteins
            expressed in mouse lens
  JOURNAL   Genomics 28 (1), 39-43 (1995)
   PUBMED   7590745
REFERENCE   8  (residues 1 to 470)
  AUTHORS   Brady,J.P. and Piatigorsky,J.
  TITLE     Cloning and characterization of a novel zinc-finger
            protein-encoding cDNA from the mouse eye lens
  JOURNAL   Gene 124 (2), 207-214 (1993)
   PUBMED   8444344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935264.12.
            
            On May 20, 2019 this sequence version replaced XP_006538792.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.2217895.1,
                                           SRR7652917.564742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     Protein         1..470
                     /product="zinc finger protein 436 isoform 2"
                     /note="zinc finger protein 436; zinc finger protein MLZ-4"
                     /calculated_mol_wt=54097
     Region          14..82
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          140..160
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          163..>470
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          168..188
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          196..216
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(201,203,205,207..208,211..212,215,229,231,235..236,
                     239..240,243,257,259,261,263..264,267..268,271)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          224..244
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          252..272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          280..300
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          308..328
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(313,315,317,319..320,323..324,327,341,343,347..348,
                     351..352,355,369,371,373,375..376,379..380,383)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          336..356
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          364..384
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          392..412
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(397,399,401,403..404,407..408,411,425,427,431..432,
                     435..436,439,453,455,457,459..460,463..464,467)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          420..440
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          448..468
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..470
                     /gene="Zfp46"
                     /gene_synonym="Mlz-4; Zfp-46; Znf436"
                     /coded_by="NM_001370651.2:450..1862"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:22704"
                     /db_xref="MGI:MGI:99192"
ORIGIN      
        1 maatllmsgt qapvtfedma myltreewrp ldptqrdlyr dvmqenygnv vsldfeirse
       61 neanpkqefs ddvefatmse eplenaeknp gseeafesgd qaerpwgdlt aeewvsyplq
      121 qvtdllvhke ahagiryhic sqcgkafsqi sdlnrhqkth tgdrpykcye cgkgfsrssh
      181 liqhqrthtg erpydcnecg ksfgrsshli qhqtihtgek phkctecgks fcrlshliqh
      241 qrthsgekpy eceecgksfs rsshlaqhqr thtgekpyec hecgrgfser sdlikhyrvh
      301 tgerpykcde cgknfsqnsd lvrhrrahtg ekpyhcnecg enfsrishlv qhqrthtgek
      361 pyectacgks fsrsshlith qkihtgekpy ecnecwrsfg ersdlikhqr thtgekpyec
      421 vqcgkgftqs snlithqrvh tgekpyecte cdksfsrssa likhkrvhtd
//
