LOCUS       NM_177811               3331 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 459 (Zfp459), mRNA.
ACCESSION   NM_177811
VERSION     NM_177811.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3331)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3331)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3331)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 3331)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3331)
  AUTHORS   Krebs,C.J., Larkins,L.K., Price,R., Tullis,K.M., Miller,R.D. and
            Robins,D.M.
  TITLE     Regulator of sex-limitation (Rsl) encodes a pair of KRAB
            zinc-finger genes that control sexually dimorphic liver gene
            expression
  JOURNAL   Genes Dev 17 (21), 2664-2674 (2003)
   PUBMED   14563677
REFERENCE   7  (bases 1 to 3331)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154510.2.
            
            On Apr 9, 2011 this sequence version replaced NM_177811.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036923.1, BC100389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC154510.2         116597-116673       c
            78-204              AC154510.2         109089-109215       c
            205-300             AC154510.2         108363-108458       c
            301-3331            AC154510.2         100967-103997       c
FEATURES             Location/Qualifiers
     source          1..3331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..3331
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /note="zinc finger protein 459"
                     /db_xref="GeneID:328274"
                     /db_xref="MGI:MGI:3040701"
     exon            1..77
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            78..204
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..884
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /codon_start=1
                     /product="zinc finger protein 459"
                     /protein_id="NP_808479.1"
                     /db_xref="CCDS:CCDS26615.1"
                     /db_xref="GeneID:328274"
                     /db_xref="MGI:MGI:3040701"
                     /translation="MLSFRDVAVDFSAEEWECLEPAQWHLYRDVMLENYSHLVFLGLA
                     DSKPQLVTFLEQRQGSTGEERQAVKAVFPGITPNDPNHYSKPTNCESLLLKRRRINTG
                     EKPYKCEECGKALSSHKTLSIHQRLHTGDKPYKCEVCHKAFCAPSSLFIHQKNHTDEK
                     NFKCEDCGRTFYYLSMLKQHQRIHSGEKCYKCKNCGYASYDPSFLEQHQKINCREKCY
                     KCEDCHKAFHHQPLGYTREFILERNLSNVKSVADVLGYLNPLSNIKKST"
     exon            205..300
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /inference="alignment:Splign:2.1.0"
     exon            301..3331
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1467..1472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /note="hexamer: AATAAA"
     polyA_site      1485
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /note="major polyA site"
     regulatory      3302..3307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /note="hexamer: AATAAA"
     polyA_site      3323
                     /gene="Zfp459"
                     /gene_synonym="9930025G17Rik; Rslcan-14"
                     /note="major polyA site"
ORIGIN      
        1 aacactcgtc aatcttcccg aaagttggac tggagtcctg tgatgctgaa gattcctgta
       61 gcatctctga cttagaggaa atgctgtcat tcagggatgt ggccgttgat ttctctgcag
      121 aagagtggga atgcctggag cctgctcagt ggcatctgta cagggatgtg atgctggaga
      181 attacagcca ccttgtgttc ctggggcttg ctgactctaa gccacagctg gtgacatttc
      241 tggagcaaag acaaggctct actggtgaag agagacaagc agtaaaagca gtgttcccag
      301 gaataacacc caatgatcct aaccattaca gcaagcccac taattgtgaa tcactccttc
      361 ttaaacgaag aagaattaat acaggggaga aaccctacaa gtgtgaagaa tgtggtaagg
      421 cccttagttc tcataaaaca ctttctatac accagagact tcatactgga gacaaaccct
      481 acaagtgtga agtgtgtcat aaggccttct gtgctccctc atcacttttt atacaccaga
      541 aaaatcatac tgatgaaaaa aacttcaagt gtgaagactg tggcagaaca ttttactatc
      601 tttcaatgct gaagcaacat cagagaattc attctgggga gaaatgttac aagtgcaaaa
      661 attgtggata cgcttcttat gacccttcat tccttgagca gcatcaaaaa attaattgta
      721 gggagaaatg ctacaagtgt gaagactgtc acaaagcctt tcatcatcag cccttaggat
      781 acacaagaga gttcatactg gagagaaacc tttcaaatgt gaaaagtgtg gcagatgttt
      841 tagggtatct aaatccctta agcaacataa aaaaatccac ttaaaaaagg aaccctacac
      901 ctgccaagac tgtggcagat ctttttcaaa ttatttgaga cttagacgac atgaagtgat
      961 tcattctgaa tataatcctc acaagtgtga aaaatgtgac aaaaggtttt cccattctgc
     1021 aaatcttcgg aaccatcaaa gagttcatag tagagagaga ccttgcaagt gttaagcatg
     1081 tcaccaagcc ttttaaatat cgttcaaccc tttcgaaaca caagaacact catgcaagag
     1141 agaaatccta ccagtgtgaa gatgtggtat gatggtttgt atatgcttgg ctcagggagt
     1201 tgcagtatta ggaggtgtgg ccttgttgga gtaagtgtgt caatgtgggt gtgggggtgg
     1261 gcgctaatac ccttgtccta caagccagtc ttgtagcagc cttcagatga agatgtacaa
     1321 ctcttagctc ttcctgcacc atgtctgcct ggatgctgcc atgctcctgc cttgatgata
     1381 atagactaag tctttaatct gtaagcaagc ctctattaag tgttgttctt acaagagttg
     1441 ctttggttat ggtgtctgtt cacagcaata aacccctaag acatatggga agtgtgataa
     1501 agcctagtta atcttgatag ccttactcaa cacaggatag ttcataatgg agtgaagtcc
     1561 tatgaatttt taaaatattt aatcttcttc cactcttaaa acaaatctgt gctgcccagt
     1621 tttatgtcag cttgacaggc aaactagagc tatctgaaag gacagaactt caactgagta
     1681 aatgtttgca taagatccag ctttaactgt tttcttaatt agtgattgat gggagggccc
     1741 agcccattgt gagtgcggtc attcctgagc tgggaggcct ggattgtata agaaagcaga
     1801 ttgagcagtc catagggagc aagcatccct ccatgccctc ctctatgtga gttctttttt
     1861 tttttttttt tgaggcaggt tttttctgtg tagccctggc tgtcctggaa ctcactttgt
     1921 agaccaggct ggcctcaaac tcagaaatcc gcctgcctct gcctcccaag tgctgggatt
     1981 aaaagcgtgt gccaccacgc ccggccccta tgtgagttct tgtcctggct tcctttaata
     2041 atggactaca atgtgttggt gtaactcaaa ccctttcctg cccaacttgc ttcagtagta
     2101 gtgtttctta gaagcaatag gaaccccaat tgactgacta aggcaacact cattctgact
     2161 acaaactcca tgagtgtgtg gaatatggtg aaatgtttgc taacaattca gattttatcc
     2221 aattcaaaag gatctgcagt gaagactatt aagtgaatta ttttggaata tcaacacaaa
     2281 catcttactt ctaatagcac aaatgctaag aaagtcacca gaagctgggt ggtggtggtg
     2341 cacaccttta atcccagcac ttgggaggca gaggcaggtg gatttctgag ttcgaggcca
     2401 gcctggtcta caaagtgagt tccaggacgg ccggggctat acagagaaac cctgtctcaa
     2461 aaccctccta ccccccaaaa aaagtcacca gaggagtaga gacttctctt tgatgtaacc
     2521 tccccaccaa tgtgttcaac caatgtgctt gaatcttgca tggatggatg agtttcatcc
     2581 ctctgtaact atatatattt catgaaactg ttgctctgtt gtataacttg gtcctttggg
     2641 tgcctggaat ctgatttgtg ggctgtggta cagtttctgt tgttttaacc agtggcggtg
     2701 tcacccatac tctttaaata acgcattccc tgggtgtgta agaagctcca taaactcaca
     2761 ttcctcacca acttggactt tatgaagatg atttacattg gatctaatct aagctaactg
     2821 gccactagtg tttgtgtccc caggaaaagc taacagaaat cattgtcagt tgtatttggc
     2881 ttcagaatga agaatctctt cattttcttt aaacctatag attgtttttc atatgactcc
     2941 aactgtcatg tcatagaact tggcagcata ttgaaataat aattgaaaag atgcatttga
     3001 ttagtatgta tatgatgtca atcatgaaac attgtagatg cagttcttac ataaataact
     3061 attgataggg atcctaaaag tgatctcaca gttgtgttta ttcatttatg ggaacactta
     3121 tattagggcc attaaaacct aaaagttatc agtcattaac ttagaaatga tcaaatatct
     3181 ctaatgtgcc caaattttgt ttttagtcat gctaagtata aaatgaaatt taataagtac
     3241 aagatgggag ggagagacca atttatatct gtcattttat agttttctgt ttatactatt
     3301 aaataaagta catcctaaaa caagtttaaa a
//
