LOCUS       NM_001110309            3419 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus zinc finger protein 426 (Zfp426), transcript variant
            2, mRNA.
ACCESSION   NM_001110309
VERSION     NM_001110309.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3419)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3419)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 3419)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3419)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   5  (bases 1 to 3419)
  AUTHORS   Marine,J.C., Gilbert,D.J., Bellefroid,E.J., Martial,J.A.,
            Ihle,J.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   6  (bases 1 to 3419)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Matera,A.G., Bourguignon,C.,
            Desai,T., Healy,K.C., Bray-Ward,P., Martial,J.A., Ihle,J.N. and
            Ward,D.C.
  TITLE     Emergence of the ZNF91 Kruppel-associated box-containing zinc
            finger gene family in the last common ancestor of anthropoidea
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10757-10761 (1995)
   PUBMED   7479878
REFERENCE   7  (bases 1 to 3419)
  AUTHORS   Ihle,J.N., Smith-White,B., Sisson,B., Parker,D., Blair,D.G.,
            Schultz,A., Kozak,C., Lunsford,R.D., Askew,D., Weinstein,Y. et al.
  TITLE     Activation of the c-H-ras proto-oncogene by retrovirus insertion
            and chromosomal rearrangement in a Moloney leukemia virus-induced
            T-cell leukemia
  JOURNAL   J Virol 63 (7), 2959-2966 (1989)
   PUBMED   2542606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085144.1 and BC024805.1.
            
            Transcript Variant: This variant (2) uses alternate splice sites in
            the 5' UTR compared to variant 1. Variants 1 and 2 encode the same
            protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024805.1, SRR13862062.16466.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK085144.1         2-5
            5-2179              BC024805.1         1-2175
            2180-2941           AK085144.1         2319-3080
            2942-3419           AK085144.1         3082-3559
FEATURES             Location/Qualifiers
     source          1..3419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.55 cM"
     gene            1..3419
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /note="zinc finger protein 426"
                     /db_xref="GeneID:235028"
                     /db_xref="MGI:MGI:1920248"
     exon            1..49
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            50..115
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            116..223
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            224..345
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1973
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 68, related sequence 1"
                     /codon_start=1
                     /product="zinc finger protein 426 isoform 1"
                     /protein_id="NP_001103779.1"
                     /db_xref="CCDS:CCDS40544.1"
                     /db_xref="GeneID:235028"
                     /db_xref="MGI:MGI:1920248"
                     /translation="MAAPASSHGPSEDSGCLQERKIAAEMMLVDCLTDDQELVSFEDV
                     IVDFTQEEWSSLNPDQRNLYRDVMLENYQNLATVGYQLIKPSLISWLEQEEFSKGQKI
                     VFPEWKLQLETKCSAFQQEFLRGNISSRMQMQTGINRGRELCDGTQYGDFFSELSPLR
                     TDMKTQPAQDNYGCSQYRKDFLMLQRKNCAGEKLSEFSQSEETGMTPVKEKIDTQEKG
                     FECSDCGKSFMSQSHLQTHQRTHSGDKLYEWNECGRSFINSRLAVLIETLNAKKPHRC
                     KECGKGYRYPAYLNIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCSQ
                     CGKAFTQHSGLSIHVRSHTGDKPYGCKECGKAFLTSSRLIQHIRTHTGEKPFVCVKCG
                     KAFAISSNLNGHLKLHAEEKTCECKICGKAFGYLSCLNNHMRTHNAKKSYTCKECGKA
                     FNYSTHLKIHMRIHTGEKPYECKQCGKAFSHSTSFQIHERTHTGEKPYECKECGKAFI
                     CPSSFRIHEISHTHTEEKPYKCQQCGKAYSHPRSLRRHERIH"
     exon            346..428
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            429..555
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            556..636
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            637..719
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     exon            720..3419
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3021..3026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /note="hexamer: AATAAA"
     polyA_site      3043
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
                     /note="major polyA site"
     polyA_site      3267
                     /gene="Zfp426"
                     /gene_synonym="2900057C04Rik; KRAB1; mKIAA4237; Zfo61;
                     Zfp68-rs1; Znf426"
ORIGIN      
        1 tcttccggct cttatctgca ctgaagagtt gcggagttgc ctggcattca aatgaaattt
       61 tgccggagta gttggagtga tcagcgccat acaccttgcg atttcagcgc ctctgtcttg
      121 ttttcagact ggactcaggc tggccttgaa ctcccagtgt agctgaggat gacctttcgc
      181 tcatggactt cctgtttcca cttcctaagt gctgggattc caggtgacag agtgccactg
      241 tccactgaaa ttcatcagct gcactaaagc aaagcttgcc tcagtgaaag gagtattcat
      301 gcagacttct gtgttacagg atggcagctc ctgcttcgtc ccatggtcct tcagaggact
      361 caggctgcct tcaggaacga aaaatagcag cagaaatgat gttggttgat tgcctgacag
      421 atgatcagga gttagtgagc tttgaggatg tgattgtgga ctttacccaa gaggagtgga
      481 gctcactgaa cccagatcag aggaacctct acagagatgt gatgctggag aactaccaga
      541 acctggccac agtagggtat cagctcatca aacccagttt gatctcttgg ttggaacaag
      601 aagagtttag taaaggtcag aagatagttt tcccagaatg gaaattacag ctcgaaacca
      661 aatgttcagc gttccagcag gaatttctga ggggtaacat atccagtaga atgcaaatgc
      721 agacaggaat caacagagga agggagctct gtgatgggac gcaatatgga gacttcttca
      781 gtgaactctc acccctcagg acagatatga aaactcaacc tgcacaggat aattatggtt
      841 gtagtcagta cagaaaagac tttctaatgc ttcagaggaa aaactgtgct ggtgagaaac
      901 tttctgagtt cagtcagagt gaagaaaccg gcatgacccc agttaaagag aaaattgata
      961 cacaagagaa agggtttgaa tgcagcgact gtgggaagtc ctttatgagc cagtcacacc
     1021 ttcagacaca ccagagaact cacagtggag acaaacttta tgaatggaat gagtgtggga
     1081 gaagttttat aaactcaaga cttgctgtgc ttatagaaac tctcaatgca aagaaacctc
     1141 acagatgtaa ggaatgtggg aaaggctatc gatatcctgc atatctaaat attcacatgc
     1201 gaacccacac tggcgaaaag ccctatgaat gtaaggagtg tgggaaagcc ttcaattatt
     1261 ccaattcatt tcagatccat ggaagaactc acacaggaga gaagccctat gtatgtagtc
     1321 agtgtgggaa agccttcact cagcactcag gtcttagtat ccatgtaagg tctcacactg
     1381 gagacaagcc ctatgggtgt aaggagtgcg ggaaagcctt tcttacgtcc tctcgactga
     1441 tccaacatat aagaactcac acaggagaga agccttttgt gtgtgtgaaa tgtgggaaag
     1501 cctttgctat ttcttccaac cttaatgggc atctgaagtt gcatgctgaa gagaagacct
     1561 gtgagtgcaa gatttgtggg aaagcatttg gatatctttc atgtcttaat aaccacatga
     1621 gaactcacaa tgctaaaaaa tcatacacgt gcaaggaatg tgggaaggcc tttaactatt
     1681 ccacccacct taaaattcac atgcgaatcc acactggaga aaaaccctat gagtgtaaac
     1741 agtgtgggaa agccttcagt cactccactt catttcagat ccatgaaaga acccacactg
     1801 gagagaagcc ctatgaatgt aaggagtgtg ggaaagcctt catctgtccc agttccttca
     1861 ggattcatga aataagtcac acccacactg aagagaaacc ctataagtgt cagcagtgtg
     1921 gaaaagccta cagtcatcct cgttcacttc gcagacatga aagaattcac tagagagaag
     1981 cctaattgat ggaagcaatg tgaggaagcc cttgtttgtg ctcatgtact ttgaagacat
     2041 gatggtactc acactgggga gaaactatga aaattagata cttagcttag agcagtgctg
     2101 tgttgccata ctgagcaaca caaatactcc atgtcaaaaa aattaaagtg gatgctggca
     2161 agatagctca gtgggtaaaa gcacttgatg gaaatgtctg acagcttgaa tctgacccac
     2221 actcacgtaa atcagacaga tgtagtggca tgcatctgta ttctcagcat tcctacaaga
     2281 tcacctgcaa ccttgcaggc cagctagttt atgtagcatg gcagagagga agactgactc
     2341 aacaaggtag aagatttaat gccttaaagt tgacctctca tctccatgtt tctgcccacc
     2401 ctcctacata taccacagta ataaaaaaaa atgttttttc aaacaaaagc attctccata
     2461 cactcctgac tacccatttt ctatccctga atcccacatt gtaaagagag aattggctcc
     2521 taaaaagctg ccctctgacc tccacatgaa tgctgtggca tgcactcccc ccaataatag
     2581 tacattttaa aaattcaagt gagggactgc agagatgatt gaaatagtta caggcacctg
     2641 ctgtactttc agagagccag gcttcagttc ccagcactca catggtagct tgtagccatt
     2701 cataactagg tgaaggggat ttgggcccct tctggcctct gtgatcactc agcatacaca
     2761 tgagtgcata tgtgcaggca aaccatgtat aaaataaaaa taataaaaag caaatgaggt
     2821 tgccatgagt ccattagaag tgactaatgt cctcaagagg ttaagatgct gcaggatgca
     2881 cacagagaag accatggaaa cttcagacag ccttctgcaa atggagacaa gtggctacca
     2941 caagtgtttc tactaaggcc tccagaggga aactacctga attatgctga tctctgattt
     3001 ccagctgcca gattgtaaga aataaataac catgtttaag ttactggtct atgactttgc
     3061 tgcattaact ctaacaaatt gtgtgtgtaa ggagagaact gacttccaca aactgtcctc
     3121 tagtctccat gaatacacac tggcatattg gcttatgcac acacacgtga gaaaaaaagc
     3181 ctagatttta aagttatttg tcctgcattc tcaaccattc tattattttt gaagtcagta
     3241 attgaaaagg agtgaccttt tggaggagtc ttgttgcctt gtttttgttt tgtggtttta
     3301 ttttgttgtt tatttgtttt aagataaggt ttctcaatgt agccccgtct ttctgtctgt
     3361 cctggaactt gctattgatc tgcttgtgtt tctaagctgt gatttacata tgtggttgg
//
