LOCUS       NM_175558               3284 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus zinc finger protein 446 (Zfp446), transcript variant
            1, mRNA.
ACCESSION   NM_175558
VERSION     NM_175558.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3284)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   2  (bases 1 to 3284)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121301.8.
            
            On Apr 8, 2022 this sequence version replaced NM_175558.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041761.1, BC048909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC121301.8         53378-53642
            266-646             AC121301.8         54528-54908
            647-842             AC121301.8         54981-55176
            843-937             AC121301.8         55415-55509
            938-1019            AC121301.8         57376-57457
            1020-3284           AC121301.8         57649-59913
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.71 cM"
     gene            1..3284
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /note="zinc finger protein 446"
                     /db_xref="GeneID:269870"
                     /db_xref="MGI:MGI:2442185"
     exon            1..265
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1576
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 446 isoform 1"
                     /protein_id="NP_780767.1"
                     /db_xref="CCDS:CCDS20820.1"
                     /db_xref="GeneID:269870"
                     /db_xref="MGI:MGI:2442185"
                     /translation="MRKEANPQSAPSYVSPTAAVAREERLPSQEWEPPPELCSNATPR
                     RGAKSLARERPWKRAVVLAEAHGRRSPSEGGRSGGADAGLAGLVPLSPPKRPFKTRMP
                     SPRGTPHLSLRDSRTTLEEPEAARLRFRGFCYEEVEGPREALAQLRELCHQWLQPESS
                     SKEHIIELLILEQFLGVLPPEIQAWVRGQRPGSPEEAAVLVEGLQHDPGQLLGWITAH
                     ILKPKMLPLVQKESSGSHHISAATESSKAGLAEAPLKAGIDRSTQISCSVKEEVSADG
                     QEMVSPSALLSTQDSEGHLEHQETVSISFQTGRIQEWGLLDSSQKELCWGVMPEKYDT
                     VVSQASLPLLQPETHVDSELRPKQEMPHEGPESLRSHPPEVGAIADPRLVQATPSERQ
                     SPCKDPSVLSPTPLLEAPARPTPRKLYVCEQCGLSFDWKSVFIIHLRTHTRGPGLERP
                     SQVAREPAMKRSPGLRGYTCVECGRSFSWKSQLVIHRKSHAGQRRHFCRDCGCSFDWK
                     FQLVIHRKIHQPEGP"
     exon            266..646
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
     exon            647..842
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
     exon            843..937
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1019
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..3284
                     /gene="Zfp446"
                     /gene_synonym="A630035I11Rik; A930031C22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacatgcgt aaggaggcta acccacagtc ggctccgtcc tacgtgagtc ctacggctgc
       61 ggttgcaaga gaagaacggc tgccaagtca ggagtgggaa ccccccccgg aactctgcag
      121 caacgcgacc ccaaggagag gagcgaagag tctcgcgcgt gagaggcctt ggaagcgtgc
      181 tgtcgttctt gctgaggctc acgggagacg tagtccgagc gaagggggcc gatccggcgg
      241 agcagatgca ggattggccg ggctggtccc tctgtcacct ccaaaaagac ccttcaaaac
      301 aagaatgcca tctcctcggg gtaccccaca cctatccctc agagactcca ggaccaccct
      361 tgaggagcct gaggctgcac gactccgttt ccggggtttc tgctatgagg aggttgaggg
      421 accccgagag gcactggccc agcttcgaga gttgtgtcac cagtggctac agcctgagtc
      481 atcctccaaa gaacacataa tagagttgct gattttggaa cagttcctgg gtgtgttgcc
      541 ccctgagatc caggcctggg ttcgagggca gcgaccagga agccccgagg aggccgcagt
      601 tcttgttgag gggctgcagc atgatcctgg gcagctgctg ggctggatca cagcccacat
      661 cctgaagcca aagatgcttc ctctagtcca gaaggagtcc tcagggagtc accacatctc
      721 agcagcaacg gagtcctcca aggcaggcct tgcggaggca ccgctgaagg ccgggataga
      781 tcgatctacc cagatcagtt gcagtgtgaa ggaggaagtc agtgctgatg ggcaggagat
      841 ggtatctcca agtgccctcc tttcaaccca ggattccgag ggacatcttg aacatcagga
      901 aacggtctcc atatccttcc aaacaggaag gatccaggag tggggcctgt tggactcatc
      961 acaaaaagag ctgtgctggg gtgtgatgcc ggagaagtac gacacagtgg tgtcccaggc
     1021 aagcctgccg ctgctacagc cagagacaca tgttgactct gagctgagac caaaacagga
     1081 gatgccacac gaaggaccag aatccctccg gagccatccc ccagaagtgg gagccattgc
     1141 agatccaagg ctagttcaag ccactccaag tgaaaggcag agcccttgca aggacccttc
     1201 agtcttgtct cccacaccac tgcttgaagc cccagcgagg cccacacctc ggaagctgta
     1261 cgtttgtgag cagtgtggcc tcagctttga ctggaagtcc gttttcatca tccacctccg
     1321 cacacacacg agagggccag gcctggagag accatcacag gtggcccggg agccggccat
     1381 gaagcgctcc cctggccttc ggggatacac atgcgtggag tgtgggcgca gcttcagctg
     1441 gaagtcacag ctggtcatcc accgcaagag ccatgcaggc cagcggcgcc acttctgccg
     1501 cgactgtggc tgtagctttg actggaagtt tcagctggtc attcacagga agatccacca
     1561 gccagagggt ccatgagtag ctggagaggc atgtctcacc ttggattcct ccatccccta
     1621 atgcaccact ttagcatcct ctctagccaa gaggaggttc taaggtaccc caaataggtc
     1681 agggattgca agaagattgc cctgtccaac accagactat ccagtgtaag gagaagaggc
     1741 tagtcccttc ctttggcccc tgctttgtgg agccaggcct gggttcgatg actaacctat
     1801 ccagcttgtg caaaaggtgg acactcccta cttcaggatg ctcagaaatt gcctcaggtc
     1861 cctccttgca gtggctgggc aagaagtctc tgtggaaggt actggaaacc acagttgcct
     1921 ttctcccctg ctgcatgtga cccttagaca aacatgctag atttgtttgt tttgttttgt
     1981 tttttgagac agggtttttt ctgtgtaacc ctggctatcc tggaacttac tctgaagacc
     2041 aggctggcct tgaactcaga aattcacctg cctctgcctc ccaagtgctg gaattaaagg
     2101 catgtgccac cactgcctgg ctaacatggt agatttttaa tgtaagttat acgtctataa
     2161 caatttctaa gtaaaactcc tgacttctag cttccattga ccaaaagagc agccgtgtgt
     2221 gctggctagc agactacagg aaccacaggg cagctgagcc ctaaaaggcc taattagtta
     2281 cttctctcct ccagcctacc tagtttcctg actacacaca ttgctcccca cccgccctgg
     2341 cctttgaact cctgaacttg aacttggatg aacaactgac tctcctttgg gtgcatgaga
     2401 gcacatgagt ggattctgag aagttagata acccatgggt acctcaggcc atgcatgctt
     2461 ctgggtgaag gctacaccgc acaatggcca gttaaactgg aagacaaagg gtcattcctt
     2521 gatgcccagg gaactgtgac cctcttaaca atcactcaga atttttcagt gcatggtggc
     2581 ctactaactc tgcctgtaaa ctaggtagag caaaacagat ttacttacta attgttccag
     2641 tgtcaaagca ctgaagcatg tctcattaga tcaaagacag acttaccctg ggagctaccc
     2701 gagacccttg gcttaggacc tctttttcca tctgcttaaa gagcctttga atggcatggg
     2761 tccccttaga tattccaggg tgatcacctg aagctcaggt gatgagatgg gagcttttct
     2821 tttgtttgag acagggtctc ctaatgcagc agctgctgcc tctaactggt gatcctcctg
     2881 tctcagcttc ctatgtgttg gaactatagg cttgtaccac caagcccagg ttggtatttt
     2941 aaactctctg tatatatgtt taagacagtc tcactttaat gccctcaaac tatctgtagt
     3001 ccttcaacct cagcccctga gtgttggaat taaagttgtg tgtcactgcg ccagactaag
     3061 actttaaata cttttgattt taaaatttcg aactatggag caggattcag tgctgtaggc
     3121 agatctctgt tagtttgagg tcagattgct ttgcatagtg tgttccagga cagccagggg
     3181 ctattgtgag accctgtctt aaaaataagt aaagagaaaa aaaataagta aagaaataag
     3241 caaataaatt ctgcagatgg gcacatcaaa gtgtcgtcta gaaa
//
