LOCUS       NM_133817               4030 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger protein 451 (Zfp451), transcript variant
            1, mRNA.
ACCESSION   NM_133817
VERSION     NM_133817.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Peng,H., Zhang,Y., Min,J., Tan,Y. and Liu,S.
  TITLE     Loss of ZNF451 mediates fibroblast activation and promotes lung
            fibrosis
  JOURNAL   Respir Res 25 (1), 160 (2024)
   PUBMED   38600524
  REMARK    GeneRIF: Loss of ZNF451 mediates fibroblast activation and promotes
            lung fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Zhang,Y., Wang,W., Min,J., Liu,S., Wang,Q., Wang,Y., Xiao,Y.,
            Li,X., Zhou,Z. and Liu,S.
  TITLE     ZNF451 favors triple-negative breast cancer progression by
            enhancing SLUG-mediated CCL5 transcriptional expression
  JOURNAL   Cell Rep 42 (6), 112654 (2023)
   PUBMED   37342906
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Antonio Urrutia,G., Ramachandran,H., Cauchy,P., Boo,K.,
            Ramamoorthy,S., Boller,S., Dogan,E., Clapes,T., Trompouki,E.,
            Torres-Padilla,M.E., Palvimo,J.J., Pichler,A. and Grosschedl,R.
  TITLE     ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell
            differentiation
  JOURNAL   Genes Dev 35 (15-16), 1142-1160 (2021)
   PUBMED   34244292
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   Koidl,S., Eisenhardt,N., Fatouros,C., Droescher,M., Chaugule,V.K.
            and Pichler,A.
  TITLE     The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability
  JOURNAL   Int J Biochem Cell Biol 79, 478-487 (2016)
   PUBMED   27343429
  REMARK    GeneRIF: a regulatory role of ZNF451-1 in fine-tuning physiological
            PML levels
REFERENCE   6  (bases 1 to 4030)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4030)
  AUTHORS   Karvonen,U., Jaaskelainen,T., Rytinki,M., Kaikkonen,S. and
            Palvimo,J.J.
  TITLE     ZNF451 is a novel PML body- and SUMO-associated transcriptional
            coregulator
  JOURNAL   J Mol Biol 382 (3), 585-600 (2008)
   PUBMED   18656483
REFERENCE   8  (bases 1 to 4030)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 4030)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 4030)
  AUTHORS   Eggenschwiler,J.T., Espinoza,E. and Anderson,K.V.
  TITLE     Rab23 is an essential negative regulator of the mouse Sonic
            hedgehog signalling pathway
  JOURNAL   Nature 412 (6843), 194-198 (2001)
   PUBMED   11449277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163668.5, AK015797.1, AK030088.1 and AI596398.1.
            
            On Mar 19, 2014 this sequence version replaced NM_133817.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030088.1, SRR1660817.264543.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC163668.5         79434-79459
            27-168              AK015797.1         2-143
            169-3818            AK030088.1         2-3651
            3819-4026           AI596398.1         3-210               c
            4027-4030           AC163668.5         132485-132488
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 12.81 cM"
     gene            1..4030
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /note="zinc finger protein 451"
                     /db_xref="GeneID:98403"
                     /db_xref="MGI:MGI:2137896"
     exon            1..258
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..3408
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     SUMO-protein ligase ZNF451; E3 SUMO-protein transferase
                     ZNF451"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase ZNF451 isoform 1"
                     /protein_id="NP_598578.1"
                     /db_xref="CCDS:CCDS14865.1"
                     /db_xref="GeneID:98403"
                     /db_xref="MGI:MGI:2137896"
                     /translation="MGDPGPEIIESVPPAGPEASESTTDENEDDIQFVSEGPLRPVLE
                     YIDLVSSDDEEPSTSHSDENFKCKDYIDHQKDKVALTLARLARHVEVEKQQKEEKNRA
                     FREKIDFQHAHGLQELEFIQGHSETEAARQCVDQWLKMPGLRTNAANSGTKRSFQRGG
                     RMWRSEKPILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPLANSFACAVCY
                     EHFVTQQQYKDHLLSRTAAADGHSNSLLPQIIQCYACPQCFLLFSTKDECLKHMSTKN
                     HFHQSFKLSDNKGTARPISFPSFAKKRLVSLCKDVPFQVKCVACHQTLRSHMELTAHF
                     RVRCQNAGPVAIAEKSITQVAKEFIVRGYCSDCNQVFMDVASTQSHKNSGHKITLANS
                     VEESVLLYCHISEGSRPPCDLHLFSQPKISSLKRILSVKESSAEDCIVPTKKVNLGVE
                     SLGGATRVQRQSPAVTAWFCECRRQFPSEEAVEKHVFSANTMCYKCVVCGKVCEDSGV
                     MRLHMSRFHGGAHLNNFLFWCRTCKKELVKKDAIMAHITEFHSGHRYFYEMDEVEEEE
                     EEAMPSSSVESHLNTDKPPSPIAVVDHCPANSPPRGRWQCRICEDMFESQECVKQHCM
                     SLTSHRFHRYSCAHCRKTFHKVETLYRHCQDEHDSEIMMKYFCGLCDLIFNKEEEFLS
                     HYKEHHSIDYVFVSEKTKTSIKTEGDFKIVETSSLLSCGCHESYMCKINRKEDYDRCL
                     PVLLEKGRLWFRCSSCSATAQNVTDINTHVCQVHRKEKSEEEQQYVIKCGICTKAFQN
                     TESAQQHFHRKHAALQKPTATPGGANRSSTCQLAASASHAEKNLKQPSSQKHSDVEKG
                     AEHDVRCQNIEEEVELPDVDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQG
                     GNTNWKPPLSCKVYNYLSRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFT
                     ILSGDQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDSSGMK
                     GSPAEELRATEDVELEEAIRRSLEEM"
     exon            259..342
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            343..423
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            424..549
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            550..661
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            662..812
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            813..939
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1093
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1241
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..2836
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2977
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3108
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3295
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3361
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..4030
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4005..4010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /note="hexamer: AATAAA"
     polyA_site      4026
                     /gene="Zfp451"
                     /gene_synonym="4930515K21Rik; 4933435G09Rik; COASTER;
                     Kiaa0576-hp; mKIAA1702; Znf451"
                     /note="major polyA site"
ORIGIN      
        1 aatccctcgc ggggcgggag gaaggcgggg agcgtacaaa gcggcgctgg aagctagcgg
       61 cagtgaggcc gcgcttgggg tccggcagct tggcgtcccc gcggcctgag gcgtcagctg
      121 cgtgggcgct cacgcagggc gggtcgcgcg gcgccgggcg agagggaagt cgtggcggcg
      181 gcgtcgggaa cagcagcggc ggcggcggga gcgtggtgct gacaggccgt gggagaaatg
      241 ggagacccag ggccggagat aatagaatct gtcccaccag ctgggcccga ggcatcagag
      301 tctaccacgg atgaaaacga agatgacatt cagtttgtta gtgaaggacc gttaagaccc
      361 gttttggaat acattgatct agtcagcagt gatgatgaag agcctagtac ctctcacagt
      421 gatgagaatt ttaaatgcaa agactatata gatcaccaga aggataaagt tgctttaact
      481 ttggctcgcc tggcccgcca tgttgaagta gaaaaacaac agaaagaaga gaagaacagg
      541 gcatttaggg aaaaaattga ttttcagcac gctcatggtt tacaagagtt ggagtttatt
      601 caaggacatt cagaaacaga agcagcaaga cagtgtgtgg accagtggct aaaaatgcca
      661 ggactcagaa caaatgcagc taattctgga acaaaaagat cattccaacg tggaggcagg
      721 atgtggaggt ctgagaagcc aattttgtgt cctataatgc actgtaacaa ggaatttgac
      781 aatgggcacc ttctgttggg acatttgaaa aggtttgatc actccccatg tgatcccaca
      841 attacgttac atggacctct ggctaattcg tttgcatgtg cagtgtgcta tgaacatttc
      901 gttactcaac agcagtacaa ggaccatctt ctctccagga cagctgcagc cgatggacat
      961 agcaatagcc ttcttcctca gattattcaa tgttatgctt gtccacagtg cttccttttg
     1021 tttagcacca aggatgagtg tttgaagcat atgtctacaa agaatcattt ccatcagagc
     1081 tttaaactga gtgataataa aggaacggcc cgcccaatat catttccatc ttttgcaaag
     1141 aagcgtttgg tctctctgtg caaagatgtt ccatttcagg ttaagtgtgt ggcctgccac
     1201 cagactctgc gttctcacat ggagctcact gcccatttca gggttcgttg tcaaaatgct
     1261 ggacctgttg ctatagctga aaaaagcatt actcaggttg caaaagaatt catagtaaga
     1321 ggttattgtt cagattgcaa ccaggtcttt atggatgtag ccagcaccca aagtcacaag
     1381 aattcaggac acaaaattac acttgcgaac tcggtggaag aatctgtctt gctttattgc
     1441 cacatcagtg aagggagtcg gcctccttgt gatttacatt tatttagtca accaaaaatt
     1501 tcatcactta aacggattct gtccgttaaa gagtccagtg cagaggattg tatcgttccg
     1561 acaaagaagg tgaacttagg tgttgaaagc cttggaggtg caactcgtgt gcagaggcag
     1621 agtccagcag tcacagcctg gttttgtgaa tgcagacggc agtttcccag tgaagaggcg
     1681 gtagaaaagc atgttttctc ggcaaacaca atgtgttata agtgtgtggt ctgtggaaag
     1741 gtttgtgaag attcgggggt catgcgttta cacatgagcc ggtttcatgg aggggcgcat
     1801 ttaaataact ttctattttg gtgtcggacg tgcaaaaagg agttagtaaa gaaagatgcc
     1861 atcatggcac acattactga gtttcatagt gggcatagat atttttatga gatggatgag
     1921 gtagaggagg aagaggagga ggccatgccg tcatcctctg tggagagcca tttgaatact
     1981 gacaaacctc cttcacccat tgctgttgtt gatcactgcc cggccaacag tcctcccagg
     2041 ggcaggtggc agtgccgcat ctgtgaggac atgtttgaat cccaggagtg tgtgaagcag
     2101 cactgcatgt ccttgacaag ccaccggttt cacagataca gctgtgccca ctgcagaaag
     2161 actttccata aagtggaaac tctgtaccga cattgccagg acgagcatga cagtgagatc
     2221 atgatgaagt acttctgtgg gctttgtgat ctcattttta acaaggaaga agaatttctg
     2281 agtcactata aggaacacca cagcatagat tatgtgtttg tgtcagaaaa aactaaaacc
     2341 tcaattaaaa ctgaaggcga ttttaaaata gtagagacca gtagtttact aagctgtggc
     2401 tgtcatgaga gttacatgtg taaaatcaac agaaaggaag actatgaccg atgccttcca
     2461 gtcctgctgg agaaaggtag gctgtggttt cgctgcagct cgtgctcagc cacagcacag
     2521 aatgtgaccg acattaacac tcacgtctgc caagtgcaca gaaaagagaa aagtgaggag
     2581 gagcagcagt atgtgatcaa gtgtggcatc tgcaccaagg cattccagaa cacggagagc
     2641 gctcagcagc acttccacag gaagcacgcg gccctccaga aacccaccgc gaccccaggg
     2701 ggagccaaca gaagcagcac atgccagctg gctgctagtg cctcacatgc tgagaaaaac
     2761 ctgaaacagc ctagctctca gaaacattca gacgtggaaa aaggagctga gcatgatgta
     2821 cgctgccaga acatagagga ggaagttgag cttccggatg tggactacct gcggaccatg
     2881 actcacatag tctttgtaga ttttgataac tggtccaact tttttggtca tctacctggg
     2941 catcttaatc aaggaacgtt tatttggggc tttcaagggg gaaacaccaa ctggaagccc
     3001 ccgctcagct gtaaggtcta taattacttg agcaggattg gctgcttctt ccttcatcct
     3061 cgctgcagta aaagaaaaga tgccgcggat tttgccatat gtatgcatgc tggccgtcta
     3121 gatgagcaac ttcccaaaca aattcctttc accatcctct cgggagacca aggctttctg
     3181 gagctagaga atcaatttaa gaagacccag aggccagctc atatactaaa ccctcaccac
     3241 ttagagggag acatgatgtg tgccttgtta aatagcatat ctgatactac caaagagtgt
     3301 gacagtgacg atagctcggg gatgaaagga tctccagcag aggagctcag ggccacggag
     3361 gatgtggaat tagaagaagc tattagaaga agtcttgagg agatgtaatt aaagatatta
     3421 ccacacagca tcaagtggcc ttgaagagac tcaggaaaat gaaaccttga ccctgttttc
     3481 taaaagagac caggaagcta ctaggataaa tgtatcccaa acgtgttctt ttctatgttc
     3541 agaatctcgt atttgctttg tattttgtgc tattatgtaa ataatgaatg gaaggaagag
     3601 aatgcatacc aatggaaaca taaactcata ttctaatatg atgggtgaca cgtttctcca
     3661 actaacgcag aattcatgca tttgggttac agccgttttc taggaggaaa ggtgtgtaaa
     3721 gttctctttc cttagcagtg cgtctttttt tgtactttac aaatgactct tttatttttt
     3781 taggaatgaa aatgaatata aataaaaggt gccataactc agtttttttc cagaaattct
     3841 ctgtgttatg tgaccctaat gtataatata ccttggagat gactgtttat gattattaga
     3901 agagagcgat acacattgat cacagaaaca gattcaagtc agtgcggttc catgtgctat
     3961 tatgcagctg tatgcttgct ctgattacag ttgcacctta ccacaataaa aacatcttta
     4021 aagcaactaa
//
