LOCUS       NM_033327               4916 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger protein 423 (Zfp423), transcript variant
            1, mRNA.
ACCESSION   NM_033327 XM_912080 XM_922241 XM_922246 XM_922251
VERSION     NM_033327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4916)
  AUTHORS   Roth,L., Hoffmann,A., Hagemann,T., Wagner,L., Strehlau,C.,
            Sheikh,B., Donndorf,L., Ghosh,A., Noe,F., Wolfrum,C., Krohn,K.,
            Weiner,J., Heiker,J.T., Kloting,N., Stumvoll,M., Tonjes,A.,
            Bluher,M., Mittag,J. and Krause,K.
  TITLE     Thyroid hormones are required for thermogenesis of beige adipocytes
            induced by Zfp423 inactivation
  JOURNAL   Cell Rep 43 (12), 114987 (2024)
   PUBMED   39580797
REFERENCE   2  (bases 1 to 4916)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   3  (bases 1 to 4916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4916)
  AUTHORS   Roth,L., Johann,K., Hones,G.S., Oelkrug,R., Wagner,L., Hoffmann,A.,
            Krohn,K., Moeller,L.C., Weiner,J., Heiker,J.T., Kloting,N.,
            Tonjes,A., Stumvoll,M., Bluher,M., Mittag,J. and Krause,K.
  TITLE     Thyroid hormones regulate Zfp423 expression in regionally distinct
            adipose depots through direct and cell-autonomous action
  JOURNAL   Cell Rep 42 (2), 112088 (2023)
   PUBMED   36753417
  REMARK    GeneRIF: Thyroid hormones regulate Zfp423 expression in regionally
            distinct adipose depots through direct and cell-autonomous action.
REFERENCE   5  (bases 1 to 4916)
  AUTHORS   Shao,M., Zhang,Q., Truong,A., Shan,B., Vishvanath,L., Li,L.,
            Seale,P. and Gupta,R.K.
  TITLE     ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes
  JOURNAL   Genes Dev 35 (21-22), 1461-1474 (2021)
   PUBMED   34620682
  REMARK    GeneRIF: ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes.
REFERENCE   6  (bases 1 to 4916)
  AUTHORS   Warming,S., Liu,P., Suzuki,T., Akagi,K., Lindtner,S.,
            Pavlakis,G.N., Jenkins,N.A. and Copeland,N.G.
  TITLE     Evi3, a common retroviral integration site in murine B-cell
            lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein
  JOURNAL   Blood 101 (5), 1934-1940 (2003)
   PUBMED   12393497
REFERENCE   7  (bases 1 to 4916)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 4916)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4916)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 4916)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ180174.1, AK122365.1, BU519630.1, BB788751.1 and BF021428.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_922241.1, XM_922246.1, XM_922251.1, XM_912080.1, NM_033327.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079586.1, AY256893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BQ180174.1         53-86
            35-4061             AK122365.1         1-4027
            4062-4071           BU519630.1         285-294
            4072-4558           AK122365.1         4038-4524
            4559-4762           BB788751.1         236-439
            4763-4807           AK122365.1         4729-4773
            4808-4916           BF021428.1         1-109               c
FEATURES             Location/Qualifiers
     source          1..4916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.29 cM"
     gene            1..4916
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /note="zinc finger protein 423"
                     /db_xref="GeneID:94187"
                     /db_xref="MGI:MGI:1891217"
     exon            1..400
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..4239
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /note="isoform 1 is encoded by transcript variant 1; early
                     B-cell factor associated zinc finger protein;
                     olf1/EBF-associated zinc finger protein; smad- and
                     Olf-interacting zinc finger protein; zinc finger protein
                     104; early B-cell factor associated zinc finger
                     transcription factor"
                     /codon_start=1
                     /product="zinc finger protein 423 isoform 1"
                     /protein_id="NP_201584.2"
                     /db_xref="CCDS:CCDS52627.1"
                     /db_xref="GeneID:94187"
                     /db_xref="MGI:MGI:1891217"
                     /translation="MSRRKQAKPRSVKVEEGEASDFSLAWDSSVAAAGGLEGEPECDR
                     KTSRALEDRNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDG
                     DDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSY
                     LKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLK
                     IHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYC
                     EDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCP
                     MCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTP
                     DSTLKPLRGQKKMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHT
                     CQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIR
                     VSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVVQPTQS
                     FMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPK
                     RQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQ
                     ESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSK
                     VSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETF
                     STEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFDAAAENGTANGVPPT
                     STKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRL
                     RDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPIC
                     GERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRC
                     VVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLV
                     RLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESH
                     MQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGI
                     NHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQ
                     EDKIYDCSQCPQKFFFQTELQNHTMSQHAQ"
     exon            401..460
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            461..661
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            662..3876
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3961
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4093
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4209
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4907
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4881..4886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /note="hexamer: AATAAA"
     polyA_site      4907
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tttttttttt ttttgcataa ctcggctcgg ccgagtggcc tccggactcc
       61 ccgcgccgct gggaccgccg ctgggacccg gagcccccgg ctgccgcatt gcaacaggca
      121 gggccccggc gcgccccccg ggcctccccc ggtcccccag cggcctgggc cgtccagggc
      181 tgtcccctac agggaggctg cccgggacct gcggtccgtt ccttacggcc gccgacccgg
      241 ctgcaaaaaa caaagtttcc gagaggcagg aggagaaggg ggagaagggc tgcccggagc
      301 ggcggggggc ggtgcgggga gccgaccgcg gacggcgacg gagcgcccgg agccccggac
      361 atgtccaggc ggaagcaggc gaagccgcga tcggtgaaag ttgaagaggg ggaggcctcg
      421 gacttctcgc tggcctggga ttcctctgtg gcagcagcag gaggcctgga aggagagcca
      481 gagtgtgatc ggaaaaccag ccgtgcgctg gaagacagga acagcgtgac aagtcaagag
      541 gagagaaatg aggacgatga agacgtggaa gatgagtcaa tttacacctg cgatcactgt
      601 cagcaggact tcgagtctct ggcagacctg acggaccacc gggcccaccg ctgtcctgga
      661 gatggtgatg acgacccaca gctctcctgg gtggcttcat ctccctccag caaggatgtt
      721 gcgtcaccta cgcagatgat aggagatggt tgtgacctcg gcctcggcga ggaggaaggc
      781 ggcaccggcc tgccctaccc ttgccagttc tgcgacaagt ccttcatccg cctgagctac
      841 ttgaagaggc atgaacagat ccacagcgac aagctgccgt tcaagtgcac cttctgcagc
      901 cgcctcttca aacacaagag gagccgagac cggcacatca agctgcacac gggcgacaag
      961 aagtaccact gtcacgagtg cgaggcagct ttctcccgca gcgaccacct caagatccac
     1021 ctgaagaccc acagctccag caagccgttc aagtgcagcg tgtgcaagcg cggcttctcc
     1081 tccaccagct ccctgcagag ccacatgcag gcccacaaga agaacaagga acacctggcc
     1141 aagtcggaga aggaagccaa gaaggacgac ttcatgtgcg actactgcga ggataccttt
     1201 agccagacag aggagctgga gaagcacgtg ctcaccctcc acccgcagct ctcagagaag
     1261 gcggatctac agtgcatcca ctgcccagag gtctttgttg atgagagcac gctgcttgcc
     1321 cacatccacc aagcccacgc caaccagaaa cacaagtgcc ccatgtgccc tgagcagttc
     1381 tcctctgtgg agggtgtgta ctgccacctg gacagccacc ggcagcccga ctccagtaac
     1441 cacagcgtca gccctgaccc tgtgctgggc agtgtggctt ccatgagcag tgctacacct
     1501 gactccagcg cctctgtgga gcgcgggtcc acgccagact ccaccttgaa gccactgagg
     1561 gggcagaaga agatgcggga tgatgggcag agctggccca aggtcgtcta cagctgcccc
     1621 tattgttcta agcgggactt taccagcctg gctgtgctag agattcatct gaagaccatt
     1681 cacgcggata aacctcagca gagtcacacg tgtcagatct gccttgactc catgcccacg
     1741 ctctacaacc tcaatgagca tgtgcgcaag ctgcacaaga gccacgccta ccccgtcatg
     1801 cagtttggca acatctctgc cttccactgc aactactgcc ccgagatgtt tgctgacatc
     1861 aacagcctgc aggagcacat tcgagtctcg cactgtggcc ccaatgccaa cccccctgat
     1921 gggaataatg ctttcttctg caaccagtgc tccatgggct tcctcaccga gtcctcgctc
     1981 acagagcaca tccaacaggc gcattgcagt gtggggagca ccaagctgga gtctcctgtt
     2041 gttcagccca cacagtcctt catggaggtc tactcctgcc cttactgtac caactcccct
     2101 atctttggct ccatcctgaa gctcactaaa cacattaaag agaaccacaa gaacatcccg
     2161 ctggcacaca gcaagaagtc caaggctgag cagagcccag tctcctccga cgtcgaggtg
     2221 tcttccccga aacgacagcg cctctcgggg agcgccaact ccatctctaa tggcgagtac
     2281 ccctgcaatc agtgcgacct caagttctcc aacttcgaga gcttccagac ccacctgaag
     2341 ctgcacctgg agctgctgct tcggaaacag gcctgccccc agtgcaaaga ggacttcgac
     2401 tctcaggagt ccctcctgca gcatctgacg gtgcattaca tgactacatc cacccactac
     2461 gtgtgcgaga gctgtgacaa gcagttctcc tcggtggatg acctacagaa gcacctgctg
     2521 gacatgcaca cctttgtgct ataccactgc acgctgtgtc aggaggtctt cgactccaag
     2581 gtgtccatcc aggtgcacct ggccgtgaag cacagcaacg agaagaagat gtaccgctgc
     2641 acagcctgca actgggactt ccgcaaggag gctgacctgc aggtgcacgt caaacacagc
     2701 cacctcggca acccggccaa ggcccacaag tgcatcttct gcggcgagac cttcagcacc
     2761 gaggtggagc tgcagtgcca catcaccaca cacagcaaga agtacaactg caggttctgc
     2821 agcaaggcct tccatgccgt catcctgctg gagaagcacc tgcgggagaa gcactgcgtg
     2881 tttgacgctg ccgcggagaa tggcacggcc aacggggtgc cccccacctc caccaagaag
     2941 gcagagcccg ccgacctgca gggcatgctg ctcaagaatc ctgaggcgcc gaacagccac
     3001 gaggccagtg aggatgacgt ggacgcatca gagcccatgt atggctgtga catctgcggt
     3061 gcagcctaca ccatggaggt gttgctgcag aaccaccgcc tccgggatca caacatccgg
     3121 cccggcgagg acgacggctc acgcaagaag gcagaattca taaagggcag ccataagtgt
     3181 aacgtgtgct ctcggacttt cttctcggag aacgggctcc gggaacacct gcagacgcac
     3241 cggggccctg ccaagcacta catgtgtccc atctgtggcg agcgcttccc ctcgctgctg
     3301 acactcaccg agcacaaggt gacccacagc aagagtctgg acacgggcac ctgtcgcatc
     3361 tgcaaaatgc cactgcagag tgaggaggag ttcattgagc actgccagat gcaccccgac
     3421 ttacggaact ccctcaccgg cttccgctgt gtggtctgta tgcagactgt cacctcgacg
     3481 ctggaactca agatccatgg cacctttcac atgcagaagc tggctggcag ctcagctgcc
     3541 tcctccccca atggccaggg actgcagaag ctctacaaat gcgccctgtg cctcaaagag
     3601 ttccgtagca agcaggacct ggtcaggctt gatgtcaatg ggctgcccta tggcctgtgt
     3661 gccggctgca tggcccggag tgccaatgga caggtgggtg gcctggcccc acccgaacct
     3721 gctgaccggc cctgtgccgg cctccgctgc cctgaatgta acgtgaagtt cgagagtgct
     3781 gaggacctgg agagccacat gcaggtggac caccgtgatc ttacaccaga gaccagtggg
     3841 ccccggaaag gtgcccagac gtcaccagtg cccaggaaga agacgtacca gtgtatcaag
     3901 tgccagatga cgttcgagaa cgagagagag attcagatcc acgtcgccaa ccacatgatc
     3961 gaggaaggca ttaaccatga gtgtaaactg tgcaaccaga tgttcgactc cccagccaag
     4021 ctcctctgcc acctcattga gcacagcttc gagggcatgg gcggtacctt caagtgcccc
     4081 gtctgcttca cagtcttcgt ccaggccaac aagctgcaac agcatatctt tgccgtgcac
     4141 gggcaggagg acaaaatcta cgactgctcg cagtgcccac agaagttttt cttccagaca
     4201 gagttgcaga accacacgat gagccagcac gcacagtgag ggacctcgcg acaggacacc
     4261 tctccgcaga aggcttgccg gagacgccgt ggggagggcc atttgaacat tacatccaat
     4321 caaagtgtca tttgcaaccc agatgtaaaa ctctaatgat ttggccatga ggcgctgcta
     4381 ttataagcag ctggaaatga atattaatgg cagagattaa aagtattcca tgctcagtgt
     4441 ttttattgtc ctgctccagc tagtgtgctt ttagagtttt cgccgcagac tacatttcta
     4501 gtgttagaga aacctgcttt ttgaggctat tgtcctttgt tccttcatgt attatattaa
     4561 tagttttttt tttaaggatt agtgtgattt tttttttgct tcttttctat ttctttcttg
     4621 tttttctttc tccccccccc ccccttcagt taactacttt ttaattgcaa ttctaggtaa
     4681 ttgtgcatcg tgatgtgatt gcttggctat tgtctgaata tttcctttta attttttaat
     4741 taaagactaa tgctttgatt ggatttgcca gttcaccgga cagtgattaa aactctgtaa
     4801 tgaatataat cggtttccgt gcaactggat ggtctgcttt taaatgtgac ttgatctgac
     4861 tgcagtaact agttcagctc aataaaggga atccatgcga tcagcaaaaa aaaaaa
//
