LOCUS       NP_001346863             998 aa            linear   ROD 02-MAY-2024
DEFINITION  zinc finger protein 445 isoform 2 [Mus musculus].
ACCESSION   NP_001346863 XP_006512180
VERSION     NP_001346863.1
DBSOURCE    REFSEQ: accession NM_001359934.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 998)
  AUTHORS   Takahashi,N., Coluccio,A., Thorball,C.W., Planet,E., Shi,H.,
            Offner,S., Turelli,P., Imbeault,M., Ferguson-Smith,A.C. and
            Trono,D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
  REMARK    GeneRIF: ZFP445 and ZFP57 act together, maintaining all but one
            imprinting control region in vivo
REFERENCE   3  (residues 1 to 998)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (residues 1 to 998)
  AUTHORS   Yang,D., Ma,Z., Lin,W., Yang,J., Tian,C., Wei,H., Jiang,Y. and
            He,F.
  TITLE     Identification of KAP-1-associated complexes negatively regulating
            the Ey and beta-major globin genes in the beta-globin locus
  JOURNAL   J Proteomics 80, 132-144 (2013)
   PUBMED   23291531
  REMARK    GeneRIF: KAP-1 may contribute to the repression of Ey and
            beta-major globin gene transcription through recruitment to the
            promoters of these two genes, mediated by the interaction of KAP-1
            with either Zfp445 or MafK, respectively
REFERENCE   5  (residues 1 to 998)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 998)
  AUTHORS   Purcell,P., Joo,B.W., Hu,J.K., Tran,P.V., Calicchio,M.L.,
            O'Connell,D.J., Maas,R.L. and Tabin,C.J.
  TITLE     Temporomandibular joint formation requires two distinct
            hedgehog-dependent steps
  JOURNAL   Proc Natl Acad Sci U S A 106 (43), 18297-18302 (2009)
   PUBMED   19815519
REFERENCE   7  (residues 1 to 998)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   8  (residues 1 to 998)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 998)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 998)
  AUTHORS   Agata,Y., Matsuda,E. and Shimizu,A.
  TITLE     Rapid and efficient cloning of cDNAs encoding Kruppel-like zinc
            finger proteins by degenerate PCR
  JOURNAL   Gene 213 (1-2), 55-64 (1998)
   PUBMED   9630514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125374.4.
            
            On Jan 19, 2018 this sequence version replaced XP_006512180.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.12107.1,
                                           SRR17784651.327290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.18 cM"
     Protein         1..998
                     /product="zinc finger protein 445 isoform 2"
                     /calculated_mol_wt=115922
     Region          48..160
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          231..289
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          445..472
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2V3.2)"
     Region          <461..611
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          484..504
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          499..519
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          512..532
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          566..995
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          648..668
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(653,655,657,659..660,663..664,667,737,739,743..744,
                     747..748,751,765,767,769,771..772,775..776,779)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          676..694
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          732..752
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          760..780
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          810..830
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          838..858
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          947..967
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          975..995
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..998
                     /gene="Zfp445"
                     /gene_synonym="mszf29; mszf50; ZNF168; Znf445"
                     /coded_by="NM_001359934.2:279..3275"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:235682"
                     /db_xref="MGI:MGI:2143340"
ORIGIN      
        1 mppgrwhaar saqvsreqgc lrmvkeeeed gyismqtarp qtlnrpgqel frqlfrqlry
       61 hessgpletl srlqelcrww mrpdvlskaq mlellvleqf lsilpgelrt wvqlhcpesg
      121 aevvalleel qrdldgtplk dpcltqnpdv hwigtsalqp aqiwspashl knssaledhl
      181 etshgigicd vlaeqtdspa vsvpdyfqle egieyqvtas kplviklqea ltfqdvevtf
      241 sqeewgclns aqrnlyrdvi lenygnvvsv vgsspkpali swlearkpwg vnictvqlkr
      301 dadaapeggk lqikpnkfil kqkpseyiea cvktsvspet svseetglke sfkqksrlqt
      361 scgdsiqmke mkegadisqr tgresevlrn ndilelkhvk cvsvsrkrls fkhgydrnfr
      421 ksshhynnky geglrgtgeg fgvyqntglk engkdryget srkswhahpe hrqpsyseeg
      481 lfqcrvcgka fkwrsnrirh ekihtgvkpy qcslcekafq rlssyrlhqk thskqkrgss
      541 kyknaltcsl dvshhltdrd erkhlhcnqc gknfscksya iehqrihtqe kpykctrcrk
      601 tfrwksnfsr hmklhhkevy kqekrqedfk qsyrqsqvis tvektfpcqn cgktftqkks
      661 liehqrihtg ekpyqcsgcg etftyrssyi ihmkrtqhai kikpehgclt fsqgavfpip
      721 rgshntegsn kckycgkafh nrsflliher vhtrekpyqc recekafrws snlyrhqrkh
      781 flhkrykyre sketsnlqsk ilidqkpfwc qecgktftrk rslldhkgih sgerrfkcnl
      841 ceksfdrnyr lvnhqrihtt eqpqwrdkdf vgiharsvdq rkhsntlqse yglhsdkpgl
      901 sycqdvrlni qelsgklrke cdnpsdessk siafqnvptk kkachkcstc gktfkkhshl
      961 ishkrchtke rpfkcivcgk tfrwssnltr hmknhvrn
//
