LOCUS       NM_001359934            6310 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus zinc finger protein 445 (Zfp445), transcript variant
            2, mRNA.
ACCESSION   NM_001359934 XM_006512117
VERSION     NM_001359934.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6310)
  AUTHORS   Takahashi N, Coluccio A, Thorball CW, Planet E, Shi H, Offner S,
            Turelli P, Imbeault M, Ferguson-Smith AC and Trono D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
  REMARK    GeneRIF: ZFP445 and ZFP57 act together, maintaining all but one
            imprinting control region in vivo
REFERENCE   2  (bases 1 to 6310)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 6310)
  AUTHORS   Yang D, Ma Z, Lin W, Yang J, Tian C, Wei H, Jiang Y and He F.
  TITLE     Identification of KAP-1-associated complexes negatively regulating
            the Ey and beta-major globin genes in the beta-globin locus
  JOURNAL   J Proteomics 80, 132-144 (2013)
   PUBMED   23291531
  REMARK    GeneRIF: KAP-1 may contribute to the repression of Ey and
            beta-major globin gene transcription through recruitment to the
            promoters of these two genes, mediated by the interaction of KAP-1
            with either Zfp445 or MafK, respectively
REFERENCE   4  (bases 1 to 6310)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6310)
  AUTHORS   Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L,
            Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J and
            Blackshaw S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   6  (bases 1 to 6310)
  AUTHORS   Purcell P, Joo BW, Hu JK, Tran PV, Calicchio ML, O'Connell DJ, Maas
            RL and Tabin CJ.
  TITLE     Temporomandibular joint formation requires two distinct
            hedgehog-dependent steps
  JOURNAL   Proc Natl Acad Sci U S A 106 (43), 18297-18302 (2009)
   PUBMED   19815519
REFERENCE   7  (bases 1 to 6310)
  AUTHORS   Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg
            I and Ko MS.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   8  (bases 1 to 6310)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6310)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 6310)
  AUTHORS   Agata Y, Matsuda E and Shimizu A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125374.4.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_001359934.2.
            
            On Jan 19, 2018 this sequence version replaced XM_006512117.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.10153.1,
                                           SRR10223969.9599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC125374.4         91101-91193
            94-729              AC125374.4         94763-95398
            730-898             AC125374.4         99469-99637
            899-993             AC125374.4         99946-100040
            994-1120            AC125374.4         100282-100408
            1121-1231           AC125374.4         102290-102400
            1232-6310           AC125374.4         103119-108197
FEATURES             Location/Qualifiers
     source          1..6310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..6310
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /note="zinc finger protein 445"
                     /db_xref="GeneID:235682"
                     /db_xref="MGI:MGI:2143340"
     exon            1..93
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     exon            94..729
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..3306
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 445 isoform 2"
                     /protein_id="NP_001346863.1"
                     /db_xref="GeneID:235682"
                     /db_xref="MGI:MGI:2143340"
                     /translation="MPPGRWHAARSAQVSREQGCLRMVKEEEEDGYISMQTARPQTLN
                     RPGQELFRQLFRQLRYHESSGPLETLSRLQELCRWWMRPDVLSKAQMLELLVLEQFLS
                     ILPGELRTWVQLHCPESGAEVVALLEELQRDLDGTPLKDPCLTQNPDVHWIGTSALQP
                     AQIWSPASHLKNSSALEDHLETSHGIGICDVLAEQTDSPAVSVPDYFQLEEGIEYQVT
                     ASKPLVIKLQEALTFQDVEVTFSQEEWGCLNSAQRNLYRDVILENYGNVVSVVGSSPK
                     PALISWLEARKPWGVNICTVQLKRDADAAPEGGKLQIKPNKFILKQKPSEYIEACVKT
                     SVSPETSVSEETGLKESFKQKSRLQTSCGDSIQMKEMKEGADISQRTGRESEVLRNND
                     ILELKHVKCVSVSRKRLSFKHGYDRNFRKSSHHYNNKYGEGLRGTGEGFGVYQNTGLK
                     ENGKDRYGETSRKSWHAHPEHRQPSYSEEGLFQCRVCGKAFKWRSNRIRHEKIHTGVK
                     PYQCSLCEKAFQRLSSYRLHQKTHSKQKRGSSKYKNALTCSLDVSHHLTDRDERKHLH
                     CNQCGKNFSCKSYAIEHQRIHTQEKPYKCTRCRKTFRWKSNFSRHMKLHHKEVYKQEK
                     RQEDFKQSYRQSQVISTVEKTFPCQNCGKTFTQKKSLIEHQRIHTGEKPYQCSGCGET
                     FTYRSSYIIHMKRTQHAIKIKPEHGCLTFSQGAVFPIPRGSHNTEGSNKCKYCGKAFH
                     NRSFLLIHERVHTREKPYQCRECEKAFRWSSNLYRHQRKHFLHKRYKYRESKETSNLQ
                     SKILIDQKPFWCQECGKTFTRKRSLLDHKGIHSGERRFKCNLCEKSFDRNYRLVNHQR
                     IHTTEQPQWRDKDFVGIHARSVDQRKHSNTLQSEYGLHSDKPGLSYCQDVRLNIQELS
                     GKLRKECDNPSDESSKSIAFQNVPTKKKACHKCSTCGKTFKKHSHLISHKRCHTKERP
                     FKCIVCGKTFRWSSNLTRHMKNHVRN"
     exon            730..898
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     exon            899..993
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1120
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1231
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..6310
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacttccgc tctcgcagag aggcccgcgg aggaagtggg ccctgggagc gaacagccat
       61 taggaagaat gctgagtgct ccggcgtgag tcggactgag ctcaatcatg tgtgcggata
      121 tcattttctt gtctcttctt ttctgaacat cagtgttggt tgttcattct tttaccagtg
      181 acttctgatg acctagcaaa taatgccaca cactgcaata ctgtgaagac actcgcaagg
      241 atacagcagt gatttagtga aagcaacaga tttcttttgt gttcatctgt gtgaccctgg
      301 ataggagtga tgcctccagg caggtggcat gctgcccgct cagctcaggt gtcaagggaa
      361 caaggctgcc ttcgaatggt aaaagaagag gaggaggatg gctatatttc aatgcagact
      421 gccaggccac agacacttaa ccgccctggc caggagctat tccgtcagct ctttagacag
      481 cttcgctatc atgaatcttc tgggccccta gaaactctga gccggctcca ggagctctgc
      541 cgctggtgga tgaggcctga tgttctttca aaagcacaga tgttagagtt gttggtcttg
      601 gagcaattcc tgagcatctt gcctggagag ctccggacat gggtccaact ccattgccct
      661 gagagtggtg cagaggttgt ggccctgctg gaagagctgc agagggatct tgatggaacc
      721 ccactgaagg atccatgtct tactcagaat ccagatgtgc attggatagg cactagtgct
      781 ctgcagcccg cacagatatg gtcccctgca tcacatctca agaacagttc tgctctagag
      841 gaccacttgg agacttcaca tggaatagga atttgtgacg tcctggctga acaaactgat
      901 tctcctgctg tctcggtgcc tgactatttc cagttagaag agggcataga ataccaggta
      961 acagccagca agcctttggt aatcaagctg caggaagctt tgactttcca ggatgtggag
     1021 gtgaccttct ctcaggaaga gtggggatgt ttgaactcag ctcagcgcaa tctttatcgg
     1081 gatgttatcc tggagaatta tgggaatgta gtttctgtgg tgggctcctc tcccaaacct
     1141 gctctgatct cctggctaga agccaggaag ccatggggcg tgaacatctg cacggttcag
     1201 cttaagagag atgctgatgc tgcgcctgaa ggaggtaagc ttcagattaa gccaaacaaa
     1261 ttcatcttga aacagaaacc ttctgaatac atagaagcct gtgtaaagac atcagtaagt
     1321 cctgagacaa gtgtttctga ggagacaggg ctcaaagaat cttttaaaca gaagagtagg
     1381 ctacagacgt cctgtggaga ctccatacaa atgaaagaga tgaaggaagg agccgacatt
     1441 agtcaaagga caggaagaga atctgaagta ttgagaaaca atgatattct tgagttaaaa
     1501 catgttaaat gtgtgagtgt ttctagaaaa aggctatcct ttaaacatgg ctatgacaga
     1561 aacttcagaa aaagttcaca ccattataat aataaatatg gggaaggact cagaggcaca
     1621 ggtgaggggt ttggtgtgta tcagaatact ggactgaaag aaaatggaaa ggacagatat
     1681 ggagagacct caaggaagag ctggcatgcc catcctgaac atcggcagcc aagctacagt
     1741 gaagagggcc tgtttcaatg cagggtgtgt gggaaagcgt tcaagtggcg ttcaaaccgt
     1801 atacggcatg agaaaattca cactggagtg aaaccttacc aatgcagctt atgtgagaaa
     1861 gctttccaac gtttgtcatc ctaccgtctg caccaaaaaa cccatagtaa acagaaacgt
     1921 ggatccagta agtacaaaaa tgccctcacc tgcagcttgg atgtcagtca ccatttgaca
     1981 gaccgggatg agaggaaaca cttacactgt aaccagtgtg ggaaaaactt ctcctgtaag
     2041 tcctatgcta ttgaacacca aaggattcac acacaggaga aaccttataa atgtaccaga
     2101 tgtaggaaaa cctttcggtg gaagtcaaac ttttctcgtc atatgaaatt acatcacaaa
     2161 gaggtgtata aacaagagaa acgtcaagaa gacttcaagc agagttacag gcagtctcag
     2221 gttatctcta ctgtagagaa aacttttcca tgtcagaatt gtgggaaaac ttttactcaa
     2281 aagaaatcac tcattgagca ccagaggatt catacagggg agaaaccgta ccagtgtagt
     2341 gggtgtggag aaacatttac ctataggtca tcttatatta ttcatatgaa gcgaacgcaa
     2401 catgctatta aaataaagcc tgagcatggc tgcctaactt ttagtcaggg tgcagtgttt
     2461 cccattcctc ggggtagtca taatactgag gggtctaata agtgtaaata ctgtggcaaa
     2521 gcctttcaca atcgctcatt tcttctcatt catgagagag ttcacactag agagaagccc
     2581 tatcagtgca gggagtgtga aaaagccttc cgatggagtt ccaatctcta ccgacatcag
     2641 agaaaacact ttttgcacaa gcggtataag tatcgtgaaa gtaaagagac ttcaaatcta
     2701 cagtcaaaaa ttctcattga tcagaagccc ttttggtgtc aagaatgtgg aaaaaccttt
     2761 acacgtaaaa gaagcctttt agatcataag ggaatacaca gtggagagag acgctttaag
     2821 tgcaacttgt gtgaaaaatc ttttgataga aactatcgac ttgttaatca ccagaggatc
     2881 cacactacag agcaaccaca gtggcgtgat aaagattttg ttgggataca tgcccgttct
     2941 gttgaccaga gaaaacacag caacacgctg cagtctgaat atggcctaca ttcagataag
     3001 cctggcttat cttactgtca ggatgtaagg ttaaatattc aggaactaag tggaaagctc
     3061 cgtaaagagt gtgataaccc ttctgatgag agttccaagt caattgcatt ccagaatgtg
     3121 cccaccaaga agaaagcctg ccacaaatgc agcacttgcg ggaaaacatt taaaaagcat
     3181 tcacatctta ttagccacaa gagatgtcac acaaaagaga ggcccttcaa atgcatagtg
     3241 tgtgggaaga ccttcaggtg gtcttccaat ttgactcggc atatgaaaaa ccatgttaga
     3301 aattagcctg gggtcttcga tgacagtggg ggtggggaat agttcttggt cacattctag
     3361 agaactttag tggtaggcac tggggaaaac ctttgtaaag gtccagtcct ttttggcttg
     3421 gatgttcttg gtgtggaatc ttgatgattt caaaactcag gaatttctca gtcttccttc
     3481 tggaaagaga tgttgaaaaa taacagaaag ttctctgggg tcttttaggg attctggccc
     3541 ctaggtttag cccaggcctc tgacagccag gtctccttag ataattcttg ctgtttgtga
     3601 ttattggaaa gcatgtctgt agcctagtaa gcgttgtctg ttgggaaggg cccatttaga
     3661 tccctagttc ttcagggtca gcttgtgttg gtgctgttct gctgacttta aaacctagaa
     3721 cttgtattct acatcagatg tctcctgggg gcccctggtt ggggcttcag tttataattg
     3781 gtttttggtt attagctatg gtcctaaagt agtctcagtg tcaagtgaaa aggacagggt
     3841 gctaggctcc gttgcttgat ctggacaggc agcattactc catcatttca gctaagatac
     3901 aagagcactc ctcatgtgcc agtgaccaga acagacaaaa accctgctgt ttggggatct
     3961 gtaagtcact aaatgagtta gatcctattt tggatggtga tatgtgttga ggacaaagtc
     4021 atccagagac gaatggcaag gaatctggtt aggatgtgga ttgtaatttt aaacaaactg
     4081 tccaggaaat aatgttactg acagtgaaac taagtaggac caggtgttag gaggcattga
     4141 catctctagg agttgcaaga cagacagaca aggctacata gagaaacctt atttcaaaaa
     4201 aataaaaaat aggataaata aacaagacac ccctcccccc aaacctaaca aacaaaatcc
     4261 ctaattgact aaaaagctaa aggaagttgg aattgggggt ggaggggttg agccatgttg
     4321 ctctattggg aaagagtgca agttagagaa ggtaggatct tatctggtga ctttagggta
     4381 atatagagtc ccttgggtgg agtagatgag ctcctgaaga atggaccaag ctttacagag
     4441 gtattgtttg cacattagtt ataatgtcgt gtctggtata gccctttgtt catagtcctg
     4501 attatcctgg aactttgtcc tttaagctct cctgctccta tttcttttga ggactatgcc
     4561 ttaactgcta gtgtgacctg ggttcccagt tatgcttgtc actgcagcct gaccacttgg
     4621 gaaagctgtg ctagggtgca tatgttgaca gattttgcaa aacaagtgaa aaatgctgct
     4681 tctccaatct gaaaaaaatg agtctgcaca gtgcttatgt tacctttgcc tgggttcagt
     4741 tcctagcatc tatgtggcag ctcacaacca ttggcaatcc cagagaatcc catgctctgt
     4801 cctgaatttt gtgtgctcca gacatgcaca tggctcacag acatgcaaac aaaacacgca
     4861 tacaaaatac attttaaaaa tagcatgggt atgaaaacaa atctgtattt tcaaattgcc
     4921 tctctgaaag aatctagttc tgccaagaca ggagtagaac tgtattttaa atgggtcttg
     4981 atcagatagg ttggggggta ctttataaaa caggccttga gtccagtatt gaatgaaagt
     5041 tgtactcaaa agtacacagc tgctaggtac gagcccaatt actgacgggt ttgagtagta
     5101 gagtgccagt tgacagattc tgattgtctt ggcaaccctg tctaatcttg aacttggcct
     5161 ggaaagcaca ggcttctttg agcatggcct ttccactgcc tgaggaactg aagttgggga
     5221 tggggatagg catatgggct gagaccatta tggagtaatg ggtatcagat ggcctcttaa
     5281 ctcacctggt tagtgtggtc agttacatcc ttactgaagg atatcaaacc acagtgtgca
     5341 gagaggaaac catgtaggct ttcttagtaa tctcttagag aagttagttt ttgaaagctt
     5401 aagtatgaaa tgggtggaat aacgggagtt cagatcccct tgtaagtaga ttgccagggg
     5461 acttggaaag gcttataaaa aaaaatgtgt gttctatctg tgtgtccctt cctggaccaa
     5521 tgtgaagaat gatgaacacg agtcaactca ctacaacagt gtttagatag tgggacctac
     5581 agaaccctgt ttgccgttag cagaacacac catgcagaag atgtttggta cttcagaaag
     5641 aatataaagc tcagtgtgga ggaacacact ctaatcctaa tgtgggatgc caaagcaaga
     5701 ggaccaaaag tgtaaagcca cttggggata acgaataata agatcctgtt caagcaacta
     5761 ccaccacaac aaaaatacac aattatagcg aatgtggaag acatatcctc gagcttagaa
     5821 tactacatga agagttgcag aagctgtata taatatacca tttatatgaa ttttaagcac
     5881 attcaaagtg ctcatatcac ttccactggt ttgggtttcc ttattctgta cgtgggatgg
     5941 agttctaacc tcatagggtg gtggtgggga cagtaataaa atgcatgtgt gacgttaaga
     6001 ctagtgtctg tcatataacc attcctgatg tatagtagag ttaatatttt gtcaattttc
     6061 tgtggattca aaaggcatga cataagagtg taaacttatg aaatgggttg atgtatgcta
     6121 tactgctcta tattctctca gtatgagatg ctagtgaaat cacaatggaa acgttcttca
     6181 cttgtttttc taattattga tgcagataca acctaagatt gttacaattt aacaggataa
     6241 tatggtgact tctttcaact gttaaaagta aataaaaata aacaaaaatt aatcatggcc
     6301 tctgacatct
//
